Adverse Outcome Pathways (AOPs) are multi-scale models of biological mechanisms connecting molecular initiating events to adverse outcomes through measurable key events. AOPs can guide the use and development of new approach methodologies (NAMs) aimed at reducing animal experimentation in chemical safety assessment. Here, we present a comprehensive molecular annotation of AOPs relevant to human health to embed the AOP framework into molecular data interpretation, which supports the development and application of novel AOP-based approaches in biomedical research. Please cite the following publication alongside this Zenodo entry when using the data: Saarimäki, L.A., Fratello, M., Pavel, A. et al. A curated gene and biological system annotation of adverse outcome pathways related to human health. Sci Data 10, 409 (2023). https://doi.org/10.1038/s41597-023-02321-w

The objective of the caLIBRAte project was to establish a state-of-the-art versatile Risk Governance framework for assessment and management of human and environmental risks of MN and MN-enabled products. Since 1 October 2022 the data gathered in the project are publicly available via the caLIBRAte - eNanoMapper database. A standalone Docker instance is also available. The caLIBRAte database is subject to updates during completion of supplemental analysis after publication as an open database entity.