aristaless related homeobox Enables DNA-binding transcription repressor activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and chromatin binding activity. Involved in negative regulation of transcription by RNA polymerase II and positive regulation of transcription by RNA polymerase II. Acts upstream of or within several processes, including lipid digestion; nervous system development; and positive regulation of organ growth. Predicted to be located in nucleus. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; limb; and musculature. Used to study early infantile epileptic encephalopathy; lissencephaly; and syndromic X-linked intellectual disability. Human ortholog(s) of this gene implicated in X-linked lissencephaly 2; X-linked recessive disease (multiple); corpus callosum agenesis-abnormal genitalia syndrome; and syndromic X-linked intellectual disability Hedera type. Orthologous to human ARX (aristaless related homeobox). PHENOTYPE: Males hemizygous for targeted null mutations die perinatally. Male mice hemizygous for various alleles with point mutations or triple repeat expansion exhibit defective GABAergic neuron migration and numbers, seizures, and/or behavioral defects. [provided by MGI curators]

The homeobox containing gene Arx is expressed during ventral telencephalon development and it is required for correct GABAergic interneuron tangential migration from the ganglionic eminences to the olfactory bulbs, cerebral cortex and striatum. Its human ortholog is associated with a variety of neurological clinical manifestations whose syntoms are compatible with a loss of cortical interneurons and altered basal ganglia related-activities in humans. Herein, we reported the identification by global expression profiling of a group of genes whose expression is consistently altered in Arx mutant ganglionic eminences. Following analysis revealed the striking ectopic expression in the ganglionic eminences of a number of genes normally not, or only marginally, expressed in the ventral telencephalon. Among them, we functionally analyzed Ebf3, whose ectopic expression in ventral telencephalon is preventingneuronal tangential migration. Further, we showed that Arx is sufficient to repress Ebf3 endogenous expression and that its silencing in Arx mutant tissue might marginally rescue tangential cell movements. Together, these data provide an initial analysis of the molecular pathways regulated by Arx and how their networking might regulate those specific cellular processes during telencephalon development strongly altered by loss of Arx. Three timed-pregnant Arx heterozygous dams crossed with C57Bl/6 males were sacrificed at E14.5, the embryos harvested and placed into cold PBS. After brain isolarion, meninges and olfactory bulbs were removed, and the ventral telencephalon separated from the overlying cerebral cortex. The same procedure was repeated for 5 wt and 5 Arx mutant embryos.

These data correspond to the complete address of the municipality of Arx (40 - Landes). They were produced by the community and then distributed by ADACL. The data is in BAL AITF v1.3 format.

This gene is a homeobox-containing gene expressed during development. The expressed protein contains two conserved domains, a C-peptide (or aristaless domain) and the prd-like class homeobox domain. It is a member of the group-II aristaless-related protein family whose members are expressed primarily in the central and/or peripheral nervous system. This gene is thought to be involved in CNS development. Expansion of a polyalanine tract and other mutations in this gene cause X-linked cognitive disability and epilepsy. [provided by RefSeq, Jul 2016]

NetPhos3.1 prediction (scores greater than 0.9) of likely phosphorylation sites in ARX.

Protein-Protein, Genetic, and Chemical Interactions for ARX (Homo sapiens) curated by BioGRID (https://thebiogrid.org); DEFINITION: aristaless related homeobox

Reversible leaching of palladium nanoparticles occurs in a variety of catalytic reactions including cross-couplings, amination, the Heck reaction, etc. It is complemented by capturing of soluble palladium species on the surface of nanoparticles and de novo formation of nanoparticles from Pd precatalysts. We report here a detailed computational study of leaching/capture pathways and analysis of related stabilization energies. We demonstrate the validity of the “cocktail-of-species” model for the description of Pd catalysts in ArX oxidative-addition-dependent reactions. Three pools of Pd species were evaluated, including (1) the pool of catalytically active Pd nanoparticles with a high concentration of surface defects, (2) the pool of monomeric and oligomeric L[ArPdX]nL species, and (3) the pool of irreversibly deactivated Pd. Stabilization by ArX oxidative addition, coordination of base species, and binding of X– anions were found to be crucial for “cocktail”-type systems, and the corresponding reaction energies were estimated. An inherent process of ArX homocoupling, leading to the formation of Pd halides that require reactivation, was considered as well. The pool of irreversibly deactivated Pd comprises nanoparticles with (1 1 1) and (1 0 0) facets and Pd in the bulk form. The study is based on DFT modeling and specifies the role of Pd nanoparticles in (quasi-)homogeneous coupling reactions involving ArX reagents.

Microbes play essential roles in arsenic transformation in the environment. Microbial arsenite oxidation is catalyzed by either of two distantly related arsenite oxidases, referred to as AIO and ARX. The arx genes encoding ARX and its regulatory proteins were originally defined in the genomes of gammaproteobacteria isolated from an alkaline soda lake. The arx gene cluster has been identified in a limited number of bacteria, predominantly in gammaproteobacteria isolated from lakes characterized by high pH and high salinity. In the present study, a novel arsenite-oxidizing betaproteobacterium, strain M52, was isolated from a hot spring microbial mat. The strain oxidized arsenite under both microaerophilic and nitrate-reducing conditions at nearly neutral pH. Genome analysis revealed that the strain possesses the arx gene cluster in its genome and lacks genes encoding AIO. Inspection of the bacterial genomes available in the GenBank database revealed that the presence of this gene cluster is restricted to genomes of Proteobacteria, mainly in the classes Gammaproteobacteria and Betaproteobacteria. In these genomes, the structure of the gene cluster was generally well-conserved, but genes for regulatory proteins were lacking in genomes of strains belonging to a specific lineage. Phylogenetic analysis suggested that ARX encoded in the genomes can be divided into three groups, and strain M52 belongs to a group specific for organisms living in low-salt environments. The ArxA protein encoded in the genome of strain M52 was characterized by the presence of a long insertion, which was specifically observed in the same group of ARX. In clone library analyses with a newly designed primer pair, a diverse ArxA sequence with a long insertion was detected in samples of lake water and hot spring microbial mat, characterized by low salinity and a nearly neutral pH. Among the isolated bacterial strains whose arsenite oxidation has been demonstrated, strain M52 is the first betaproteobacterium that possesses the arx genes, the first strain encoding ARX of the group specific for low-salt environments, and the first organism possessing the gene encoding ArxA with a long insertion.

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The selected inputs and parameters of the Hill function and frequency response curves of the nonlinear ARX model.

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GindaChen/megatron-prof-data-v15-arx dataset hosted on Hugging Face and contributed by the HF Datasets community

ENCODES a protein that exhibits chromatin binding (inferred); DNA binding (inferred); DNA-binding transcription activator activity, RNA polymerase II-specific (inferred); INVOLVED IN neuron development (ortholog); ASSOCIATED WITH Agenesis of Corpus Callosum (ortholog); Aicardi syndrome (ortholog); autistic disorder (ortholog); FOUND IN nucleus (inferred)

ENCODES a protein that exhibits chromatin binding (ortholog); DNA-binding transcription activator activity, RNA polymerase II-specific (ortholog); DNA-binding transcription factor activity, RNA polymerase II-specific (ortholog); INVOLVED IN axon guidance (ortholog); cell proliferation in forebrain (ortholog); cerebral cortex GABAergic interneuron migration (ortholog); ASSOCIATED WITH Agenesis of Corpus Callosum (ortholog); Aicardi syndrome (ortholog); autistic disorder (ortholog); FOUND IN nucleus (ortholog)

Examples of Arx-immunoprecipitated genes and their corresponding functional category.

FunCoup network information for gene ARX in Bos taurus. A0A3Q1MA72_BOVIN Aristaless related homeobox

Protein-Protein, Genetic, and Chemical Interactions for ARX (Drosophila melanogaster) curated by BioGRID (https://thebiogrid.org); DEFINITION: asterix

This dataset is about books. It has 1 row and is filtered where the author is J. A. von Arx. It features 7 columns including author, publication date, language, and book publisher.

La voirie nommée complète de la commune de Arx au format shapefile

Arc Resources reported CAD12.4M in Stock for its fiscal quarter ending in December of 2024. Data for Arc Resources | ARX - Stock including historical, tables and charts were last updated by Trading Economics this last August in 2025.