The child mortality rate in the United States, for children under the age of five, was 462.9 deaths per thousand births in 1800. This means that for every thousand babies born in 1800, over 46 percent did not make it to their fifth birthday. Over the course of the next 220 years, this number has dropped drastically, and the rate has dropped to its lowest point ever in 2020 where it is just seven deaths per thousand births. Although the child mortality rate has decreased greatly over this 220 year period, there were two occasions where it increased; in the 1870s, as a result of the fourth cholera pandemic, smallpox outbreaks, and yellow fever, and in the late 1910s, due to the Spanish Flu pandemic.

The child mortality rate in the United Kingdom, for children under the age of five, was 329 deaths per thousand births in 1800. This means that approximately one in every three children born in 1800 did not make it to their fifth birthday. Over the course of the next 220 years, this number has dropped drastically, particularly in the first half of the twentieth century, and the rate has dropped to its lowest point ever in 2020 where it is just four deaths per thousand births.

Over the past 160 years, life expectancy (from birth) in the United States has risen from 39.4 years in 1860, to 78.9 years in 2020. One of the major reasons for the overall increase of life expectancy in the last two centuries is the fact that the infant and child mortality rates have decreased by so much during this time. Medical advancements, fewer wars and improved living standards also mean that people are living longer than they did in previous centuries.

Despite this overall increase, the life expectancy dropped three times since 1860; from 1865 to 1870 during the American Civil War, from 1915 to 1920 during the First World War and following Spanish Flu epidemic, and it has dropped again between 2015 and now. The reason for the most recent drop in life expectancy is not a result of any specific event, but has been attributed to negative societal trends, such as unbalanced diets and sedentary lifestyles, high medical costs, and increasing rates of suicide and drug use.