CDI toxins are expressed by Gram-negative bacteria as part of a mechanism to inhibit the growth of neighbouring cells. This entry represents the inhibitor (CdiI, also called CdiI immunity protein) of the CdiA effector protein from Escherichia coli A0 34/86, and similar proteins. E.coli A0 CdiI adopts an alpha/beta structure consisting of a central antiparallel beta-sheet and alpha-helices packed on it PDB:5T86.

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The California Health Care Quality Report Cards show the quality of health care for millions of Californians who get their care through medical groups and commercial insurance plans. Quality health care is getting the right care at the right time. The Health Plan Report Card data includes the 10 largest Health Maintenance Organizations (HMOs) and the 5 largest Preferred Provider Organizations (PPOs). The Medical Group - Commercial Report Card data includes 204 medical groups that have contracts with the HMOs listed in the Health Plan Report Card. The Medical Group - Medicare Report Card data includes 186 medical groups that have contracts with the Medicare Advantage plans listed in the Health Plan Report Card and serve Medicare Advantage members. The Counties data lists the counties served by each health plan and medical group included in the Report Cards. Note: This data is maintained by CDII and was formerly created by the CA Office of the Patient Advocate. For more information please visit the CDII OPA webpage

A flexible tris-formylpyridine subcomponent A was observed to produce three distinct products following CdII-templated self-assembly with different anilines. Two of the products were CdII4L4 tetrahedra, one with ligands puckered inward, and the other outward. The third product was a CdII8L8 structure having all mer stereochemistry, contrasting with the fac stereochemistry of the tetrahedra. These three complexes were observed to coexist in solution. The equilibrium between them could be influenced through guest binding and specific interactions between aniline subcomponents, allowing a selected one of the three to predominate under defined conditions.

This is the C-terminal domain of Contact-dependent growth inhibition immunity (CdiI) proteins present in Enterobacter cloacae. CdiI proteins neutralize CdiA-CT toxins to protect toxin-producing cells from auto-inhibition. Structural homology searches reveal that Enterobacter cloacae's CdiI is most similar to the Whirly family of single-stranded DNA-binding protein .

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To investigate the influence of spatial extended direction and flexibility of secondary ligand on the resulting structure, eight new ferrocene-containing complexes with various dimensionalities have been synthesized by the reactions of CdII salts and 1,1′-bis(3-carboxy-1-oxopropyl)ferrocene (H2bfcs) with series of rationally selected N-heterocyclic spacers. When the small organic molecule 4-aminopyridine (apy) was employed as a secondary ligand, a one-dimensional (1D) linear complex {[Cd(bfcs)(apy)2]·H2O}n (1) was furnished, while the use of bis(azole) bridging ligands resulted in the formation of a 1D ribbon complex {[Cd(bfcs)(bbbm)1.5]·CH3OH·2H2O}n (2), a rare 1D quadruple-chain complex {[Cd(bfcs)(btmb)]·3H2O}n (3) and two two-dimensional (2D) puckered complexes {[Cd2(bfcs)2(pbbm)2]·2H2O}n (4) and {[Cd(bfcs)(bix)]·H2O}n (5) (bbbm = 1,1′-(1,4-butanediyl)bis-1H-benzimidazole, btmb = 4,4′-bis(1,2,4-triazole-1-ylmethyl)biphenyl, pbbm = 1,1′-(1,3-propanediyl)bis-1H-benzimidazole, bix = 1,4-bis(imidazole-1 -ylmethyl)benzene). In addition, the tripodal bridging secondary ligand led to an unusual three-dimensional (3D) layer pillar complex {[Cd2(bfcs)(titb)2Cl2]·2CH3OH·4H2O}n (6) (titb =1,3,5-tris(imidazol-1-ylmethyl)-2,4,6-trimethylbenzene). Employment of a flexible multidentate molecule tris(2-benzimidazolylmethyl)amine (ntb) as the secondary ligand gave birth to a mononuclear complex [Cd(bfcs)(ntb)]·DMF·5H2O (7) and a binuclear complex [Cd2(bfcs)(ntb)2]·bfcs·5H2O (8), in which ntb adopted the chelating coordination mode. It can be observed from the coordination architectures of 1−8 that secondary ligands had great effects on the spatial connective fashions of CdII centers, resulting in the formation of various dimensional complexes.

Inventory of cdiBCAI-type loci in Xenorhabdus and Photorhabdus genomes.

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The California Department of Public Health (CDPH), Center for Health Care Quality, Licensing and Certification (L&C) Program licenses and certifies more than 30 types of healthcare facilities. The Electronic Licensing Management System (ELMS) is a CDPH data system created to manage state licensing-related data and enforcement actions. This file includes California healthcare facilities that are operational and have a current license issued by the CDPH and/or a current U.S. Department of Health and Human Services’ Centers for Medicare and Medicaid Services (CMS) certification.

To link the CDPH facility IDs with those from other Departments, like HCAI, please reference the "Licensed Facility Cross-Walk" Open Data table at https://data.chhs.ca.gov/dataset/licensed-facility-crosswalk. Facility geographic variables are updated monthly, if latitude/longitude information is missing at any point in time, it should be available when the next time the Open Data facility file is refreshed.

Please note that the file contains the data from ELMS as of the 11th business day of the month. See DATA_DATE variable for the specific date of when the data was extracted.

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Note: This web page provides data on health facilities only. To file a complaint against a facility, please see: https://www.cdph.ca.gov/Programs/CHCQ/LCP/Pages/FileAComplaint.aspx

The California Department of Public Health (CDPH), Center for Health Care Quality, Licensing and Certification (L&C) Program licenses and certifies more than 30 types of healthcare facilities. The Electronic Licensing Management System (ELMS) is a CDPH data system created to manage state licensing-related data and enforcement actions. This file includes California healthcare facilities that are operational and have a current license issued by the CDPH and/or a current U.S. Department of Health and Human Services’ Centers for Medicare and Medicaid Services (CMS) certification.

To link the CDPH facility IDs with those from other Departments, like HCAI, please reference the "Licensed Facility Cross-Walk" Open Data table at https://data.chhs.ca.gov/dataset/licensed-facility-crosswalk. Facility geographic variables are updated monthly, if latitude/longitude information is missing at any point in time, it should be available when the next time the Open Data facility file is refreshed.

Please note that the file contains the data from ELMS as of the 11th business day of the month. See DATA_DATE variable for the specific date of when the data was extracted. To access the CDPH Facilities map, follow this link: https://go.cdii.ca.gov/cdph-facilities

Four new cadmium(II) complexes [Cd2(bz)4(H2O)4(μ2-hmt)]·Hbz·H2O (1), [Cd3(bz)6(H2O)6(μ2-hmt)2]·6H2O (2), [Cd(pa)2(H2O)(μ2-hmt)]n (3), and {[Cd3(ac)6(H2O)3(μ3-hmt)2]·6H2O}n (4) with hexamine (hmt) and monocarboxylate ions, benzoate (bz), phenylacetate (pa), or acetate (ac) have been synthesized and characterized structurally. Structure determinations reveal that 1 is dinuclear, 2 is trinuclear, 3 is a one-dimensional (1D) infinite chain, and 4 is a two-dimensional (2D) polymer with fused hexagonal rings consisting of CdII and hmt. All the CdII atoms in the four complexes (except one CdII in 2) possess seven-coordinate pentagonal bipyramidal geometry with the various chelating bidentate carboxylate groups in equatorial sites. One of the CdII ions in 2, a complex that contains two monodentate carboxylates is in a distorted octahedral environment. The bridging mode of hmt is μ2- in complexes 1−3 but is μ3- in complex 4. In all complexes, there are significant numbers of H-bonds, C−H/π, and π−π interactions which play crucial roles in forming the supramolecular networks. The importance of the noncovalent interactions in terms of energies and geometries has been analyzed using high level ab initio calculations. The effect of the cadmium coordinated to hmt on the energetic features of the C−H/π interaction is analyzed. Finally, the interplay between C−H/π and π−π interactions observed in the crystal structure of 3 is also studied.

ITC data were fit using one-site binding model for CdiA-CT(M)/CdiI and two site binding model for rest of the complexes. The parameters for the second binding site are shown in the parentheses.

The reaction of a conjugated bispyridyl-based Schiff base ligand L (L = 1,4-bis(4-pyridyl)-2,3-diaza-1,3-butadiene) with transition metal ions afforded two different structure types of coordination polymers depending on the choice of counteranions. The combination of ZnII or MnII acetate and L in solution yielded two novel infinite one-dimensional (1D) molecular ladder complexes 1 and 2 with a molecular composition of [M2L2(OAc)4·2(MeOH)]n, (M = ZnII or MnII), in which acetate anions serve as bridges. However, when replacing ZnII or MnII acetate with ZnII or CdII nitrate in the same reaction condition, two isomorphous 1D linear coordination polymers 3 and 4 with a molecular composition of [ML(NO3)2(H2O)2]n, (M = ZnII or CdII) were obtained. Interestingly, the 1D polymeric chains of 3 and 4 could be further assembled to a three-dimensional (3D) microporous cross-like array with layer-to-layer alternate arrangement resulting from interchain π···π stacking and hydrogen-bonding interactions with the presence of coordinated nitrate anions and water molecules. There are remarkably distinct coordination and molecular packing modes in the two types of complexes regardless of the nature of the metal ions used. These results indicate that the nature of the anions, which play different roles in forming two types of crystals, is the key factor directing the structural topologies. IR spectra and thermal behaviors of all four complexes have been characterized, and photoluminescent studies revealed that the ZnII and CdII complexes were fluorescent with medium intensity in the solid state.

A series of CdII, CoII, NiII, and PbII mixed-ligand coordination complexes 1−8 based on 5-sulfoisophthalic acid (H3sip) and the bent dipyridyl ligand 2,5-bis(3-pyridyl)-1,3,4-oxadiazole (3-bpo) or its 4-pyridyl N-donor analogue (4-bpo) have been synthesized and fully characterized by IR spectra, microanalyses, and single crystal and powder X-ray diffraction techniques. The significant pH effect on assembly of the CdII complexes 1−4 has been demonstrated, which leads to the formation of distinct crystalline products, whereas the CoII, NiII, and PbII systems 5−8 are independent to pH condition of the synthetic reaction. Complexes 1−8 display various coordination motifs with different existing forms, conformations, and coordination modes of the organic ligands. Further, extended supramolecular networks are constructed via secondary interactions such as hydrogen-bonding and aromatic stacking. Solid-state properties of thermal stability and fluorescence for these crystalline materials are also presented.

Immunity protein component of a toxin-immunity protein module, which functions as a cellular contact-dependent growth inhibition (CDI) system. CDI modules allow bacteria to communicate with and inhibit the growth of closely related neighboring bacteria in a contact-dependent fashion. Neutralizes the toxic activity of cognate toxin CdiA-NC101 (the C-terminal 154 residue CT fragment) (PubMed:26305955). Does not inhibit toxic activity of CdiA from other toxin-immunity modules or strains of E.coli (Probable). Mediates dimerization of the ternary CdiA-CT-NC101, CdiI-NC101 and EF-Tu complex; both CdiI molecules contact both EF-Tu molecules (PubMed:28973472)

2-Ammoniumethanethiolate, -SCH2CH2NH3+, the first structurally characterized zwitterionic ammoniumthiolate, is the stable form of cysteamine (HL) in the solid state and in aqueous solution. Reactions of ZnCl2, Cd(Oac)2, and HgCl2 with cysteamine and NaOH in a 1:2:2 ratio, respectively, lead to the homoleptic complexes ML2. Their single-crystal X-ray structures demonstrate basic differences in the coordination chemistry of ZnII, CdII, and HgII. While chelating N,S-coordination modes are found for all metal ions, ZnII forms a mononuclear complex with a distorted tetrahedral Zn(N2S2) coordination mode, whereas HgII displays a dimer with Hg(N2S2) coordinated monomers being connected by two long Hg···S contacts. Solid-state 199Hg NMR spectra of HgL2 and [Hg(HL)2]Cl2 reveal a low-field shift of the signals with increasing coordination number. Strong and nearly symmetric Cd−S−Cd bridges in solid CdL2 lead to a chain structure, CdII displaying a distorted square pyramidal Cd(N2S3) coordination mode. The ab initio [MP2/LANL2DZ(d,f)] structures of isolated ML2 show a change from a distorted tetrahedral to bisphenoidal coordination mode in the sequence ZnII−CdII−HgII. A natural bond orbital analysis showed a high ionic character for the M−S bonds and suggests that the S−M−S fragment is best described by a 3c4e bond. The strength of the M···N interactions and the stability of ML2 toward decomposition to M and L−L decreases in the sequence Zn > Cd > Hg. Ab initio calculations further suggest that a tetrahedral S−M−S angle stabilizes ZnII against substitution by CdII and HgII in a M(N2S2) environment. Such geometry is provided in zinc-finger proteins, as was found by a database survey.

The condensation reaction of 2,6-diformylpyridine with an equimolar mixture of opposite enantiomers of trans-1,2-diaminocyclopentane and trans-1,2-diaminocyclohexane using a dynamic combinatorial chemistry approach has been examined. In nonmetal-templated reactions, depending on reaction conditions, mixed 2 + 1 + 1 macrocyclic imine or bigger mixed 4 + 2 + 2 imine macrocycle are formed selectively. The 2 + 1 + 1 imine used as a precursor in the templated by CdII ions produces a library of enlarged chiral mixed imines coordinated with metal cations among which the hexanuclear CdII complex of 6 + 3 + 3 imine was isolated and characterized. All macrocyclic imine compounds have been reduced to the corresponding macrocyclic amines, which have been further transformed into their hydrochlorides. Each macrocyclic compound has been obtained as two enantiomers. For imine macrocycles and for the hydrochloride derivatives of macrocyclic amines, their X-ray crystal structures have been determined. In particular, the crystals of protonated 4 + 2 + 2 macrocyclic amine, which contains two types of diastereomeric cations differing in terms of inverted twists of pyridine moieties, and hexanuclear CdII complex of 6 + 3 + 3 imine, which gives a deeper insight into the expansion reaction, have been investigated. A heterochiral self-sorting of 2 + 2 and 2 + 1 + 1 macrocyclic imines has been confirmed by a competition reaction of 2,6-diformylpyridine, racemic trans-1,2-diaminocyclopentane, and racemic trans-1,2-diaminocyclohexane and theoretical calculations.

The macrocycles L1−L3 incorporating N2S3-, N2S2O-, and N2S2-donor sets, respectively, and containing the 1,10-phenanthroline unit interact in acetonitrile solution with heavy metal ions such as PbII, CdII, and HgII to give 1:1 ML, 1:2 ML2, and 2:1 M2L complex species, which specifically modulate the photochemical properties of the ligands. The stoichiometry of the complex species formed during spectrofluorometric titrations and their formation constants in MeCN at 25 °C were determined from fluorescence vs MII/L molar ratio data. The complexes [Pb(L1)][ClO4]2·1/2H2O (1), [Pb(L2)][ClO4]2·MeNO2 (1a), [Pb(L3)2][ClO4]2·2MeCN (1b), and [Cd(L3)][NO3]2 (2b) were also characterized by X-ray diffraction studies. The conformation adopted by L1−L3 in these species reveals the aliphatic portion of the rings folded over the plane containing the heteroaromatic moiety with the ligands trying to encapsulate the metal center within their cavity. In 1, 1a, and 2b the metal ion completes the coordination sphere by interacting with counteranion units and solvent molecules. On the contrary, the 1:2 complex 1b shows PbII sandwiched between two symmetry-related molecules of L3 reaching an overall [4N + 4S] eight-coordination.

Metal-center-driven spontaneous resolution of a chiral coordination polymer, [Ni(SDB)(BIX)]n (1), from achiral precursors has been probed by single-crystal X-ray diffraction and circular dichroism spectroscopy. Enantiomorphs 1P and 1M showed a parallel interpenetrated 2D → 3D chiral framework with (82.10) topology. Switching of the metal center under the same reaction parameters resulted in isostructural achiral and noninterpenetrating (4,4) grid-type sql networks [M(SDB)(BIX)]n, where M = CoII, ZnII, and CdII for 2–4, respectively.