Abstract MIMIC-III is a large, freely-available database comprising deidentified health-related data associated with over 40,000 patients who stayed in critical care units of the Beth Israel Deaconess Medical Center between 2001 and 2012 [1]. The MIMIC-III Clinical Database is available on PhysioNet (doi: 10.13026/C2XW26). Though deidentified, MIMIC-III contains detailed information regarding the care of real patients, and as such requires credentialing before access. To allow researchers to ascertain whether the database is suitable for their work, we have manually curated a demo subset, which contains information for 100 patients also present in the MIMIC-III Clinical Database. Notably, the demo dataset does not include free-text notes.

Background In recent years there has been a concerted move towards the adoption of digital health record systems in hospitals. Despite this advance, interoperability of digital systems remains an open issue, leading to challenges in data integration. As a result, the potential that hospital data offers in terms of understanding and improving care is yet to be fully realized.

MIMIC-III integrates deidentified, comprehensive clinical data of patients admitted to the Beth Israel Deaconess Medical Center in Boston, Massachusetts, and makes it widely accessible to researchers internationally under a data use agreement. The open nature of the data allows clinical studies to be reproduced and improved in ways that would not otherwise be possible.

The MIMIC-III database was populated with data that had been acquired during routine hospital care, so there was no associated burden on caregivers and no interference with their workflow. For more information on the collection of the data, see the MIMIC-III Clinical Database page.

Methods The demo dataset contains all intensive care unit (ICU) stays for 100 patients. These patients were selected randomly from the subset of patients in the dataset who eventually die. Consequently, all patients will have a date of death (DOD). However, patients do not necessarily die during an individual hospital admission or ICU stay.

This project was approved by the Institutional Review Boards of Beth Israel Deaconess Medical Center (Boston, MA) and the Massachusetts Institute of Technology (Cambridge, MA). Requirement for individual patient consent was waived because the project did not impact clinical care and all protected health information was deidentified.

Data Description MIMIC-III is a relational database consisting of 26 tables. For a detailed description of the database structure, see the MIMIC-III Clinical Database page. The demo shares an identical schema, except all rows in the NOTEEVENTS table have been removed.

The data files are distributed in comma separated value (CSV) format following the RFC 4180 standard. Notably, string fields which contain commas, newlines, and/or double quotes are encapsulated by double quotes ("). Actual double quotes in the data are escaped using an additional double quote. For example, the string she said "the patient was notified at 6pm" would be stored in the CSV as "she said ""the patient was notified at 6pm""". More detail is provided on the RFC 4180 description page: https://tools.ietf.org/html/rfc4180

Usage Notes The MIMIC-III demo provides researchers with an opportunity to review the structure and content of MIMIC-III before deciding whether or not to carry out an analysis on the full dataset.

CSV files can be opened natively using any text editor or spreadsheet program. However, some tables are large, and it may be preferable to navigate the data stored in a relational database. One alternative is to create an SQLite database using the CSV files. SQLite is a lightweight database format which stores all constituent tables in a single file, and SQLite databases interoperate well with a number software tools.

DB Browser for SQLite is a high quality, visual, open source tool to create, design, and edit database files compatible with SQLite. We have found this tool to be useful for navigating SQLite files. Information regarding installation of the software and creation of the database can be found online: https://sqlitebrowser.org/

Release Notes Release notes for the demo follow the release notes for the MIMIC-III database.

Acknowledgements This research and development was supported by grants NIH-R01-EB017205, NIH-R01-EB001659, and NIH-R01-GM104987 from the National Institutes of Health. The authors would also like to thank Philips Healthcare and staff at the Beth Israel Deaconess Medical Center, Boston, for supporting database development, and Ken Pierce for providing ongoing support for the MIMIC research community.

Conflicts of Interest The authors declare no competing financial interests.

References Johnson, A. E. W., Pollard, T. J., Shen, L., Lehman, L. H., Feng, M., Ghassemi, M., Mo...

MIMIC-III is a large, freely-available database comprising deidentified health-related data associated with over forty thousand patients who stayed in critical care units of the Beth Israel Deaconess Medical Center between 2001 and 2012. The database includes information such as demographics, vital sign measurements made at the bedside (~1 data point per hour), laboratory test results, procedures, medications, caregiver notes, imaging reports, and mortality (including post-hospital discharge).MIMIC supports a diverse range of analytic studies spanning epidemiology, clinical decision-rule improvement, and electronic tool development. It is notable for three factors: it is freely available to researchers worldwide; it encompasses a diverse and very large population of ICU patients; and it contains highly granular data, including vital signs, laboratory results, and medications.

MIMIC-II documents a diverse and large population of intensive care unit patient stays and contains comprehensive and detailed clinical data, including physiological waveforms and minute-by-minute trends for a subset of records. It establishes a unique public-access resource for critical care research, supporting a diverse range of analytic studies spanning epidemiology, clinical decision-rule development, and electronic tool development. The MIMIC-II Clinical Database, although de-identified, still contains detailed information regarding the clinical care of patients, and must be treated with appropriate care and respect.

The Medical Information Mart for Intensive Care (MIMIC)-IV database is comprised of deidentified electronic health records for patients admitted to the Beth Israel Deaconess Medical Center. Access to MIMIC-IV is limited to credentialed users. Here, we have provided an openly-available demo of MIMIC-IV containing a subset of 100 patients. The dataset includes similar content to MIMIC-IV, but excludes free-text clinical notes. The demo may be useful for running workshops and for assessing whether the MIMIC-IV is appropriate for a study before making an access request.

The Clinical Trials Registry and Results Database compiles information on publicly and privately supported clinical trial studies on a wide range of diseases and conditions. Its main goal is to provide an easy access to both privately and publicly funded clinical trials information for patients, their family members, healthcare professionals, researchers, and the public.

Overview: The goal of the project was to develop a unique database linking chronic disease clinical data from an electronic medical record (EMR) of a large academic healthcare system to multi-payer claims data. The longitudinal relational database can be used to study clinical effectiveness of many diagnostic and treatment interventions. The population of patients used consisted of those patients who were attributed to the University of Michigan Health System (UMHS) as continuing care patients, who are also in adjudicated and validated chronic disease registries. Data Access: These data are not available from ICPSR. The data are restricted to use by the principal investigator and cannot be shared.

The National Database for Clinical Trials Related to Mental Illness (NDCT) is an extensible informatics platform for relevant data at all levels of biological and behavioral organization (molecules, genes, neural tissue, behavioral, social and environmental interactions) and for all data types (text, numeric, image, time series, etc.) related to clinical trials funded by the National Institute of Mental Health. Sharing data, associated tools, methodologies and results, rather than just summaries or interpretations, accelerates research progress. Community-wide sharing requires common data definitions and standards, as well as comprehensive and coherent informatics approaches for the sharing of de-identified human subject research data. Built on the National Database for Autism Research (NDAR) informatics platform, NDCT provides a comprehensive data sharing platform for NIMH grantees supporting clinical trials.

Health Canada's Clinical Trials Database is a listing of information about phase I, II and III clinical trials in patients. The database is managed by Health Canada and provides a source of information about Canadian clinical trials involving human pharmaceutical and biological drugs. Additional information on Health Canada’s CTD is available at: https://www.canada.ca/en/health-canada/services/drugs-health-products/drug-products/health-canada-clinical-trials-database/frequently-asked-questions.html

This data package contains datasets on clinical trials conducted in the United States. Diseases include cervical cancer, diabetes, acute respiratory infection as well as stress. This data package also includes clinical trials registry and results database.

Abstract The Medical Information Mart for Intensive Care (MIMIC)-IV database is comprised of deidentified electronic health records for patients admitted to the Beth Israel Deaconess Medical Center. Access to MIMIC-IV is limited to credentialed users. Here, we have provided an openly-available demo of MIMIC-IV containing a subset of 100 patients. The dataset includes similar content to MIMIC-IV, but excludes free-text clinical notes. The demo may be useful for running workshops and for assessing whether the MIMIC-IV is appropriate for a study before making an access request.

Background The increasing adoption of digital electronic health records has led to the existence of large datasets that could be used to carry out important research across many areas of medicine. Research progress has been limited, however, due to limitations in the way that the datasets are curated and made available for research. The MIMIC datasets allow credentialed researchers around the world unprecedented access to real world clinical data, helping to reduce the barriers to conducting important medical research. The public availability of the data allows studies to be reproduced and collaboratively improved in ways that would not otherwise be possible.

Methods First, the set of individuals to include in the demo was chosen. Each person in MIMIC-IV is assigned a unique subject_id. As the subject_id is randomly generated, ordering by subject_id results in a random subset of individuals. We only considered individuals with an anchor_year_group value of 2011 - 2013 or 2014 - 2016 to ensure overlap with MIMIC-CXR v2.0.0. The first 100 subject_id who satisfied the anchor_year_group criteria were selected for the demo dataset.

All tables from MIMIC-IV were included in the demo dataset. Tables containing patient information, such as emar or labevents, were filtered using the list of selected subject_id. Tables which do not contain patient level information were included in their entirety (e.g. d_items or d_labitems). Note that all tables which do not contain patient level information are prefixed with the characters 'd_'.

Deidentification was performed following the same approach as the MIMIC-IV database. Protected health information (PHI) as listed in the HIPAA Safe Harbor provision was removed. Patient identifiers were replaced using a random cipher, resulting in deidentified integer identifiers for patients, hospitalizations, and ICU stays. Stringent rules were applied to structured columns based on the data type. Dates were shifted consistently using a random integer removing seasonality, day of the week, and year information. Text fields were filtered by manually curated allow and block lists, as well as context-specific regular expressions. For example, columns containing dose values were filtered to only contain numeric values. If necessary, a free-text deidentification algorithm was applied to remove PHI from free-text. Results of this algorithm were manually reviewed and verified to remove identified PHI.

Data Description MIMIC-IV is a relational database consisting of 26 tables. For a detailed description of the database structure, see the MIMIC-IV Clinical Database page [1] or the MIMIC-IV online documentation [2]. The demo shares an identical schema and structure to the equivalent version of MIMIC-IV.

Data files are distributed in comma separated value (CSV) format following the RFC 4180 standard [3]. The dataset is also made available on Google BigQuery. Instructions to accessing the dataset on BigQuery are provided on the online MIMIC-IV documentation, under the cloud page [2].

An additional file is included: demo_subject_id.csv. This is a list of the subject_id used to filter MIMIC-IV to the demo subset.

Usage Notes The MIMIC-IV demo provides researchers with the opportunity to better understand MIMIC-IV data.

CSV files can be opened natively using any text editor or spreadsheet program. However, as some tables are large it may be preferable to navigate the data via a relational database. We suggest either working with the data in Google BigQuery (see the "Files" section for access details) or creating an SQLite database using the CSV files. SQLite is a lightweight database format which stores all constituent tables in a single file, and SQLite databases interoperate well with a number software tools.

Code is made available for use with MIMIC-IV on the MIMIC-IV code repository [4]. Code provided includes derivation of clinical concepts, tutorials, and reproducible analyses.

Release Notes Release notes for the demo follow the release notes for the MIMIC-IV database.

Ethics This project was approved by the Institutional Review Boards of Beth Israel Deaconess Medical Center (Boston, MA) and the Massachusetts Institute of Technology (Cambridge, MA). Requirement for individual patient consent was waived because the pr...

This controlled data release focuses on CP-NET's initial Clinical Database which solely focused on children and youth, aged 2-18, with a confirmed diagnosis of hemiplegic cerebral palsy (CP). The Hemi-NET Clinical Database has data on 320 children and youth from across Ontario. The released data is organized around the following platforms: (1) Clinical Risk Factor Platform: clinically relevant neonatal and obstetric risk factors from obstetrical and neonatal health charts, (2) Genomics Platform: saliva samples acquired from the index child and both biological parent(s), (3) Neuroimaging Platform: standardized coding of clinically acquired neuroimaging, (4) Neurodevelopmental Platform: standardized assessments of gross motor, fine motor, language, cognitive, behavioural function, and self-reported quality of life.

Digitization of healthcare data along with algorithmic breakthroughts in AI will have a major impact on healthcare delivery in coming years. Its intresting to see application of AI to assist clinicians during patient treatment in a privacy preserving way. While scientific knowledge can help guide interventions, there remains a key need to quickly cut through the space of decision policies to find effective strategies to support patients during the care process.

Offline Reinforcement learning (also referred to as safe or batch reinforcement learning) is a promising sub-field of RL which provides us with a mechanism for solving real world sequential decision making problems where access to simulator is not available. Here we assume that learn a policy from fixed dataset of trajectories with further interaction with the environment(agent doesn't receive reward or punishment signal from the environment). It has shown that such an approach can leverage vast amount of existing logged data (in the form of previous interactions with the environment) and can outperform supervised learning approaches or heuristic based policies for solving real world - decision making problems. Offline RL algorithms when trained on sufficiently large and diverse offline datasets can produce close to optimal policies(ability to generalize beyond training data).

As Part of my PhD, research, I investigated the problem of developing a Clinical Decision Support System for Sepsis Management using Offline Deep Reinforcement Learning.

MIMIC-III ('Medical Information Mart for Intensive Care') is a large open-access anonymized single-center database which consists of comprehensive clinical data of 61,532 critical care admissions from 2001–2012 collected at a Boston teaching hospital. Dataset consists of 47 features (including demographics, vitals, and lab test results) on a cohort of sepsis patients who meet the sepsis-3 definition criteria.

we try to answer the following question:

Given a particular patient’s characteristics and physiological information at each time step as input, can our DeepRL approach, learn an optimal treatment policy that can prescribe the right intervention(e.g use of ventilator) to the patient each stage of the treatment process, in order to improve the final outcome(e.g patient mortality)?

we can use popular state-of-the-art algorithms such as Deep Q Learning(DQN), Double Deep Q Learning (DDQN), DDQN combined with BNC, Mixed Monte Carlo(MMC) and Persistent Advantage Learning (PAL). Using these methods we can train an RL policy to recommend optimum treatment path for a given patient.

Data acquisition, standard pre-processing and modelling details can be found here in Github repo: https://github.com/asjad99/MIMIC_RL_COACH

ntphuc149/MIMIC-III-Clinical-Database dataset hosted on Hugging Face and contributed by the HF Datasets community

Abstract (en): Overview: The goal of the project was to develop a unique database linking chronic disease clinical data from an electronic medical record (EMR) of a large academic healthcare system to multi-payer claims data. The longitudinal relational database can be used to study clinical effectiveness of many diagnostic and treatment interventions. The population of patients used consisted of those patients who were attributed to the University of Michigan Health System (UMHS) as continuing care patients, who are also in adjudicated and validated chronic disease registries. Data Access: These data are not available from ICPSR. The data are restricted to use by the principal investigator and cannot be shared. This project concerned AHRQ priority populations, including low income and uninsured patients, older adult patients, and patients with diabetes. The population of patients used consisted of those patients who were attributed to the UMHS as continuing care patients, who were also in adjudicated and validated chronic disease registries. These registries organize EMR diagnostic and management information for patients with physician adjudicated chronic disease diagnoses. Complete claims are available for most of the relevant patient population. Funding insitution(s): United States Department of Health and Human Services. Agency for Healthcare Research and Quality (R24 HS019459).

Dataset II and dictionary II. Excel spreadsheet and Data Dictionary that contain information on tissue samples of suspected Melanoma cases including specimens such as presence of tumor, tissue source and other relevant tissue information relevant to genomic analysis.

Dataset III and dictionary III. Excel spreadsheet and Data Dictionary that contain information on tissue samples of suspected Melanoma cases including specimens such as presence of tumor, tissue source and other relevant tissue information relevant to genomic analysis.

Comprehensive database of 840,000+ clinical trials aggregated from 20+ registries worldwide including ClinicalTrials.gov, Chinese Clinical Trial Registry, EU Clinical Trials Register, Japanese Registry, and more.

Discover the booming medical database software market, projected to reach $45 billion by 2033, with a CAGR of 12%. This analysis explores key drivers, trends, restraints, and regional insights for EHR and HIM systems, featuring leading companies like NextGen and Epic. Learn more about this rapidly evolving sector.

A virtual database currently indexing clinical trials databases including EU Clinical Trials Register and Clinicaltrials.gov.

A database of Alzheimer's disease and dementia clinical trials currently in progress at centers throughout the U.S.