From the mid-19th century until today, life expectancy at birth in the United States has roughly doubled, from 39.4 years in 1850 to 79.6 years in 2025. It is estimated that life expectancy in the U.S. began its upward trajectory in the 1880s, largely driven by the decline in infant and child mortality through factors such as vaccination programs, antibiotics, and other healthcare advancements. Improved food security and access to clean water, as well as general increases in living standards (such as better housing, education, and increased safety) also contributed to a rise in life expectancy across all age brackets. There were notable dips in life expectancy; with an eight year drop during the American Civil War in the 1860s, a seven year drop during the Spanish Flu empidemic in 1918, and a 2.5 year drop during the Covid-19 pandemic. There were also notable plateaus (and minor decreases) not due to major historical events, such as that of the 2010s, which has been attributed to a combination of factors such as unhealthy lifestyles, poor access to healthcare, poverty, and increased suicide rates, among others. However, despite the rate of progress slowing since the 1950s, most decades do see a general increase in the long term, and current UN projections predict that life expectancy at birth in the U.S. will increase by another nine years before the end of the century.

In the past four centuries, the population of the Thirteen Colonies and United States of America has grown from a recorded 350 people around the Jamestown colony in Virginia in 1610, to an estimated 346 million in 2025. While the fertility rate has now dropped well below replacement level, and the population is on track to go into a natural decline in the 2040s, projected high net immigration rates mean the population will continue growing well into the next century, crossing the 400 million mark in the 2070s. Indigenous population Early population figures for the Thirteen Colonies and United States come with certain caveats. Official records excluded the indigenous population, and they generally remained excluded until the late 1800s. In 1500, in the first decade of European colonization of the Americas, the native population living within the modern U.S. borders was believed to be around 1.9 million people. The spread of Old World diseases, such as smallpox, measles, and influenza, to biologically defenseless populations in the New World then wreaked havoc across the continent, often wiping out large portions of the population in areas that had not yet made contact with Europeans. By the time of Jamestown's founding in 1607, it is believed the native population within current U.S. borders had dropped by almost 60 percent. As the U.S. expanded, indigenous populations were largely still excluded from population figures as they were driven westward, however taxpaying Natives were included in the census from 1870 to 1890, before all were included thereafter. It should be noted that estimates for indigenous populations in the Americas vary significantly by source and time period. Migration and expansion fuels population growth The arrival of European settlers and African slaves was the key driver of population growth in North America in the 17th century. Settlers from Britain were the dominant group in the Thirteen Colonies, before settlers from elsewhere in Europe, particularly Germany and Ireland, made a large impact in the mid-19th century. By the end of the 19th century, improvements in transport technology and increasing economic opportunities saw migration to the United States increase further, particularly from southern and Eastern Europe, and in the first decade of the 1900s the number of migrants to the U.S. exceeded one million people in some years. It is also estimated that almost 400,000 African slaves were transported directly across the Atlantic to mainland North America between 1500 and 1866 (although the importation of slaves was abolished in 1808). Blacks made up a much larger share of the population before slavery's abolition. Twentieth and twenty-first century The U.S. population has grown steadily since 1900, reaching one hundred million in the 1910s, two hundred million in the 1960s, and three hundred million in 2007. Since WWII, the U.S. has established itself as the world's foremost superpower, with the world's largest economy, and most powerful military. This growth in prosperity has been accompanied by increases in living standards, particularly through medical advances, infrastructure improvements, clean water accessibility. These have all contributed to higher infant and child survival rates, as well as an increase in life expectancy (doubling from roughly 40 to 80 years in the past 150 years), which have also played a large part in population growth. As fertility rates decline and increases in life expectancy slows, migration remains the largest factor in population growth. Since the 1960s, Latin America has now become the most common origin for migrants in the U.S., while immigration rates from Asia have also increased significantly. It remains to be seen how immigration restrictions of the current administration affect long-term population projections for the United States.

Life expectancy in the United Kingdom was below 39 years in the year 1765, and over the course of the next two and a half centuries, it is expected to have increased by more than double, to 81.1 by the year 2020. Although life expectancy has generally increased throughout the UK's history, there were several times where the rate deviated from its previous trajectory. These changes were the result of smallpox epidemics in the late eighteenth and early nineteenth centuries, new sanitary and medical advancements throughout time (such as compulsory vaccination), and the First world War and Spanish Flu epidemic in the 1910s.

The child mortality rate in the United States, for children under the age of five, was 462.9 deaths per thousand births in 1800. This means that for every thousand babies born in 1800, over 46 percent did not make it to their fifth birthday. Over the course of the next 220 years, this number has dropped drastically, and the rate has dropped to its lowest point ever in 2020 where it is just seven deaths per thousand births. Although the child mortality rate has decreased greatly over this 220 year period, there were two occasions where it increased; in the 1870s, as a result of the fourth cholera pandemic, smallpox outbreaks, and yellow fever, and in the late 1910s, due to the Spanish Flu pandemic.