Following a spike to 2.5 children per woman in the mid-1960s (during the second wave of the post-WWII baby boom), Germany's fertility rate then fell sharply to around 1.5 children per woman in the 1970s, and it has fluctuated between 1.2 and 1.6 children per woman ever since. Germany's fertility rate has been below the natural replacement level of roughly 2.1 children per woman since 1970, meaning that long-term natural population growth is unsustainable. In fact, Germany has experienced a natural population decline in every year since 1972, and its population has only grown or been sustained at its current level through high net immigration rates.Find more statistics on other topics about Germany with key insights such as crude birth rate, life expectancy of women at birth, and total life expectancy at birth.

a. Comparing Birth Outcomes in Mothers by Composite Serology/Self-Report Before Vaccine EUA (N = 116). b. Comparing Birth Outcomes in Mothers by Composite Serology Before Vaccine EUA (N = 116). c. Comparing Birth Outcomes in Mothers by IgM Serotype Before Vaccine EUA (N = 116). d. Comparing Birth Outcomes in Mothers by Composite Serology/Self-Report in First Wave (N = 83). e. Comparing Birth Outcomes in Mothers by Composite Serology/Self-Report in Fourth Wave (N = 84). f. Comparing Birth Outcomes in Mothers by Composite Serology in First Wave (N = 83). g. Comparing Birth Outcomes in Mothers by Composite Serology in Fourth Wave (N = 84). h. Comparing Birth Outcomes in Mothers by IgM Serology in First Wave (N = 83). i. Comparing Birth Outcomes in Mothers by IgM Serology in Fourth Wave (N = 84).

In 1925, the total fertility rate in Iraq was approximately 7.1 children per woman, meaning that the average woman born in Iraq at this time could expect to have seven children over the course of her reproductive years. This number increased to eight babies per woman by the 1950s, however, modernization and a decline in child mortality led to many families opting to have fewer children from the fifties onwards. This decline was interrupted by a temporary spike throughout the 1960s, which some studies attribute to disruptions in family planning services during the First Iraqi-Kurdish War. From the 1970s onwards, Iraq's fertility rate would continue its decline, falling to just over five children per woman by 2000. While Iraq’s fertility rate remains one of the highest in the region, the rate has continued to fall in the 21st century, and in 2020, the average woman born in Iraq can expect to have approximately 3.7 children over the course of her reproductive years.

Associations of pandemic stress with birth outcomes (N = 122).

The goal of this study was to investigate the relationship between anti-SARS-CoV-2-Spike IgG titers passively transferred to the fetus from maternal vaccination during pregnancy and timing of infant SARS-CoV-2 infection. Pregnant, vaccinated individuals (n = 105) and their infants (n = 107) were enrolled in a prospective cohort study from July 2021 to June 2022, linking infant anti-Spike IgG titer at birth to risk of SARS-CoV-2 infection in the first fifteen months of life. Cord blood sera were collected at delivery and infant sera were collected at two and six months of age. Anti-SARS-CoV-2-Spike IgG levels were quantified in cord and infant sera using an enzyme-linked immunosorbent assay. Infants were followed for SARS-CoV-2 infection through fifteen months of age. Anti-SARS-CoV-2-Spike IgG titers in infants declined significantly with increased age (p < 0.001). Infants with higher anti-Spike cord blood levels had significantly longer disease-free intervals prior to infection with SARS-CoV-2 (p = 0.027). While higher anti-Spike IgG titer at two months of age was associated with a longer interval to infection through nine months of age (p = 0.073), infant anti-Spike IgG titers by six months of age had no impact on disease-free interval. This cohort study suggests that passively transferred maternal IgG is protective against infant SARS-CoV-2 infection, with higher antibody levels at birth significantly associated with longer disease-free intervals. Infant antibodies and protection from SARS-CoV-2 infection wane significantly after six months, suggesting that vaccination is needed at this stage to optimize protection against COVID-19.

Studies suggest perinatal infection with SARS-CoV-2 can induce adverse birth outcomes, but studies published to date have substantial limitations. We therefore conducted an observational study of 211 births occurring between January 2020-September 2021 in three urban cohorts participating in the Environmental Influences on Child Health Outcomes Program. Serology was assessed for IgG, IgM and IgA antibodies to nucleocapsid, S1 spike, S2 spike, and receptor-binding domain. There were no differences in gestational age (GA), birth weight, preterm birth (PTB) or low birth weight (LBW) among seropositive mothers. However, the few (n = 9) IgM seropositive mothers had children with lower BW (434g, 95% CI: 116–752), BW Z score-for-GA (0.73 SD, 95% CI 0.10–1.36) and were more likely to deliver preterm (OR 8.75, 95% CI 1.22–62.4). Though there are limits to interpretation, the data support efforts to prevent SARS-CoV-2 infections in pregnancy.

In the mid-1800s, women in Ireland could expect to have over four children throughout the course of their reproductive years. More so than most European countries, the total fertility rate of Ireland would be influenced not only by the number of births, which would remain largely high compared to much of the continent, but would rather be influenced by emigration from the country. While the largest wave of Irish emigration (driven by the Great Famine) occurred before the years shown, the spikes in 1870, and particularly the spikes of the 1940s to early 1960s, can be attributed in part to significant declines in emigration among young adult females (rather than an increase in the number of births).

Another significant impact on Ireland's fertility rate in the 20th century was the influence of the Catholic Church in Irish society, education and healthcare. The church controlled the majority of primary and secondary education establishments, as well as hospitals; their influence on government meant that contraception and divorce remained illegal until 1985 and 1996 respectively, while the prohibition of abortion was not repealed until 2018. The promotion of traditional Catholic family values saw Ireland's fertility rate peak at over four children per woman in the early 1960s (double replacement level), however the gradual liberalization of Irish society and the decline of the church's influence, saw Ireland's fertility rate drop below two births per woman by the 1990s. (below replacement level). While fertility has remained below replacement level in the past three decades, the country still remains above the European average, with a total fertility rate of more than 1.8 children per woman in 2020, compared to the continental average of 1.6 children.

Importance: Serosurveys can be used to monitor population-level dynamics of COVID-19 and vaccination. Dried blood spots (DBSs) collected from infants contain maternal IgG antibodies and are useful for serosurveys of individuals recently giving birth. Objectives: To examine SARS-CoV-2 antibody prevalence in pregnant individuals in New York State, identify associations between SARS-CoV-2 antibody status and maternal and infant characteristics, and detect COVID-19 vaccination among this population. Design, setting, and participants: A population-based, repeated cross-sectional study was conducted to detect SARS-CoV-2 nucleocapsid (N) and spike (S) IgG antibodies. Deidentified DBS samples and data submitted to the New York State Newborn Screening Program between November 1, 2019, and November 30, 2021, were analyzed. Exposures: Prenatal exposure to SARS-CoV-2 antibodies. Main outcomes and measures: The presence of IgG antibodies to SARS-CoV-2 N and S antigens was measured using a microsphere immunoassay. Data were analyzed by geographic region and compared with reported COVID-19 cases and vaccinations among reproductive-aged females (15-44 years of age). Data were stratified by infant birth weight, gestational age, maternal age, and multiple birth status. Results: Dried blood spot samples from 415 293 infants (median [IQR] age, 1.04 [1.00-1.20] days; 210 805 [51.1%] male) were analyzed for SARS-CoV-2 antibodies. The first known antibody-positive infant in New York State was born on March 29, 2020. SARS-CoV-2 seroprevalence reflected statewide and regional COVID-19 cases among reproductive-aged females in the prevaccine period. From February through November 2021, S seroprevalence was strongly correlated with cumulative vaccinations in each New York State region and in the state overall (rs = 0.92-1.00, P ≤ .001). S and N seroprevalences were significantly lower in newborns with very low birth weight (720 [14.8%] for S and 138 [2.8%] for N, P < .001) and low birth weight (5160 [19.3%] for S and 1233 [4.6%] for N, P = .009) compared with newborns with normal birth weight (77 116 [20.1%] for S and 19 872 [5.2%] for N). Lower N and higher S seroprevalences were observed in multiple births (odds ratio [OR], 0.84; 95% CI, 0.75-0.94; P = .002 for N and OR, 1.24; 95% CI, 1.18-1.31; P < .001 for S) vs single births and for maternal age older than 30 years (OR, 0.87; 95% CI, 0.80-0.94; P < .001 for N and OR, 1.17; 95% CI, 1.11-1.23; P < .001 for S) vs younger than 20 years. Conclusions and relevance: In this study, seroprevalence in newborn DBS samples reflected COVID-19 case fluctuations and vaccinations among reproductive-aged women during the study period. These results demonstrate the utility of using newborn DBS testing to estimate SARS-CoV-2 seroprevalence in pregnant individuals.

We use administrative data from Washington State to perform a large-scale analysis of the impact of family formation on crime. Our estimates indicate that pregnancy triggers sharp declines in arrests rivaling any known intervention, supporting the view that childbirth is a "turning point" that reduces deviant behavior through social bonds. For mothers, criminal arrests drop precipitously in the first few months of pregnancy, stabilizing at half of pre-pregnancy levels three years after birth. Men show a sustained 20 percent decline in crime that begins at pregnancy, although arrests for domestic violence spike at birth. These effects are concentrated among first-time parents, suggesting that a permanent change in preferences---rather than transitory time and budget shocks---may be responsible. A separate design using parents of stillborn children to estimate counterfactual arrest rates reinforces the main findings. Marriage, in contrast, is not associated with any sudden changes and marks the completion of a gradual 50 percent decline in arrests for both men and women.

This figure mimics Fig 5 from the main text, except that it presents global population size when long-run life expectancy is 100 years (left axis) or 120 years (right axis). (TXT)

Preterm birth (PTB) is one of major causes of perinatal mortality and neonatal morbidity, but knowledge of its complex etiology is still limited. Here we present cervicovaginal fluid (CVF) protein profiles of pregnant women who subsequently delivered at spontaneous preterm or term, aiming to identify differentially expressed CVF proteins in PTB and term birth. The CVF proteome of women who sequentially delivered at preterm and term was analyzed using isobaric tags for relative and absolute quantitation (iTRAQ) coupled with two-dimensional nanoflow liquid chromatography-tandem mass spectrometry (2D-nLC-MS/MS). We compared the CVF proteome of PTB (n=5) and control subjects (term birth, n=7) using pooled control CVF (term birth, n=20) as spike-in standard. We identified 1294 CVF proteins, of which 605 were newly identified proteins. Of 990 proteins quantified in both PTB and term birth, 52 proteins were significantly up/down-regulated in PTB compared to term birth. The differentially expressed proteins were functionally associated to immune response, endopeptidase inhibitors and structural constituent of cytoskeleton. Taken together, our study provide quantitative CVF proteome profiles of pregnant women who ultimately delivered at preterm and term. These promising results could help to improve the understanding of PTB etiology and to discover biomarkers for asymptomatic PTB.

The global vented vial spike access device market is experiencing robust growth, driven by increasing demand for safe and efficient drug delivery in healthcare settings. The market's expansion is fueled by several key factors. Firstly, the rising prevalence of chronic diseases, such as diabetes and cancer, necessitates frequent intravenous medication administration, thus increasing the demand for these devices. Secondly, stringent regulatory guidelines emphasizing infection control and patient safety are pushing healthcare providers to adopt safer and more reliable drug delivery systems, favoring vented vial spike access devices over traditional methods. Finally, technological advancements leading to the development of improved designs with enhanced features like integrated safety mechanisms and reduced contamination risks further contribute to market growth. While precise market sizing is not provided, considering the presence of major players like Becton Dickinson and B. Braun, a conservative estimate places the 2025 market value at approximately $500 million, projecting a Compound Annual Growth Rate (CAGR) of 7% over the forecast period (2025-2033). This CAGR reflects the continuous adoption of these devices across hospitals, clinics, and other healthcare facilities. Market restraints include the high initial investment costs associated with adopting these devices, particularly for smaller healthcare facilities. However, the long-term cost savings achieved through reduced contamination risks and improved patient safety are likely to offset these initial expenses. The market is segmented by device type (e.g., needleless systems, traditional needle-based systems), application (e.g., chemotherapy, antibiotics administration), and end-user (hospitals, clinics, home healthcare). Regional growth varies, with North America and Europe expected to dominate, due to higher healthcare expenditure and technological advancements in these regions. However, developing economies in Asia-Pacific and Latin America present significant growth opportunities due to improving healthcare infrastructure and increasing healthcare awareness. Competitive intensity is moderate, with several established players and emerging companies vying for market share through product innovation and strategic partnerships.

BackgroundData on SARS-CoV-2 infection in pregnancy and infancy has accumulated throughout the course of the pandemic, though evidence regarding asymptomatic SARS-CoV-2 infection and adverse birth outcomes are scarce. Limited information is available from countries in sub-Saharan Africa (SSA). The pregnant woman and infant COVID in Africa study (PeriCOVID Africa) is a South-South-North partnership involving hospitals and health centres in five countries: Malawi, Uganda, Mozambique, The Gambia, and Kenya. The study leveraged data from three ongoing prospective cohort studies: Preparing for Group B Streptococcal Vaccines (GBS PREPARE), SARS-CoV-2 infection and COVID-19 in women and their infants in Kampala and Mukono (COMAC) and Pregnancy Care Integrating Translational Science Everywhere (PRECISE). In this paper we describe the seroepidemiology of SARS-CoV-2 infection in pregnant women enrolled in sites in Uganda and Malawi, and the impact of SARS-CoV-2 infection on pregnancy and infant outcomes.OutcomeSeroprevalence of SARS-CoV-2 antibodies in maternal blood, reported as the proportion of seropositive women by study site and wave of COVID-19 within each country.MethodsThe PeriCOVID study was a prospective mother-infant cohort study that recruited pregnant women at any gestation antenatally or on the day of delivery. Maternal and cord blood samples were tested for SARS-CoV-2 antibodies using Wantai and Euroimmune ELISA. In periCOVID Uganda and Malawi nose and throat swabs for SARS-Cov-2 RT-PCR were obtained.ResultsIn total, 1379 women were enrolled, giving birth to 1387 infants. Overall, 63% of pregnant women had a SARS-CoV-2 positive serology. Over subsequent waves (delta and omicron), in the absence of vaccination, seropositivity rose from 20% to over 80%. The placental transfer GMR was 1.7, indicating active placental transfer of anti-spike IgG. There was no association between SARS-CoV-2 antibody positivity and adverse pregnancy or infancy outcomes.

BackgroundData on SARS-CoV-2 infection in pregnancy and infancy has accumulated throughout the course of the pandemic, though evidence regarding asymptomatic SARS-CoV-2 infection and adverse birth outcomes are scarce. Limited information is available from countries in sub-Saharan Africa (SSA). The pregnant woman and infant COVID in Africa study (PeriCOVID Africa) is a South-South-North partnership involving hospitals and health centres in five countries: Malawi, Uganda, Mozambique, The Gambia, and Kenya. The study leveraged data from three ongoing prospective cohort studies: Preparing for Group B Streptococcal Vaccines (GBS PREPARE), SARS-CoV-2 infection and COVID-19 in women and their infants in Kampala and Mukono (COMAC) and Pregnancy Care Integrating Translational Science Everywhere (PRECISE). In this paper we describe the seroepidemiology of SARS-CoV-2 infection in pregnant women enrolled in sites in Uganda and Malawi, and the impact of SARS-CoV-2 infection on pregnancy and infant outcomes.OutcomeSeroprevalence of SARS-CoV-2 antibodies in maternal blood, reported as the proportion of seropositive women by study site and wave of COVID-19 within each country.MethodsThe PeriCOVID study was a prospective mother-infant cohort study that recruited pregnant women at any gestation antenatally or on the day of delivery. Maternal and cord blood samples were tested for SARS-CoV-2 antibodies using Wantai and Euroimmune ELISA. In periCOVID Uganda and Malawi nose and throat swabs for SARS-Cov-2 RT-PCR were obtained.ResultsIn total, 1379 women were enrolled, giving birth to 1387 infants. Overall, 63% of pregnant women had a SARS-CoV-2 positive serology. Over subsequent waves (delta and omicron), in the absence of vaccination, seropositivity rose from 20% to over 80%. The placental transfer GMR was 1.7, indicating active placental transfer of anti-spike IgG. There was no association between SARS-CoV-2 antibody positivity and adverse pregnancy or infancy outcomes.

Baby Swing Cradle Market Outlook

In 2023, the global market size for baby swing cradles was valued at approximately USD 1.3 billion, and it is projected to reach USD 2.4 billion by 2032, growing at a compound annual growth rate (CAGR) of 7.1%. This growth is primarily driven by increasing birth rates in several regions, growing consumer awareness of infant comfort and safety products, and technological advancements in baby care equipment.

The primary growth factor of the baby swing cradle market is the rising emphasis on infant safety and comfort. Parents are increasingly focusing on purchasing high-quality products that can provide a soothing and secure environment for their infants. The growing disposable income in emerging economies allows parents to invest in advanced baby products, including swing cradles equipped with various features like automated swinging, music, and vibration settings. Additionally, the spike in dual-income households means more parents are willing to spend on such conveniences, elevating the market demand.

Technological advancements in the baby products sector have also significantly contributed to market growth. Innovations such as smart baby cradles, which integrate IoT (Internet of Things) to allow parents to monitor and control the cradle's functions via smartphones, are gaining popularity. These features not only offer convenience but also enhance the overall safety and comfort of the infant, thereby driving the adoption of electric baby swing cradles. Moreover, the integration of eco-friendly materials and designs in cradle manufacturing is attracting environmentally conscious consumers, further boosting market growth.

The proliferation of online retail channels plays a pivotal role in the expansion of the baby swing cradle market. E-commerce platforms provide a wide range of products, often at competitive prices and with the convenience of home delivery. The increasing smartphone penetration and internet usage enable parents to easily access product information, reviews, and ratings, influencing their purchase decisions. The ability to compare prices and features online also encourages higher sales through these channels, contributing to market growth.

Regionally, the Asia Pacific market is expected to exhibit significant growth during the forecast period. Countries such as China and India are witnessing a surge in birth rates and increasing disposable incomes, which are major drivers of market growth in this region. Additionally, cultural factors that emphasize large family structures in these countries contribute to the higher demand for baby products, including swing cradles. North America and Europe also hold substantial market shares due to higher awareness and the established presence of key market players.

Product Type Analysis

The baby swing cradle market can be segmented based on product type into electric baby swing cradles and manual baby swing cradles. The electric baby swing cradle segment is projected to dominate the market during the forecast period. These products offer numerous features such as automated swinging, vibrating functions, and music playback, which provide comfort and convenience to both infants and parents. The increasing trend of smart home devices further pushes the demand for electric cradles, which can be integrated with mobile apps for remote monitoring and control.

On the other hand, manual baby swing cradles continue to hold a significant market share due to their lower cost and simplicity. These cradles are preferred by budget-conscious consumers and those who value traditional methods of infant care. Manual cradles are often portable and do not require a power source, making them a practical choice for some families. Despite the slower growth compared to electric cradles, the market for manual cradles remains robust, especially in regions with lower disposable incomes.

The innovation in electric baby swing cradles is a critical driver for this segment. Manufacturers are continuously developing new features such as customizable swinging speeds, built-in lullabies, and ergonomic designs that promote better sleep and comfort. These advancements make electric cradles more appealing to tech-savvy parents who prioritize convenience and functionality. Additionally, the rising trend of dual-income households means that parents have more financial resources to spend on such premium baby products.

Moreover, the increasing awareness of Sudden Infant Death Syndrome (SIDS) and other infant health issues has led to a

In 2023, there were estimated to be 956,116 people who were aged 35 in the United Kingdom, the most of any age in this year. The two largest age groups during this year were 30-34, and 35 to 39, at 4.7 million and 4.64 million people respectively. There is also a noticeable spike of 693,679 people who were aged 76, which is due to the high number of births that followed in the aftermath of the Second World War. Over one million born in 1964 In post-war Britain, there have only been two years when the number of live births was over one million, in 1947 and in 1964. The number of births recorded in the years between these two years was consistently high as well, with 1955 having the fewest births in this period at 789,000. This meant that until relatively recently, Baby Boomers were the largest generational cohort in the UK. As of 2022, there were approximately 13.76 million Baby Boomers, compared with 14 million in Generation X, 14.48 million Millennials, and 12.9 million members of Gen Z. The youngest generation in the UK, Generation Alpha numbered approximately 7.5 million in the same year. Median age to hit 44.5 years by 2050 The population of the United Kingdom is aging at a substantial rate, with the median age of the population expected to reach 44.5 years by 2050. By comparison, in 1950 the average age in the United Kingdom stood at 34.9 years. This phenomenon is not unique to the United Kingdom, with median age of people worldwide increasing from 23.6 years in 1950 to a forecasted 41.9 years by 2100. As of 2022, the region with the oldest median age in the UK was South West England, at 43.9 years, compared with 35.9 in London, the region with the youngest median age.

Impact of infection (seropositivity) on key pregnancy and neonatal outcomes in periCOVID Malawi and periCOVID Uganda.

The global COVID-19 pandemic has lasted for 3 years since its outbreak, however its origin is still unknown. Here, we analyzed the genotypes of 3.14 million SARS-CoV-2 genomes based on the amino acid 614 of the Spike (S) and the amino acid 84 of NS8 (nonstructural protein 8), and identified 16 linkage haplotypes. The GL haplotype (S_614G and NS8_84L) was the major haplotype driving the global pandemic and accounted for 99.2% of the sequenced genomes, while the DL haplotype (S_614D and NS8_84L) caused the pandemic in China in the spring of 2020 and accounted for approximately 60% of the genomes in China and 0.45% of the global genomes. The GS (S_614G and NS8_84S), DS (S_614D and NS8_84S), and NS (S_614N and NS8_84S) haplotypes accounted for 0.26%, 0.06%, and 0.0067% of the genomes, respectively. The main evolutionary trajectory of SARS-CoV-2 is DS→DL→GL, whereas the other haplotypes are minor byproducts in the evolution. Surprisingly, the newest haplotype GL had the oldest time of most recent common ancestor (tMRCA), which was May 1 2019 by mean, while the oldest haplotype DS had the newest tMRCA with a mean of October 17, indicating that the ancestral strains that gave birth to GL had been extinct and replaced by the more adapted newcomer at the place of its origin, just like the sequential rise and fall of the delta and omicron variants. However, the haplotype DL arrived and evolved into toxic strains and ignited a pandemic in China where the GL strains had not arrived in by the end of 2019. The GL strains had spread all over the world before they were discovered, and ignited the global pandemic, which had not been noticed until the virus was declared in China. However, the GL haplotype had little influence in China during the early phase of the pandemic due to its late arrival as well as the strict transmission controls in China. Therefore, we propose two major onsets of the COVID-19 pandemic, one was mainly driven by the haplotype DL in China, the other was driven by the haplotype GL globally.

For most of the world, throughout most of human history, the average life expectancy from birth was around 24. This figure fluctuated greatly depending on the time or region, and was higher than 24 in most individual years, but factors such as pandemics, famines, and conflicts caused regular spikes in mortality and reduced life expectancy. Child mortality The most significant difference between historical mortality rates and modern figures is that child and infant mortality was so high in pre-industrial times; before the introduction of vaccination, water treatment, and other medical knowledge or technologies, women would have around seven children throughout their lifetime, but around half of these would not make it to adulthood. Accurate, historical figures for infant mortality are difficult to ascertain, as it was so prevalent, it took place in the home, and was rarely recorded in censuses; however, figures from this source suggest that the rate was around 300 deaths per 1,000 live births in some years, meaning that almost one in three infants did not make it to their first birthday in certain periods. For those who survived to adolescence, they could expect to live into their forties or fifties on average. Modern figures It was not until the eradication of plague and improvements in housing and infrastructure in recent centuries where life expectancy began to rise in some parts of Europe, before industrialization and medical advances led to the onset of the demographic transition across the world. Today, global life expectancy from birth is roughly three times higher than in pre-industrial times, at almost 73 years. It is higher still in more demographically and economically developed countries; life expectancy is over 82 years in the three European countries shown, and over 84 in Japan. For the least developed countries, mostly found in Sub-Saharan Africa, life expectancy from birth can be as low as 53 years.

Alleles of the amino acid 614 in the spike protein (spike_614) of SARS-CoV-2.