The files available here are not part of the AHA Database. The 0001.* and 0201.* files have been derived from a sample given to us in 1980 by the creators of the AHA Database. The original recording had been a candidate for inclusion in the database and was digitized and annotated using the same methods used for the AHA Database records. After the annotation process was complete, the recording was excluded from the AHA Database since it was found to contain ectopy of a higher grade than the class for which it had been chosen as a candidate.

Comprehensive dataset containing 135 verified American Heart Association locations in United States with complete contact information, ratings, reviews, and location data.

Grant Maker: American Heart Association Program: AHA Institutional Research Enhancement Award Project Title: Investigation of the Platelet 5HT2A and P2Y1 Receptors Award Number: 18AIREA33960421

The American Heart Association is a leading entity in the healthcare industry, dedicated to promoting cardiovascular health and studying the root causes of heart disease. With a rich history spanning over a century, the organization has made significant contributions to the field of cardiology, publishing groundbreaking research and providing vital health information to the public.

The American Heart Association's online presence is a treasure trove of information, offering insights into the organization's research and initiatives. The data extracted from their website provides valuable details about heart health, including statistics on heart disease, tips for healthy living, and stories of patients who have benefited from the organization's work. From researchers to the general public, anyone interested in learning more about heart health and the American Heart Association's efforts can find valuable information on their website.

Comprehensive dataset containing 8 verified American Heart Association locations in Florida, United States with complete contact information, ratings, reviews, and location data.

AHA = American Heart Association, ACC = American College of Cardiology EF = ejection fraction, LV = left ventricle, LVESV = left ventricular end systolic volume, LVEDV = left ventricular end diastolic volume, SV = stroke volume.Statistical comparison of parameters from the patient data for each American Heart Association/American College of Cardiology heart failure stage, using 2-tailed Student's T-Test.

The American Heart Association's Protein Atlas Data Portal is a cutting-edge, open-source atlas of the structural determinants of the binding of drugs to (all of) their target proteins as an unbiased means to accelerate drug discovery. The portal will provide researchers with access to comprehensive data that can help increase the selection of effective drugs and cut the time-to-market of new drugs by half.

Comprehensive dataset containing 3 verified American Heart Association locations in Massachusetts, United States with complete contact information, ratings, reviews, and location data.

Figure 1. Sirt1 is inactivated by HFD feeding. (A) Sirt1 at protein levels were examined after 1 month of HFD feeding in Sirt1cKO mice, and after 3 months of HFD feeding in wild type mice. (B) Sirt1 at protein level was examined in Sirt1cTG mice. (C) Expression of Sirt1 in 3 months of HFD feeding. (D) Decrease in NAD/NADH ratio by HFD feeding. After 1 month of HFD feeding, NAD and NADH levels were examined. (E-F) HFD-induced protein acetylation and acetylation of p65 at K310 are enhanced in Sirt1cKO (E) but inhibited in Sirt1cTG (F) mice. The numbers of mice examined in each experimental group were: 6 (A), 6-7 (B), 7(C), 8 (D), 7 (acetyl lysine, E), 6-8 (acetyl-RelA at K310, E), 5 (acetyl lysine, F) and 6-8 (acetyl-RelA at K310, E). Statistical significance was determined with Student t test (A and D) and ANOVA (B, E to F).Figure 2. Sirt1 negatively regulates HFD-induced diastolic dysfunction. (A) HFD-induced diastolic dysfunction is exacerbated in Sirt1cKO mice. (B-C) HFD or loss of Sirt1 does not significantly affect cardiac systolic function (B) and cardiac hypertrophy (C). (D) HFD-induced increase in body weight was not significantly changed Sirt1cKO mice. (E) HFD-induced diastolic dysfunction is ameliorated in Sirt1cTG mice. (F-G) HFD or gain of Sirt1 does not significantly affect cardiac systolic function (F) and cardiac hypertrophy (G). (H) HFD-induced increase in body weight was not significantly changed Sirt1cKO mice. PV loop analyses (A and E), echocardiographic measurement (B and F), and heart (C and G) and body weight (D and H) measurements were performed after 3 months of HFD feeding. The numbers of mice examined in each experimental group were: 6-10 (A), 7-8 (B), 14-20 (C and D), 5-8 (E), 7-13 (F), and 10-15 (G and H). Statistical significance was determined with ANOVA (A,B,C,D,E,F, and G) and Kruskall-Wallis (H).Figure 3. Exogenous Sirt1 expression with AAV inhibits HFD-induced diastolic dysfunction, fibrosis and TGFβ1 signaling. After 1 month of HFD feeding, AAV-Sirt1 or AAV-GFP (control) were injected. PV loop analyses (A) and PASR staining (B) were performed after 2 month of AAV injection. The numbers of mice examined in each experimental group were: 5 (A) and 8 (B). Statistical significance was determined with ANOVA.

Statistical comparison of the lumped parameter variables for each American Heart Association/American College of Cardiology heart failure stage model, using 2-tailed Student's T-test.

Comprehensive dataset containing 8 verified American Heart Association locations in Texas, United States with complete contact information, ratings, reviews, and location data.

The American Heart Association/American College of Cardiology Heart Failure classification From Jessup et al. (2009) [4].

Data generated for American Heart Association project 18IPA34170108

Comprehensive dataset containing 1 verified American Heart Association locations in Nebraska, United States with complete contact information, ratings, reviews, and location data.

ACC/AHA = American College of Cardiology/American Heart Association; ATS = American Thoracic Society; CDISC = Clinical Data Interchange Standards Consortium; NCI = National Cancer Institute; SF-36 = Short-form 36 questionnaire.

Comprehensive dataset containing 3 verified American Heart Association locations in Wisconsin, United States with complete contact information, ratings, reviews, and location data.

BackgroundLimited data exist regarding cardiac manifestations of Chagas disease in migrants living in non-endemic regions.MethodsA retrospective cohort analysis of 109 patients with Chagas disease seen at Boston Medical Center (BMC) between January 2016 and January 2023 was performed. Patients were identified by screening and testing migrants from endemic regions at a community health center and BMC. Demographic, laboratory, and cardiac evaluation data were collected.ResultsMean age of the 109 patients was 43 years (range 19–76); 61% were female. 79% (86/109) were diagnosed with Chagas disease via screening and 21% (23/109) were tested given symptoms or electrocardiogram abnormalities. Common symptoms included palpitations (25%, 27/109) and chest pain (17%, 18/109); 52% (57/109) were asymptomatic. Right bundle branch block (19%, 19/102), T-wave changes (18%, 18/102), and left anterior fascicular block (11%, 11/102) were the most common electrocardiogram abnormalities; 51% (52/102) had normal electrocardiograms. Cardiomyopathy stage was ascertained in 94 of 109 patients: 51% (48/94) were indeterminate stage A and 49% (46/94) had cardiac structural disease (stages B1-D). Clinical findings that required clinical intervention or change in management were found in 23% (25/109), and included cardiomyopathy, apical hypokinesis/aneurysm, stroke, atrial or ventricular arrhythmias, and apical thrombus.ConclusionsThese data show high rates of cardiac complications in a cohort of migrants living with Chagas disease in a non-endemic setting. We demonstrate that Chagas disease diagnosis prompts cardiac evaluation which often identifies actionable cardiac disease and provides opportunities for prevention and treatment.

Data deposit for the American Heart Association (AHA) Career Development Award (CDA) entitled: Mechanosensation in Brain Capillaries [20CDA35310097]. The award was received by Osama F. Harraz (University of Vermont).

Heart failure with preserved ejection fraction (HFpEF) has few effective therapies yet exacts substantial mortality. Its multi-system nature has made animal modeling difficult, but recent efforts combining diet-induced obesity and hemodynamic stress are popular: mouse - L-NAME/high-fat diet (HFD), the ZSF1 rat which combines leptin deficiency with genetic-based diabetes, hypertensive and heart failure phenotypes, and an obese/hypertensive Göttingen minipig. We have reported that human HFpEF myocytes particular from patients who are obese display a profound reduction in systolic Ca2+-activated tension, that is negatively correlated with body mass index (Circulation. 2021;143:965–967). Here we tested whether such deficits are found in these three HFpEF animal models. Of the three models, we only find a change in systolic level calcium activated tension in the Göttingen minipig. The mouse and rat models show results that are superimposable with their respective controls. The data are from permeabilized myocytes obtained from the heart tissue for each model and respective controls. The data file provides the raw data for myocyte cross section area, measured force at fixed sarcomere length (2.1 µ), and then the different calcium concentrations used.

BackgroundThe American Heart Association (AHA) recently introduced a new metric for promoting cardiovascular health (CVH) called Life’s Essential 8 (LE8). However, there has been no investigation into the relationship between levels of LE8 and the risk of depression symptom. Therefore, our objective was to determine this association using a nationally representative sample of U.S adults.MethodsUtilizing cross-sectional data from the NHANES spanning the years 2005 to 2018, we computed scores for both overall CVH and individual LE8 components. The survey-weighted logistic regression models were conducted to determine whether LE8 was associated with depression symptom.ResultsA total of 25,357 adults aged 20 and above were included in the study, representing a population of 1,184 million non-institutionalized U.S residents. The study revealed that individuals with positive scores in both individual and total LE8 metrics were less likely to experience depressive symptoms compared to those with negative scores. Furthermore, a significant negative linear trend was observed, showing that as the overall number of favorable LE8 scores increased, the likelihood of depressive symptoms decreased.ConclusionAttaining a higher CVH score, as defined by the LE8, is strongly linked to a lower risk of experiencing depressive symptoms in adult residents of the U.S.