Over the past 160 years, life expectancy (from birth) in the United States has risen from 39.4 years in 1860, to 78.9 years in 2020. One of the major reasons for the overall increase of life expectancy in the last two centuries is the fact that the infant and child mortality rates have decreased by so much during this time. Medical advancements, fewer wars and improved living standards also mean that people are living longer than they did in previous centuries.

Despite this overall increase, the life expectancy dropped three times since 1860; from 1865 to 1870 during the American Civil War, from 1915 to 1920 during the First World War and following Spanish Flu epidemic, and it has dropped again between 2015 and now. The reason for the most recent drop in life expectancy is not a result of any specific event, but has been attributed to negative societal trends, such as unbalanced diets and sedentary lifestyles, high medical costs, and increasing rates of suicide and drug use.

A global phenomenon, known as the demographic transition, has seen life expectancy from birth increase rapidly over the past two centuries. In pre-industrial societies, the average life expectancy was around 24 years, and it is believed that this was the case throughout most of history, and in all regions. The demographic transition then began in the industrial societies of Europe, North America, and the West Pacific around the turn of the 19th century, and life expectancy rose accordingly. Latin America was the next region to follow, before Africa and most Asian populations saw their life expectancy rise throughout the 20th century.

Life expectancy in the United Kingdom was below 39 years in the year 1765, and over the course of the next two and a half centuries, it is expected to have increased by more than double, to 81.1 by the year 2020. Although life expectancy has generally increased throughout the UK's history, there were several times where the rate deviated from its previous trajectory. These changes were the result of smallpox epidemics in the late eighteenth and early nineteenth centuries, new sanitary and medical advancements throughout time (such as compulsory vaccination), and the First world War and Spanish Flu epidemic in the 1910s.

Life expectancy in India was 25.4 in the year 1800, and over the course of the next 220 years, it has increased to almost 70. Between 1800 and 1920, life expectancy in India remained in the mid to low twenties, with the largest declines coming in the 1870s and 1910s; this was because of the Great Famine of 1876-1878, and the Spanish Flu Pandemic of 1918-1919, both of which were responsible for the deaths of up to six and seventeen million Indians respectively; as well as the presence of other endemic diseases in the region, such as smallpox. From 1920 onwards, India's life expectancy has consistently increased, but it is still below the global average.

At the beginning of the 1840s, life expectancy from birth in Ireland was just over 38 years. However, this figure would see a dramatic decline with the beginning of the Great Famine in 1845, and dropped below 21 years in the second half of the decade (in 1849 alone, life expectancy fell to just 14 years). The famine came as a result of a Europe-wide potato blight, which had a disproportionally devastating impact on the Irish population due to the dependency on potatoes (particularly in the south and east), and the prevalence of a single variety of potato on the island that allowed the blight to spread faster than in other areas of Europe. Additionally, authorities forcefully redirected much of the country's surplus grain to the British mainland, which exacerbated the situation. Within five years, mass starvation would contribute to the deaths of over one million people on the island, while a further one million would emigrate; this also created a legacy of emigration from Ireland, which saw the population continue to fall until the mid-1900s, and the total population of the island is still well below its pre-famine level of 8.5 million people.

Following the end of the Great Famine, life expectancy would begin to gradually increase in Ireland, as post-famine reforms would see improvements in the living standards of the country’s peasantry, most notably the Land Wars, a largely successful series of strikes, boycotts and protests aimed at reform of the country's agricultural land distribution, which began in the 1870s and lasted into the 20th century. As these reforms were implemented, life expectancy in Ireland would rise to more than fifty years by the turn of the century. While this rise would slow somewhat in the 1910s, due to the large number of Irish soldiers who fought in the First World War and the Spanish Flu pandemic, as well as the period of civil unrest leading up to the island's partition in 1921, life expectancy in Ireland would rise greatly in the 20th century. In the second half of the 20th century, Ireland's healthcare system and living standards developed similarly to the rest of Western Europe, and today, it is often ranks among the top countries globally in terms of human development, GDP and quality of healthcare. With these developments, the increase in life expectancy from birth in Ireland was relatively constant in the first century of independence, and in 2020 is estimated to be 82 years.

Life expectancy in China was just 32 in the year 1850, and over the course of the next 170 years, it is expected to more than double to 76.6 years in 2020. Between 1850 and 1950, finding reliable data proved difficult for anthropologists, however some events, such as the Taiping Rebellion and Dungan Revolt in the nineteenth century did reduce life expectancy by a few years, and also the Chinese Civil War and Second World War in the first half of the twentieth century. In the second half of the 1900s, Chinese life expectancy increased greatly, as the country became more industrialized and the standard of living increased.

Life expectancy in Russia was 29.6 in the year 1845, and over the course of the next 175 years, it is expected to have increased to 72.3 years by 2020. Generally speaking, Russian life expectancy has increased over this 175 year period, however events such as the World Wars, Russian Revolution and a series of famines caused fluctuations before the mid-twentieth century, where the rate fluctuated sporadically. Between 1945 and 1950, Russian life expectancy more than doubled in this five year period, and it then proceeded to increase until the 1970s, when it then began to fall again. Between 1970 and 2005, the number fell from 68.5 to 65, before it then grew again in more recent years.

Life expectancy in Canada was just below forty in the year 1800, and over the course of the next 220 years, it is expected to have increased by more than double to 82.2 by the year 2020. Throughout this time, life expectancy in Canada progressed at a steady rate, with the most noticeable changes coming during the interwar period, where the rate of increase was affected by the Spanish Flu epidemic and both World Wars.

In 1875, the average person born in Chile could expect to live to the age of 32 years, a figure that would remain largely stagnante throughout the late 19th and early 20th century, as the country’s Parliamentary era would see relatively little change in the day to day lives of the country’s citizens. Outside of two dips in 1910 and 1920, the latter primarily driven by the 1918 Spanish Flu epidemic. Life expectancy would see two sharp increases following the end of the First World War; the first in the 1920s, and the most dramatic in the early 1950s.

The first of these spikes, under President Ibáñez del Campo, can be attributed primarily to large increases in spending on public healthcare and improvements in public sanitation by the Campo administration. The second and larger spike, under President González Videla, can be attributed to a combination of mass immunization and vaccination, and the implementation of a national health care system, drastically cutting child mortality in the country. As a result of these reforms, life expectancy in Chile would more than double in just thirty years, rising from just over 33 years in 1925 to 69 years by 1955. Following the end of the Videla administration in 1952, life expectancy would continue to rise in Chile, as increasing urbanization, and the successful eradication of many childhood diseases would see both child and overall mortality decline. This rise has continued even into the 21st century, and as a result, life expectancy in Chile rose to over 78 years by the end of the century, and in 2020, it is estimated that the average person born in Chile will live to over 82 years old, the highest in South America.

The child mortality rate in the United States, for children under the age of five, was 462.9 deaths per thousand births in 1800. This means that for every thousand babies born in 1800, over 46 percent did not make it to their fifth birthday. Over the course of the next 220 years, this number has dropped drastically, and the rate has dropped to its lowest point ever in 2020 where it is just seven deaths per thousand births. Although the child mortality rate has decreased greatly over this 220 year period, there were two occasions where it increased; in the 1870s, as a result of the fourth cholera pandemic, smallpox outbreaks, and yellow fever, and in the late 1910s, due to the Spanish Flu pandemic.