Additional file 2. This file includes the results of the manual evaluation performed by three experts about the explanatory character of predictive features.

Data sets used in the experiments reported in the review article to predict adverse drug reactions.

Graph and download economic data for Nasdaq-Brooklyn ADR Net Total Return Index (NASDAQNBADRN) from 2023-08-23 to 2025-09-05 about return, NASDAQ, Net, indexes, and USA.

Adverse drug reactions (ADRs) are a major public health concern, and early detection is crucial for drug development and patient safety. Together with the increasing availability of large-scale literature data, machine learning has the potential to predict unknown ADRs from current knowledge. By the machine learning methods, we constructed a Tumor-Biomarker Knowledge Graph (TBKG) which contains four types of node: Tumor, Biomarker, Drug, and ADR using biomedical literatures. Based on this knowledge graph, we not only discovered potential ADRs of antitumor drugs but also provided explanations. Experiments on real-world data show that our model can achieve 0.81 accuracy of three cross-validation and the ADRs discovery of Osimertinib was chosen for the clinical validation. Calculated ADRs of Osimertinib by our model consisted of the known ADRs which were in line with the official manual and some unreported rare ADRs in clinical cases. Results also showed that our model outperformed traditional co-occurrence methods. Moreover, each calculated ADRs were attached with the corresponding paths of “tumor-biomarker-drug” in the knowledge graph which could help to obtain in-depth insights into the underlying mechanisms. In conclusion, the tumor-biomarker knowledge-graph based approach is an explainable method for potential ADRs discovery based on biomarkers and might be valuable to the community working on the emerging field of biomedical literature mining and provide impetus for the mechanism research of ADRs.

The average daily rate (ADR) of luxury hotels in Paris, France, amounted to just over ***** euros in 2023. This figure denoted a ** percentage increase compared to the previous year. Over the same period, the ADR of economy hotels in the French capital rose by ** percent.

The average daily rate (ADR) represents the average rental income earned for an occupied room per day. In 2022, the ADR of the United States hotel industry was forecast to reach *** U.S. dollars. By 2024, that figure was forecast to increase to *** U.S. dollars.

Network of 46 papers and 56 citation links related to "DrugPathSeeker: Interactive UI for exploring drug-ADR relation via pathways".

ObjectiveThe aim of this retrospective study was to evaluate the effectiveness and safety of topical gabapentin solution (250 mg/mL) for the management of burning mouth syndrome (BMS).Study designA retrospective chart review was conducted of all patients diagnosed with BMS and managed with gabapentin 250 mg/mL solution (swish and spit) between January 2021 and October 2022. Patient-reported outcomes included changes in burning score ranked on a 10-point numeric rating scale (NRS) and reported adverse drug reactions (ADR). Wilcoxon signed-rank test was used to assess differences in the oral burning score ranked on a NRS (0–10) between the baseline visit and the second visit.ResultsA total of 19 patients (68.4% females) with BMS were included and evaluated for follow-up at a median of 86 days (range: 29–195). Overall, patients reported a median 2-point burning decrease on a 0–10 NRS between the baseline visit and the second visit (p < 0.01). ADRs were reported by 3 patients (15.8%).ConclusionAlthough this was a small retrospective study, BMS management with topical gabapentin (250 mg/mL) appears to be effective and well-tolerated. Future randomized prospective studies are needed to verify these preliminary findings.

This statistic shows the average daily rate of hotels in Paris, France from 2011 to 2017, with a forecast for 2018 and 2019. The average daily hotel rate in Paris measured *** euros in 2017. This figure is forecast to increase in 2019 to *** euros. Looking at performance across the European hotel market, Paris has one of the highest average daily rates compared to other leading city destinations.

The average daily rate (ADR) of hotels in Jakarta, Indonesia was projected to reach around 1.1 million Indonesian rupiah in 2024, while Bali had a significantly higher value at around 2.4 million Indonesian rupiah. By comparison, Jakarta's ADR stood at 988,700 Indonesian rupiah in 2023.