In 2024, there were *** organ transplants for individuals between the ages of 11 and 17 years old. Organ donation can be given through both a deceased and living donor if blood and oxygen are flowing through the organs until the time of recovery to ensure viability. There are over 100,000 people in the country waiting for an organ transplant. This statistic displays the number of organ transplants performed in the United States, by age group, in 2024.

Those aged 50 to 64 years account for the largest portion of deceased organ donors in the United States. Organs can be donated for transplantation from both living and deceased donors depending on the organ. Organ donors in the U.S. In 2023, there were almost ****** organ donors in the United States, compared to just below ***** in the year 1988. Kidneys are the most recovered organ from donors, followed by the liver and heart. Although the number of organ donors has increased over the years, there are still thousands of candidates waiting for an organ donation. Organ transplantation In 2023, there were ****** organ transplants in the United States. Heart transplants are still much less common than other organ transplants, but this type of transplantation has increased over the years. The average length of stay in the hospital following a heart transplantation is the longest for any organ transplantation. The average heart transplant patient stays in the hospital almost ** days following the procedure, compared to just * days for kidney transplant patients.

The age group with the largest number of individuals on the transplant waiting list in the U.S. as of May 7, 2025 was those aged 50-64 years. This age group had 44,025 patients waiting to receive transplants at that time. There is an extensive need for organ donations in the United States. Organ donations In the U.S. deceased donors can donate kidneys, liver, lungs, heart, pancreas and intestines. Living donors can donate one kidney, one lung or a portion of the liver, pancreas or intestine. Organs are donated mostly from middle-aged U.S. adults. Among all age groups, those aged 50 to 64 years had the highest number of organ donors in 2024. Waiting lists The number of organ donors in the U.S. has increased dramatically since 1988. Despite such a dramatic increase in the number of donors, there is still a great need among U.S. patients. As of May 2025, the organs with the most patients waiting for transplants in the U.S. were kidneys and livers. Over 91 thousand patients required a kidney at that time.

According to the data, in 2024 there were a total of around ****** liver transplants in the United States, of which ***** recipients were ***** years of age. This statistic depicts the number of liver transplant recipients in the U.S. in 2024, by age.

This statistic displays the distribution of organ donors in the United Kingdom (UK) in 2024/25, by age. The organ donation rate was highest among individuals aged between 18 and 49 years at 35 percent, followed by those aged 50 to 59 years and 60 to 69 years, which had 25 and 24 percent of donors in this year, respectively.

Introduction: Living donor kidney transplant (LDKT) is one of the best therapeutic options for end-stage kidney disease (ESKD). Guidelines identify different estimated glomerular filtration rate (eGFR) thresholds to determine the eligibility of donors. The aim of our study was to evaluate whether pretransplant donor eGFR was associated with kidney function in the recipient. Methods: We retrospectively studied LDKT recipients who received a kidney graft between September 1, 2005, and June 30, 2016 in the same transplant center in France and that had eGFR data available at 3, 12, 24, and 36 months posttransplant. Results: We studied 90 donor-recipient pairs. The average age at time of transplant was 51.47 ± 10.95 for donors and 43.04 ± 13.52 years for recipients. Donors’ average eGFR was 91.99 ± 15.37 mL/min/1.73 m2. Donor’s age and eGFR were significantly correlated (p < 0.0001, r2 0.023). Donor’s age and eGFR significantly correlated with recipient’s eGFR at 3, 12, and 24 months posttransplant (age: p < 0.001 at all intervals; eGFR p = 0.001, 0.003, and 0.016, respectively); at 36 months, only donor’s age significantly correlated with recipient’s eGFR. BMI, gender match, and year of kidney transplant did not correlate with graft function. In the multivariable analyses, donor’s eGFR and donor’s age were found to be associated with graft function; correlation with eGFR was lost at 36 months; and donor’s age retained a strong correlation with graft function at all intervals (p < 0.001). Conclusions: Donor’s eGFR and age are strong predictors of recipient’s kidney function at 3 years. We suggest that donor’s eGFR should be clinically balanced with other determinants of kidney function and in particular with age.

BackgroundDonation after circulatory death (DCD) liver allografts are associated with higher rates of primary non-function (PNF) and ischemic cholangiopathy (IC). Advanced recovery techniques, including thoracoabdominal normothermic regional perfusion (TA-NRP), may improve organ utilization and patient and allograft outcomes. Given the increasing US experience with TA-NRP DCD recovery, we evaluated outcomes of DCD liver allografts transplanted after TA-NRP.MethodsLiver allografts transplanted from DCD donors after TA-NRP were identified from 5/1/2021 to 1/31/2022 across 8 centers. Donor data included demographics, functional warm ischemic time (fWIT), total warm ischemia time (tWIT) and total time on TA-NRP. Recipient data included demographics, model of end stage liver disease (MELD) score, etiology of liver disease, PNF, cold ischemic time (CIT), liver function tests, intensive care unit (ICU) and hospital length of stay (LOS), post-operative transplant related complications.ResultsThe donors' median age was 32 years old and median BMI was 27.4. Median fWIT was 20.5 min; fWIT exceeded 30 min in two donors. Median time to initiation of TA-NRP was 4 min and median time on bypass was 66 min. The median recipient listed MELD and MELD at transplant were 22 and 21, respectively. Median allograft CIT was 292 min. The median length of follow up was 257 days. Median ICU and hospital LOS were 2 and 7 days, respectively. Three recipients required management of anastomotic biliary strictures. No patients demonstrated IC, PNF or required re-transplantation.ConclusionLiver allografts from TA-NRP DCD donors demonstrated good early allograft and recipient outcomes.

Organ transplantations can save many lives. Our study aimed to compare knowledge, attitude, and perception regarding organ donation and itsthe impact on same through an educational intervention. This cross–sectional study was conducted on students attending regular classes in medical and non-medical colleges in a south-Asian peninsular city. The sStudents were asked to fill -in online forms shared through social media applications, containing questions about organ donation as a pre-intervention assessment. A session on organ donation was then delivered. Post-intervention forms were then shared, and data were collected. The questions were based on three domains: knowledge, attitude, and perception towards organ donation. Data werewas collected from 220 medical and 220 non-medical students. A total of 276 females, 164 males participated in study. Average age of participants was 19.4+1.5 years. Knowledge regarding the organizations involved and the regulationregulating of organ donation improved post-intervention significantly. Knowledge about cost involved in donation, role of clinician in organ donation, and types of organs that can be donated can be improved. Attitude assessed using binary and Likert scale-based questions statistically improved post-intervention among non-medical students. Perception towards commitment to pledge self-organs and supporting relative’s pledging of organs showed statistically significant improvement. Our study found improvement in knowledge, attitude, and perception of students regarding organ donation after educational intervention.

Individual semi-structured interviews were conducted with 27 adult survivors of childhood liver transplants. Each interview was conducted at a place of the participant's choice, with the majority of interviews undertaken at participants' homes. These followed a topic guide created from the clinical and social science literature, plus the experience of one of the research team of nursing children post liver transplant during the 1980s. In addition, individual semi-structured interviews were conducted with eight clinicians involved in the childhood liver transplant programme, which gave context to the transplant recipients' data. Interviews lasted 82 minutes on average (range 20-163 minutes). All were audio-recorded with the participant's permission, transcribed verbatim, anonymised, and imported into NVivo for data analysis. Alongside the profound social and economic changes arising from general population ageing, the past half century has seen the emergence of ‘new’ ageing populations. These populations have arisen through rapid medical progress in tandem with changes in social attitudes to issues surrounding disability and chronic illness.This has led to increasing numbers of people with rare and/or complex disease or disability living considerably longer lives than was historically possible. Many are pioneers; facing issues as they age that have never before been encountered, either by themselves or by professionals leading their treatment and care. One such new ageing population is the first cohort of pediatric liver transplant recipients in the world. Childhood liver transplantation began in the early-mid 1980s in Britain and North America.Thirty years later, many of the British pioneers, still receiving specialist care, are living adult lives. While clinical outcomes are documented, social and ontological issues for these adults, who have lived their whole lives within the context of their body as a project, have never been studied. Through in-depth interviews with transplant recipients and clinicians, we aim to explore both the health and social implications of living with transplanted livers from infancy and wider existential questions surrounding such transforming ‘experimental’ surgery. We sampled the first ten years of the paediatric liver transplant programme (1984-1994) at Addenbrooke’s hospital, Cambridge, where the programme began in the UK, and at King’s College Hospital, London, which had strong ties to Addenbrooke’s and also began liver transplant surgery during this time. We included those who had had a liver-only transplant at age 13 years or younger, as we were interested to talk to adults who had lived the majority of their life as a transplant pioneer and who had not reached adolescence at the time of their surgery. Letters of invitation and study information were sent by the two hospitals to eligible patients, who were asked to contact the study team if interested. All participants were assured anonymity and confidentiality, and that the research team did not know who the letters had been sent to until an individual chose to reply to the invitation. Early hospital data for the cohort is patchy, as many pioneer recipients have been lost to follow-up, although from discussion with clinicians we believe we interviewed around half of the 1984-1994 surviving UK cohort; around 60 were known to fit our criteria at the time of recruitment.

ABSTRACT Objective: to characterize the profile of potential and effective organ donors, and to identify the factors related to non-donation. Methods: the data was collected from the Organization of Organ Donation forms during the period of January 2013 to April 2018. The statistical analysis was done by the Biostatistic Service of the School of Medical Sciences of UNICAMP. Results: the study analyzed 1,772 potential donors; the male gender was predominant (57.39%). Vascular injuries (n=996) were the main cause of brain death. The family refusal (42.8%) was the leading cause of non-donation of organs. There was statistical difference between donors and non-donors in regard to the mean age and mean systolic blood pressure. There was also a relationship between the donation of organs and the absence of diabetes and smoking. Conclusion: the majority of effective organ donors were young males. The main causes of brain death (BD) and family refusal of organ donation were cerebrovascular disorder and no desire to donate organs after death, respectively. Alcoholics and males were more frequently found in traumatic causes of BD. Therefore, initiatives for population awareness and discussion among the families regarding organ donation can lead to increase the number of effective organ donors.

In the year 2020, patients who received a heart transplant had a ** percent chance of surviving the first year after transplantation. The statistic shows the percentage of organ transplant patients who survived one, three, and five-years after transplantation in the U.S. in 2020, by organ type.

Importance: Expansion of donor acceptance criteria for liver transplant increased the risk for early allograft failure (EAF), and although EAF prediction is pivotal to optimize transplant outcomes, there is no consensus on specific EAF indicators or timing to evaluate EAF. Recently, the Liver Graft Assessment Following Transplantation (L-GrAFT) algorithm, based on aspartate transaminase, bilirubin, platelet, and international normalized ratio kinetics, was developed from a single-center database gathered from 2002 to 2015.

Objective: To develop and validate a simplified comprehensive model estimating at day 10 after liver transplant the EAF risk at day 90 (the Early Allograft Failure Simplified Estimation [EASE] score) and, secondarily, to identify early those patients with unsustainable EAF risk who are suitable for retransplant.

Design, setting, and participants: This multicenter cohort study was designed to develop a score capturing a continuum from normal graft function to nonfunction after transplant. Both parenchymal and vascular factors, which provide an indication to list for retransplant, were included among the EAF determinants. The L-GrAFT kinetic approach was adopted and modified with fewer data entries and novel variables. The population included 1609 patients in Italy for the derivation set and 538 patients in the UK for the validation set; all were patients who underwent transplant in 2016 and 2017.

Main outcomes and measures: Early allograft failure was defined as graft failure (codified by retransplant or death) for any reason within 90 days after transplant.

Results: At day 90 after transplant, the incidence of EAF was 110 of 1609 patients (6.8%) in the derivation set and 41 of 538 patients (7.6%) in the external validation set. Median (interquartile range) ages were 57 (51-62) years in the derivation data set and 56 (49-62) years in the validation data set. The EASE score was developed through 17 entries derived from 8 variables, including the Model for End-stage Liver Disease score, blood transfusion, early thrombosis of hepatic vessels, and kinetic parameters of transaminases, platelet count, and bilirubin. Donor parameters (age, donation after cardiac death, and machine perfusion) were not associated with EAF risk. Results were adjusted for transplant center volume. In receiver operating characteristic curve analyses, the EASE score outperformed L-GrAFT, Model for Early Allograft Function, Early Allograft Dysfunction, Eurotransplant Donor Risk Index, donor age × Model for End-stage Liver Disease, and Donor Risk Index scores, estimating day 90 EAF in 87% (95% CI, 83%-91%) of cases in both the derivation data set and the internal validation data set. Patients could be stratified in 5 classes, with those in the highest class exhibiting unsustainable EAF risk.

Conclusions and relevance: This study found that the developed EASE score reliably estimated EAF risk. Knowledge of contributing factors may help clinicians to mitigate risk factors and guide them through the challenging clinical decision to allocate patients to early liver retransplant. The EASE score may be used in translational research across transplant centers.

BackgroundFraction of exhaled nitric oxide with an expiratory flow of 50 mL/s (FENO50) is a biomarker of eosinophilic airway inflammation. Liver transplant recipients have an increased risk of pulmonary infections, but little is known about the burden of chronic pulmonary diseases in this group. We aimed to assess the prevalence of elevated FENO50 in liver transplant recipients and compare it to controls from the general population.MethodsFENO50 was measured in 271 liver transplant recipients from The Danish Comorbidity in Liver Transplant Recipients (DACOLT) study and 1,018 age- and sex-matched controls from The Copenhagen General Population Study (CGPS). Elevated FENO50 was defined as ≥25 or ≥50 parts per billion (ppb). The analyses were adjusted for known and suspected confounders.ResultsThe median age of the liver transplant recipients was 55 years (interquartile range (IQR) 46–64), and 58% were men. The liver transplant recipients had a higher median FENO50 than the controls [16 ppb (IQR 10–26) vs. 13 ppb (IQR 8–18.), p < 0.001]. Furthermore, the liver transplant recipients had a higher prevalence of elevated FENO50 (for FENO50 ≥25 ppb 27% vs. 11%, p < 0.001 and ≥50 ppb 4% vs. 2%, p = 0.02). The results were similar after adjusting for age, sex, smoking status, use of airway medication, and blood eosinophil counts [the adjusted odds ratio (OR) for FENO50 ≥25 ppb was 3.58 (95% CI: 2.50–5.15, p < 0.0001) and the adjusted OR for FENO50 ≥50 ppb was 3.14 (95% CI: 1.37–7.20, p = 0.007)].ConclusionThe liver transplant recipients had elevated FENO50, implying increased eosinophilic airway inflammation. The clinical impact of this finding needs further investigation.

The kidney is the most transplanted organ worldwide, followed by the liver and the heart. In 2023, there were a total of ******* organ transplants worldwide. Organ transplantation is frequently the best or only treatment for end stage organ failure, although transplantation can be challenging and complex. Kidney transplantation Kidney transplantation, or renal transplantation, is by far the most common type of organ transplantation worldwide. Although end stage renal disease can be treated through other means, such as dialysis, kidney transplantation is largely viewed as the best treatment option. Most kidney transplants are done in the Americas and in Europe, where there are a larger number of donors and better access to such procedures. Organ donors Organs can be donated either from a living donor or a deceased donor, depending on the type of organ. Organ donation frequency is different from country to country, as laws that permit or refuse donation vary. Spain, the United States, and Portugal have the highest rates of deceased organ donors worldwide; however, there are still high numbers of patients waiting for organ transplants. In the United States alone, there are almost *** thousand candidates waiting for organ donations, the majority of which require a kidney transplantation.

BackgroundThe cytomegalovirus (CMV) mismatch rate in deceased donor kidney transplant (DDKT) recipients in the US remains above 40%. Since CMV mismatching is common in DDKT recipients, the cumulative effects may be significant in the context of overall patient and graft survival. Our primary objective was to describe the short- and long-term risks associated with high-risk CMV donor positive/recipient negative (D+/R-) mismatching among DDKT recipients with the explicit goal of deriving a mathematical mismatching penalty.MethodsWe conducted a retrospective, secondary analysis of the Scientific Registry of Transplant Recipients (SRTR) database using donor-matched DDKT recipient pairs (N=105,608) transplanted between 2011-2022. All-cause mortality and graft failure hazard ratios were calculated from one year to ten years post-DDKT. All-cause graft failure included death events. Survival curves were calculated using the Kaplan-Meier estimation at 10 years post-DDKT and extrapolated to 20 years to provide the average graft days lost (aGDL) and average patient days lost (aPDL) due to CMV D+/R- serostatus mismatching. We also performed an age-based stratification analysis to compare the relative risk of CMV D+ mismatching by age.ResultsAmong 31,518 CMV D+/R- recipients, at 1 year post-DDKT, the relative risk of death increased by 29% (p

In 2024, California had the highest number of liver transplants performed among all U.S. states. That year, there were around 1,243 liver transplants performed in California. The state with the second-highest number of liver transplants was Texas. Liver transplants are the second most common transplant in the United States, behind kidney transplants. Liver transplants in the United States In 2023, there were just over 10,660 liver transplants carried out in the United States. Most liver transplants in the U.S. are among adults aged 50 to 64 years, with this age group accounting for around 43 percent of all liver transplants. The current need for liver transplants exceeds availability, with over nine thousand people in the United States waiting to receive a liver transplant. Liver transplantation is a treatment option for those suffering from end-stage chronic liver disease, in which the liver is damaged beyond repair. Liver disease End-stage chronic liver disease, or liver failure, has various causes including cirrhosis, hepatitis B and C, and liver cancer. Around half of all deaths in the United States caused by liver cirrhosis are related to alcohol use. Liver cirrhosis is scarring of the liver because of long-term damage. The death rate due to alcohol-related cirrhosis in the United States has increased over the past couple decades. Men are much more likely to die from liver cirrhosis than women.

BackgroundThe transplant community increasingly accepts extended criteria live kidney donors, however, great (geographical) differences are present in policies regarding the acceptance of these donors, and guidelines do not offer clarity. The aim of this survey was to reveal these differences and to get an insight in both centre policies as well as personal beliefs of transplant professionals.MethodsAn online survey was sent to 1128 ESOT-members. Questions were included about several extended donor criteria; overweight/obesity, older age, vascular multiplicity, minors as donors and comorbidities; hypertension, impaired fasting glucose, kidney stones, malignancies and renal cysts. Comparisons were made between transplant centres of three regions in Europe and between Europe and other countries worldwide.Results331 questionnaires were completed by professionals from 55 countries. Significant differences exist between regions in Europe in acceptance of donors with several extended criteria. Median refusal rate for potential live donors is 15%. Furthermore, differences are seen regarding pre-operative work-up, both in specialists who perform screening as in preoperative imaging.ConclusionsRemarkably, 23.4% of transplant professionals sometimes deviate from their centre policy, resulting in more or less comparable personal beliefs regarding extended criteria. Variety is seen, proving the need for a standardized approach in selection, preferably evidence based.

Identified variants in 15 kidney transplant recipients and donors.

Total body irradiation (TBI) is a commonly used conditioning regimen for hematopoietic stem cell transplant (HCT), but dose heterogeneity and long-term organ toxicity pose significant challenges. Total marrow irradiation (TMI), an evolving radiation conditioning regimen for HCT can overcome the limitations of TBI by delivering the prescribed dose targeted to the bone marrow (BM) while sparing organs at risk. Recently, our group demonstrated that TMI up to 20 Gy in relapsed/refractory AML patients was feasible and efficacious, significantly improving 2-year overall survival compared to the standard treatment. Whether such dose escalation is feasible in elderly patients, and how the organ toxicity profile changes when switching to TMI in patients of all ages are critical questions that need to be addressed. We used our recently developed 3D image-guided preclinical TMI model and evaluated the radiation damage and its repair in key dose-limiting organs in young (~8 weeks) and old (~90 weeks) mice undergoing congenic bone marrow transplant (BMT). Engraftment was similar in both TMI and TBI-treated young and old mice. Dose escalation using TMI (12 to 16 Gy in two fractions) was well tolerated in mice of both age groups (90% survival ~12 Weeks post-BMT). In contrast, TBI at the higher dose of 16 Gy was particularly lethal in younger mice (0% survival ~2 weeks post-BMT) while old mice showed much more tolerance (75% survival ~13 weeks post-BMT) suggesting higher radio-resistance in aged organs. Histopathology confirmed worse acute and chronic organ damage in mice treated with TBI than TMI. As the damage was alleviated, the repair processes were augmented in the TMI-treated mice over TBI as measured by average villus height and a reduced ratio of relative mRNA levels of amphiregulin/epidermal growth factor (areg/egf). These findings suggest that organ sparing using TMI does not limit donor engraftment but significantly reduces normal tissue damage and preserves repair capacity with the potential for dose escalation in elderly patients.

ABSTRACT Objectives Verify the knowledge of ICU physicians about the diagnosis of brain death and the opinions of ICU physicians about organ donation. Methods Quantitative, exploratory, descriptive and cross-sectional study. Methods We interviewed 38 physicians at an adult ICU of a State hospital in the city of Rio de Janeiro. The data collection instrument was split into three parts: the first to gather professional information; the second was composed of nine closed-ended, multiple-choice questions, which addressed technical criteria for the diagnosis of brain death; a further seven questions asked for the interviewee’s opinion on brain death and organ donation. Results The study population had a mean age of 38.45 years (DP = 10.58). In relation to training time, the average was 11.87 years (DP = 8.94). The overall quantity of correct answers to the conceptual questions was 8.07 (DP = 0.78). Of the 38 participants, only 12 (31.57%) correctly answered all the questions. Two interviewees (5.2%) did not feel confident about conducting the clinical examination. No significant differences were found between the number of correct anwers and the age and/or gender of the interviewee. Conclusion Only the professional group of intensivists had participants who answered all the technical questions correctly. However, some basic issues require deeper discussion. It is important to incorporate disciplines that approach this subject in undergraduate courses in the health area, which may help diffuse educational attitudes. Such themes should also be extensively addressed in specialization courses in intensive care in order to improve training about the whole context involving brain death and the donation-transplant process, since this process must be absolutely watertight at every step.