100+ datasets found
  1. Table1_Formulation and Development of Transferrin Targeted Solid Lipid...

    • frontiersin.figshare.com
    • datasetcatalog.nlm.nih.gov
    docx
    Updated Jun 3, 2023
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    Geeta S. Bhagwat; Rajani B. Athawale; Rajeev P. Gude; Shadab Md; Nabil A. Alhakamy; Usama A. Fahmy; Prashant Kesharwani (2023). Table1_Formulation and Development of Transferrin Targeted Solid Lipid Nanoparticles for Breast Cancer Therapy.DOCX [Dataset]. http://doi.org/10.3389/fphar.2020.614290.s001
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    docxAvailable download formats
    Dataset updated
    Jun 3, 2023
    Dataset provided by
    Frontiers Mediahttp://www.frontiersin.org/
    Authors
    Geeta S. Bhagwat; Rajani B. Athawale; Rajeev P. Gude; Shadab Md; Nabil A. Alhakamy; Usama A. Fahmy; Prashant Kesharwani
    License

    Attribution 4.0 (CC BY 4.0)https://creativecommons.org/licenses/by/4.0/
    License information was derived automatically

    Description

    Breast cancer is conventionally treated by surgery, chemotherapy and radiation therapy followed by post operational hormonal therapy. Tamoxifen citrate is a best option to treat breast cancer because its selective estrogen receptor modulation activity. Owing to its antiestrogenic action on breast as well as uterine cells, Tamoxifen citrate shows uterine toxicity. The dose 20 mg per day of Tamoxifen citrate required to show therapeutic effect causes side effects and toxicity to vital organs such as liver, kidney and uterus. In the present study, transferrin-conjugated solid lipid nanoparticles (SLNs) were successfully prepared to enhance the active targeting of tamoxifen citrate in breast cancer. Developed formulations were evaluated for particle size, surface charge, surface morphology and in vitro dissolution studies. Developed formulations exhibited more cytotoxicity as compared to pure Tamoxifen citrate solution in time as well as concentration dependent manner on human breast cancer MCF-7 cells. Further, cell uptake and flow cytometry studies confirmed the qualitative uptake of developed D-SLN and SMD-SLN by human breast cancer MCF-7 cells. Overall, proposed study highlights that transferrin engineered nanocarriers could enhance the therapeutic response of nanomedicines for breast cancer treatment.

  2. D

    Drug Delivery in Cancer Report

    • marketresearchforecast.com
    doc, pdf, ppt
    Updated Jun 1, 2025
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    Market Research Forecast (2025). Drug Delivery in Cancer Report [Dataset]. https://www.marketresearchforecast.com/reports/drug-delivery-in-cancer-153543
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    doc, ppt, pdfAvailable download formats
    Dataset updated
    Jun 1, 2025
    Dataset authored and provided by
    Market Research Forecast
    License

    https://www.marketresearchforecast.com/privacy-policyhttps://www.marketresearchforecast.com/privacy-policy

    Time period covered
    2025 - 2033
    Area covered
    Global
    Variables measured
    Market Size
    Description

    Discover the booming drug delivery in cancer market, projected to reach $27.4 Billion by 2033. Explore key drivers, trends, and leading companies shaping this rapidly evolving landscape of targeted therapies and innovative delivery systems. Learn about market size, growth rate, and regional analysis.

  3. w

    Global Nano Therapy Market Research Report: By Application (Cancer Therapy,...

    • wiseguyreports.com
    Updated Aug 15, 2025
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    (2025). Global Nano Therapy Market Research Report: By Application (Cancer Therapy, Cardiovascular Therapy, Neurological Therapy, Infectious Disease Therapy), By Product Type (Nanoparticles, Nanocarriers, Nanosheets, Nanorobots), By End User (Hospitals, Research Institutions, Pharmaceutical Companies), By Technology (Targeted Drug Delivery, Diagnostic Imaging, Gene Therapy) and By Regional (North America, Europe, South America, Asia Pacific, Middle East and Africa) - Forecast to 2035 [Dataset]. https://www.wiseguyreports.com/reports/nano-therapy-market
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    Dataset updated
    Aug 15, 2025
    License

    https://www.wiseguyreports.com/pages/privacy-policyhttps://www.wiseguyreports.com/pages/privacy-policy

    Time period covered
    Aug 1, 2025
    Area covered
    Global
    Description
    BASE YEAR2024
    HISTORICAL DATA2019 - 2023
    REGIONS COVEREDNorth America, Europe, APAC, South America, MEA
    REPORT COVERAGERevenue Forecast, Competitive Landscape, Growth Factors, and Trends
    MARKET SIZE 20244,400(USD Million)
    MARKET SIZE 20254,800(USD Million)
    MARKET SIZE 203510.5(USD Billion)
    SEGMENTS COVEREDApplication, Product Type, End User, Technology, Regional
    COUNTRIES COVEREDUS, Canada, Germany, UK, France, Russia, Italy, Spain, Rest of Europe, China, India, Japan, South Korea, Malaysia, Thailand, Indonesia, Rest of APAC, Brazil, Mexico, Argentina, Rest of South America, GCC, South Africa, Rest of MEA
    KEY MARKET DYNAMICSincreasing prevalence of diseases, advancements in nanotechnology, rising investments in research, growing demand for targeted therapies, favorable government regulations
    MARKET FORECAST UNITSUSD Billion
    KEY COMPANIES PROFILEDEli Lilly and Company, AstraZeneca, Johnson & Johnson, Amgen, Seagen, Pfizer, BristolMyers Squibb, Roche, Novartis, Sanofi, NantKwest, Stryker, Thermo Fisher Scientific, Regenesis Biomedical, Merck KGaA, NanoComposix
    MARKET FORECAST PERIOD2025 - 2035
    KEY MARKET OPPORTUNITIESInnovative drug delivery systems, Targeted cancer treatments, Nanoparticle-based vaccines, Personalized medicine advancements, Regenerative medicine applications
    COMPOUND ANNUAL GROWTH RATE (CAGR) 8.1% (2025 - 2035)
  4. N

    Novel Drug Delivery Systems for Cancer Therapy Report

    • datainsightsmarket.com
    doc, pdf, ppt
    Updated Apr 20, 2025
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    Data Insights Market (2025). Novel Drug Delivery Systems for Cancer Therapy Report [Dataset]. https://www.datainsightsmarket.com/reports/novel-drug-delivery-systems-for-cancer-therapy-1467305
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    ppt, doc, pdfAvailable download formats
    Dataset updated
    Apr 20, 2025
    Dataset authored and provided by
    Data Insights Market
    License

    https://www.datainsightsmarket.com/privacy-policyhttps://www.datainsightsmarket.com/privacy-policy

    Time period covered
    2025 - 2033
    Area covered
    Global
    Variables measured
    Market Size
    Description

    The global market for novel drug delivery systems in cancer therapy is experiencing robust growth, driven by the increasing prevalence of cancer, the limitations of traditional chemotherapy, and the rising demand for targeted therapies with minimized side effects. The market, estimated at $15 billion in 2025, is projected to witness a Compound Annual Growth Rate (CAGR) of 12% from 2025 to 2033, reaching approximately $45 billion by 2033. This expansion is fueled by several key factors. Firstly, advancements in nanotechnology and biotechnology are leading to the development of innovative drug delivery systems, such as liposomes, nanoparticles, and microspheres, which enhance drug efficacy and reduce toxicity. Secondly, the growing adoption of personalized medicine is further driving market growth, as tailored drug delivery approaches allow for more precise targeting of cancerous cells, resulting in improved patient outcomes. Finally, increased research and development funding, coupled with strategic partnerships between pharmaceutical companies and biotechnology firms, is accelerating the commercialization of novel drug delivery systems. The market is segmented by application (hospitals, clinics, others) and type (various embolization particles, liquid embolics, etc.), with embolization particles currently dominating due to their widespread use in interventional oncology. Significant regional variations exist, with North America currently holding the largest market share due to high healthcare expenditure and advanced medical infrastructure. However, rapidly growing economies in Asia-Pacific, particularly in China and India, are expected to witness substantial growth in the coming years, presenting lucrative opportunities for market players. Challenges remain, including regulatory hurdles for novel drug approvals, high development costs, and the need for robust clinical trial data to demonstrate efficacy and safety. Despite these challenges, the long-term outlook for the novel drug delivery systems market in cancer therapy remains exceptionally positive, driven by continuous innovation, increasing demand for effective cancer treatments, and favorable government regulations supporting the development and adoption of these advanced technologies. This growth will likely be further stimulated by the continuous development of novel drug formulations and delivery methods that enhance efficacy and reduce adverse effects for various cancer types.

  5. f

    Table_1_Ditelluride-Bridged PEG-PCL Copolymer as Folic Acid-Targeted and...

    • frontiersin.figshare.com
    docx
    Updated Jun 3, 2023
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    Zekun Pang; Jiayan Zhou; Chunyang Sun (2023). Table_1_Ditelluride-Bridged PEG-PCL Copolymer as Folic Acid-Targeted and Redox-Responsive Nanoparticles for Enhanced Cancer Therapy.DOCX [Dataset]. http://doi.org/10.3389/fchem.2020.00156.s001
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    docxAvailable download formats
    Dataset updated
    Jun 3, 2023
    Dataset provided by
    Frontiers
    Authors
    Zekun Pang; Jiayan Zhou; Chunyang Sun
    License

    Attribution 4.0 (CC BY 4.0)https://creativecommons.org/licenses/by/4.0/
    License information was derived automatically

    Description

    The development of the nanosized delivery systems with targeting navigation and efficient cargo release for cancer therapy has attracted great attention in recent years. Herein, a folic acid (FA) modified PEGylated polycaprolactone containing ditelluride linkage was synthesized through a facile coupling reaction. The hydrophobic doxorubicin (DOX) can be encapsulated into the polymeric micelles, and such nanoparticles (F-TeNPDOX) exhibited redox-responsive drug release under abundant glutathione (GSH) condition due to the degradation of ditelluride bonds. In addition, flow cytometric analyses showed that the FA ligands on F-TeNPDOX could facilitate their cellular uptake in 4T1 breast cancer cells. Therefore, F-TeNPDOX led to the promoted drug accumulation and enhanced growth inhibition on 4T1 tumor in vivo. The obtained results suggest F-TeNPDOX excellent potential as nanocarriers for anticancer drug delivery.

  6. New Strategy for the Development of Targeted Drug Delivery Systems in Cancer...

    • zenodo.org
    • data.niaid.nih.gov
    Updated Sep 13, 2022
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    Balázs Vári; Levente Dókus; Adina Borbély; Anikó Gaál; Diána Vári-Mező; Ivan Ranđelović; Zoltán Varga; Norbert Szoboszlai; Gábor Mező; József Tóvári; Balázs Vári; Levente Dókus; Adina Borbély; Anikó Gaál; Diána Vári-Mező; Ivan Ranđelović; Zoltán Varga; Norbert Szoboszlai; Gábor Mező; József Tóvári (2022). New Strategy for the Development of Targeted Drug Delivery Systems in Cancer Therapy [Dataset]. http://doi.org/10.5281/zenodo.7075436
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    Dataset updated
    Sep 13, 2022
    Dataset provided by
    Zenodohttp://zenodo.org/
    Authors
    Balázs Vári; Levente Dókus; Adina Borbély; Anikó Gaál; Diána Vári-Mező; Ivan Ranđelović; Zoltán Varga; Norbert Szoboszlai; Gábor Mező; József Tóvári; Balázs Vári; Levente Dókus; Adina Borbély; Anikó Gaál; Diána Vári-Mező; Ivan Ranđelović; Zoltán Varga; Norbert Szoboszlai; Gábor Mező; József Tóvári
    Description

    Rare dataset of the experiments performed during the investigation of our newly developed SREKA pentapeptide, and its use for liposome preparation.

  7. N

    Nanoparticle Drug Delivery Systems Report

    • archivemarketresearch.com
    doc, pdf, ppt
    Updated Aug 16, 2025
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    Archive Market Research (2025). Nanoparticle Drug Delivery Systems Report [Dataset]. https://www.archivemarketresearch.com/reports/nanoparticle-drug-delivery-systems-758988
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    pdf, doc, pptAvailable download formats
    Dataset updated
    Aug 16, 2025
    Dataset authored and provided by
    Archive Market Research
    License

    https://www.archivemarketresearch.com/privacy-policyhttps://www.archivemarketresearch.com/privacy-policy

    Time period covered
    2025 - 2033
    Area covered
    Global
    Variables measured
    Market Size
    Description

    The global nanoparticle drug delivery systems market is experiencing robust growth, projected to reach $6.109 billion in 2025 and maintain a Compound Annual Growth Rate (CAGR) of 10% from 2025 to 2033. This significant expansion is driven by several key factors. Advances in nanotechnology are enabling the development of more targeted and efficient drug delivery methods, leading to improved therapeutic efficacy and reduced side effects. The increasing prevalence of chronic diseases, such as cancer and diabetes, fuels demand for innovative drug delivery solutions that offer better patient outcomes. Furthermore, a growing research and development pipeline focusing on nanoparticle-based therapies and supportive regulatory frameworks are accelerating market growth. Major players like Johnson & Johnson, Sun Pharmaceutical, and Pfizer are heavily investing in R&D and strategic partnerships to consolidate their market positions and capitalize on emerging opportunities within this rapidly evolving sector. The market's segmentation, while not explicitly provided, is likely diverse, encompassing various nanoparticle types (e.g., liposomes, polymeric nanoparticles, solid lipid nanoparticles), drug classes, and applications (e.g., oncology, infectious diseases). Competitive intensity is high, with numerous established pharmaceutical companies and emerging biotech firms vying for market share. Regional variations in market penetration are expected, driven by factors such as healthcare infrastructure, regulatory landscapes, and disease prevalence. North America and Europe are anticipated to maintain significant market shares initially, while Asia-Pacific is projected to witness substantial growth driven by rising healthcare expenditure and increasing awareness of advanced therapies. Challenges remain, including concerns about the long-term safety and toxicity of some nanoparticle formulations, as well as regulatory hurdles and high development costs. However, ongoing innovation and regulatory clarity are expected to mitigate these challenges, sustaining the market's long-term growth trajectory.

  8. D

    Drug Delivery in Cancer Report

    • archivemarketresearch.com
    doc, pdf, ppt
    Updated Oct 31, 2025
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    Archive Market Research (2025). Drug Delivery in Cancer Report [Dataset]. https://www.archivemarketresearch.com/reports/drug-delivery-in-cancer-144421
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    doc, pdf, pptAvailable download formats
    Dataset updated
    Oct 31, 2025
    Dataset authored and provided by
    Archive Market Research
    License

    https://www.archivemarketresearch.com/privacy-policyhttps://www.archivemarketresearch.com/privacy-policy

    Time period covered
    2025 - 2033
    Area covered
    Global
    Variables measured
    Market Size
    Description

    The global market for Drug Delivery in Cancer is poised for substantial growth, estimated to reach approximately USD 25,000 million by 2025. This market is projected to expand at a Compound Annual Growth Rate (CAGR) of around 12% throughout the forecast period (2025-2033). This robust expansion is primarily driven by advancements in therapeutic technologies, increasing cancer incidence worldwide, and a growing demand for more targeted and effective cancer treatments. Key innovations in drug delivery systems, such as liposomes, PEGylated proteins and polypeptides, polymer nanoparticles, and protein-drug conjugates, are revolutionizing how cancer therapies are administered, leading to improved patient outcomes and reduced side effects. The expanding research and development efforts by leading pharmaceutical and biotechnology companies are further fueling market expansion. The market landscape for Drug Delivery in Cancer is characterized by a dynamic interplay of technological innovation and strategic collaborations among major industry players like Amgen, Roche, Pfizer, and Novartis. Hospitals and clinic settings, along with specialized cancer treatment centers, represent the dominant application segments, reflecting the primary sites of cancer therapy administration. North America is expected to lead the market due to significant investments in cancer research, a well-established healthcare infrastructure, and a high prevalence of cancer cases. However, the Asia Pacific region is anticipated to exhibit the fastest growth, driven by increasing healthcare expenditure, rising awareness of advanced treatment options, and a growing patient pool. While the market benefits from strong growth drivers, challenges such as high development costs for novel drug delivery systems and regulatory hurdles could pose minor restraints to its otherwise impressive trajectory.

  9. f

    DataSheet1_PSMA-Targeted Supramolecular Nanoparticles Prepared From...

    • frontiersin.figshare.com
    docx
    Updated Jun 4, 2023
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    Xueyan Zhang; Shaolong Qi; Dahai Liu; Jianshi Du; Jingji Jin (2023). DataSheet1_PSMA-Targeted Supramolecular Nanoparticles Prepared From Cucurbit[8]uril-Based Ternary Host–Guest Recognition for Prostate Cancer Therapy.docx [Dataset]. http://doi.org/10.3389/fchem.2022.847523.s001
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    docxAvailable download formats
    Dataset updated
    Jun 4, 2023
    Dataset provided by
    Frontiers
    Authors
    Xueyan Zhang; Shaolong Qi; Dahai Liu; Jianshi Du; Jingji Jin
    License

    Attribution 4.0 (CC BY 4.0)https://creativecommons.org/licenses/by/4.0/
    License information was derived automatically

    Description

    Nanomedicines play an important role in cancer therapy; however, some drawbacks including unsatisfactory efficacy and side effects arising from indiscriminate drug release retard their clinical applications. Although functionalization of nanomedicines through covalent interactions can improve the pharmacokinetics and efficacy of the loaded drugs, complicated and tedious synthesis greatly limits the exploration of multifunctional nanoparticles. Herein, we utilize a supramolecular strategy to design a nanomedicine for targeted drug delivery through cucurbit[8]uril-based host–guest ternary complexation and successfully prepare prostate-specific membrane antigen (PSMA)-targeted supramolecular nanoparticles encapsulating doxorubicin (DOX). In vitro studies exhibit targeted modification via noncovalent enhance anticancer efficiency of DOX due to the increased cell uptake on account of receptor-mediated endocytosis. This design provides a new strategy for the development of sophisticated drug delivery systems and holds perspective potentials in precise cancer treatments.

  10. N

    Nano Therapy Report

    • marketresearchforecast.com
    doc, pdf, ppt
    Updated Aug 8, 2025
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    Market Research Forecast (2025). Nano Therapy Report [Dataset]. https://www.marketresearchforecast.com/reports/nano-therapy-150351
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    ppt, pdf, docAvailable download formats
    Dataset updated
    Aug 8, 2025
    Dataset authored and provided by
    Market Research Forecast
    License

    https://www.marketresearchforecast.com/privacy-policyhttps://www.marketresearchforecast.com/privacy-policy

    Time period covered
    2025 - 2033
    Area covered
    Global
    Variables measured
    Market Size
    Description

    The nanotherapy market is poised for significant growth, driven by advancements in nanotechnology and the increasing prevalence of chronic diseases. The market's size in 2025 is estimated at $5 billion, reflecting a substantial increase from its value in 2019. A Compound Annual Growth Rate (CAGR) of 15% is projected from 2025 to 2033, indicating robust expansion. This growth is fueled by several key factors, including the development of targeted drug delivery systems that enhance therapeutic efficacy and minimize side effects, the rising incidence of cancer and other debilitating diseases requiring innovative treatment options, and ongoing research and development efforts leading to novel nanotherapeutic agents. Leading companies such as Nanoprobes, Nanospectra Biosciences, and Smith & Nephew are driving innovation and market expansion through their investments in research, development, and commercialization of nanotherapy products. The market segmentation is expected to be diverse, with different types of nanotherapies (e.g., liposomal drug delivery, polymeric nanoparticles, etc.) targeting various disease areas (e.g., oncology, infectious diseases, cardiovascular diseases). While regulatory hurdles and high manufacturing costs represent potential restraints, the long-term outlook remains positive. The increasing investment in nanotechnology research by both private and public sectors, coupled with a growing understanding of the therapeutic potential of nanomaterials, positions the nanotherapy market for sustained growth and a substantial impact on healthcare in the coming years. Regional variations in market penetration are anticipated, with North America and Europe expected to dominate the market initially due to advanced healthcare infrastructure and robust regulatory frameworks. However, emerging economies are projected to witness significant growth as healthcare infrastructure improves and adoption rates increase.

  11. A

    Application of Nanomedicines in Tumor Treatment Report

    • datainsightsmarket.com
    doc, pdf, ppt
    Updated Sep 28, 2025
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    Data Insights Market (2025). Application of Nanomedicines in Tumor Treatment Report [Dataset]. https://www.datainsightsmarket.com/reports/application-of-nanomedicines-in-tumor-treatment-1014704
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    ppt, pdf, docAvailable download formats
    Dataset updated
    Sep 28, 2025
    Dataset authored and provided by
    Data Insights Market
    License

    https://www.datainsightsmarket.com/privacy-policyhttps://www.datainsightsmarket.com/privacy-policy

    Time period covered
    2025 - 2033
    Area covered
    Global
    Variables measured
    Market Size
    Description

    The market for nanomedicines in tumor treatment is poised for significant expansion, driven by their unparalleled ability to target cancer cells with precision, thereby minimizing damage to healthy tissues and enhancing therapeutic efficacy. The estimated market size for nanomedicines in tumor treatment is approximately $20,000 million, with a projected Compound Annual Growth Rate (CAGR) of 12% over the forecast period (2025-2033). This robust growth is fueled by continuous advancements in nanotechnology, increasing prevalence of cancer globally, and substantial investments in research and development by leading pharmaceutical and biotechnology companies. Key drivers include the development of novel drug delivery systems that overcome biological barriers and improve drug bioavailability, alongside the growing demand for personalized medicine and targeted therapies. The market's value is projected to reach over $45,000 million by 2033, underscoring the transformative potential of nanomedicines in oncology. The competitive landscape is characterized by the presence of major global pharmaceutical players like Merck, Pfizer, Novartis, and Roche, who are actively engaged in the development and commercialization of nanomedicine-based cancer therapies. These companies are focusing on a diverse range of applications, including targeted drug delivery, immune therapy, and advanced diagnostic imaging, all aimed at improving patient outcomes. While the market benefits from strong growth drivers, restraints such as the high cost of development and manufacturing, stringent regulatory approvals, and potential long-term toxicity concerns need to be addressed. Nevertheless, ongoing innovation in nanocarrier design, such as nanoliposomes and nanoparticles, coupled with strategic collaborations and acquisitions, will continue to shape the market, leading to a paradigm shift in cancer treatment strategies. The Asia Pacific region is expected to emerge as a rapidly growing market due to increasing healthcare expenditure, a rising cancer burden, and expanding R&D activities. This report delves into the dynamic landscape of nanomedicine applications in tumor treatment, offering a detailed examination of its evolution, current state, and future trajectory. The study encompasses a broad spectrum of market dynamics, from technological innovations and regulatory landscapes to key industry players and emerging trends.

  12. f

    Targeting Anticancer Drug Delivery to Pancreatic Cancer Cells Using a...

    • datasetcatalog.nlm.nih.gov
    • plos.figshare.com
    Updated Jul 11, 2012
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    Tamura, Fumito; Sato, Yasushi; Hayashi, Tsuyoshi; Kato, Junji; Kobune, Masayoshi; Osuga, Takahiro; Iyama, Satoshi; Yoshida, Makoto; Miyanishi, Koji; Sato, Tsutomu; Takimoto, Rishu; Takada, Kohichi; Murase, Kazuyuki; Hirakawa, Masahiro (2012). Targeting Anticancer Drug Delivery to Pancreatic Cancer Cells Using a Fucose-Bound Nanoparticle Approach [Dataset]. https://datasetcatalog.nlm.nih.gov/dataset?q=0001140505
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    Dataset updated
    Jul 11, 2012
    Authors
    Tamura, Fumito; Sato, Yasushi; Hayashi, Tsuyoshi; Kato, Junji; Kobune, Masayoshi; Osuga, Takahiro; Iyama, Satoshi; Yoshida, Makoto; Miyanishi, Koji; Sato, Tsutomu; Takimoto, Rishu; Takada, Kohichi; Murase, Kazuyuki; Hirakawa, Masahiro
    Description

    Owing to its aggressiveness and the lack of effective therapies, pancreatic ductal adenocarcinoma has a dismal prognosis. New strategies to improve treatment and survival are therefore urgently required. Numerous fucosylated antigens in sera serve as tumor markers for cancer detection and evaluation of treatment efficacy. Increased expression of fucosyltransferases has also been reported for pancreatic cancer. These enzymes accelerate malignant transformation through fucosylation of sialylated precursors, suggesting a crucial requirement for fucose by pancreatic cancer cells. With this in mind, we developed fucose-bound nanoparticles as vehicles for delivery of anticancer drugs specifically to cancer cells. L-fucose-bound liposomes containing Cy5.5 or Cisplatin were effectively delivered into CA19-9 expressing pancreatic cancer cells. Excess L-fucose decreased the efficiency of Cy5.5 introduction by L-fucose-bound liposomes, suggesting L-fucose-receptor-mediated delivery. Intravenously injected L-fucose-bound liposomes carrying Cisplatin were successfully delivered to pancreatic cancer cells, mediating efficient tumor growth inhibition as well as prolonging survival in mouse xenograft models. This modality represents a new strategy for pancreatic cancer cell-targeting therapy.

  13. G

    Targeted Lipid Nanoparticles for Oncology Market Research Report 2033

    • growthmarketreports.com
    csv, pdf, pptx
    Updated Oct 7, 2025
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    Growth Market Reports (2025). Targeted Lipid Nanoparticles for Oncology Market Research Report 2033 [Dataset]. https://growthmarketreports.com/report/targeted-lipid-nanoparticles-for-oncology-market
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    pdf, csv, pptxAvailable download formats
    Dataset updated
    Oct 7, 2025
    Dataset authored and provided by
    Growth Market Reports
    Time period covered
    2024 - 2032
    Area covered
    Global
    Description

    Targeted Lipid Nanoparticles for Oncology Market Outlook




    According to our latest research, the global Targeted Lipid Nanoparticles for Oncology market size reached USD 1.23 billion in 2024, reflecting robust momentum driven by technological advancements and increasing oncology drug development. The market is projected to grow at a CAGR of 14.7% from 2025 to 2033, reaching an estimated USD 4.01 billion by 2033. This impressive growth is primarily fueled by the rising prevalence of cancer worldwide, the surge in demand for precision medicine, and the expanding adoption of lipid nanoparticle-based drug delivery systems in oncology therapeutics. As per the latest research, the market is entering a transformative phase, marked by innovation in nanoparticle engineering and a growing emphasis on targeted therapies that minimize off-target effects and enhance patient outcomes.




    One of the core growth factors propelling the Targeted Lipid Nanoparticles for Oncology market is the escalating global cancer burden. According to the World Health Organization, cancer incidence continues to rise, with over 19 million new cases diagnosed annually. This surge in cancer cases has intensified research and development efforts focused on next-generation drug delivery systems that can specifically target tumor cells while sparing healthy tissues. Lipid nanoparticles have emerged as a highly effective vehicle for encapsulating chemotherapeutic agents, nucleic acids, and immunomodulators, thereby improving therapeutic indices and reducing systemic toxicity. Furthermore, the growing body of clinical evidence supporting the efficacy and safety of lipid nanoparticle-based formulations has prompted regulatory agencies and healthcare providers to increasingly favor these advanced platforms, thus reinforcing market growth.




    Another significant driver of the Targeted Lipid Nanoparticles for Oncology market is the rapid advancement in nanotechnology and personalized medicine. With the evolution of nanostructured lipid carriers, solid lipid nanoparticles, and liposomes, pharmaceutical companies are now able to design highly customizable drug delivery systems tailored to individual patient profiles and tumor characteristics. This customization is crucial in oncology, where tumor heterogeneity often necessitates precise targeting to achieve optimal therapeutic outcomes. In addition, the emergence of gene therapy and immunotherapy as viable cancer treatment modalities has further expanded the application scope of lipid nanoparticles. These nanoparticles can efficiently deliver genetic material and immune modulators directly to tumor sites, thereby enhancing the potency of cutting-edge therapies and opening new avenues for market expansion.




    The increasing collaboration between academic research institutes, biotechnology firms, and pharmaceutical giants is also accelerating innovation within the Targeted Lipid Nanoparticles for Oncology market. Strategic partnerships and investments are enabling the translation of promising preclinical findings into clinical applications, expediting the development of novel lipid nanoparticle formulations for a wide range of cancer types. Furthermore, government initiatives and funding aimed at advancing cancer research and nanomedicine are providing a conducive environment for market growth. The integration of artificial intelligence and machine learning in nanoparticle design and screening is expected to further refine the targeting capabilities of lipid nanoparticles, thereby enhancing their therapeutic potential in oncology and contributing to sustained market expansion over the forecast period.




    From a regional perspective, North America currently dominates the Targeted Lipid Nanoparticles for Oncology market, accounting for the largest share in 2024 due to its advanced healthcare infrastructure, high R&D expenditure, and strong presence of leading pharmaceutical and biotechnology companies. Europe follows closely, driven by substantial investments in cancer research and favorable regulatory frameworks supporting nanomedicine. Meanwhile, the Asia Pacific region is witnessing the fastest growth, propelled by rising cancer incidence, increasing healthcare expenditure, and expanding clinical trial activities. Latin America and the Middle East & Africa are also experiencing steady growth, albeit from a smaller base, as awareness of advanced oncology therapies and access to innovative drug delivery systems continue to improve. This regional diversification is expected to further

  14. N

    Nanoparticle Drug Delivery System Report

    • marketreportanalytics.com
    doc, pdf, ppt
    Updated Mar 22, 2025
    + more versions
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    Market Report Analytics (2025). Nanoparticle Drug Delivery System Report [Dataset]. https://www.marketreportanalytics.com/reports/nanoparticle-drug-delivery-system-22817
    Explore at:
    ppt, pdf, docAvailable download formats
    Dataset updated
    Mar 22, 2025
    Dataset authored and provided by
    Market Report Analytics
    License

    https://www.marketreportanalytics.com/privacy-policyhttps://www.marketreportanalytics.com/privacy-policy

    Time period covered
    2025 - 2033
    Area covered
    Global
    Variables measured
    Market Size
    Description

    The global nanoparticle drug delivery system market is experiencing robust growth, driven by the increasing prevalence of chronic diseases like cancer and diabetes, coupled with the rising demand for targeted and efficient drug therapies. The market's expansion is fueled by advancements in nanotechnology, leading to the development of innovative delivery systems such as bioadhesive, magnetic, and polymeric microspheres. These systems offer superior drug bioavailability, reduced side effects, and enhanced therapeutic efficacy compared to traditional drug administration methods. The market is segmented by application (chronic disease treatment, cancer treatment, others), type (bioadhesive, magnetic, polymeric, and other microsphere systems), and geography. North America currently holds a significant market share due to advanced healthcare infrastructure, robust research and development activities, and high adoption rates of novel drug delivery technologies. However, the Asia-Pacific region is projected to witness the fastest growth in the forecast period (2025-2033), driven by rising healthcare expenditure, increasing prevalence of target diseases, and a growing awareness of advanced treatment options. While the market faces certain restraints, such as regulatory hurdles and high development costs associated with novel nanoparticle systems, the overall outlook remains positive, with significant potential for growth fueled by ongoing research and technological advancements. Key players are actively involved in research, development, and commercialization, further propelling market expansion. The competitive landscape is characterized by a mix of established pharmaceutical companies and specialized nanotechnology firms. Strategic collaborations, mergers, and acquisitions are anticipated to shape the market dynamics in the coming years. The market's future trajectory will depend on factors such as the successful clinical trials of new nanoparticle-based drugs, regulatory approvals, and the successful commercialization of innovative products. The focus on personalized medicine and the increasing adoption of targeted therapies are further expected to contribute to the market's substantial growth. Companies are actively investing in research and development to improve the efficacy and safety of nanoparticle drug delivery systems, leading to an ever-evolving landscape with numerous opportunities for innovation and growth.

  15. N

    Nanomaterials in Theranostics Report

    • archivemarketresearch.com
    doc, pdf, ppt
    Updated Jun 29, 2025
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    Archive Market Research (2025). Nanomaterials in Theranostics Report [Dataset]. https://www.archivemarketresearch.com/reports/nanomaterials-in-theranostics-142692
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    ppt, pdf, docAvailable download formats
    Dataset updated
    Jun 29, 2025
    Dataset authored and provided by
    Archive Market Research
    License

    https://www.archivemarketresearch.com/privacy-policyhttps://www.archivemarketresearch.com/privacy-policy

    Time period covered
    2025 - 2033
    Area covered
    Global
    Variables measured
    Market Size
    Description

    The nanomaterials in theranostics market is experiencing robust growth, driven by advancements in nanotechnology and the increasing demand for precise and personalized medicine. The market size in 2025 is estimated at $2.5 billion, exhibiting a Compound Annual Growth Rate (CAGR) of 5% from 2025 to 2033. This growth is fueled by several key drivers, including the development of novel nanomaterials with enhanced drug delivery capabilities, improved diagnostic imaging techniques, and the rising prevalence of chronic diseases necessitating effective theranostic solutions. The increasing adoption of targeted drug delivery systems, minimizing side effects and maximizing therapeutic efficacy, further contributes to market expansion. Various segments within this market, including different types of nanomaterials (e.g., liposomes, nanoparticles, quantum dots) and therapeutic applications (e.g., cancer treatment, cardiovascular diseases, infectious diseases), exhibit unique growth trajectories influenced by specific technological advancements and regulatory approvals. Companies such as ACS Materials, Arkema, Nanocyl, NanoIntegris, and Nanophase Technologies are actively contributing to this growth through continuous innovation and strategic partnerships. The projected CAGR of 5% indicates a steady and sustained market expansion throughout the forecast period. However, challenges such as the high cost of nanomaterial development and manufacturing, along with potential toxicity concerns related to certain nanomaterials, pose restraints to market growth. Addressing these challenges through rigorous research and development, enhanced regulatory frameworks, and improved manufacturing processes will be crucial for sustained market expansion and the wider adoption of nanomaterials in theranostics. Ongoing research focusing on biocompatibility, targeted delivery mechanisms, and improved diagnostic sensitivity will pave the way for further market growth in the coming years, potentially exceeding the projected CAGR if breakthroughs in these areas are achieved. Regional variations in market growth are expected, influenced by factors such as healthcare infrastructure, regulatory landscapes, and the prevalence of target diseases.

  16. N

    NDDS Cancer Therapy Report

    • datainsightsmarket.com
    doc, pdf, ppt
    Updated Oct 25, 2025
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    Data Insights Market (2025). NDDS Cancer Therapy Report [Dataset]. https://www.datainsightsmarket.com/reports/ndds-cancer-therapy-581559
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    doc, ppt, pdfAvailable download formats
    Dataset updated
    Oct 25, 2025
    Dataset authored and provided by
    Data Insights Market
    License

    https://www.datainsightsmarket.com/privacy-policyhttps://www.datainsightsmarket.com/privacy-policy

    Time period covered
    2025 - 2033
    Area covered
    Global
    Variables measured
    Market Size
    Description

    The Nanoparticle Drug Delivery Systems (NDDS) for Cancer Therapy market is poised for significant expansion, projected to reach a robust market size of approximately $25,000 million by 2025. This growth is fueled by a compound annual growth rate (CAGR) of around 15%, indicating a dynamic and evolving landscape. The value unit is in millions, underscoring the substantial financial investment and revenue potential within this sector. Key drivers of this market include the escalating global cancer incidence, the increasing demand for targeted and personalized cancer treatments, and the continuous advancements in nanotechnology that enable more effective drug delivery. The inherent limitations of traditional chemotherapy, such as systemic toxicity and poor bioavailability, are driving the adoption of NDDS, which offer improved therapeutic efficacy with reduced side effects. Furthermore, significant investments in research and development by leading pharmaceutical and biotechnology companies are accelerating the innovation pipeline for novel NDDS-based cancer therapies. The market is characterized by a diverse range of applications, with hospitals and clinics serving as primary end-users, accounting for a substantial share of the market. The 'Others' segment, likely encompassing research institutions and specialized treatment centers, is also expected to witness steady growth. On the product type front, Embolization Particles and Liquid Embolic formulations are currently dominant, driven by their established efficacy in interventional radiology procedures. However, Nanoparticles are rapidly gaining traction due to their versatility and potential for advanced drug targeting and combination therapies. Restraints such as the high cost of development and manufacturing, stringent regulatory hurdles, and the need for extensive clinical validation are present challenges. Nevertheless, the overarching trend towards precision medicine, coupled with growing patient and physician awareness of NDDS benefits, is expected to overcome these limitations and propel the market forward, particularly in regions like North America and Europe, which are at the forefront of technological adoption and healthcare innovation. This comprehensive report delves into the dynamic landscape of Nanoparticle Drug Delivery Systems (NDDS) for cancer therapy, projecting a significant market expansion from the historical period of 2019-2024 through to 2033. Our analysis, anchored by 2025 as the base and estimated year, forecasts a robust trajectory, with projections extending throughout the forecast period of 2025-2033. The study meticulously examines market dynamics, key players, technological advancements, and the evolving regulatory environment, offering invaluable insights for stakeholders seeking to capitalize on this rapidly developing sector.

  17. f

    Table2_Drug-loaded PEG-PLGA nanoparticles for cancer treatment.XLSX

    • frontiersin.figshare.com
    xlsx
    Updated Jun 16, 2023
    + more versions
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    Dan Zhang; Lin Liu; Jian Wang; Hong Zhang; Zhuo Zhang; Gang Xing; Xuan Wang; Minghua Liu (2023). Table2_Drug-loaded PEG-PLGA nanoparticles for cancer treatment.XLSX [Dataset]. http://doi.org/10.3389/fphar.2022.990505.s002
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    xlsxAvailable download formats
    Dataset updated
    Jun 16, 2023
    Dataset provided by
    Frontiers
    Authors
    Dan Zhang; Lin Liu; Jian Wang; Hong Zhang; Zhuo Zhang; Gang Xing; Xuan Wang; Minghua Liu
    License

    Attribution 4.0 (CC BY 4.0)https://creativecommons.org/licenses/by/4.0/
    License information was derived automatically

    Description

    Nanoparticles based on single-component synthetic polymers, such as poly (lactic acid-co-glycolic acid) (PLGA), have been extensively studied for antitumor drug delivery and adjuvant therapy due to their ability to encapsulate and release drugs, as well as passively target tumors. Amphiphilic block co-polymers, such as polyethylene glycol (PEG)-PLGA, have also been used to prepare multifunctional nanodrug delivery systems with prolonged circulation time and greater bioavailability that can encapsulate a wider variety of drugs, including small molecules, gene-targeting drugs, traditional Chinese medicine (TCM) and multi-target enzyme inhibitors, enhancing their antitumor effect and safety. In addition, the surface of PEG-PLGA nanoparticles has been modified with various ligands to achieve active targeting and selective accumulation of antitumor drugs in tumor cells. Modification with two ligands has also been applied with good antitumor effects, while the use of imaging agents and pH-responsive or magnetic materials has paved the way for the application of such nanoparticles in clinical diagnosis. In this work, we provide an overview of the synthesis and application of PEG-PLGA nanoparticles in cancer treatment and we discuss the recent advances in ligand modification for active tumor targeting.

  18. D

    Targeted Lipid Nanoparticles For Oncology Market Research Report 2033

    • dataintelo.com
    csv, pdf, pptx
    Updated Oct 1, 2025
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    Dataintelo (2025). Targeted Lipid Nanoparticles For Oncology Market Research Report 2033 [Dataset]. https://dataintelo.com/report/targeted-lipid-nanoparticles-for-oncology-market
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    csv, pdf, pptxAvailable download formats
    Dataset updated
    Oct 1, 2025
    Dataset authored and provided by
    Dataintelo
    License

    https://dataintelo.com/privacy-and-policyhttps://dataintelo.com/privacy-and-policy

    Time period covered
    2024 - 2032
    Area covered
    Global
    Description

    Targeted Lipid Nanoparticles for Oncology Market Outlook



    As per our latest research, the global market size for Targeted Lipid Nanoparticles for Oncology reached USD 1.87 billion in 2024, with a robust year-on-year growth trajectory. The market is currently advancing at a CAGR of 13.2% and is projected to attain a value of USD 5.23 billion by 2033. This impressive growth is primarily driven by the increasing adoption of lipid nanoparticle-based drug delivery systems in oncology, fueled by technological advancements and the urgent demand for more effective, targeted cancer therapies. The evolving landscape of personalized medicine and the integration of nanotechnology in cancer therapeutics are further catalyzing market expansion.




    One of the primary growth factors for the Targeted Lipid Nanoparticles for Oncology market is the rising global cancer burden. According to the World Health Organization, cancer remains a leading cause of morbidity and mortality worldwide, with millions of new cases diagnosed each year. This escalating incidence has intensified the need for innovative, targeted therapies that can improve efficacy while minimizing adverse effects. Lipid nanoparticles (LNPs) have emerged as a promising solution, offering enhanced drug solubility, stability, and precision targeting of tumor cells. Their ability to encapsulate a wide range of therapeutic agents, including chemotherapeutics, nucleic acids, and immunomodulators, positions them as a critical technology in the fight against cancer, driving substantial investments and research activities in this sector.




    Another significant driver is the evolution of nanotechnology and its integration into oncology therapeutics. Advances in lipid nanoparticle engineering have enabled the development of formulations with improved biocompatibility, controlled release profiles, and tumor-specific targeting capabilities. The rise of gene therapies and RNA-based drugs, such as siRNA and mRNA, has further highlighted the utility of LNPs as efficient delivery vehicles, particularly in overcoming biological barriers and enhancing intracellular uptake. This technological progress has not only expanded the therapeutic arsenal available to oncologists but has also attracted considerable funding from both public and private sectors, accelerating the pace of clinical translation and commercialization of lipid nanoparticle-based oncology treatments.




    Furthermore, the regulatory landscape is evolving favorably for targeted lipid nanoparticles in oncology. Regulatory agencies such as the FDA and EMA have shown increased willingness to expedite review and approval processes for novel nanomedicines, especially those demonstrating significant clinical benefits in hard-to-treat cancers. This supportive environment has encouraged pharmaceutical and biotechnology companies to intensify their focus on LNP-based platforms, resulting in a surge of pipeline candidates and market launches. Additionally, collaborations between academia, research institutes, and industry players are fostering innovation and facilitating the translation of cutting-edge research into viable therapeutic products, further propelling market growth.




    From a regional perspective, North America currently dominates the Targeted Lipid Nanoparticles for Oncology market, accounting for the largest share due to its advanced healthcare infrastructure, strong presence of leading pharmaceutical companies, and a high prevalence of cancer. Europe follows closely, benefiting from robust research funding and a proactive regulatory framework. The Asia Pacific region is emerging as a high-growth market, driven by increasing healthcare expenditure, rising cancer incidence, and growing investments in biotechnology. Latin America and the Middle East & Africa, while still developing, are witnessing steady growth as awareness of advanced cancer therapies and access to innovative treatments improve. The regional dynamics underscore the global nature of this market and the widespread recognition of lipid nanoparticles as a transformative approach in oncology.



    Product Type Analysis



    The Product Type segment in the Targeted Lipid Nanoparticles for Oncology market is characterized by a diverse array of formulations, including Solid Lipid Nanoparticles (SLNs), Nanostructured Lipid Carriers (NLCs), Liposomes, and other specialized lipid-based systems. SLNs have garnered signific

  19. Nanoparticle Drug Delivery Systems Market Analysis North America, Europe,...

    • technavio.com
    pdf
    Updated Oct 1, 2024
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    Technavio (2024). Nanoparticle Drug Delivery Systems Market Analysis North America, Europe, Asia, Rest of World (ROW) - US, Germany, UK, China, Japan, France, Spain, Canada, South Korea, Brazil - Size and Forecast 2024-2028 [Dataset]. https://www.technavio.com/report/nanoparticle-drug-delivery-systems-market-industry-analysis
    Explore at:
    pdfAvailable download formats
    Dataset updated
    Oct 1, 2024
    Dataset provided by
    TechNavio
    Authors
    Technavio
    License

    https://www.technavio.com/content/privacy-noticehttps://www.technavio.com/content/privacy-notice

    Time period covered
    2024 - 2028
    Area covered
    France, Japan, United States, Canada, United Kingdom
    Description

    Snapshot img

    Nanoparticle Drug Delivery Systems Market Size 2024-2028

    The nanoparticle drug delivery systems market size is forecast to increase by USD 54.90 billion at a CAGR of 10% between 2023 and 2028. Nanoparticle drug delivery systems (NP-DDS) have gained significant attention in the healthcare industry due to their ability to enhance the efficacy of digital therapeutic and safety of various drug formulations. The market for NP-DDS is driven by the increasing prevalence of chronic diseases and the growing innovations in nanomedicine. However, the high cost of research and development associated with these systems poses a challenge. To address patient-centric concerns, there is a focus on improving toxicity and retention effects. Clinical care providers in hospitals are increasingly adopting NP-DDS for personalized treatment plans. Virtual modeling and self-amplifying mRNA technologies are key trends in the development of NP-DDS. As the healthcare industry continues to evolve, the use of NP-DDS is expected to grow, offering opportunities for advancements in clinical care.

    What will be the Size of the Market During the Forecast Period?

    Request Free Sample

    Nanoparticle drug delivery systems represent a significant advancement in healthcare, offering innovative approaches to address various chronic conditions, including (cardiovascular market) cardiovascular diseases (CVDs), neurological disorders, cancer, diabetes, and infection treatment. These systems leverage the unique properties of nanoscale materials, such as nanoparticles, nanocrystals, liposomes, and micelles, to improve therapeutic efficacy and reduce side effects. The integration of nanotechnology in drug delivery systems has led to the development of personalized therapies, enabling targeted delivery of therapeutic solutions to specific areas of the body. This targeted approach is particularly crucial in treating complex conditions, such as CVDs, where achieving optimal bioavailability is essential.

    For instance, statins, widely used to manage CVDs, can be encapsulated in nanocarriers to enhance their solubility and bioavailability, thereby improving their therapeutic impact. Nanoparticle drug delivery systems also demonstrate immense potential in addressing drug-resistant bacteria, a growing concern in infection treatment. By encapsulating antibiotics in nanocarriers, their effectiveness can be significantly enhanced, reducing the risk of bacterial resistance and minimizing the potential for collateral damage to healthy cells. In the context of oncology and hematology, nanoparticle drug delivery systems have shown remarkable progress, with nanomedicines offering targeted delivery of anticancer and antitumor agents. This targeted approach reduces the overall healthcare costs associated with traditional chemotherapy treatments, which often come with debilitating side effects.

    Moreover, nanoparticle drug delivery systems hold immense promise in the treatment of neurodegenerative disorders, such as Alzheimer's disease (Alzheimer's therapeutics market). By enabling the targeted delivery of therapeutic agents across the blood-brain barrier, these systems can help mitigate the progressive damage caused by these conditions. The clinical trials of nanoparticle drug delivery systems are ongoing, with numerous studies demonstrating their potential to revolutionize therapeutic approaches for various chronic conditions. As research in this field continues to advance, the application of nanotechnology in drug delivery systems is poised to significantly impact the healthcare landscape.

    Market Segmentation

    The market research report provides comprehensive data (region-wise segment analysis), with forecasts and estimates in 'USD billion' for the period 2024-2028, as well as historical data from 2018-2022 for the following segments.

    Route Of Administration
    
      Intravenous
      Oral
      Topical
    
    
    End-user
    
      Hospitals and clinics
      Pharmaceutical companies
      Research institutions
    
    
    Geography
    
      North America
    
        Canada
        US
    
    
      Europe
    
        Germany
        UK
        France
        Spain
    
    
      Asia
    
        China
        Japan
        South Korea
    
    
      Rest of World (ROW)
    

    By Route Of Administration Insights

    The intravenous segment is estimated to witness significant growth during the forecast period. Nanotechnology has revolutionized the field of DDS (Drug Delivery Systems market), offering innovative therapeutic solutions for various chronic conditions, including cancer, cardiovascular diseases (CVDs), and neurological disorders. Nanoscale materials, such as nanoparticles, nanocrystals, liposomes, micelles, nanotubes, and others, play a crucial role in enhancing the bioavailability and targeted delivery of drugs.

    Get a glance at the market share of various segments Request Free Sample

    The intravenous segment accounted for USD 26.06 billion in 2018 and showed a gradual increase during the forecast period. In

  20. v

    Drug Delivery in Cancer Market Size By Cancer Type (Breast Cancer, Lung...

    • verifiedmarketresearch.com
    pdf,excel,csv,ppt
    Updated Aug 12, 2025
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    Verified Market Research (2025). Drug Delivery in Cancer Market Size By Cancer Type (Breast Cancer, Lung Cancer, Prostate Cancer, Colorectal Cancer), By Technology (Nanoparticle Drug Delivery, Liposomes, Transdermal Drug Delivery, Polymeric Micelles), By Route of Administration (Injectable, Oral, Topical, Implantable), By End-User (Hospitals, Cancer Research Institutes, Ambulatory Surgical Centers), By Geographic Scope And Forecast [Dataset]. https://www.verifiedmarketresearch.com/product/drug-delivery-in-cancer-market/
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    pdf,excel,csv,pptAvailable download formats
    Dataset updated
    Aug 12, 2025
    Dataset authored and provided by
    Verified Market Research
    License

    https://www.verifiedmarketresearch.com/privacy-policy/https://www.verifiedmarketresearch.com/privacy-policy/

    Time period covered
    2026 - 2032
    Area covered
    Global
    Description

    Drug Delivery in Cancer Market size was valued at USD 19.7 Billion in 2024 and is projected to reach USD 41.37 Billion by 2032, growing at a CAGR of 10.8% during the forecast period 2026-2032.Rising Global Cancer Incidence Rates: An increasing number of cancer cases worldwide is expected to accelerate the demand for targeted and efficient drug delivery systems.Advancements in Nanotechnology-Based Delivery Systems: The adoption of nanocarriers such as liposomes and nanoparticles is anticipated to enhance precision and bioavailability in cancer therapy.Adoption of Personalized Medicine Approaches: Tailored drug delivery mechanisms aligned with individual genetic profiles are projected to gain traction due to their therapeutic effectiveness and reduced systemic toxicity.Focus on Minimally Invasive Drug Administration Techniques: Non-invasive and site-specific delivery routes such as transdermal and intratumoral systems are estimated to witness growing utilization for patient comfort and reduced side effects.

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Geeta S. Bhagwat; Rajani B. Athawale; Rajeev P. Gude; Shadab Md; Nabil A. Alhakamy; Usama A. Fahmy; Prashant Kesharwani (2023). Table1_Formulation and Development of Transferrin Targeted Solid Lipid Nanoparticles for Breast Cancer Therapy.DOCX [Dataset]. http://doi.org/10.3389/fphar.2020.614290.s001
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Table1_Formulation and Development of Transferrin Targeted Solid Lipid Nanoparticles for Breast Cancer Therapy.DOCX

Related Article
Explore at:
docxAvailable download formats
Dataset updated
Jun 3, 2023
Dataset provided by
Frontiers Mediahttp://www.frontiersin.org/
Authors
Geeta S. Bhagwat; Rajani B. Athawale; Rajeev P. Gude; Shadab Md; Nabil A. Alhakamy; Usama A. Fahmy; Prashant Kesharwani
License

Attribution 4.0 (CC BY 4.0)https://creativecommons.org/licenses/by/4.0/
License information was derived automatically

Description

Breast cancer is conventionally treated by surgery, chemotherapy and radiation therapy followed by post operational hormonal therapy. Tamoxifen citrate is a best option to treat breast cancer because its selective estrogen receptor modulation activity. Owing to its antiestrogenic action on breast as well as uterine cells, Tamoxifen citrate shows uterine toxicity. The dose 20 mg per day of Tamoxifen citrate required to show therapeutic effect causes side effects and toxicity to vital organs such as liver, kidney and uterus. In the present study, transferrin-conjugated solid lipid nanoparticles (SLNs) were successfully prepared to enhance the active targeting of tamoxifen citrate in breast cancer. Developed formulations were evaluated for particle size, surface charge, surface morphology and in vitro dissolution studies. Developed formulations exhibited more cytotoxicity as compared to pure Tamoxifen citrate solution in time as well as concentration dependent manner on human breast cancer MCF-7 cells. Further, cell uptake and flow cytometry studies confirmed the qualitative uptake of developed D-SLN and SMD-SLN by human breast cancer MCF-7 cells. Overall, proposed study highlights that transferrin engineered nanocarriers could enhance the therapeutic response of nanomedicines for breast cancer treatment.

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