The Oxytocin Market Report is Segmented by Indication (Antepartum, Postpartum), Route of Administration (Parenteral, Intranasal, Oromucosal), Distribution Channel (Hospital Pharmacies, Retail Pharmacies, Online Pharmacies), and Geography (North America, Europe, Asia-Pacific, Middle East and Africa, South America). The Market Forecasts are Provided in Terms of Value (USD).

It has been demonstrated that secretion of several hormones can be classically conditioned, however, the underlying brain responses of such conditioning have never been investigated before. In this study we aimed to investigate how oxytocin administration and classically conditioned oxytocin influence brain responses. In total, 88 females were allocated to one of three groups: oxytocin administration, conditioned oxytocin, or placebo, and underwent an experiment consisting of three acquisition and three evocation days. Participants in the conditioned group received 24 IU of oxytocin together with a conditioned stimulus (CS) during three acquisition days and placebo with the CS on three evocation days. The oxytocin administration group received 24 IU of oxytocin and the placebo group received placebo during all days. On the last evocation day, fMRI scanning was performed for all participants during three tasks previously shown to be affected by oxytocin: presentation of emotional faces, crying baby sounds and heat pain. Region of interest analysis revealed that there was significantly lower activation in the right amygdala and in two clusters in the left superior temporal gyrus in the oxytocin administration group compared to the placebo group in response to observing fearful faces. The activation in the conditioned oxytocin group was in between the other two groups for these clusters but did not significantly differ from either group. No group differences were found in the other tasks. Preliminary evidence was found for brain activation of a conditioned oxytocin response; however, despite this trend in the expected direction, the conditioned group did not significantly differ from other groups. Future research should, therefore, investigate the optimal timing of conditioned endocrine responses and study whether the findings generalize to other hormones as well.

The global oxytocin testing kits market is anticipated to reach USD 1,351.4 million by 2035, rising from USD 740.5 million in 2025 at a 6.2% CAGR.

Top Countries Manufacturing, Distributing, and Scaling Oxytocin Testing Kits

The neurohormone oxytocin regulates many aspects of physiology primarily by binding to its receptor, the oxytocin receptor. The oxytocin receptor gene (Oxtr) has been shown to have alternative transcripts in the mouse brain which may each have different biological functions or be used in specific contexts. A popular animal model for studying oxytocin-dependent social behaviors is the prairie vole, a biparental and monogamous rodent. Alternative transcriptional capacity of Oxtr in prairie voles is unknown. We used 5′ rapid amplification of cDNA ends to identify alternative Oxtr transcription start sites in prairie vole brain tissue and uterine tissue. We then validated expression of specific transcripts in fetal brains and assessed the impact of exogenous oxytocin administration in utero on offspring brain development. We identified seven distinct Oxtr transcripts, all of which are present in both brain and uterine tissue. We then demonstrated that maternal oxytocin administration alters expression of a specific subset of Oxtr transcripts and that these different transcripts are under unique epigenetic regulation, such that in the perinatal period only one of the alternative transcripts is associated with DNA methylation in the Oxtr promoter. These data establish the existence of multiple Oxtr transcripts in prairie vole brain and uterine tissue and implicate oxytocin in the regulation of alternative transcript expression. These data have significant implications for our understanding of null mutant models in both mice and voles and translation in human birth and behavior.

Detailed oxytocin protocol in each study.

Abstract: Affectionate touch, which is vital for mental and physical health, was restricted during the Covid-19 pandemic. This study investigated the association between momentary affectionate touch and subjective well-being, as well as salivary oxytocin and cortisol in everyday life during the pandemic. In the first step, we measured anxiety and depression symptoms, loneliness, and attitude toward social touch in a large cross-sectional online survey (N=1,050). From this sample, N=247 participants completed ecologically momentary assessments (EMA) over two days with six daily assessments by answering smartphone-based questions on affectionate touch and momentary mental state and providing concomitant saliva samples for cortisol and oxytocin assessment. Multilevel models showed that on a within-person level, affectionate touch was associated with decreased self-reported anxiety, general burden, stress, and increased oxytocin levels. On a between-person level, affectionate touch was associated with decreased cortisol levels and higher happiness. Moreover, individuals with a positive attitude towards social touch experiencing loneliness reported more mental health problems. Our results suggest that affectionate touch is linked to higher endogenous oxytocin in times of pandemic and lockdown and might buffer stress on a subjective and hormonal level. These findings might have implications for preventing mental burden during social contact restrictions.

A collection of 56 brain maps. Each brain map is a 3D array of values representing properties of the brain at different locations.

Collection description

This collection includes unthresholded maps for all the analyses conducted in the study. Only the conjunction maps are presented thresholded at voxel level p=0.002.

Demographic data, illness characteristics, basal and induced oxytocin levels and dimensions of empathy in patients with schizophrenia and healthy controls.

A collection of 5 brain maps. Each brain map is a 3D array of values representing properties of the brain at different locations.

Collection description

Randomized, double-blind, placebo-controlled, cross-over design to compare the impacts of a single intranasal oxytocin dose on amygdala connectivity among individuals with schizophrenia (n = 22) versus healthy controls (n = 24).

This dataset accompanies the research article "Oxytocin signaling regulates maternally-directed behavior during early life". It includes Matlab data structures for each of the figures in the article. Within each structure are entries for each panel in the figure, including all data points presented in the panel. Panels that do not include any quantitative data (for example images) are also associated with entries in the matlab structures, but these entries are empty.

Oxytocin Market Outlook

The global oxytocin market size was estimated at USD 173.5 million in 2023 and is projected to reach a valuation of approximately USD 257.4 million by 2032, growing at a compound annual growth rate (CAGR) of 4.5% during the forecast period from 2024 to 2032. This expansion is primarily driven by the increasing demand for oxytocin in various medical applications, especially in obstetrics, due to its critical role in labor induction and management of postpartum hemorrhage. The rising awareness and education about maternal health, coupled with technological advancements in healthcare, are key factors that are likely to positively impact the growth trajectory of the oxytocin market over the coming years.

The growth of the oxytocin market is largely fueled by the increasing global birth rate and the subsequent demand for effective labor induction methods. As more women seek medical assistance during childbirth, the usage of oxytocin for labor induction has seen a significant rise. This trend is further bolstered by the availability of improved healthcare infrastructure and medical personnel trained in handling childbirth procedures efficiently across various developing regions. Additionally, the increasing awareness about maternal and neonatal health prompts healthcare providers to adopt best practices in labor management, where oxytocin plays an indispensable role, thereby driving market growth.

Another growth factor contributing to the oxytocin market is the rising incidence of postpartum hemorrhage, a major cause of maternal mortality worldwide. The use of oxytocin as a uterotonic agent to control bleeding after delivery has made it an essential drug in maternity care settings. Governments and health organizations are actively promoting the use of oxytocin as a preventive measure against postpartum hemorrhage, further boosting its demand. Initiatives to enhance maternal health and reduce childbirth-related complications are crucial in ensuring the wide adoption of oxytocin, particularly in regions with high maternal mortality rates.

In addition to its role in labor management, oxytocin is also gaining recognition for its potential benefits in lactation enhancement. The hormone stimulates milk ejection in breastfeeding mothers, helping to improve breastfeeding rates and infant nutrition. With the rising emphasis on breastfeeding and infant health, the demand for oxytocin to support lactation is expected to increase, contributing to market growth. Furthermore, the ongoing research into the broader therapeutic applications of oxytocin, such as its use in treating certain psychiatric conditions, could open new avenues for market expansion.

Carbetocin Injection is emerging as a promising alternative to oxytocin in the management of postpartum hemorrhage, particularly in settings where cold chain storage is a challenge. Unlike oxytocin, Carbetocin Injection does not require refrigeration, making it highly suitable for use in low-resource settings where maintaining a cold chain is difficult. This stability under ambient conditions allows for broader distribution and accessibility, especially in rural and remote areas. Moreover, clinical studies have shown that Carbetocin Injection is as effective as oxytocin in preventing postpartum hemorrhage, offering a viable option for healthcare providers. As global health initiatives continue to focus on reducing maternal mortality, the adoption of Carbetocin Injection could play a critical role in enhancing maternal health outcomes, particularly in developing regions.

From a regional perspective, the oxytocin market is witnessing varied growth patterns. North America and Europe are prominent markets due to their advanced healthcare systems and high awareness of maternal health issues. Meanwhile, the Asia Pacific region is anticipated to exhibit the fastest growth during the forecast period, driven by a substantial rise in birth rates and improving healthcare facilities. The Middle East & Africa and Latin America are also emerging as significant markets due to increasing healthcare investments and initiatives aimed at reducing maternal mortality. Overall, the global oxytocin market is poised for steady growth, supported by multiple regional dynamics and healthcare trends.

Product Type Analysis

Within the oxytocin market, the segmentation by product type into synthetic and natural oxytocin presents a comprehensive landscape of choices available to healthcare providers. Synthetic oxy

Explore insights from Market Research Intellect's Injection Oxytocin Manufacturers Profiles Market Report, valued at USD 1.5 billion in 2024, expected to reach USD 2.5 billion by 2033 with a CAGR of 7.5% during 2026-2033.Uncover opportunities across demand patterns, technological innovations, and market leaders.

The implementation of an institutional oxytocin checklist did not affect expert assessment of the use of oxytocin in labor. Checklist is included within the publication's appendix.

SPM{T_[416.0]} - contrast 6: Main Effect of Drug: Plac > Oxyt

Collection description

The present study assessed the effects of intranasal oxytocin on the neural basis of processing emotional faces in patients with body dysmorphic disorder (BDD). Twenty BDD patients and 22 matched healthy control participants participated in a randomized, double-blind placebo-controlled within-subject functional magnetic resonance imaging study. Following acute intranasal OXT (24 IU) or placebo administration, we examined group and OXT related differences in task-based amygdala activation and related functional connectivity in response to an emotional face-matching task of fearful, angry, disgusted, sad, surprised and happy faces.

Subject species

homo sapiens

Map type

T

Breastfeeding behaviors can significantly change mothers’ physiological and psychological states. The hormone oxytocin may mediate breastfeeding and mothers’ emotion recognition. This study examined the effects of endogenous oxytocin fluctuation via breastfeeding on emotion recognition in 51 primiparous mothers. Saliva oxytocin was assessed before and after the manipulation (breastfeeding or holding an infant), and emotion recognition tasks were conducted. Among mothers who breastfed daily, mothers with more increased levels of oxytocin after breastfeeding showed greater reduced negative recognition and enhanced positive recognition of adult facial expressions. These oxytocin functions accompanying breastfeeding may support continued nurturing behaviors and also affect the general social cognition of other adults beyond any specific effect on infants.

Trust underpins much of social and economic exchanges across human societies. In experimental economics, the Trust Game has served as the workhorse for the study of trust in a controlled incentivized setting. Recent evidence using intranasal drug administration, aka ‘sniffing’, suggests that oxytocin (OT) can function as a social hormone facilitating trust and other affiliative behaviors. Here we hypothesized that baseline plasma OT is a biomarker that partially predicts the degree of trust and trustworthiness observed in the trust game. Using a large sample of 1,158 participants, we observed a significant U-shaped relationship between plasma OT with the level of trust, and marginally with the level of trustworthiness, especially among males. Specifically, subjects with more extreme levels of plasma OT were more likely to be trusting as well as trustworthy than those with moderate levels of plasma OT. Our results contribute to a deeper understanding of the biological basis of human trust and underscore the usefulness of peripheral plasma OT measures in characterizing human social behavior.

Spearman correlation coefficients for associations between basal / induced oxytocin levels and MET cognitive and emotional empathy in patients with schizophrenia and healthy controls.

Social behavior plays an essential role in daily life. The neuropeptide oxytocin has generated considerable interest for its role in social behavior and potential to treat psychiatric disorders characterised by social dysfunction. This study advances our understanding of the neurobiological substrates of social behavior by interrogating human whole-brain maps of oxytocin pathway gene expression, demonstrating these genes are enriched in central, temporal, and olfactory brain regions. We also show via large-scale fMRI meta-analysis that these gene expression patterns correspond with brain regions involved in emotion and motivation processing. These results provide a proof-of-principle demonstration of corresponding mental states with gene expression patterns of a neuropeptide pathway involved in complex human behaviors, and identify neural network targets for future oxytocin trials.

The table includes 76 products with the active ingredient Oxytocin.