From the mid-19th century until today, life expectancy at birth in the United States has roughly doubled, from 39.4 years in 1850 to 79.6 years in 2025. It is estimated that life expectancy in the U.S. began its upward trajectory in the 1880s, largely driven by the decline in infant and child mortality through factors such as vaccination programs, antibiotics, and other healthcare advancements. Improved food security and access to clean water, as well as general increases in living standards (such as better housing, education, and increased safety) also contributed to a rise in life expectancy across all age brackets. There were notable dips in life expectancy; with an eight year drop during the American Civil War in the 1860s, a seven year drop during the Spanish Flu empidemic in 1918, and a 2.5 year drop during the Covid-19 pandemic. There were also notable plateaus (and minor decreases) not due to major historical events, such as that of the 2010s, which has been attributed to a combination of factors such as unhealthy lifestyles, poor access to healthcare, poverty, and increased suicide rates, among others. However, despite the rate of progress slowing since the 1950s, most decades do see a general increase in the long term, and current UN projections predict that life expectancy at birth in the U.S. will increase by another nine years before the end of the century.

For most of the world, throughout most of human history, the average life expectancy from birth was around 24. This figure fluctuated greatly depending on the time or region, and was higher than 24 in most individual years, but factors such as pandemics, famines, and conflicts caused regular spikes in mortality and reduced life expectancy. Child mortality The most significant difference between historical mortality rates and modern figures is that child and infant mortality was so high in pre-industrial times; before the introduction of vaccination, water treatment, and other medical knowledge or technologies, women would have around seven children throughout their lifetime, but around half of these would not make it to adulthood. Accurate, historical figures for infant mortality are difficult to ascertain, as it was so prevalent, it took place in the home, and was rarely recorded in censuses; however, figures from this source suggest that the rate was around 300 deaths per 1,000 live births in some years, meaning that almost one in three infants did not make it to their first birthday in certain periods. For those who survived to adolescence, they could expect to live into their forties or fifties on average. Modern figures It was not until the eradication of plague and improvements in housing and infrastructure in recent centuries where life expectancy began to rise in some parts of Europe, before industrialization and medical advances led to the onset of the demographic transition across the world. Today, global life expectancy from birth is roughly three times higher than in pre-industrial times, at almost 73 years. It is higher still in more demographically and economically developed countries; life expectancy is over 82 years in the three European countries shown, and over 84 in Japan. For the least developed countries, mostly found in Sub-Saharan Africa, life expectancy from birth can be as low as 53 years.

Life expectancy in India was 25.4 in the year 1800, and over the course of the next 220 years, it has increased to almost 70. Between 1800 and 1920, life expectancy in India remained in the mid to low twenties, with the largest declines coming in the 1870s and 1910s; this was because of the Great Famine of 1876-1878, and the Spanish Flu Pandemic of 1918-1919, both of which were responsible for the deaths of up to six and seventeen million Indians respectively; as well as the presence of other endemic diseases in the region, such as smallpox. From 1920 onwards, India's life expectancy has consistently increased, but it is still below the global average.

Life expectancy in the United Kingdom was below 39 years in the year 1765, and over the course of the next two and a half centuries, it is expected to have increased by more than double, to 81.1 by the year 2020. Although life expectancy has generally increased throughout the UK's history, there were several times where the rate deviated from its previous trajectory. These changes were the result of smallpox epidemics in the late eighteenth and early nineteenth centuries, new sanitary and medical advancements throughout time (such as compulsory vaccination), and the First world War and Spanish Flu epidemic in the 1910s.