The Detailed Mortality - Underlying Cause of Death data on CDC WONDER are county-level national mortality and population data spanning the years 1999-2009. Data are based on death certificates for U.S. residents. Each death certificate contains a single underlying cause of death, and demographic data. The number of deaths, crude death rates, age-adjusted death rates, standard errors and 95% confidence intervals for death rates can be obtained by place of residence (total U.S., region, state, and county), age group (including infants and single-year-of-age cohorts), race (4 groups), Hispanic ethnicity, sex, year of death, and cause-of-death (4-digit ICD-10 code or group of codes, injury intent and mechanism categories, or drug and alcohol related causes), year, month and week day of death, place of death and whether an autopsy was performed. The data are produced by the National Center for Health Statistics.

WONDER online databases include county-level Compressed Mortality (death certificates) since 1979; county-level Multiple Cause of Death (death certificates) since 1999; county-level Natality (birth certificates) since 1995; county-level Linked Birth / Death records (linked birth-death certificates) since 1995; state & large metro-level United States Cancer Statistics mortality (death certificates) since 1999; state & large metro-level United States Cancer Statistics incidence (cancer registry cases) since 1999; state and metro-level Online Tuberculosis Information System (TB case reports) since 1993; state-level Sexually Transmitted Disease Morbidity (case reports) since 1984; state-level Vaccine Adverse Event Reporting system (adverse reaction case reports) since 1990; county-level population estimates since 1970. The WONDER web server also hosts the Data2010 system with state-level data for compliance with Healthy People 2010 goals since 1998; the National Notifiable Disease Surveillance System weekly provisional case reports since 1996; the 122 Cities Mortality Reporting System weekly death reports since 1996; the Prevention Guidelines database (book in electronic format) published 1998; the Scientific Data Archives (public use data sets and documentation); and links to other online data sources on the "Topics" page.

The Mortality - Infant Deaths (from Linked Birth / Infant Death Records) online databases on CDC WONDER provide counts and rates for deaths of children under 1 year of age, occuring within the United States to U.S. residents. Information from death certificates has been linked to corresponding birth certificates. Data are available by county of mother's residence, child's age, underlying cause of death, sex, birth weight, birth plurality, birth order, gestational age at birth, period of prenatal care, maternal race and ethnicity, maternal age, maternal education and marital status. Data are available since 1995. The data are produced by the National Center for Health Statistics.

The United States Cancer Statistics (USCS) online databases in WONDER provide cancer incidence and mortality data for the United States for the years since 1999, by year, state and metropolitan areas (MSA), age group, race, ethnicity, sex, childhood cancer classifications and cancer site. Report case counts, deaths, crude and age-adjusted incidence and death rates, and 95% confidence intervals for rates. The USCS data are the official federal statistics on cancer incidence from registries having high-quality data and cancer mortality statistics for 50 states and the District of Columbia. USCS are produced by the Centers for Disease Control and Prevention (CDC) and the National Cancer Institute (NCI), in collaboration with the North American Association of Central Cancer Registries (NAACCR). Mortality data are provided by the Centers for Disease Control and Prevention (CDC), National Center for Health Statistics (NCHS), National Vital Statistics System (NVSS).

The Mortality - Multiple Cause of Death data on CDC WONDER are county-level national mortality and population data spanning the yehttps://healthdata.gov/d/2sz9-6c59ars 1999-2006. These data are available in two separate data sets: one data set for years 1999-2004 with 3 race groups, and another data set for years 2005-2006 with 4 race groups and 3 Hispanic origin categories. Data are based on death certificates for U.S. residents. Each death certificate contains a single underlying cause of death, up to twenty additional multiple causes, and demographic data. The number of deaths, crude death rates, age-adjusted death rates, standard errors and 95% confidence intervals for death rates can be obtained by place of residence (total U.S., state, and county), age group (including infants), race, Hispanic ethnicity (years 2005-2006 only), sex, year of death, and cause-of-death (4-digit ICD-10 code or group of codes). The data are produced by the National Center for Health Statistics.

The AIDS Public Information Data Set (APIDS) for years 1981-2002 on CDC WONDER online database contains counts of AIDS (Acquired Immune Deficiency Syndrome) cases reported by state and local health departments, by demographics; location (region and selected metropolitan areas); case-definition; month/year and quarter-year of diagnosis, report, and death (if applicable); and HIV exposure group (risk factors for AIDS). Data are produced by the US Department of Health and Human Services (US DHHS), Public Health Service (PHS), Centers for Disease Control and Prevention (CDC), National Center for HIV, STD and TB Prevention (NCHSTP), Division of HIV/AIDS Prevention (DHP).

Around 7.7% of Americans have asthma, including 20.2 million adults and 4.6 million children. This study examines asthma mortality trends and disparities across U.S. demographic and geographic groups from 1999 to 2020. A retrospective analysis was conducted using the CDC WONDER database to examine asthma-related deaths in the U.S. from 1999 to 2020. Age-adjusted mortality rates (AAMRs) and crude mortality rates (CMRs) per 100,000 were calculated. Trends and annual percent changes (APCs) were assessed overall and stratified by sex, race, region, and age. From 1999 to 2020, the U.S. recorded 221 161 asthma-related deaths (AAMR: 3.07), mostly in medical facilities. Mortality declined from 1999 to 2018 (APC: −1.53%) but surged from 2018 to 2020 (APC: 28.63%). Females, NH Blacks, and NH American Indians had the highest mortality rates. Older adults (≥65) had the greatest burden, with younger groups showing notable increases post-2018. Rural areas and the West reported slightly higher rates than urban and other regions. Hawaii and the District of Columbia had the highest AAMRs, while Florida and Nevada had the lowest. Asthma-related mortality in the U.S. declined until 2018 but sharply increased from 2018 to 2020, with rises across all demographic groups, regions, and settings. Females, NH Blacks, and older adults consistently had higher mortality rates, while younger age groups showed recent alarming increases. Targeted interventions are urgently needed to address inequities and recent mortality surges.

IntroductionDespite advancements in cervical cancer screening and HPV vaccines, demographic disparities perpetuate the burden of cervical cancer. The aim of this study is to utilize the most up-to-date CDC WONDER data of cervical cancer mortality to provide a comprehensive temporal analysis of demographic variables and account for patients missed in other database studies. In doing so, temporal trends found in this study may be used to guide future efforts and studies to understand nuanced barriers to cervical cancer screening and prevention.MethodsWith CDC WONDER Data, cervical cancer-related mortality was assessed in the U.S. from 1999 to 2023. Using age-adjusted mortality rates (AAMR), temporal trends were analyzed using the Joinpoint Regression Program for women 25 years and older across race, census regions, urban/rural residence, and states. Annual percentage change (APC) and average annual percentage change (AAPC) were calculated with 95% confidence intervals.ResultsCervical cancer-related mortality declined over the study period with an AAPC of –1.043*. Between 2015 and 2023, there was a concerning positive change in AAMR [APC of 0.1272 (95% CI –0.3393 to 1.7502)], though not statistically significant. Black or African American patients experienced the highest AAMR across races but maintained a decrease in mortality rate over the study period [AAPC of -2.670* (95% CI -2.931 to -2.356)]. Region and race analysis demonstrated Black or African American patients in the Northeast held the largest decline in AAMR [AAPC of –3.218* (95% CI –3.708 to –2.390)], while Hispanic or Latino and Black or African American patients in the South closely followed AAPC of –1.347* (–1.898 to –0.824) and –2.656* (95% CI –2.939 to -2.350), respectively]. Rural areas (NonCore and Micropolitan) and the Southern region displayed a concerning positive trend after 2009 and 2010, though not statistically significant [APC values of 0.772 (95% CI -0.328 to 4.888), 0.986 (95% CI –0.252 to 4.887), and 0.286 (95% CI –0.061 to 0.772), respectively].ConclusionThese findings underscore the need for targeted interventions with consideration of regional and racial temporal disparities in cervical cancer-related mortality.

The Vaccine Adverse Event Reporting System (VAERS) online database on CDC WONDER provides counts and percentages of adverse event case reports after vaccination, by symptom, vaccine product, manufacturer, onset interval, outcome category, year and month vaccinated, year and month reported, age, sex and state / territory. The Vaccine Adverse Event Reporting System is a cooperative program for vaccine safety of the Centers for Disease Control and Prevention (CDC) and the Food and Drug Administration (FDA). VAERS is a post-marketing safety surveillance program, collecting information about adverse events (possible side effects) that occur after the administration of US licensed vaccines. Data are from the US Department of Health and Human Services (DHHS), Public Health Service (PHS), Food and Drug Administration (FDA)/ Centers for Disease Control (CDC), Vaccine Adverse Event Reporting System (VAERS).

The Population online databases contain data from the US Census Bureau. The Census Estimates online database contains contains county-level population counts for years 1970 - 2000. The data comprise the April 1st Census counts for years 1970, 1980, 1990 and 2000, the July 1st intercensal estimates for years 1971-1979 and 1981-1989, and the July 1st postcensal estimates for years 1991-1999. The Census Projections online database contains population projections for years 2004-2030 by year, state, age, race and sex, prodyced by teh Cenus Bureau in 2005. The data are produced by the United States Department of Commerce, U.S. Census Bureau, Population Division.

PurposeCardiovascular disease (CVD) is the leading cause of death in the United States, and sepsis significantly contributes to hospitalization and mortality. This study aims to assess the trends of sepsis-associated CVD mortality rates and variations in mortality based on demographics and regions in the US.MethodsThe Centers for Disease Control and Prevention Wide-ranging Online Data for Epidemiologic Research (CDC WONDER) database was used to identify CVD and sepsis-related deaths from 1999 to 2022. Data on gender, race and ethnicity, age groups, region, and state classification were statistically analyzed to obtain crude and age-adjusted mortality rates (AAMR). The Joinpoint Regression Program was used to determine trends in mortality within the study period.ResultsDuring the study period, there were a total of 1,842,641 deaths with both CVD and sepsis listed as a cause of death. Sepsis-associated CVD mortality decreased between 1999 and 2013, from AAMR of 65.7 in 1999 to 58.8 in 2013 (APC −1.06*%, 95% CI: −2.12% to −0.26%), then rose to 74.3 in 2022 (APC 3.23*%, 95% CI: 2.18%–5.40%). Throughout the study period, mortality rates were highest in men, NH Black adults, and elderly adults (65+ years old). The Northeast region, which had the highest mortality rate in the initial part of the study period, was the only region to see a decline in mortality, while the Northwest, Midwest, and Southern regions experienced significant increases in mortality rates.ConclusionSepsis-associated CVD mortality has increased in the US over the past decade, and both this general trend and the demographic disparities have worsened since the onset of the COVID-19 pandemic.

Data on drug overdose death rates in the United States, by age, sex, race, Hispanic origin, and drug type. Data are from Health, United States. SOURCE: National Center for Health Statistics, National Vital Statistics System, Mortality File. Search, visualize, and download these and other estimates from a wide range of health topics with the NCHS Data Query System (DQS), available from: https://www.cdc.gov/nchs/dataquery/index.htm.

The CDC WONDER Mortality - Underlying Cause of Death online database is a county-level national mortality and population database spanning the years since 1979 -2008. The number of deaths, crude death rates, age-adjusted death rates, standard errors and 95% confidence intervals for death rates can be obtained by place of residence (total U.S., Census region, Census division, state, and county), age group (including infant age groups), race (years 1979-1998: White, Black, and Other; years 1999-2008: American Indian or Alaska Native, Asian or Pacific Islander, Black or African American, and White), Hispanic origin (years 1979-1998: not available; years 1999-present: Hispanic or Latino, not Hispanic or Latino, Not Stated), gender, year of death, and underlying cause of death (years 1979-1998: 4-digit ICD-9 code and 72 cause-of-death recode; years 1999-present: 4-digit ICD-10 codes and 113 cause-of-death recode, as well as the Injury Mortality matrix classification for Intent and Mechanism), and urbanization level of residence (2006 NCHS urban-rural classification scheme for counties). The Compressed Mortality data are produced by the National Center for Health Statistics.

BackgroundEsophageal cancer continues to pose a significant public health challenge worldwide. However, the extent to which advancements in treatment have reduced mortality at the population level remains unclear. This study examines trends in esophageal cancer mortality in the United States from 1999 to 2023, focusing on variations based on sex, ethnicity, urbanization level, census region, and age group.MethodsMortality data were obtained from the Centers for Disease Control and Prevention’s Wide-Ranging Online Data for Epidemiologic Research (CDC WONDER) database using ICD-10 codes (C15.0–C15.9) to identify esophageal cancer-related deaths. The analysis included individuals aged 25 years and older. Temporal trends in age-adjusted mortality rates (AAMR) were analyzed using the Joinpoint Regression Program. Data were stratified by census region, metropolitan/non-metropolitan residence, and state. Annual percentage change (APC) and average annual percentage change (AAPC) were calculated along with their 95% confidence intervals (CI).ResultsBetween 1999 and 2023, a total of 357,606 deaths from esophageal cancer were recorded. A significant decline in the mortality rate was observed over this period, with the overall AAMR decreasing from 6.74 to 5.61 per 100,000, corresponding to an AAPC of −0.81* (p-value < 0.05). Decline in the mortality rate was evident across nearly all ethnic groups, with the exception of the non-Hispanic (NH) white group. The most significant reduction was observed among non-Hispanic Black individuals (AAPC: −4.07). Significant sex-based disparities persisted throughout the study period, with men consistently experiencing higher mortality rates than women. Geographically, mortality trends diverged: metropolitan areas experienced a significant decline (AAPC: −1.09*), whereas non-metropolitan areas experienced a significant increase (AAPC: 0.48*). Pronounced regional disparities were also noted, with the western and northeastern regions demonstrating the most substantial improvements. Age-specific analyses revealed a significant reduction in the mortality rate across the majority of age groups; however, among adults aged 85 years and older, the mortality rates remained stable.ConclusionDespite an overall decline in the mortality rate of esophageal cancer, significant disparities persist across geographic, urban–rural, and age subgroups. These findings highlight the need for targeted public health interventions to address ongoing inequalities, particularly among NH white individuals, those living in non-metropolitan areas, and older adult.

This dataset of U.S. mortality trends since 1900 highlights the differences in age-adjusted death rates and life expectancy at birth by race and sex.

Age-adjusted death rates (deaths per 100,000) after 1998 are calculated based on the 2000 U.S. standard population. Populations used for computing death rates for 2011–2017 are postcensal estimates based on the 2010 census, estimated as of July 1, 2010. Rates for census years are based on populations enumerated in the corresponding censuses. Rates for noncensus years between 2000 and 2010 are revised using updated intercensal population estimates and may differ from rates previously published. Data on age-adjusted death rates prior to 1999 are taken from historical data (see References below).

Life expectancy data are available up to 2017. Due to changes in categories of race used in publications, data are not available for the black population consistently before 1968, and not at all before 1960. More information on historical data on age-adjusted death rates is available at https://www.cdc.gov/nchs/nvss/mortality/hist293.htm.

SOURCES

CDC/NCHS, National Vital Statistics System, historical data, 1900-1998 (see https://www.cdc.gov/nchs/nvss/mortality_historical_data.htm); CDC/NCHS, National Vital Statistics System, mortality data (see http://www.cdc.gov/nchs/deaths.htm); and CDC WONDER (see http://wonder.cdc.gov).

REFERENCES

1. National Center for Health Statistics, Data Warehouse. Comparability of cause-of-death between ICD revisions. 2008. Available from: http://www.cdc.gov/nchs/nvss/mortality/comparability_icd.htm.

2. National Center for Health Statistics. Vital statistics data available. Mortality multiple cause files. Hyattsville, MD: National Center for Health Statistics. Available from: https://www.cdc.gov/nchs/data_access/vitalstatsonline.htm.

3. Kochanek KD, Murphy SL, Xu JQ, Arias E. Deaths: Final data for 2017. National Vital Statistics Reports; vol 68 no 9. Hyattsville, MD: National Center for Health Statistics. 2019. Available from: https://www.cdc.gov/nchs/data/nvsr/nvsr68/nvsr68_09-508.pdf.

4. Arias E, Xu JQ. United States life tables, 2017. National Vital Statistics Reports; vol 68 no 7. Hyattsville, MD: National Center for Health Statistics. 2019. Available from: https://www.cdc.gov/nchs/data/nvsr/nvsr68/nvsr68_07-508.pdf.

5. National Center for Health Statistics. Historical Data, 1900-1998. 2009. Available from: https://www.cdc.gov/nchs/nvss/mortality_historical_data.htm.

The Births (Natality) online databases in CDC WONDER report birth rates, fertility rates and counts of live births occurring within the United States to U.S. residents and non-residents. Counts can be obtained by state, county, child's gender and weight, mother's race, mother's age, mother's education, gestation period, prenatal care, birth plurality, and mother's medical and tobacco use risk factors. The data are derived from birth certificates. Data are available since 1995. The data are produced by the National Center for Health Statistics.

This dataset tracks the updates made on the dataset "CDC WONDER: Detailed Mortality - Underlying Cause of Death" as a repository for previous versions of the data and metadata.

The Population - Bridged-Race July 1st Estimates online databases report bridged-race population estimates of the July 1st resident population of the United States, based on Census 2000 counts, for use in calculating vital rates. These estimates result from "bridging" the 31 race categories used in Census 2000, as specified in the 1997 Office of Management and Budget (OMB) standards for the collection of data on race and ethnicity, to the four race categories specified under the 1977 standards (Asian or Pacific Islander, Black or African American, American Indian or Alaska Native, White). Many data systems, such as vital statistics, are continuing to use the 1977 OMB standards during the transition to full implementation of the 1997 OMB standards. Postcensal estimates are available for year 2000 - 2009; intercensal estimates are available for the years 1990-1999. Obtain population counts by Year, State, County, Race (4-categories), Ethnicity, Sex and Age (1-year or 5-year groups). The data are released by the National Center for Health Statistics.

BackgroundOvarian cancer contributes significantly to the morbidity and mortality rates for women worldwide. As observed with other types of cancer, health disparities disproportionately affect ovarian cancer incidence rates and outcomes, especially in African American and older women. However, the trends in ovarian cancer mortality rates up until 2023 with regard to various demographic identifiers have not been fully elucidated, which this study aims to rectify.MethodsMortality trends due to malignant neoplasms of the ovary in individuals 25 and older in the US from 1999 to 2023 were analyzed using the Centers for Disease Control Wide Ranging Online Data for Epidemiological Research (CDC WONDER) database. Trends in age-adjusted mortality rate (AAMR) were analyzed on the basis of race, 10-year age-group, region and urban/rural designation.ResultsBetween 1999 and 2023, the AAMR related to malignant neoplasms of the ovary fell from 14.62 in 1999 to 9.52 in 2023. All races analyzed saw a decrease in overall mortality related to malignant neoplasms of the ovary, with the largest decrease being observed in White patients (AAPC: -1.78). Regionally, the Northeast (AAPC: -1.95), Midwest (AAPC: -1.99), South (AAPC: -1.72), and West (AAPC: -1.73) regions of the United States (US) all saw reduced ovarian neoplasm mortality rates. Similarly, rates also decreased in urban (AAPC: -1.83) and rural (AAPC: -1.75) localities, as well as in each ten-year age category analyzed, with the largest decrease seen in the 55–64 years old category (AAPC: -2.15). States such as Delaware, South Carolina, and Idaho experienced some of the largest decreases in AAMR, whereas the District of Columbia saw an increase in AAMR during this period.ConclusionsOver the last twenty-years, mortality rates for malignant neoplasms of the ovary have declined, with the largest decreases being seen in White patients, those residing in the Midwest, urban locality, and women between 55–64 years olds. While mortality rates have declined, health disparities still continue to negatively affect ovarian cancer outcomes, and more research is needed to improve accessibility, availability, and affordability of care for patients.

The Sexually Transmitted Disease (STD) Morbidity online databases on CDC WONDER contain case reports reported from the 50 United States and D.C., Puerto Rico, Virgin Islands and Guam. The online databases report the number of cases and disease incidence rates by year, state, disease, age, sex of patient, type of STD, and area of report. Data are produced by the U.S. Department of Health and Human Services, Public Health Service, Centers for Disease Control and Prevention (CDC), National Center for HIV/AIDS, viral Hepatitis, STD and TB Prevention (NCHHSTP).