Number of deaths and age-specific mortality rates for selected grouped causes, by age group and sex, 2000 to most recent year.

BackgroundEven in low and middle income countries most deaths occur in older adults. In Europe, the effects of better education and home ownership upon mortality seem to persist into old age, but these effects may not generalise to LMICs. Reliable data on causes and determinants of mortality are lacking. Methods and FindingsThe vital status of 12,373 people aged 65 y and over was determined 3–5 y after baseline survey in sites in Latin America, India, and China. We report crude and standardised mortality rates, standardized mortality ratios comparing mortality experience with that in the United States, and estimated associations with socioeconomic factors using Cox's proportional hazards regression. Cause-specific mortality fractions were estimated using the InterVA algorithm. Crude mortality rates varied from 27.3 to 70.0 per 1,000 person-years, a 3-fold variation persisting after standardisation for demographic and economic factors. Compared with the US, mortality was much higher in urban India and rural China, much lower in Peru, Venezuela, and urban Mexico, and similar in other sites. Mortality rates were higher among men, and increased with age. Adjusting for these effects, it was found that education, occupational attainment, assets, and pension receipt were all inversely associated with mortality, and food insecurity positively associated. Mutually adjusted, only education remained protective (pooled hazard ratio 0.93, 95% CI 0.89–0.98). Most deaths occurred at home, but, except in India, most individuals received medical attention during their final illness. Chronic diseases were the main causes of death, together with tuberculosis and liver disease, with stroke the leading cause in nearly all sites. ConclusionsEducation seems to have an important latent effect on mortality into late life. However, compositional differences in socioeconomic position do not explain differences in mortality between sites. Social protection for older people, and the effectiveness of health systems in preventing and treating chronic disease, may be as important as economic and human development. Please see later in the article for the Editors' Summary

MMWR Surveillance Summary 66 (No. SS-1):1-8 found that nonmetropolitan areas have significant numbers of potentially excess deaths from the five leading causes of death. These figures accompany this report by presenting information on potentially excess deaths in nonmetropolitan and metropolitan areas at the state level. They also add additional years of data and options for selecting different age ranges and benchmarks. Potentially excess deaths are defined in MMWR Surveillance Summary 66(No. SS-1):1-8 as deaths that exceed the numbers that would be expected if the death rates of states with the lowest rates (benchmarks) occurred across all states. They are calculated by subtracting expected deaths for specific benchmarks from observed deaths. Not all potentially excess deaths can be prevented; some areas might have characteristics that predispose them to higher rates of death. However, many potentially excess deaths might represent deaths that could be prevented through improved public health programs that support healthier behaviors and neighborhoods or better access to health care services. Mortality data for U.S. residents come from the National Vital Statistics System. Estimates based on fewer than 10 observed deaths are not shown and shaded yellow on the map. Underlying cause of death is based on the International Classification of Diseases, 10th Revision (ICD-10) Heart disease (I00-I09, I11, I13, and I20–I51) Cancer (C00–C97) Unintentional injury (V01–X59 and Y85–Y86) Chronic lower respiratory disease (J40–J47) Stroke (I60–I69) Locality (nonmetropolitan vs. metropolitan) is based on the Office of Management and Budget’s 2013 county-based classification scheme. Benchmarks are based on the three states with the lowest age and cause-specific mortality rates. Potentially excess deaths for each state are calculated by subtracting deaths at the benchmark rates (expected deaths) from observed deaths. Users can explore three benchmarks: “2010 Fixed” is a fixed benchmark based on the best performing States in 2010. “2005 Fixed” is a fixed benchmark based on the best performing States in 2005. “Floating” is based on the best performing States in each year so change from year to year. SOURCES CDC/NCHS, National Vital Statistics System, mortality data (see http://www.cdc.gov/nchs/deaths.htm); and CDC WONDER (see http://wonder.cdc.gov). REFERENCES Moy E, Garcia MC, Bastian B, Rossen LM, Ingram DD, Faul M, Massetti GM, Thomas CC, Hong Y, Yoon PW, Iademarco MF. Leading Causes of Death in Nonmetropolitan and Metropolitan Areas – United States, 1999-2014. MMWR Surveillance Summary 2017; 66(No. SS-1):1-8. Garcia MC, Faul M, Massetti G, Thomas CC, Hong Y, Bauer UE, Iademarco MF. Reducing Potentially Excess Deaths from the Five Leading Causes of Death in the Rural United States. MMWR Surveillance Summary 2017; 66(No. SS-2):1–7.

Rates are standardised to the population distribution of adult men in the South African population [12]*refers to average change per year in rate of cause-specific death.

Experimental analysis of ethnic differences in cause-specific mortality rates in England and Wales based on 2011 Census and death registrations.

Statistics Finland annually produces statistics on causes of death and the development of mortality. Statistics Finland also maintains death certificate archives from where death certificate data or copies of death certificates are released for purposes defined by law. The archives contain Finnish residents' death certificates from 1936 onwards. The death certificates from 1936 to 1965 are located in the National Archive and newer certificates are archived at Statistics Finland.

This dataset of U.S. mortality trends since 1900 highlights trends in age-adjusted death rates for five selected major causes of death. Age-adjusted death rates (deaths per 100,000) after 1998 are calculated based on the 2000 U.S. standard population. Populations used for computing death rates for 2011–2017 are postcensal estimates based on the 2010 census, estimated as of July 1, 2010. Rates for census years are based on populations enumerated in the corresponding censuses. Rates for noncensus years between 2000 and 2010 are revised using updated intercensal population estimates and may differ from rates previously published. Data on age-adjusted death rates prior to 1999 are taken from historical data (see References below). Revisions to the International Classification of Diseases (ICD) over time may result in discontinuities in cause-of-death trends. SOURCES CDC/NCHS, National Vital Statistics System, historical data, 1900-1998 (see https://www.cdc.gov/nchs/nvss/mortality_historical_data.htm); CDC/NCHS, National Vital Statistics System, mortality data (see http://www.cdc.gov/nchs/deaths.htm); and CDC WONDER (see http://wonder.cdc.gov). REFERENCES National Center for Health Statistics, Data Warehouse. Comparability of cause-of-death between ICD revisions. 2008. Available from: http://www.cdc.gov/nchs/nvss/mortality/comparability_icd.htm. National Center for Health Statistics. Vital statistics data available. Mortality multiple cause files. Hyattsville, MD: National Center for Health Statistics. Available from: https://www.cdc.gov/nchs/data_access/vitalstatsonline.htm. Kochanek KD, Murphy SL, Xu JQ, Arias E. Deaths: Final data for 2017. National Vital Statistics Reports; vol 68 no 9. Hyattsville, MD: National Center for Health Statistics. 2019. Available from: https://www.cdc.gov/nchs/data/nvsr/nvsr68/nvsr68_09-508.pdf. Arias E, Xu JQ. United States life tables, 2017. National Vital Statistics Reports; vol 68 no 7. Hyattsville, MD: National Center for Health Statistics. 2019. Available from: https://www.cdc.gov/nchs/data/nvsr/nvsr68/nvsr68_07-508.pdf. National Center for Health Statistics. Historical Data, 1900-1998. 2009. Available from: https://www.cdc.gov/nchs/nvss/mortality_historical_data.htm.

Analysis of ‘NCHS - Potentially Excess Deaths from the Five Leading Causes of Death’ provided by Analyst-2 (analyst-2.ai), based on source dataset retrieved from https://catalog.data.gov/dataset/3d1da62a-9f1c-47e8-b5a1-b473f57d7fdc on 28 January 2022.

--- Dataset description provided by original source is as follows ---

MMWR Surveillance Summary 66 (No. SS-1):1-8 found that nonmetropolitan areas have significant numbers of potentially excess deaths from the five leading causes of death. These figures accompany this report by presenting information on potentially excess deaths in nonmetropolitan and metropolitan areas at the state level. They also add additional years of data and options for selecting different age ranges and benchmarks.

Potentially excess deaths are defined in MMWR Surveillance Summary 66(No. SS-1):1-8 as deaths that exceed the numbers that would be expected if the death rates of states with the lowest rates (benchmarks) occurred across all states. They are calculated by subtracting expected deaths for specific benchmarks from observed deaths.

Not all potentially excess deaths can be prevented; some areas might have characteristics that predispose them to higher rates of death. However, many potentially excess deaths might represent deaths that could be prevented through improved public health programs that support healthier behaviors and neighborhoods or better access to health care services.

Mortality data for U.S. residents come from the National Vital Statistics System. Estimates based on fewer than 10 observed deaths are not shown and shaded yellow on the map.

Underlying cause of death is based on the International Classification of Diseases, 10th Revision (ICD-10)

Heart disease (I00-I09, I11, I13, and I20–I51) Cancer (C00–C97) Unintentional injury (V01–X59 and Y85–Y86) Chronic lower respiratory disease (J40–J47) Stroke (I60–I69) Locality (nonmetropolitan vs. metropolitan) is based on the Office of Management and Budget’s 2013 county-based classification scheme.

Benchmarks are based on the three states with the lowest age and cause-specific mortality rates.

Potentially excess deaths for each state are calculated by subtracting deaths at the benchmark rates (expected deaths) from observed deaths.

Users can explore three benchmarks:

“2010 Fixed” is a fixed benchmark based on the best performing States in 2010. “2005 Fixed” is a fixed benchmark based on the best performing States in 2005. “Floating” is based on the best performing States in each year so change from year to year.

SOURCES

CDC/NCHS, National Vital Statistics System, mortality data (see http://www.cdc.gov/nchs/deaths.htm); and CDC WONDER (see http://wonder.cdc.gov).

REFERENCES

1. Moy E, Garcia MC, Bastian B, Rossen LM, Ingram DD, Faul M, Massetti GM, Thomas CC, Hong Y, Yoon PW, Iademarco MF. Leading Causes of Death in Nonmetropolitan and Metropolitan Areas – United States, 1999-2014. MMWR Surveillance Summary 2017; 66(No. SS-1):1-8.

2. Garcia MC, Faul M, Massetti G, Thomas CC, Hong Y, Bauer UE, Iademarco MF. Reducing Potentially Excess Deaths from the Five Leading Causes of Death in the Rural United States. MMWR Surveillance Summary 2017; 66(No. SS-2):1–7.

--- Original source retains full ownership of the source dataset ---

We introduce a new framework for forecasting age-sex-country-cause-specific mortality rates that incorporates considerably more information, and thus has the potential to forecast much better, than any existing approach. Mortality forecasts are used in a wide variety of academic fields, and for global and national health policy making, medical and pharmaceutical research, and social security and retirement planning. As it turns out, the tools we developed in pursuit of this goal also have broader statistical implications, in addition to their use for forecasting mortality or other variables with similar statistical properties. First, our methods make it possible to include different explanatory variables in a time series regression for each cross-section, while still borrowing strength from one regression to improve the estimation of all. Second, we show that many existing Bayesian (hierarchi cal and spatial) models with explanatory variables use prior densities that incorrectly formalize prior knowledge. Many demographers and public health researchers have fortuitously avoided this problem so prevalent in other fields by using prior knowledge only as an ex post check on empirical results, but this approach excludes considerable information from their models. We show how to incorporate this demographic knowledge into a model in a statistically appropriate way. Finally, we develop a set of tools useful for developing models with Bayesian priors in the presence of partial prior ignorance. This approach also provides many of the attractive features claimed by the empirical Bayes approach, but fully within the standard Bayesian theory of inference. See also: Mortality Studies , Event Counts and Durations

Age-adjusted mortality rates for the contiguous United States in 2000–2005 were obtained from the Wide-ranging Online Data for Epidemiologic Research system of the U.S. Centers for Disease Control and Prevention (CDC) (2015). Age-adjusted mortality rates were weighted averages of the age-specific death rates, and they were used to account for different age structures among populations (Curtin and Klein 1995). The mortality rates for counties with < 10 deaths were suppressed by the CDC to protect privacy and to ensure data reliability; only counties with ≥ 10 deaths were included in the analyses. The underlying cause of mortality was specified using the World Health Organization’s International Statistical Classification of Diseases and Related Health Problems (10th revision; ICD-10). In this study, we focused on the all-cause mortality rate (A00-R99) and on mortality rates from the three leading causes: heart disease (I00-I09, I11, I13, and I20-I51), cancer (C00-C97), and stroke (I60- I69) (Heron 2013). We excluded mortality due to external causes for all-cause mortality, as has been done in many previous studies (e.g., Pearce et al. 2010, 2011; Zanobetti and Schwartz 2009), because external causes of mortality are less likely to be related to environmental quality. We also focused on the contiguous United States because the numbers of counties with available cause-specific mortality rates were small in Hawaii and Alaska. County-level rates were available for 3,101 of the 3,109 counties in the contiguous United States (99.7%) for all-cause mortality; for 3,067 (98.6%) counties for heart disease mortality; for 3,057 (98.3%) counties for cancer mortality; and for 2,847 (91.6%) counties for stroke mortality. The EQI includes variables representing five environmental domains: air, water, land, built, and sociodemographic (2). The _domain-specific indices include both beneficial and detrimental environmental factors. The air _domain includes 87 variables representing criteria and hazardous air pollutants. The water _domain includes 80 variables representing overall water quality, general water contamination, recreational water quality, drinking water quality, atmospheric deposition, drought, and chemical contamination. The land _domain includes 26 variables representing agriculture, pesticides, contaminants, facilities, and radon. The built _domain includes 14 variables representing roads, highway/road safety, public transit behavior, business environment, and subsidized housing environment. The sociodemographic environment includes 12 variables representing socioeconomics and crime. This dataset is not publicly accessible because: EPA cannot release personally identifiable information regarding living individuals, according to the Privacy Act and the Freedom of Information Act (FOIA). This dataset contains information about human research subjects. Because there is potential to identify individual participants and disclose personal information, either alone or in combination with other datasets, individual level data are not appropriate to post for public access. Restricted access may be granted to authorized persons by contacting the party listed. It can be accessed through the following means: Human health data are not available publicly. EQI data are available at: https://edg.epa.gov/data/Public/ORD/NHEERL/EQI. Format: Data are stored as csv files. This dataset is associated with the following publication: Jian, Y., L. Messer, J. Jagai, K. Rappazzo, C. Gray, S. Grabich, and D. Lobdell. Associations between environmental quality and mortality in the contiguous United States 2000-2005. ENVIRONMENTAL HEALTH PERSPECTIVES. National Institute of Environmental Health Sciences (NIEHS), Research Triangle Park, NC, USA, 125(3): 355-362, (2017).

Death statistics (i) Number of Deaths for Different Sexes and Crude Death Rate for the Period from 1981 to 2023 (ii) Age-standardised Death Rate (Overall and by Sex) for the Period from 1981 to 2023 (iii) Age-specific Death Rate for Year 2013 and 2023 (iv) Death Rates by Leading Causes of Death for the Period from 2001 to 2023 (v) Number of Deaths by Leading Causes of Death for the Period from 2001 to 2023 (vi) Age-standardised Death Rates by Leading Causes of Death for the Period from 2001 to 2023 (vii) Late Foetal Mortality Rate for the Period from 1981 to 2023 (viii) Perinatal Mortality Rate for the Period from 1981 to 2023 (ix) Neonatal Mortality Rate for the Period from 1981 to 2023 (x) Infant Mortality Rate for the Period from 1981 to 2023 (xi) Number of Maternal Deaths for the Period from 1981 to 2023 (xii) Maternal Mortality Ratio for the Period from 1981 to 2023

Rank, number of deaths, percentage of deaths, and age-specific mortality rates for the leading causes of death, by age group and sex, 2000 to most recent year.

This dataset presents information on age-sex specific mortality rates for Alberta, by cause of death, per 100,000 population (for cause of death derived from ICD10 codes).

The dataset was originally created to allow the construction of age-specific mortality series and cohort mortality series for particular diseases, from the mid-nineteenth century to the present (in conjunction with the comparable mortality database created by the Office of National Statistics which covers 1901 – present). The dataset is fairly comprehensive and therefore allows both fine analysis of trends in single causes and also the construction of consistent aggregated categories of causes over time. Additionally, comparison of trends in individual causes can be used to infer transfers of deaths between categories over time, that may cause artifactual changes in mortality rates of particular causes. The data are presented by sex, allowing calculation of sex ratios. The age-specific and annual nature of the dataset allows the analysis of cause-specific mortality by birth cohort (assuming low migration at the national level). The database can be used in conjunction with the ONS database “Historic Mortality and Population Data, 1901-1992”, already in the UK Data Archive collection as SN 2902, to create continuous cause-of-death series for the period 1848-1992 (or later, if using more recent versions of the ONS database).

Age-sex-time standardised death rates (ASDR) per 1,000 person-years for 41,666 deaths in 5,303,232 person-years among the 15–64 year age group in twelve INDEPTH Network sites.

Abstract

Cause of death data based on VA interviews were contributed by fourteen INDEPTH HDSS sites in sub-Saharan Africa and eight sites in Asia. The principles of the Network and its constituent population surveillance sites have been described elsewhere [1]. Each HDSS site is committed to long-term longitudinal surveillance of circumscribed populations, typically each covering around 50,000 to 100,000 people. Households are registered and visited regularly by lay field-workers, with a frequency varying from once per year to several times per year. All vital events are registered at each such visit, and any deaths recorded are followed up with verbal autopsy interviews, usually 147 undertaken by specially trained lay interviewers. A few sites were already operational in the 1990s, but in this dataset 95% of the person-time observed related to the period from 2000 onwards, with 58% from 2007 onwards. Two sites, in Nairobi and Ouagadougou, followed urban populations, while the remainder covered areas that were generally more rural in character, although some included local urban centres. Sites covered entire populations, although the Karonga, Malawi, site only contributed VAs for deaths of people aged 12 years and older. Because the sites were not located or designed in a systematic way to be representative of national or regional populations, it is not meaningful to aggregate results over sites.

All cause of death assignments in this dataset were made using the InterVA-4 model version 4.02 [2]. InterVA-4 uses probabilistic modelling to arrive at likely cause(s) of death for each VA case, the workings of the model being based on a combination of expert medical opinion and relevant available data. InterVA-4 is the only model currently available that processes VA data according to the WHO 2012 standard and categorises causes of death according to ICD-10. Since the VA data reported here were collected before the WHO 2012 standard was formulated, they were all retrospectively transformed into the WHO 2012 and InterVA-4 input format for processing.

The InterVA-4 model was applied to the data from each site, yielding, for each case, up to three possible causes of death or an indeterminate result. Each cause for a case is a single record in the dataset. In a minority of cases, for example where symptoms were vague, contradictory or mutually inconsistent, it was impossible for InterVA-4 to determine a cause of death, and these deaths were attributed as entirely indeterminate. For the remaining cases, one to three likely causes and their likelihoods were assigned by InterVA-4, and if the sum of their likelihoods was less than one, the residual component was then assigned as being indeterminate. This was an important process for capturing uncertainty in cause of death outcome(s) from the model at the individual level, thus avoiding over-interpretation of specific causes. As a consequence there were three sources of unattributed cause of death: deaths registered for which VAs were not successfully completed; VAs completed but where the cause was entirely indeterminate; and residual components of deaths attributed as indeterminate.

In this dataset each case has between one and four records, each with its own cause and likelihood. Cases for which VAs were not successfully completed has a single record with the cause of death recorded as “VA not completed” and a likelihood of one. Thus the overall sum of the likelihoods equated to the total number of deaths. Each record also contains a population weighting factor reflecting the ratio of the population fraction for its site, age group, sex and year to the corresponding age group and sex fraction in the standard population (see section on weighting).

In this context, all of these data are secondary datasets derived from primary data collected separately by each participating site. In all cases the primary data collection was covered by site-level ethical approvals relating to on-going demographic surveillance in those specific locations. No individual identity or household location data are included in this secondary data.

1. Sankoh O, Byass P. The INDEPTH Network: filling vital gaps in global epidemiology. International Journal of Epidemiology 2012; 41:579-588.

2. Byass P, Chandramohan D, Clark SJ, D’Ambruoso L, Fottrell E, Graham WJ, et al. Strengthening standardised interpretation of verbal autopsy data: the new InterVA-4 tool. Global Health Action 2012; 5:19281.

Geographic coverage

Demographic surveiallance areas (countries from Africa, Asia and Oceania) of the following HDSSs:

Code  Country    INDEPTH Centre

BD011 Bangladesh   ICDDR-B : Matlab

BD012 Bangladesh   ICDDR-B : Bandarban

BD013 Bangladesh   ICDDR-B : Chakaria

BD014 Bangladesh   ICDDR-B : AMK 
BF031 Burkina Faso  Nouna 
BF041 Burkina Faso  Ouagadougou

CI011 Côte d'Ivoire Taabo 
ET031 Ethiopia    Kilite Awlaelo

GH011 Ghana     Navrongo

GH031 Ghana     Dodowa

GM011 The Gambia   Farafenni 
ID011 Indonesia   Purworejo 
IN011 India     Ballabgarh

IN021 India     Vadu

KE011 Kenya     Kilifi

KE021 Kenya     Kisumu

KE031 Kenya     Nairobi

MW011 Malawi     Karonga

SN011 Senegal    IRD : Bandafassi 
VN012 Vietnam    Hanoi Medical University : Filabavi

ZA011 South Africa  Agincourt 
ZA031 South Africa  Africa Centre 

Analysis unit

Death Cause

Universe

Surveillance population Deceased individuals Cause of death

Kind of data

Verbal autopsy-based cause of death data

Frequency of data collection

Rounds per year varies between sites from once to three times per year

Sampling procedure

No sampling, covers total population in demographic surveillance area

Mode of data collection

Face-to-face [f2f]

Research instrument

The Verbal Autopsy Questionnaires used by the various sites differed, but in most cases they were a derivation from the original WHO Verbal Autopsy questionnaire.

http://www.who.int/healthinfo/statistics/verbalautopsystandards/en/index1.html

Cleaning operations

One cause of death record was inserted for every death where a verbal autopsy was not conducted. The cuase of death assigned in these cases is "XX VA not completed"

rdata and r code for survival and cause specific mortality of american green winged teal banded on Yukon Delta

Number of deaths and mortality rates, by age group, sex, and place of residence, 1991 to most recent year.

Mortality indicators standardized by sex and cause of death. Year: 2010. Territory: Province of Lucca. Indicators: number of deaths observed, number of deaths expected, number of excess deaths, standardised mortality ratio. Standardisation method applied: indirect. Reference population (standard population): Residents in the geographical area of the Centre (Tuscany, Umbria, Marche, Lazio). Primary data source (number of deaths observed, population resident in the province of Lucca, sex- and age-specific mortality rates of the population resident in the Centro district): ISTAT. Calculation of indicators: Statistical Office of the Province of Lucca.

Nigeria’s under-five mortality rate is the eighth highest in the world. Identifying the causes of under-five deaths is crucial to achieving Sustainable Development Goal 3 by 2030 and improving child survival. National and international bodies collaborated in this study to provide the first ever direct estimates of the causes of under-five mortality in Nigeria. Verbal autopsy interviews were conducted of a representative sample of 986 neonatal and 2,268 1–59 month old deaths from 2008 to 2013 identified by the 2013 Nigeria Demographic and Health Survey. Cause of death was assigned by physician coding and computerized expert algorithms arranged in a hierarchy. National and regional estimates of age distributions, mortality rates and cause proportions, and zonal- and age-specific mortality fractions and rates for leading causes of death were evaluated. More under-fives and 1–59 month olds in the South, respectively, died as neonates (N = 24.1%, S = 32.5%, p