In 2019, the leading causes of death worldwide were ischemic heart disease, stroke, and chronic obstructive pulmonary disease (COPD). That year, ischemic heart disease and stroke accounted for a combined ** percent of all deaths worldwide. Although the leading causes of death worldwide vary by region and country, heart disease is a consistent leading cause of death regardless of income, development, size, or location. Heart disease In 2019, around **** million people worldwide died from ischemic heart disease. In comparison, around **** million people died from lung cancer that year, while *** million died from diabetes. The countries with the highest rates of death due to heart attack and other ischemic heart diseases are Lithuania, Russia, and Slovakia. Although some risk factors for heart disease, such as age and genetics, are unmodifiable, the likelihood of developing heart disease can be greatly reduced through a healthy lifestyle. The biggest modifiable risk factors for heart disease include smoking, an unhealthy diet, being overweight, and a lack of exercise. In 2019, it was estimated that around *** million deaths worldwide due to ischemic heart disease could be attributed to smoking. The leading causes of death in the United States Just as it is the leading cause of death worldwide, heart disease is also the leading cause of death in the United States. In 2023, heart disease accounted for ** percent of all deaths in the United States. Cancer was the second leading cause of death in the U.S. that year, followed by accidents. As of 2023, the odds that a person in the United States will die from heart disease is * in *. However, rates of death due to heart disease have actually declined in the U.S. over the past couple decades. From 2000 to 2022, there was a *** percent decline in heart disease deaths. On the other hand, deaths from Alzheimer’s disease saw an increase of *** percent over this period. Alzheimer’s disease is currently the sixth leading cause of death in the United States, accounting for **** deaths per 100,000 population in 2023.

In 2019, the leading causes of death globally included ischemic heart disease, stroke and chronic obstructive pulmonary disease (COPD). There were **** million deaths from ischemic heart disease at that time and about **** million deaths caused by stroke. In recent history, increases in life expectancy, increases in population and better standards of living have changed the leading causes of death over time. Non-Communicable Disease Deaths The number of deaths due to non-communicable diseases has remained relatively stable in recent years. A large majority of non-communicable or chronic disease deaths globally are caused by cardiovascular diseases, followed by cancer. Various lifestyle choices cause or exacerbate many of these chronic diseases. Drinking, smoking and lack of exercise can contribute to higher rates of non-communicable diseases and early death. It is estimated that the relative risk of death before the age of 65 was ** times greater among those that smoked and never quit. Infectious Disease Deaths Trends indicate that the number of deaths due to infectious diseases have decreased in recent years. However, infectious diseases still disproportionately impact low- and middle-income countries. In 2021, tuberculosis, malaria and HIV/AIDS were still among the leading causes of death in low-income countries. However, the leading causes of death in upper income countries are almost exclusively non-communicable, chronic conditions.

In 2021, the leading causes of death worldwide were ischemic heart disease, COVID-19, and stroke. That year, ischemic heart disease caused over nine million deaths, while COVID-19 resulted in 8.7 million deaths. In 2019, just before the COVID-19 pandemic, the leading causes of death worldwide were ischemic heart disease, stroke, and chronic obstructive pulmonary disease (COPD).

Rank, number of deaths, percentage of deaths, and age-specific mortality rates for the leading causes of death, by age group and sex, 2000 to most recent year.

The global landscape of mortality has undergone significant changes from 1990 to 2021, but cardiovascular diseases remain the leading cause of death worldwide. In 2021, cardiovascular diseases accounted for 28.6 percent of all deaths, followed by cancers at 14.6 percent. Notably, COVID-19 emerged as the third leading cause of death in 2021, responsible for 11.6 percent of global fatalities. Impact of the COVID-19 pandemic The emergence of COVID-19 as a major cause of death underscores the profound impact of the pandemic on global health. By May 2023, the virus had infected over 687 million people worldwide and claimed nearly 6.87 million lives. The United States, India, and Brazil were among the most severely affected countries. The pandemic's effects extended beyond direct mortality, influencing healthcare systems and potentially exacerbating other health conditions. Shifts in global health priorities While infectious diseases like COVID-19 have gained prominence, long-term health trends reveal significant progress in certain areas. The proportion of neonatal deaths decreased from 6.4 percent in 1990 to 2.7 percent in 2021, reflecting improvements in maternal and child health care. However, challenges persist in addressing malnutrition and hunger, particularly in Sub-Saharan Africa and South Asia. The Global Hunger Index 2024 identified Somalia, Yemen, and Chad as the countries most affected by hunger and malnutrition, highlighting the ongoing need for targeted interventions in these regions.

This dataset presents the age-adjusted death rates for the 10 leading causes of death in the United States beginning in 1999. Data are based on information from all resident death certificates filed in the 50 states and the District of Columbia using demographic and medical characteristics. Age-adjusted death rates (per 100,000 population) are based on the 2000 U.S. standard population. Populations used for computing death rates after 2010 are postcensal estimates based on the 2010 census, estimated as of July 1, 2010. Rates for census years are based on populations enumerated in the corresponding censuses. Rates for non-census years before 2010 are revised using updated intercensal population estimates and may differ from rates previously published. Causes of death classified by the International Classification of Diseases, Tenth Revision (ICD–10) are ranked according to the number of deaths assigned to rankable causes. Cause of death statistics are based on the underlying cause of death. SOURCES CDC/NCHS, National Vital Statistics System, mortality data (see http://www.cdc.gov/nchs/deaths.htm); and CDC WONDER (see http://wonder.cdc.gov). REFERENCES National Center for Health Statistics. Vital statistics data available. Mortality multiple cause files. Hyattsville, MD: National Center for Health Statistics. Available from: https://www.cdc.gov/nchs/data_access/vitalstatsonline.htm. Murphy SL, Xu JQ, Kochanek KD, Curtin SC, and Arias E. Deaths: Final data for 2015. National vital statistics reports; vol 66. no. 6. Hyattsville, MD: National Center for Health Statistics. 2017. Available from: https://www.cdc.gov/nchs/data/nvsr/nvsr66/nvsr66_06.pdf.

Data for deaths by leading cause of death categories are now available in the death profiles dataset for each geographic granularity. The cause of death categories are based solely on the underlying cause of death as coded by the International Classification of Diseases. The underlying cause of death is defined by the World Health Organization (WHO) as "the disease or injury which initiated the train of events leading directly to death, or the circumstances of the accident or violence which produced the fatal injury." It is a single value assigned to each death based on the details as entered on the death certificate. When more than one cause is listed, the order in which they are listed can affect which cause is coded as the underlying cause. This means that similar events could be coded with different underlying causes of death depending on variations in how they were entered. Consequently, while underlying cause of death provides a convenient comparison between cause of death categories, it may not capture the full impact of each cause of death as it does not always take into account all conditions contributing to the death. Cause of death categories for years 1999 and later are based on tenth revision of International Classification of Diseases (ICD-10) codes. Comparable categories are provided for years 1979 through 1998 based on ninth revision (ICD-9) codes. For more information on the comparability of cause of death classification between ICD revisions see Comparability of Cause-of-death Between ICD Revisions.

As of 2023, the countries with the highest death rates worldwide were Monaco, Bulgaria, and Latvia. In these countries, there were ** to ** deaths per 1,000 people. The country with the lowest death rate is Qatar, where there is just *** death per 1,000 people. Leading causes of death The leading causes of death worldwide are, by far, cardiovascular diseases, accounting for ** percent of all deaths in 2021. That year, there were **** million deaths worldwide from ischaemic heart disease and **** million from stroke. Interestingly, a worldwide survey from that year found that people greatly underestimate the proportion of deaths caused by cardiovascular disease, but overestimate the proportion of deaths caused by suicide, interpersonal violence, and substance use disorders. Death in the United States In 2023, there were around **** million deaths in the United States. The leading causes of death in the United States are currently heart disease and cancer, accounting for a combined ** percent of all deaths in 2023. Lung and bronchus cancer is the deadliest form of cancer worldwide, as well as in the United States. In the U.S. this form of cancer is predicted to cause around ****** deaths among men alone in the year 2025. Prostate cancer is the second-deadliest cancer for men in the U.S. while breast cancer is the second deadliest for women. In 2023, the tenth leading cause of death in the United States was COVID-19. Deaths due to COVID-19 resulted in a significant rise in the total number of deaths in the U.S. in 2020 and 2021 compared to 2019, and it was the third leading cause of death in the U.S. during those years.

In 2021, the leading causes of death in Africa were lower respiratory infections, malaria, and stroke. That year, lower respiratory infections resulted in around 65 deaths per 100,000 population in Africa. Leading causes of death in Africa vs the world Worldwide, the top three leading causes of death in 2021 were heart disease, COVID-19, and stroke. At that time, some of the leading causes of death in Africa, such as lower respiratory infections and stroke, were among the leading causes worldwide, but there were also stark differences in the leading causes of death in Africa compared to the leading causes worldwide. For example, malaria, diarrheal disease, and preterm birth complications were among the top ten leading causes of death in Africa, but not worldwide. Furthermore, HIV/AIDS was the eighth leading cause of death in Africa at that time, but was not among the top ten leading causes worldwide. HIV/AIDS in Africa Although HIV/AIDS impacts every region of the world, Africa is still the region most impacted by this deadly virus. Worldwide, there are around 40 million people currently living with HIV, with about 20.8 million found in Eastern and Southern Africa and 5.1 million in Western and Central Africa. The countries with the highest HIV prevalence worldwide include Eswatini, Lesotho, and South Africa, with the leading 20 countries by HIV prevalence all found in Africa. However, due in part to improvements in education and awareness, the prevalence of HIV in many African countries has decreased. For example, in Botswana, the prevalence of HIV decreased from 26.1 percent to 16.6 percent in the period from 2000 to 2023.

The leading cause of death in low-income countries worldwide in 2021 was lower respiratory infections, followed by stroke and ischemic heart disease. The death rate from lower respiratory infections that year was 59.4 deaths per 100,000 people. While the death rate from stroke was around 51.6 per 100,000 people. Many low-income countries suffer from health issues not seen in high-income countries, including infectious diseases, malnutrition and neonatal deaths, to name a few. Low-income countries worldwide Low-income countries are defined as those with per gross national incomes (GNI) per capita of 1,045 U.S. dollars or less. A majority of the world’s low-income countries are located in sub-Saharan Africa and South East Asia. Some of the lowest-income countries as of 2023 include Burundi, Sierra Leone, and South Sudan. Low-income countries have different health problems that lead to worse health outcomes. For example, Chad, Lesotho, and Nigeria have some of the lowest life expectancies on the planet. Health issues in low-income countries Low-income countries also tend to have higher rates of HIV/AIDS and other infectious diseases as a consequence of poor health infrastructure and a lack of qualified health workers. Eswatini, Lesotho, and South Africa have some of the highest rates of new HIV infections worldwide. Likewise, tuberculosis, a treatable condition that affects the respiratory system, has high incident rates in lower income countries. Other health issues can be affected by the income of a country as well, including maternal and infant mortality. In 2023, Afghanistan had one of the highest rates of infant mortality rates in the world.

Heart disease is currently the leading cause of death in the United States. In 2022, COVID-19 was the fourth leading cause of death in the United States, accounting for almost six percent of all deaths that year. The leading causes of death worldwide are similar to those in the United States. However, diarrheal diseases and neonatal conditions are major causes of death worldwide, but are not among the leading causes in the United States. Instead, accidents and chronic liver disease have a larger impact in the United States.

Racial differences

In the United States, there exist slight differences in leading causes of death depending on race and ethnicity. For example, assault, or homicide, accounts for around three percent of all deaths among the Black population but is not even among the leading causes of death for other races and ethnicities. However, heart disease and cancer are still the leading causes of death for all races and ethnicities.

Leading causes of death among men vs women

Similarly, there are also differences in the leading causes of death in the U.S. between men and women. For example, among men, intentional self-harm accounts for around two percent of all deaths but is not among the leading causes of death among women. On the other hand, influenza and pneumonia account for more deaths among women than men.

This dataset contains counts of deaths for California as a whole based on information entered on death certificates. Final counts are derived from static data and include out-of-state deaths to California residents, whereas provisional counts are derived from incomplete and dynamic data. Provisional counts are based on the records available when the data was retrieved and may not represent all deaths that occurred during the time period. Deaths involving injuries from external or environmental forces, such as accidents, homicide and suicide, often require additional investigation that tends to delay certification of the cause and manner of death. This can result in significant under-reporting of these deaths in provisional data.

The final data tables include both deaths that occurred in California regardless of the place of residence (by occurrence) and deaths to California residents (by residence), whereas the provisional data table only includes deaths that occurred in California regardless of the place of residence (by occurrence). The data are reported as totals, as well as stratified by age, gender, race-ethnicity, and death place type. Deaths due to all causes (ALL) and selected underlying cause of death categories are provided. See temporal coverage for more information on which combinations are available for which years.

The cause of death categories are based solely on the underlying cause of death as coded by the International Classification of Diseases. The underlying cause of death is defined by the World Health Organization (WHO) as "the disease or injury which initiated the train of events leading directly to death, or the circumstances of the accident or violence which produced the fatal injury." It is a single value assigned to each death based on the details as entered on the death certificate. When more than one cause is listed, the order in which they are listed can affect which cause is coded as the underlying cause. This means that similar events could be coded with different underlying causes of death depending on variations in how they were entered. Consequently, while underlying cause of death provides a convenient comparison between cause of death categories, it may not capture the full impact of each cause of death as it does not always take into account all conditions contributing to the death.

This dataset contains counts of deaths for California counties based on information entered on death certificates. Final counts are derived from static data and include out-of-state deaths to California residents, whereas provisional counts are derived from incomplete and dynamic data. Provisional counts are based on the records available when the data was retrieved and may not represent all deaths that occurred during the time period. Deaths involving injuries from external or environmental forces, such as accidents, homicide and suicide, often require additional investigation that tends to delay certification of the cause and manner of death. This can result in significant under-reporting of these deaths in provisional data.

The final data tables include both deaths that occurred in each California county regardless of the place of residence (by occurrence) and deaths to residents of each California county (by residence), whereas the provisional data table only includes deaths that occurred in each county regardless of the place of residence (by occurrence). The data are reported as totals, as well as stratified by age, gender, race-ethnicity, and death place type. Deaths due to all causes (ALL) and selected underlying cause of death categories are provided. See temporal coverage for more information on which combinations are available for which years.

The cause of death categories are based solely on the underlying cause of death as coded by the International Classification of Diseases. The underlying cause of death is defined by the World Health Organization (WHO) as "the disease or injury which initiated the train of events leading directly to death, or the circumstances of the accident or violence which produced the fatal injury." It is a single value assigned to each death based on the details as entered on the death certificate. When more than one cause is listed, the order in which they are listed can affect which cause is coded as the underlying cause. This means that similar events could be coded with different underlying causes of death depending on variations in how they were entered. Consequently, while underlying cause of death provides a convenient comparison between cause of death categories, it may not capture the full impact of each cause of death as it does not always take into account all conditions contributing to the death.

BackgroundOver 75% of the annual estimated 9.5 million deaths in India occur in the home, and the large majority of these do not have a certified cause. India and other developing countries urgently need reliable quantification of the causes of death. They also need better epidemiological evidence about the relevance of physical (such as blood pressure and obesity), behavioral (such as smoking, alcohol, HIV-1 risk taking, and immunization history), and biological (such as blood lipids and gene polymorphisms) measurements to the development of disease in individuals or disease rates in populations. We report here on the rationale, design, and implementation of the world's largest prospective study of the causes and correlates of mortality. Methods and FindingsWe will monitor nearly 14 million people in 2.4 million nationally representative Indian households (6.3 million people in 1.1 million households in the 1998–2003 sample frame and 7.6 million people in 1.3 million households in the 2004–2014 sample frame) for vital status and, if dead, the causes of death through a well-validated verbal autopsy (VA) instrument. About 300,000 deaths from 1998–2003 and some 700,000 deaths from 2004–2014 are expected; of these about 850,000 will be coded by two physicians to provide causes of death by gender, age, socioeconomic status, and geographical region. Pilot studies will evaluate the addition of physical and biological measurements, specifically dried blood spots. Preliminary results from over 35,000 deaths suggest that VA can ascertain the leading causes of death, reduce the misclassification of causes, and derive the probable underlying cause of death when it has not been reported. VA yields broad classification of the underlying causes in about 90% of deaths before age 70. In old age, however, the proportion of classifiable deaths is lower. By tracking underlying demographic denominators, the study permits quantification of absolute mortality rates. Household case-control, proportional mortality, and nested case-control methods permit quantification of risk factors. ConclusionsThis study will reliably document not only the underlying cause of child and adult deaths but also key risk factors (behavioral, physical, environmental, and eventually, genetic). It offers a globally replicable model for reliably estimating cause-specific mortality using VA and strengthens India's flagship mortality monitoring system. Despite the misclassification that is still expected, the new cause-of-death data will be substantially better than that available previously.

This table contains the number of deaths in the population of the Netherlands by underlying cause of death. The causes of death are shown according to the extensive list of 'three digit codes', by age and sex.

Since 2013 Statistics Netherlands is using Iris software for automatic coding for cause of death. This improved the international comparison of the data. The change in coding did cause a considerable shift in the statistic. Since 2013 the (yearly) ICD-10 updates are applied.

Data available from: 1996

Status of the figures: The figures up untill 2023 are final, the figures of 2024 are provisional.

Changes as of July 3rd 2025: The provisional figures for 2024 have been added.

Changes as of February 14th 2025: For 2023 one death by 'Acute poliomyelitis (A80)' is moved to 'Sequelae of poliomyelitis (B91)'.

When will new figures be published? The aim is to publish the final figures of 2024 in the fourth quarter of 2025.

This dataset contains counts of deaths for California residents by ZIP Code based on information entered on death certificates. Final counts are derived from static data and include out-of-state deaths of California residents. The data tables include deaths of residents of California by ZIP Code of residence (by residence). The data are reported as totals, as well as stratified by age and gender. Deaths due to all causes (ALL) and selected underlying cause of death categories are provided. See temporal coverage for more information on which combinations are available for which years.

The cause of death categories are based solely on the underlying cause of death as coded by the International Classification of Diseases. The underlying cause of death is defined by the World Health Organization (WHO) as "the disease or injury which initiated the train of events leading directly to death, or the circumstances of the accident or violence which produced the fatal injury." It is a single value assigned to each death based on the details as entered on the death certificate. When more than one cause is listed, the order in which they are listed can affect which cause is coded as the underlying cause. This means that similar events could be coded with different underlying causes of death depending on variations in how they were entered. Consequently, while underlying cause of death provides a convenient comparison between cause of death categories, it may not capture the full impact of each cause of death as it does not always take into account all conditions contributing to the death.

This dataset contains counts of deaths for California residents by ZIP Code based on information entered on death certificates. Final counts are derived from static data and include out-of-state deaths of California residents. The data tables include deaths of residents of California by ZIP Code of residence (by residence). The data are reported as totals, as well as stratified by age and gender. Deaths due to all causes (ALL) and selected underlying cause of death categories are provided. See temporal coverage for more information on which combinations are available for which years. The cause of death categories are based solely on the underlying cause of death as coded by the International Classification of Diseases. The underlying cause of death is defined by the World Health Organization (WHO) as "the disease or injury which initiated the train of events leading directly to death, or the circumstances of the accident or violence which produced the fatal injury." It is a single value assigned to each death based on the details as entered on the death certificate. When more than one cause is listed, the order in which they are listed can affect which cause is coded as the underlying cause. This means that similar events could be coded with different underlying causes of death depending on variations in how they were entered. Consequently, while underlying cause of death provides a convenient comparison between cause of death categories, it may not capture the full impact of each cause of death as it does not always take into account all conditions contributing to the death.

According to the findings of a survey by IPSOS, worldwide people generally underestimate the proportion of deaths from cardiovascular diseases and cancer, two of the leading causes of death worldwide. It was found that on average respondents thought cardiovascular diseases accounted for just 11 percent of deaths worldwide, when in reality cardiovascular diseases account for 32 percent of deaths. This statistic shows the actual vs public estimates for causes of death worldwide as of 2019.

Patients’ demographics at TB diagnosis.

Lower respiratory infections were the leading cause of death in Africa in 2021. Lower respiratory infections accounted for 8.6 percent of all deaths in Africa that year, followed by malaria, which was responsible for 6.5 percent of deaths. Although HIV is not one of the leading causes of death worldwide, it remains within the top 10 leading causes of death in Africa. As of 2023, the top 15 countries with the highest prevalence of new HIV infections are all found in Africa. HIV/AIDS HIV (human immunodeficiency virus) is an infectious sexually transmitted disease that is transmitted via exposure to infected semen, blood, vaginal and anal fluids and breast milk. HIV weakens the human immune system, resulting in the affected person being unable to fight off opportunistic infections. HIV/AIDS was the eighth leading cause of death in Africa in 2021, accounting for around 4.6 percent of all deaths, or around 405,790 total deaths. HIV Treatment Although there is currently no effective cure for HIV, death can be prevented by taking HIV antiretroviral therapy (ART). Access to ART worldwide has increased greatly over the last decade; however, there are still barriers to access in some of the countries most impacted by HIV. The African countries with the highest percentage of HIV infected children who were receiving antiretroviral treatment were Eswatini, Lesotho, and Uganda.