In this model the property of a nanomaterial is predicted not on the basis of descriptors characterizing the chemical composition of nanoparticles or physical properties of the initial nanoforms, but on the basis of descriptors describing the dispersion medium (pH, IP, D3_HeteroNonMetals) and the property of nanoparticles dependent on it (Potential ζ). The observed small size of the hydrodynamic diameter of TiO2 in solvents of strong acids and bases compared to other solvents may indicate stronger repulsive interactions between nanoparticles than in the case of other systems. Moreover, in the case of salt solutions, the observed large size of the hydrodynamic diameter of TiO2 may be the result of a thicker electrical layer surrounding the particles in the dispersion system.