IntroductionThe COVID-19 pandemic had collateral effects on many health systems. Cancer screening and diagnostic tests were postponed, resulting in delays in diagnosis and treatment. This study assessed the impact of the pandemic on screening, diagnostics and incidence of breast, colorectal, lung, and prostate cancer; and whether rates returned to pre-pandemic levels by December, 2021.MethodsThis is a cohort study of electronic health records from the United Kingdom (UK) primary care Clinical Practice Research Datalink (CPRD) GOLD database. The study included individuals registered with CPRD GOLD between January, 2017 and December, 2021, with at least 365 days of clinical history. The study focused on screening, diagnostic tests, referrals and diagnoses of first-ever breast, colorectal, lung, and prostate cancer. Incidence rates (IR) were stratified by age, sex, and region, and incidence rate ratios (IRR) were calculated to compare rates during and after lockdown with rates before lockdown. Forecasted rates were estimated using negative binomial regression models.ResultsAmong 5,191,650 eligible participants, the first lockdown resulted in reduced screening and diagnostic tests for all cancers, which remained dramatically reduced across the whole observation period for almost all tests investigated. There were significant IRR reductions in breast (0.69 [95% CI: 0.63-0.74]), colorectal (0.74 [95% CI: 0.67-0.81]), and prostate (0.71 [95% CI: 0.66-0.78]) cancer diagnoses. IRR reductions for lung cancer were non-significant (0.92 [95% CI: 0.84-1.01]). Extrapolating to the entire UK population, an estimated 18,000 breast, 13,000 colorectal, 10,000 lung, and 21,000 prostate cancer diagnoses were missed from March, 2020 to December, 2021.DiscussionThe UK COVID-19 lockdown had a substantial impact on cancer screening, diagnostic tests, referrals, and diagnoses. Incidence rates remained significantly lower than pre-pandemic levels for breast and prostate cancers and associated tests by December, 2021. Delays in diagnosis are likely to have adverse consequences on cancer stage, treatment initiation, mortality rates, and years of life lost. Urgent strategies are needed to identify undiagnosed cases and address the long-term implications of delayed diagnoses.

In 2008, the National Prostate Cancer Register (NPCR) of Sweden was linked to a number of other population-based registers through the use of personal identity numbers (PINs). The aim of this linkage, named Prostate Cancer data Base Sweden (PCBaSe), was to create a database with extensive longitudinal data for a population-based, nation-wide cohort of men diagnosed with prostate cancer in Sweden. PCBaSe 2.0 includes data on 119,777 cases and data from up to 11 national registers. Besides all prostate cancer cases in NPCR, it also contains two control series of men without prostate cancer, denoted as comparison cohorts, as well as information on brothers of men diagnosed with prostate cancer.

Despite the clinical success of Androgen Receptor (AR)-targeted therapies, reactivation of AR signalling remains the main driver of castration-resistant prostate cancer (CRPC) progression. In this study, we performed a comprehensive unbiased characterisation of LNCaP cells chronically exposed to multiple AR inhibitors (ARI). Combined proteomics and metabolomics analyses implicated an acquired metabolic phenotype common in ARI-resistant cells and associated with perturbed glucose and lipid metabolism. To exploit this phenotype, we delineated a subset of proteins consistently associated with ARI resistance.

Background The contribution of BRCA1 and BRCA2 to the incidence of male breast cancer (MBC) in the United Kingdom is not known, and the importance of these genes in the increased risk of female breast cancer associated with a family history of breast cancer in a male first-degree relative is unclear. Methods We have carried out a population-based study of 94 MBC cases collected in the UK. We screened genomic DNA for mutations in BRCA1 and BRCA2 and used family history data from these cases to calculate the risk of breast cancer to female relatives of MBC cases. We also estimated the contribution of BRCA1 and BRCA2 to this risk. Results Nineteen cases (20%) reported a first-degree relative with breast cancer, of whom seven also had an affected second-degree relative. The breast cancer risk in female first-degree relatives was 2.4 times (95% confidence interval [CI] = 1.4–4.0) the risk in the general population. No BRCA1 mutation carriers were identified and five cases were found to carry a mutation in BRCA2. Allowing for a mutation detection sensitivity frequency of 70%, the carrier frequency for BRCA2 mutations was 8% (95% CI = 3–19). All the mutation carriers had a family history of breast, ovarian, prostate or pancreatic cancer. However, BRCA2 accounted for only 15% of the excess familial risk of breast cancer in female first-degree relatives. Conclusion These data suggest that other genes that confer an increased risk for both female and male breast cancer have yet to be found.

This summary brings together information on prostate cancer incidence, mortality and survival.

Source agency: Office for National Statistics

Designation: National Statistics

Language: English

Alternative title: Prostate cancer: the most common cancer in men in England

Deaths from prostate cancer - Directly age-Standardised Rates (DSR) per 100,000 population Source: Office for National Statistics (ONS) Publisher: Information Centre (IC) - Clinical and Health Outcomes Knowledge Base Geographies: Local Authority District (LAD), Government Office Region (GOR), National, Primary Care Trust (PCT), Strategic Health Authority (SHA) Geographic coverage: England Time coverage: 2005-07, 2007 Type of data: Administrative data

National Cancer Registration And Analysis Service (NCRAS). (2019). Cancer Registration: Epidemiology of Breast, Colorectal and Prostate Cancer Patients Diagnosed in 2015. Public Health England. https://doi.org/10.25503/6ncm-aj30 This workbook contains demographic, treatment and staging information about the cohort of patients who were diagnosed with breast, colorectal and prostate cancer in 2015. The data was extracted from the CAS1812 snapshot. Cohort definition: all patients who were diagnosed with breast, colorectal or prostate cancer tumours (defined by ICD10 codes C50, C18-C20, C61 respectively) in 2015, excluding cases as advised by the 'CAS-SOP #1: Counting Cases' and excluding all stage 0 breast cancer tumours. 1 - SEX - Number of patient-site combinations broken down by sex 2 - ETHINCITY - Number of patient-site combinations broken down by ethnicity 3 - AGE - Number of patient-site combinations broken down by age group at diagnosis 4 - SITE - Number of patient-site combinations broken down by cancer site of any diagnosed tumour 5 - STAGE - Number of patient-site combinations broken down by stage at diagnosis 6 - TREATMENT - Number of patient-site combinations broken by treatment combination received 7 - SITE, SEX - Number of patient-site combinations broken down by cancer site of any diagnosed tumour and sex

Raw data from HDMSe and SWATH MS analyses of 309 prostate cancer serum samples. Prostate cancer cohort:
309 patients were divided into control (n=112), prostate cancer (PCa) (n=175), and benign prostate hyperplasia (BPH) (n=22). PCa patients were then subdivided into active surveillance (AS) (n=51) or treatment group. Treatments were radiotherapy (pre: n=26, post: n=14), hormone therapy (pre: n=7, post: n=8), prostatectomy (pre: n=21, post: n=8), and radiotherapy (pre: n=23, post: n=17)

Mortality from prostate cancer (ICD-10 C61 equivalent to ICD-9 185). To reduce deaths from prostate cancer. Legacy unique identifier: P00625

Cancer registrations for prostate cancer per 100,000 population. Directly standardised registration rate Source: Regional Cancer Registries, Office for National Statistics (ONS). Publisher: Information Centre (IC) - Clinical and Health Outcomes Knowledge Base Geographies: Local Authority District (LAD), Government Office Region (GOR), National, Strategic Health Authority (SHA) Geographic coverage: England Time coverage: 2004-2006 Type of data: Administrative data

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Precision Pathology For Cancer Market Size 2025-2029

The global precision pathology for cancer market is projected to see substantial growth, with an estimated market size and a CAGR of 8.2% during the forecast period. Access detailed market insights upon report purchase. The precision pathology for cancer market is being drives by the rising incidence of cancer and the subsequent demand for enhanced personalized therapies. Digital pathology, boosted by AI and machine learning, enhances diagnostic accuracy, accelerates diagnosis rates, and facilitates therapeutic recommendations, thereby significantly contributing to market expansion. Technological advancements, such as AI tools that improve diagnostic precision and treatment planning in cancer care, are also expected to fuel market growth. The increasing investments in research and development activities will further contribute to market expansion.

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How is this market segmented?

The market research report provides comprehensive data (region-wise segment analysis), with forecasts and estimates in USD bn for the period 2025-2029, as well as historical data from 2019-2024 for the following segments:

Product

  Consumables
  Instruments


Technology

  Next-Generation Sequencing (NGS)
  Molecular Diagnostics
  Digital Pathology
  Artificial Intelligence (AI) and Machine Learning (ML)
  Liquid Biopsies
  Imaging Technologies


Applications

  Breast Cancer
  Lung Cancer
  Colorectal Cancers
  Prostate Cancer
  Melanoma And Non-Melanoma Skin Cancers


End-use

  Hospitals
  Diagnostic Laboratories
  Research Institutes


APAC

  China
  India
  Japan
  Australia
  Rest of APAC

Europe


  Germany
  Spain
  Italy
  UK
  Rest of Europe

North America


  US
  Canada

South America & MEA


  Brazil
  UAE
  South Africa
  Others





End-use

  Hospitals: Hospitals are key end-users, utilizing precision pathology for in-house diagnostics and treatment planning.
  Research Institutes: Research institutes use precision pathology for cancer research and development of new diagnostic and therapeutic strategies.
  Diagnostic Laboratories: Diagnostic laboratories provide precision pathology services to hospitals and other healthcare providers.


Product

  Consumables: This segment includes antibodies, kits & reagents, and probes used in precision pathology, driven by the increasing volume of diagnostic tests.
  Instruments: This segment encompasses slide staining systems, tissue processing systems, and PCR instruments, crucial for accurate pathological analysis.


Technology

  Liquid Biopsies: Liquid biopsies offer non-invasive methods for detecting cancer biomarkers, aiding in early diagnosis and treatment monitoring.
  Digital Pathology: Digital pathology solutions improve diagnostic accuracy and support therapeutic recommendations, enhancing overall efficiency.
  Imaging Technologies: Imaging technologies like CT, MRI, and ultrasound provide detailed anatomical and functional information for cancer diagnosis and treatment.
  Molecular Diagnostics: Molecular diagnostics are used to detect specific biomarkers and genetic mutations in cancer cells, facilitating targeted therapies.
  Next-Generation Sequencing (NGS): NGS technology is vital for genetic profiling of tumors, enabling personalized treatment strategies.
  Artificial Intelligence (AI) and Machine Learning (ML): AI and ML algorithms aid in analyzing complex pathological data, improving diagnostic precision and treatment planning.


Applications

  Lung Cancer: Genetic profiling helps in selecting appropriate treatments for different types of lung cancer.
  Breast Cancer: Precision pathology is critical in identifying specific subtypes of breast cancer, guiding targeted therapies.
  Prostate Cancer: Precision diagnostics help in determining the aggressiveness of prostate cancer and guiding treatment decisions.
  Colorectal Cancers: Precision pathology aids in identifying genetic mutations that influence treatment response in colorectal cancer.
  Melanoma And Non-Melanoma Skin Cancers: Molecular analysis assists in identifying specific mutations in skin cancers, enabling personalized therapies.

Regional Analysis

APAC: The Asia-Pacific (APAC) region is expected to experience rapid growth in the precision pathology for cancer market, driven by increasing healthcare expenditure, a rising prevalence of cancer, and growing awareness of precision medicine. China and India are key markets in APAC, with significant investments in healthcare infrastructure and a large patient pool, making them major hubs for precision pathology services.
Europe: Europe holds a substantial share of the precision pathology for cancer market, characterized by advanced healthcare systems, a strong focus on research and development, and a high adoption rate of advance

Prostate cancer is the third most frequent cancer in men worldwide, with a notable increase in prevalence over the last two decades. The PSA is the only well-established protein biomarker for prostate cancer diagnosis, staging, and sur-veillance. It frequently leads to inaccurate diagnosis and overtreatment since it is an organ-specific biomarker rather than a tumour-specific biomarker. As a result, one of the primary goals of prostate cancer proteome research is to iden-tify novel biomarkers that can be used with or instead of PSA, particularly in non-invasive blood samples. Thousands of peptides or assays were detected in blood samples from patients with low to high-grade prostate cancer and healthy individuals, allowing data processing of sequential window acquisition of all theoretical mass spectra (SWATH-MS). By assisting in the detection of prostate cancer biomarkers in blood samples, this useful resource will improve our un-derstanding of the role of proteomics in prostate cancer diagnosis and risk assessment.

The global Cancer Immunotherapy Market was valued at USD 128.74 Billion in 2023 and is projected to reach USD 238.38 Billion by 2030, registering a CAGR of 9.2% for the forecast period 2024-2030. The key driving factors for the Cancer Immunotherapy Market

The surging worldwide incidence of cancer, coupled with significant investments in the research and development of groundbreaking oncology therapies eventually drives the cancer immunotherapy market growth.

The global population continues to grow, and as people age, the risk of developing cancer increases. With more people living longer, there is a higher prevalence of cancer diagnoses. Modern lifestyles characterized by poor dietary habits, lack of physical activity, and increased exposure to environmental carcinogens have contributed to the rising incidence of cancer. Advances in medical imaging and diagnostic technologies have led to earlier and more accurate cancer detection, leading to an increase in reported cases. The use of tobacco and alcohol, known carcinogens, remains a significant contributor to cancer incidence, particularly in lung, liver, and oral cancers.

For instance, the Parker Institute for Cancer Immunotherapy has forged partnerships with researchers and industry experts to pioneer revolutionary immune-based cancer therapies. According to data from the Global Cancer Observatory, the United States recorded approximately 2,281,658 cancer diagnoses and 612,390 cancer-related fatalities in 2020. The prevalent malignancies impacting the U.S. populace encompass breast, prostate, lung, and colorectal cancers.
For instance, data from the Cancer Council reveals that Australia documented 150,000 new cancer diagnoses and 50,000 cancer-related fatalities in 2020. Consequently, the notable increase in the incidence of cancer cases is expected to propel market growth in the foreseeable future.
For instance, the Cancer Research Institute has provided funding for over 120 clinical trials and has allocated approximately USD 474 million towards research endeavors. Additionally, the Society for Immunotherapy of Cancer (SITC) is actively committed to enhancing patient outcomes by advancing the field of oncology immunotherapy. These organizations collaborate closely with scientists and researchers to explore innovative immune therapy treatment approaches.
For instance, In June 2022, a team of researchers at Stanford University secured a grant of USD 13 million from Cancer Grand Challenges, an initiative jointly supported by Cancer Research UK and the U.S. National Cancer Institute. This financial support has been granted to advance the development of cutting-edge immunotherapies, explore extrachromosomal DNA, and delve into the study of early-stage cancer

Expanding indications & personalized medicines significantly boost the cancer immunotherapy market growth.

Immunotherapies are being explored for a wide range of cancer types, including melanoma, lung cancer, bladder cancer, breast cancer, and more. As research uncovers new targets and mechanisms, the potential applications of immunotherapy continue to expand. Advances in understanding the genetic and molecular characteristics of tumors have led to the development of personalized immunotherapies. Tailoring treatments to an individual's unique tumor profile can improve response rates and reduce side effects. Thus, expanding indications & personalized medicines eventually boost the cancer immunotherapy market growth.

The Restraining Factor of Cancer Immunotherapy Market

Autoimmune reactions & skin reactions may restrain the cancer immunotherapy market growth.

Immunotherapies can trigger autoimmune reactions where the immune system mistakenly targets and damages normal cells or tissues, leading to conditions such as colitis, hepatitis, thyroiditis, and pneumonitis. Rashes, itching, and more severe skin conditions like dermatitis and bullous pemphigoid can occur as a result of immunotherapy. These several factors may hamper the cancer immunotherapy market growth.

Impact of the COVID-19 Pandemic on the Cancer Immunotherapy Market

Clinical trials are essential for testing the safety and efficacy of new cancer immunotherapies. The pandemic disrupted many clinical trials, leading to delays in drug development and regulatory approvals. These delays have affected the introduction of new treatments to the market. Shifts in Healthcare Resources: Hea...

According to Cognitive Market Research, the global Metastatic Bones Cancer Medication Treatment Market size was USD 1514.2 million in 2024. It will expand at a compound annual growth rate (CAGR) of 5.20% from 2024 to 2031.

North America held the major market share for more than 40% of the global revenue with a market size of USD 605.68 million in 2024 and will grow at a compound annual growth rate (CAGR) of 7.2% from 2024 to 2031.
Europe accounted for a market share of over 30% of the global revenue with a market size of USD 454.26 million.
Asia Pacific held a market share of around 23% of the global revenue with a market size of USD 348.27 million in 2024 and will grow at a compound annual growth rate (CAGR) of 11.0% from 2024 to 2031.
Latin America had a market share of more than 5% of the global revenue with a market size of USD 75.71 million in 2024 and will grow at a compound annual growth rate (CAGR) of 8.4% from 2024 to 2031.
Middle East and Africa had a market share of around 2% of the global revenue and was estimated at a market size of USD 30.28 million in 2024 and will grow at a compound annual growth rate (CAGR) of 8.7% from 2024 to 2031.
The chemotherapy category is the fastest growing segment of the Metastatic Bones Cancer Medication Treatment industry

Market Dynamics of Metastatic Bones Cancer Medication Treatment Market

Key Drivers for Metastatic Bones Cancer Medication Treatment Market

Growing Cancer Awareness Campaigns Fueling Demand for Metastatic Bone Disease

An increase in cancer awareness initiatives is helping to enhance patient knowledge, which in turn is resulting in earlier screenings and diagnoses. The patient's chances of survival may significantly improve with early cancer detection and diagnosis. According to recent medical study, early detection (at stage one) of most malignancies increases their survival percentage at one and five years. Early detection and diagnosis of the disease are aided by governments' and other stakeholders' persistent efforts to promote self-screening and raise awareness of the many forms of cancer. Campaigns like "Race for Life" and "Stand Up to Cancer" are run by Cancer Research UK, and "Great American Smokeout" and "Relay for Life" are run by the American Cancer Society. Campaigns like "Race for Life" and "Stand Up to Cancer" are run by Cancer Research UK, and "Great American Smokeout" and "Relay for Life" are run by the American Cancer Society. These efforts have improved survival rates, collected money for research, and encouraged good diet and lifestyle choices.

Rise in Prevalence of Cancer to Drive Market Growth

The rise in the prevalence of cancer is a significant driver of the metastatic bone cancer medication treatment market. As cancer incidence increases globally, more patients develop bone metastases, particularly from common cancers such as breast, prostate, and lung cancer. This growing patient population fuels demand for advanced treatments targeting bone metastasis. Additionally, improved diagnostic techniques, such as advanced imaging and biomarker testing, allow for earlier detection and better management of metastatic bone cancer, further contributing to market growth. The increasing awareness of cancer treatments and the availability of new, more effective therapies, such as bone-modifying agents, targeted therapies, and immunotherapies, are helping improve patient outcomes and driving market expansions.

Restraint Factor for the Metastatic Bones Cancer Medication Treatment Market

Expensive therapies and medications, will Limit Market Growth

Expensive therapies and medications are a major restraint in the metastatic bone cancer medication treatment market. Advanced treatments like targeted therapies, immunotherapies, and bone-modifying agents often come with high costs, which can be prohibitive for patients, especially in low-income or developing regions. Additionally, the cost of these therapies places a significant burden on healthcare systems, potentially limiting access to effective treatment. Insurance coverage can also vary, further restricting patient access to necessary medications. These financial barriers can delay diagnosis and treatment, leading to poorer outcomes. As a result, affordability remains a critical challenge, hindering the widespread adoption of innovative treatments for...

Gleason grading is an important prognostic indicator for prostate adenocarcinoma and is crucial for patient treatment decisions. However, intermediate-risk patients diagnosed in Gleason Grade Groups (GG) 2 and GG3 can harbour either aggressive or non-aggressive disease, resulting in under- or over-treatment of a significant number of patients. Here, we performed proteomic, differential expression, machine learning, and survival analyses for 1,348 matched tumour and benign samples from 278 patients. Three proteins (F5, TMEM126B and EARS2) were identified as candidate biomarkers in patients with biochemical recurrence. Multivariate Cox regression yielded 18 proteins, from which a risk score was constructed to dichotomise prostate cancer patients into low- and high-risk groups. This 18-protein signature is prognostic for the risk of biochemical recurrence and completely independent of the intermediate GG. Our results suggest that markers generated by computational proteomic profiling have the potential for clinical applications including integration into prostate cancer management.

Prostate cancer (PCa) is the most common malignant tumour, with high incidence rates and heterogeneity in men around the world. It is becoming an increasing burden on the health care system due to lack of tests for precise detection of disease, risk assessment and response to treatments. We used SWATH-MS as a discovery proteomics tool to identify markers in the serum of newly diagnosed PCa patients and healthy controls to facilitate the improved diagnosis. Furthermore, identification and expression of proteins was also determined in patients undergone radiotherapy and prostatectomy for monitoring of the clinical response to respective treatment options. Thus, this study provides the basis for a proteomic signature to improve diagnostics of patients with localised prostate cancer.

Genomic and transcriptomic alterations are insufficient to explain the variance in protein expression seen in cancer. Recent evidence has highlighted the role of N6-methyladenosine (m6A) in the regulation of mRNA expression, stability and translation, supporting a potential role for post-transcriptional regulation mediated by m6A in cancer. Here we explore prostate cancer as an exemplar cancer and generate the first prostate m6A maps, and further examined how low levels of N6-adenosine-methyltransferase (METTL3) associates with advanced prostate cancer and results in altered expression at the level of transcription, translation, and protein. In particular extracellular matrix proteins have a high number of m6A sites and show significant changes in expression with METTL3 knock-down. We also discovered the upregulation of a hepatocyte nuclear factor-driven gene signature that is associated with therapy resistance in prostate cancer. Significantly, METTL3 knock-down rendered the cells resistant to androgen receptor antagonists, implicating changes in m6A as a mechanism for therapy resistance in metastatic prostate cancer.

The association between angiotensin receptor blockers (ARBs) and cancer is controversial with meta-analyses of randomized controlled trials and observational studies reporting conflicting results. Thus, the objective of this study was to determine whether ARBs are associated with an overall increased risk of the four most common cancers, namely, lung, colorectal, breast and prostate cancers, and to explore these effects separately for each cancer type. We conducted a retrospective cohort study using a nested case-control analysis within the United Kingdom (UK) General Practice Research Database. We assembled a cohort of patients prescribed antihypertensive agents between 1995, the year the first ARB (losartan) entered the UK market, and 2008, with follow-up until December 31, 2010. Cases were patients newly-diagnosed with lung, colorectal, breast and prostate cancer during follow-up. We used conditional logistic regression to estimate adjusted rate ratios (RRs) and 95% confidence intervals (CIs) of cancer incidence, comparing ever use of ARBs with ever use of diuretics and/or beta-blockers. The cohort included 1,165,781 patients, during which 41,059 patients were diagnosed with one of the cancers under study (rate 554/100,000 person-years). When compared to diuretics and/or beta-blockers, ever use of ARBs was not associated with an increased rate of cancer overall (RR: 1.00; 95% CI: 0.96–1.03) or with each cancer site separately. The use of angiotensin-converting enzyme inhibitors and calcium channel blockers was associated with an increased rate of lung cancer (RR: 1.13; 95% CI: 1.06–1.20 and RR: 1.19; 95% CI: 1.12–1.27, respectively). This study provides additional evidence that the use of ARBs does not increase the risk of cancer overall or any of the four major cancer sites. Additional research is needed to further investigate a potentially increased risk of lung cancer with angiotensin-converting enzyme inhibitors and calcium channel blockers.

In the 2021 Annual Report, we present the results for patients diagnosed between 1st April 2019 and 31st March 2020 in England and Wales including: 1. The participation of NHS providers and the completeness and quality of the data submitted to the National Cancer Registration and Analysis Service (NCRAS), Public Health England and the Wales Cancer Network, Public Health Wales. 2. Patient demographic information and key aspects of the diagnostic and staging process they underwent and the treatments they received . 3. Treatment outcomes (up to two years post-treatment) for men in England and Wales undergoing radical prostatectomy (RP) or radical external beam radiotherapy (EBRT) in 2018. 4. The variation in treatment for men with low-risk, localised disease and high-risk/locally advanced disease in Wales only. In addition, we also present: 5. The impact of COVID-19 on the diagnosis of prostate cancer, receipt of radical treatment and systemic therapy in England only. Individual provider results and reports are available enabling regional and national comparisons to support local QI. https://www.npca.org.uk/provider-results/

Prostate cancer is a heritable disease with ancestry-biased incidence and mortality. Polygenic risk scores (PRSs) offer promising advancements in predicting disease risk, including prostate cancer. While their accuracy continues to improve, research aimed at enhancing their effectiveness within African and Asian populations remains key for equitable use. Recent algorithmic developments for PRS derivation have resulted in improved pan-ancestral risk prediction for several diseases. In this study, we benchmark the predictive power of six widely used PRS derivation algorithms, including four of which adjust for ancestry, against prostate cancer cases and controls from the UK Biobank and All of Us cohorts. We find modest improvement in discriminatory ability when compared with a simple method that prioritizes variants, clumping, and published polygenic risk scores. Our findings underscore the importance of improving upon risk prediction algorithms and the sampling of diverse cohorts.