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100+ datasets found
  1. f

    Cue Reactivity Is Associated with Duration and Severity of Alcohol...

    • figshare.com
    • plos.figshare.com
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    • plos.figshare.com
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  7. N

    Acute alcohol administration dampens central extended amygdala reactivity:...

    • neurovault.org
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  8. N

    Acute alcohol administration dampens central extended amygdala reactivity:...

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    Acute alcohol administration dampens central extended amygdala reactivity:...

    • neurovault.org
    nifti
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  12. N

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    • neurovault.org
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  13. N

    Data from: Nucleus accumbens connectivity at rest is associated with alcohol...

    • neurovault.org
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  14. f

    Table_1_Functional Connectivity of Nucleus Accumbens and Medial Prefrontal...

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    • frontiersin.figshare.com
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  15. N

    Nucleus accumbens connectivity at rest is associated with alcohol...

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    nifti
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  16. N

    Nucleus accumbens connectivity at rest is associated with alcohol...

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  17. d

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  18. N

    Nucleus accumbens connectivity at rest is associated with alcohol...

    • neurovault.org
    nifti
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  19. Changes in connectivity in patients and controls.

    • figshare.com
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  20. N

    Reduced loss aversion in pathological gambling and alcohol dependence is...

    • neurovault.org
    nifti
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Zsuzsika Sjoerds; Wim van den Brink; Aartjan T. F. Beekman; Brenda W. J. H. Penninx; Dick J. Veltman (2016). Cue Reactivity Is Associated with Duration and Severity of Alcohol Dependence: An fMRI Study [Dataset]. http://doi.org/10.1371/journal.pone.0084560

Cue Reactivity Is Associated with Duration and Severity of Alcohol Dependence: An fMRI Study

20 scholarly articles cite this dataset (View in Google Scholar)
tiffAvailable download formats
Dataset updated
Feb 19, 2016
Dataset provided by
PLOS ONE
Authors
Zsuzsika Sjoerds; Wim van den Brink; Aartjan T. F. Beekman; Brenda W. J. H. Penninx; Dick J. Veltman
License

Attribution 4.0 (CC BY 4.0)https://creativecommons.org/licenses/by/4.0/
License information was derived automatically

Description

IntroductionWith the progression of substance dependence, drug cue-related brain activation is thought to shift from motivational towards habit pathways. However, a direct association between cue-induced brain activation and dependence duration has not yet been shown. We therefore examined the relationship between alcohol cue-reactivity in the brain, cue-induced subjective craving and alcohol dependence duration and severity. Since alcohol dependence is highly comorbid with depression/anxiety, which may modulate brain responses to alcohol cues, we also examined the relation between comorbid depression/anxiety and cue-reactivity.MethodsWe compared 30 alcohol dependent patients with 15 healthy controls and 15 depression/anxiety patients during a visual alcohol cue-reactivity task using functional magnetic resonance imaging blood oxygenated level-dependent responses and subjective craving as outcomes. Within the alcohol dependent group we correlated cue-reactivity with alcohol dependence severity and duration, with cue-induced craving and with depression/anxiety levels.ResultsAlcohol dependent patients showed greater cue-reactivity in motivational brain pathways and stronger subjective craving than depression/anxiety patients and healthy controls. Depression/anxiety was not associated with cue-reactivity, but depression severity in alcohol dependent patients was positively associated with craving. Within alcohol dependence, longer duration of alcohol dependence was associated with stronger cue-related activation of the posterior putamen, a structure involved in habits, whereas higher alcohol dependence severity was associated with lower cue-reactivity in the anterior putamen, an area implicated in goal-directed behavior preceding habit formation.ConclusionCue-reactivity in alcohol dependence is not modulated by comorbid depression or anxiety. More importantly, the current data confirm the hypothesis of a ventral to dorsal striatal shift of learning processes with longer dependence duration, which could underlie increasingly habitual substance use with progressing substance dependence.

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