UNAIDS estimated that there were some 630,000 people worldwide that died from acquired immune deficiency syndrome (AIDS) in 2023. This statistic depicts the total number of annual AIDS-related deaths worldwide from 2000 to 2023. HIV/AIDS burden A majority of countries with the highest burden due to HIV and AIDS are in Africa- in 2023, the highest number of AIDS-related deaths occurred in South Africa and Nigeria and the highest prevalence of HIV was found in Eswatini. Although access to life-saving antiretroviral therapy treatment (ART) has increased globally over recent years, many individuals living with HIV still lack access to ART. Barriers and interventions In part due to the development of ART, the number of people living with HIV worldwide is continuing to increase, reaching almost 40 million in 2023. Important public health measures to combat the burden of the disease include a combination of biomedical and behavioral interventions such as pre- and post-exposure prophylaxis, and context-specific structural interventions to reduce barriers to supplies and education. One prominent barrier faced by those living with HIV is stigma, which can often cause disadvantages in many areas of life, including employment, use of health services, and social support.

HIV/AIDS deaths in the U.S. have dropped significantly in recent years. In 1995, the death rate from HIV per 100,000 people was 16.2. That number has since decreased to 1.3 per 100,000 as of 2022. The reduction in the HIV death rate in the U.S. can be attributed to an increase in access to HIV medications. HIV/AIDS in the U.S. Human immunodeficiency virus (HIV) and acquired immune deficiency syndrome (AIDS) cause a systemic viral infection that damages the immune system. AIDS is a syndrome that is caused by HIV. AIDS is when the immune system is severely weakened by HIV and the body can no longer fight off infections. The number of AIDS diagnoses in the U.S. has decreased significantly in recent years. Among all U.S. states, Georgia, followed by Louisiana, had the highest rates of new HIV diagnoses in 2021. HIV/AIDS treatments in the U.S. HIV/AIDS treatments include antiretroviral medications to reduce the levels of HIV within the body. The largest funders for HIV/AIDS medications and research are the National Institutes of Health (NIH) and the Ryan White Program. The top HIV drug worldwide, based on revenue generated in 2023 was Biktarvy. Around the world, access to antiretroviral treatment has increased dramatically in recent years, a huge step in reducing the number of HIV-related deaths. There is currently no cure for HIV.

In 2023, South Africa and Nigeria had the highest number of deaths due to AIDS worldwide, with around 50 thousand and 45 thousand such deaths, respectively. African countries account for eight of the top 10 countries with the highest number of AIDS-related deaths worldwide. AIDS-related deaths worldwide have been gradually declining over the past decade, decreasing from 1.3 million deaths in 2010 to 630 thousand deaths in 2023. HIV/AIDS HIV (human immunodeficiency virus) is an infectious sexually transmitted disease that is transmitted via exposure to infected semen, blood, vaginal and anal fluids and breast milk. HIV weakens the human immune system, resulting in the affected person being unable to fight off opportunistic infections. The top 15 countries worldwide with the highest prevalence of new HIV infections as of 2023 were all African. HIV treatment Although there is currently no effective cure for HIV, death can be prevented by taking HIV antiretroviral therapy (ART). Access to antiretroviral therapy worldwide has significantly increased in the past decade. As of 2023, around 30.7 million people with HIV worldwide were receiving ART. The leading countries with the highest percentage of HIV-infected children who were receiving ART were Eswatini, Kenya, and Lesotho.

In 2023, more females than males died from HIV or AIDS in both African regions displayed, with 10,000 more deaths among women and girls in the East and Southern Africa region. This statistic shows the number of deaths from HIV/AIDS in Africa in 2023, by region and gender.

In 2021, there were around 199,615 HIV/AIDS deaths among males in Africa, compared to 206,175 deaths among females. This statistic shows the number of deaths from HIV/AIDS in Africa in 2021, by gender.

In 2024, the estimated number of deaths from AIDS in South Africa reached 68,406. This was slightly higher compared to the previous year, when the AIDS related deaths in the country amounted to 68,382. From 2006 onwards (except in 2016), the number of AIDS-related deaths dropped annually.

In 2023, India reported an estimate of 36 thousand annual AIDS related deaths (ARD) across the country. Male deaths from HIV/AIDS amounted to nearly 24 thousand, accounting for approximately 67 percent of AIDS related deaths in India that year.

The number of deaths among people diagnosed with AIDS in EU and EEA countries decreased from 2013 to 2023, declining to 663 deaths in 2023. This statistic displays number of deaths among people diagnosed with AIDS in EU and EEA countries from 2013 to 2023.

As of 2021, 1.9 million people in Nigeria were living with HIV. That year, the number of deaths due to AIDS amounted to 51 thousand, including both adults and children. The highest number of deaths was recorded among female adults, with 17 thousand deaths.

In 2022, there were 158 AIDS-related deaths in France. Since 2010, the yearly number of deaths due to AIDS has ranged from roughly 100 to 210 deaths. During this period, AIDS-related deaths were exceptionally high in 2010 and 2019.

In 2024, around 13 percent of the total deaths in South Africa were acquired immunodeficiency virus (AIDS) related. This represented a slight decrease of 0.1 percentage points compared to 2023. Since 2002, the share of AIDS-related deaths increased until 2006, reaching 40.3 percent, before declining significantly. However, the number of deaths is likely to see an increase following the United States of America's decision to cut aid funding.

In 2022, there were 2.1 male deaths from the HIV disease per 100,000 inhabitants in the United States. This statistic shows the death rate for the human immunodeficiency virus (HIV) disease among the U.S. population from 1987 to 2022, by gender.

In 2021, Brazil had the most deaths due to HIV/AIDS in the Latin American and the Caribbean region, with an estimate of 13 thousand deceases that year. Mexico followed with a total of 4.6 thousand deaths related to the human immunodeficiency virus. That year, around 1.3 thousand people died due to the disease in Argentina.

In 2022, the death rate from HIV was highest among African Americans, with around 19 deaths per 100,000 population. This statistic shows the death rate from HIV in the U.S. in 2022, by race and ethnicity, per 100,000 population.

In 2023, South Africa had the highest number of adult AIDS-related deaths in the world at 49,000 deaths among adults aged 15 years and older. However, Mozambique had the highest number of child AIDS-related deaths worldwide. This statistic presents the number of AIDS-related deaths among adults in select African countries in 2023.

In 2022, the estimated number of AIDS-related deaths in Brazil added up to approximately 13,000. During the period depicted, there has been an overall downward trend in the number of AIDS-related deaths in the country. Brazil ranks among the countries with the highest number of deaths due to AIDS worldwide.

In 2023, there were 37 deaths caused by the human immunodeficiency virus (HIV) or acquired immunodeficiency syndrome (AIDS) in Malaysia, a decrease from 48 deaths caused by the disease the year before. The number of HIV/AIDS related deaths in Malaysia has been decreasing since 2014, when the number was at 117 deaths.

In 2022, there were an estimated 40 thousand deaths due to HIV-related causes in India. That year, the number of AIDS deaths in Indonesia amounted to an estimated 26 thousand.

In 2020, an estimated number of 14 thousand people died from HIV/AIDS infections in Ghana. This was a slight decrease compared to two years earlier, but a significant reduction from 2001 and 2003, when 28 thousand people and 30 thousand people were reported to have died from these infections, respectively. Moreover, in 2019, 340 thousand people lived with HIV/AIDS in Ghana.

The states with the highest rates of HIV diagnoses in 2021 included Georgia, Louisiana, and Florida. However, the states with the highest number of people with HIV were California, Texas, and Florida. In California, there were around 4,399 people diagnosed with HIV. HIV/AIDS diagnoses The number of diagnoses of HIV/AIDS in the United States has continued to decrease in recent years. In 2021, there were an estimated 35,769 HIV diagnoses in the U.S. down from 38,433 diagnoses in the year 2017. In total, since the beginning of the epidemic in 1981 there have been around 1.25 million diagnoses in the United States. Deaths from HIV Similarly, the death rate from HIV has also decreased significantly over the past few decades. In 2019, there were only 1.4 deaths from HIV per 100,000 population, the lowest rate since the epidemic began. However, the death rate varies greatly depending on race or ethnicity, with the death rate from HIV for African Americans reaching 19.1 per 100,000 population in 2020.