In 2022, the highest cancer rate for men and women among European countries was in Denmark with 728.5 cancer cases per 100,000 population. Ireland and the Netherlands followed, with 641.6 and 641.4 people diagnosed with cancer per 100,000 population, respectively.
Lung cancer Lung cancer is the deadliest type of cancer worldwide, and in Europe, Germany was the country with the highest number of lung cancer deaths in 2022, with 47.7 thousand deaths. However, when looking at the incidence rate of lung cancer, Hungary had the highest for both males and females, with 138.4 and 72.3 cases per 100,000 population, respectively.
Breast cancer Breast cancer is the most common type of cancer among women with an incidence rate of 83.3 cases per 100,000 population in Europe in 2022. Cyprus was the country with the highest incidence of breast cancer, followed by Belgium and France. The mortality rate due to breast cancer was 34.8 deaths per 100,000 population across Europe, and Cyprus was again the country with the highest figure.

In 2022, the incidence of lung cancer among men in Europe was highest in Hungary at ***** per 100,000, while Sweden had the lowest incidence. The incidence of lung cancer recorded among women in Denmark was over ** per 100,000 population. Across the European Union overall, the rate of lung cancer diagnoses was **** per 100,000 among men and **** per 100,000 among women. Smoking and lung cancer risk The connection between smoking and the increased risk of health problems is well established. As of 2021, Hungary had one of the highest daily smoking rates in Europe, with over a quarter of adults smoking daily in the Central European country. The only other countries with a higher share of smoking adults were Bulgaria and Turkey. A positive development though, is the share of adults smoking every day has decreased in almost every European country since 2011. The rise of vaping Originally marketed as a device to help smokers quit, e-cigarettes or vapes have seen increased popularity among people who never smoked cigarettes, especially young people. The use of vapes among young people was reported to be highest in Estonia, Czechia, and Ireland. The dangers of vaping have not been examined over the long term. In the EU there have been attempts to make ‘vapes’ less accessible and appealing for young people, which would include such things as banning flavors and stopping the sale of disposable e-cigarettes.

In 2022, the mortality rate of breast cancer in women in Europe was **** per 100,000 women. Cyprus had the highest mortality rate at **** per 100,000, followed by Slovakia with **** per 100,000 women. Conversely, Spain had the lowest mortality rate at **** per 100,000. This statistic depicts the mortality rate of breast cancer in Europe in 2022 in women population, by country.

In 2022, the mortality rate of prostate cancer in Europe was **** per 100,000. Estonia had the highest mortality rate at **** per 100,000, followed by Latvia with **** per 100,000 men. Conversely, Italy had the lowest mortality rate at **** per 100,000. This statistic depicts the mortality rate of prostate cancer Europe in 2022, by country.

ObjectiveWe investigated whether there are differences in cancer incidence by geographical area of origin in North-eastern Italy.MethodsWe selected all incident cases recorded in the Veneto Tumour Registry in the period 2015-2019. Subjects were classified, based on the country of birth, in six geographical areas of origin (Italy, Highly Developed Countries-HDC, Eastern Europe, Asia, Africa, South-central America). Age-standardized incidence rates and incidence rate ratio (IRR) were calculated, for all cancer sites and for colorectal, liver, breast and cervical cancer separately.ResultsWe recorded 159,486 all-site cancer cases; 5.2% cases occurred in subjects born outside Italy, the majority from High Migratory Pressure Countries (HMPC) (74.3%). Incidence rates were significantly lower in subjects born in HMPC in both sexes. Immigrants, in particular born in Asia and Africa, showed lower rates of all site cancer incidence. The lowest IRR for colorectal cancer was observed in males from South-Central America (IRR 0.19, 95%CI 0.09-0.44) and in females from Asia (IRR 0.32, 95%CI 0.18-0.70). The IRR of breast cancer appeared significantly lower than Italian natives in all female populations, except for those coming from HDC. Females from Eastern Europe showed a higher IRR for cervical cancer (IRR 2.02, 95%CI 1.57-2.61).ConclusionCancer incidence was found lower in subjects born outside Italy, with differences in incidence patterns depending on geographical area of origin and the cancer type in question. Further studies, focused on the country of birth of the immigrant population, would help to identify specific risk factors influencing cancer incidence.

In 2022, the mortality rate of pancreatic cancer in Europe was, among men, **** per 100,000, while among women it stood at *** per 100,000. For men, Romania had the highest mortality rate at **** per 100,000, while Poland had the lowest at *** per 100,000. For women, Romania also had the highest mortality rate at **** per 100,000, while Malta had the lowest at * per 100,000. This statistic depicts the mortality rate of live cancer in Europe in 2022, by country and gender.

ObjectiveWe investigated whether there are differences in cancer incidence by geographical area of origin in North-eastern Italy.MethodsWe selected all incident cases recorded in the Veneto Tumour Registry in the period 2015-2019. Subjects were classified, based on the country of birth, in six geographical areas of origin (Italy, Highly Developed Countries-HDC, Eastern Europe, Asia, Africa, South-central America). Age-standardized incidence rates and incidence rate ratio (IRR) were calculated, for all cancer sites and for colorectal, liver, breast and cervical cancer separately.ResultsWe recorded 159,486 all-site cancer cases; 5.2% cases occurred in subjects born outside Italy, the majority from High Migratory Pressure Countries (HMPC) (74.3%). Incidence rates were significantly lower in subjects born in HMPC in both sexes. Immigrants, in particular born in Asia and Africa, showed lower rates of all site cancer incidence. The lowest IRR for colorectal cancer was observed in males from South-Central America (IRR 0.19, 95%CI 0.09-0.44) and in females from Asia (IRR 0.32, 95%CI 0.18-0.70). The IRR of breast cancer appeared significantly lower than Italian natives in all female populations, except for those coming from HDC. Females from Eastern Europe showed a higher IRR for cervical cancer (IRR 2.02, 95%CI 1.57-2.61).ConclusionCancer incidence was found lower in subjects born outside Italy, with differences in incidence patterns depending on geographical area of origin and the cancer type in question. Further studies, focused on the country of birth of the immigrant population, would help to identify specific risk factors influencing cancer incidence.

Users can access data about cancer statistics, specifically incidence and mortality worldwide for the 27 major types of cancer. Background Cancer Mondial is maintained by the Section of Cancer Information (CIN) of International Agency for Research on Cancer by the World Health Organization. Users can access CIN databases including GLOBOCAN, CI5(Cancer Incidence in Five Continents), WHO, ACCIS(Automated Childhood Cancer Information System), ECO (European Cancer Observatory), NORDCAN and Survcan. User functionality Users can access a variety of databases. CIN Databases: GLOBOCAN provides acces s to the most recent estimates (for 2008) of the incidence of 27 major cancers and mortality from 27 major cancers worldwide. CI5 (Cancer Incidence in Five Continents) provides access to detailed information on the incidence of cancer recorded by cancer registries (regional or national) worldwide. WHO presents long time series of selected cancer mortality recorded in selected countries of the world. Collaborative projects: ACCIS (Automated Childhood Cancer Information System) provides access to data on cancer incidence and survival of children collected by European cancer registries. ECO (European Cancer Observatory) provides access to the estimates (for 2008) of the incidence of, and mortality f rom 25 major cancers in the countries of the European Union (EU-27). NORDCAN presents up-to-date long time series of cancer incidence, mortality, prevalence and survival from 40 cancers recorded by the Nordic countries. SurvCan presents cancer survival data from cancer registries in low and middle income regions of the world. Data Notes Data is available in different formats depending on which type of data is accessed. Some data is available in table, PDF, and html formats. Detailed information about the data is available.

In 2022, the incidence rate of colorectal cancer in the EU was, among men, **** per 100,000, while among women it stood at **** per 100,000. For men, Hungary had the highest incidence rate at ***** per 100,000, while Austria had the lowest at **** per 100,000. For women, Denmark had the highest incidence rate at **** per 100,000, while Austria had the lowest at **** per 100,000. This statistic depicts the incidence rate of colorectal cancer in the EU in 2022, by country and gender (per 100,000 population).

In 2022, the mortality rate of lung cancer in the European was **** per 100,000 men and **** per 100,000 women. Among men the mortality rate was highest in Hungary and lowest in Sweden being *** and **** per 100,000 respectively. Hungary was also the country with the highest lung cancer mortality rate in women with **** per 100,000 women. The lowest was in Lithuania with **** per 100,000 women. In most EU countries, there was a marked difference between the mortality of lung cancer in men and women.

In 2022, the highest breast cancer incidence in women in Europe was estimated in Luxembourg with approximately 190 per 100,000 population. Belgium and Cyprus followed closely. The average breast cancer incidence across EU-27 was 147.6 per 100,00 population, in 2022. Cancer incidence in Europe In 2022, Denmark was the European country with the highest cancer incidence, with 728.5 cases per 100,000 population, followed by Ireland and Netherlands, with both around 641 cases per 100,000 people. Overall, the age-standardized incidence rate of cancer in all sites, excluding non-melanoma skin cancers, was 568.7 per 100,000 population in the whole of EU, with the most prevalent type of cancer being prostate cancer, followed by breast and colorectal cancer. Deaths from breast cancer In the same year, breast cancer also had the highest mortality rate among all types of cancers in women, standing at 34.1 deaths per 100,000 females. Cyprus had the highest mortality rate from breast cancer in all of EU with 45.1 deaths per 100,000 women. Meanwhile, the highest number of deaths due to breast cancer in the given year was reported in Germany, where approximately 20.6 thousand women lost their lives to breast cancer.

According to cognitive market research, the global lung cancer therapeutics market size was valued at USD xx billion in 2024 and is expected to reach USD xx billion at a CAGR of xx% during the forecast period.

The lungs are two spongy organs in the chest that control breathing. Lung cancer is the leading cause of cancer deaths worldwide. People who smoke have the greatest risk of lung cancer. The risk of lung cancer increases with the length of time and number of cigarettes smoked.
The market is anticipated to expand over the forecast period as a result of the high disease incidence rate and the rising number of drug approvals
The chemotherapy segment dominated the lung cancer therapeutics market revenue in 2024 and is projected to be the fastest-growing segment during the forecast period. Chemotherapy goes throughout the entire body for tumor cells, whereas radiation and surgery target a single region of the body.
Moreover, this market dominance is a result of consumers' growing propensity to buy pharmaceuticals from hospital pharmacies due to the availability of a large variety of medicines.
There are numerous products involved in the procedure of lung cancer therapeutics, which makes it costlier. Furthermore, the high maintenance cost of the instruments adds up to the total cost.

Market Dynamics of the Lung Cancer Therapeutics

Key Drivers of the Lung Cancer Therapeutics

The strong prevalence of lung cancer is notably driving market growth.

One of the most prevalent forms of cancer is lung cancer. Several reasons, including the aging population and lifestyle changes, have contributed to a notable increase in the number of new instances of cancer, particularly lung cancer, in recent years. In the United States, 6.2% of the population is at risk of developing lung cancer. Lung cancer still has a very high death rate, even with recent declines in the rate, which presents a market potential for suppliers. The market is anticipated to expand over the forecast period as a result of the high disease incidence rate and the rising number of drug approvals. • For instance, according to the 2022 report by the American Lung Association, while the disease remains the leading cause of cancer deaths among women and men, the survival rate over the past five years has increased from 21% nationally to 25% yet remains significantly lower among communities of color at 20%. Hence, the increasing prevalence of cancer and the need for effective treatment is likely to contribute to market growth. (Source:https://www.lung.org/research/state-of-lung-cancer/key-findings)

Rising pollution due to rapid industrialization increases the incidences of lung cancer

Air pollution (outdoor and indoor particulate matter and ozone) is closely linked to the rising prevalence of heart disease and strokes, lung cancer, lower respiratory infections, diabetes, and chronic obstructive pulmonary disease (COPD). The Global Burden of Disease Study Report (2019) ranks air pollution as the third leading cause of death worldwide. Globally, air pollution is responsible for 6.82 million deaths annually, of which 33% are caused by interior pollution and 66% by outdoor pollution. • For instance, According to the conference organized by the Associated Chambers of Commerce and Industry of India (ASSOCHAM), ‘Lung Cancer- Awareness, Prevention, Challenges & Treatment’, air pollution is the leading cause of the rise of lung cancer in the country. Around 63 out of the 100 most polluted places on earth belong to India. (Source:https://www.assocham.org/press-release-page.php?release-name=air-pollution-is-the-major-cause-of-lung-cancer-in-india-say-health-experts)

Restraints of the Lung Cancer Therapeutics

Regional disparities in treatment will hamper the market for lung cancer therapeutics

Lung cancer is the most prevalent cause of cancer-related deaths globally, and its impact is particularly felt in lower- and middle-income countries (LMICs), where access to early and effective diagnosis and treatment is often restricted. WHO data show that whereas 90% of cancer patients in high-income countries have access to therapy, only roughly 30% of cancer patients in low-income countries do. There are numerous products involved in the procedure of lung cancer therapeutics, which makes it costlier. Furthermore, the high maintenance cost of the i...

Breast cancer is a worldwide threat to female health with patient outcomes varying widely. The exact correlation between global outcomes of breast cancer and the national socioeconomic status is still undetermined. Mortality-to-incidence ratio (MIR) of breast cancer was calculated with the contemporary age standardized incidence and mortality rates for countries with data available at GLOBOCAN 2012 database. The MIR matched national human development indexes (HDIs) and health system attainments were respectively obtained from Human Development Report and World Health Report. Correlation analysis, regression analysis, and Tukey-Kramer post hoc test were used to explore the effects of HDI and health system attainment on breast cancer MIR. Our results demonstrated that breast cancer MIR was inversely correlated with national HDI (r = -.950; P < .001) and health system attainment (r = -.898; P < .001). Countries with very high HDI had significantly lower MIRs than those with high, medium and low HDI (P < .001). Liner regression model by ordinary least squares also indicated negative effects of both HDI (adjusted R2 = .903, standardize β = -.699, P < .001) and health system attainment (adjusted R2 =. 805, standardized β = -.009; P < .001), with greater effects in developing countries identified by quantile regression analysis. It is noteworthy that significant health care disparities exist among countries in accordance with the discrepancy of HDI. Policies should be made in less developed countries, which are more likely to obtain worse outcomes in female breast cancer, that in order to improve their comprehensive economic strength and optimize their health system performance.

In 2022, the mortality rate of colorectal cancer in Europe was, among men, **** per 100,000, while among women it stood at **** per 100,000. For men, Croatia had the highest mortality rate at **** per 100,000, while Luxembourg had the lowest at **** per 100,000. For women, Croatia also had the highest mortality rate at **** per 100,000, while Austria had the lowest at **** per 100,000. This statistic depicts the mortality rate of colorectal cancer in Europe in 2022, by country and gender.

Goal 3Ensure healthy lives and promote well-being for all at all agesTarget 3.1: By 2030, reduce the global maternal mortality ratio to less than 70 per 100,000 live birthsIndicator 3.1.1: Maternal mortality ratioSH_STA_MORT: Maternal mortality ratioIndicator 3.1.2: Proportion of births attended by skilled health personnelSH_STA_BRTC: Proportion of births attended by skilled health personnel (%)Target 3.2: By 2030, end preventable deaths of newborns and children under 5 years of age, with all countries aiming to reduce neonatal mortality to at least as low as 12 per 1,000 live births and under-5 mortality to at least as low as 25 per 1,000 live birthsIndicator 3.2.1: Under-5 mortality rateSH_DYN_IMRTN: Infant deaths (number)SH_DYN_MORT: Under-five mortality rate, by sex (deaths per 1,000 live births)SH_DYN_IMRT: Infant mortality rate (deaths per 1,000 live births)SH_DYN_MORTN: Under-five deaths (number)Indicator 3.2.2: Neonatal mortality rateSH_DYN_NMRTN: Neonatal deaths (number)SH_DYN_NMRT: Neonatal mortality rate (deaths per 1,000 live births)Target 3.3: By 2030, end the epidemics of AIDS, tuberculosis, malaria and neglected tropical diseases and combat hepatitis, water-borne diseases and other communicable diseasesIndicator 3.3.1: Number of new HIV infections per 1,000 uninfected population, by sex, age and key populationsSH_HIV_INCD: Number of new HIV infections per 1,000 uninfected population, by sex and age (per 1,000 uninfected population)Indicator 3.3.2: Tuberculosis incidence per 100,000 populationSH_TBS_INCD: Tuberculosis incidence (per 100,000 population)Indicator 3.3.3: Malaria incidence per 1,000 populationSH_STA_MALR: Malaria incidence per 1,000 population at risk (per 1,000 population)Indicator 3.3.4: Hepatitis B incidence per 100,000 populationSH_HAP_HBSAG: Prevalence of hepatitis B surface antigen (HBsAg) (%)Indicator 3.3.5: Number of people requiring interventions against neglected tropical diseasesSH_TRP_INTVN: Number of people requiring interventions against neglected tropical diseases (number)Target 3.4: By 2030, reduce by one third premature mortality from non-communicable diseases through prevention and treatment and promote mental health and well-beingIndicator 3.4.1: Mortality rate attributed to cardiovascular disease, cancer, diabetes or chronic respiratory diseaseSH_DTH_NCOM: Mortality rate attributed to cardiovascular disease, cancer, diabetes or chronic respiratory disease (probability)SH_DTH_NCD: Number of deaths attributed to non-communicable diseases, by type of disease and sex (number)Indicator 3.4.2: Suicide mortality rateSH_STA_SCIDE: Suicide mortality rate, by sex (deaths per 100,000 population)SH_STA_SCIDEN: Number of deaths attributed to suicide, by sex (number)Target 3.5: Strengthen the prevention and treatment of substance abuse, including narcotic drug abuse and harmful use of alcoholIndicator 3.5.1: Coverage of treatment interventions (pharmacological, psychosocial and rehabilitation and aftercare services) for substance use disordersSH_SUD_ALCOL: Alcohol use disorders, 12-month prevalence (%)SH_SUD_TREAT: Coverage of treatment interventions (pharmacological, psychosocial and rehabilitation and aftercare services) for substance use disorders (%)Indicator 3.5.2: Alcohol per capita consumption (aged 15 years and older) within a calendar year in litres of pure alcoholSH_ALC_CONSPT: Alcohol consumption per capita (aged 15 years and older) within a calendar year (litres of pure alcohol)Target 3.6: By 2020, halve the number of global deaths and injuries from road traffic accidentsIndicator 3.6.1: Death rate due to road traffic injuriesSH_STA_TRAF: Death rate due to road traffic injuries, by sex (per 100,000 population)Target 3.7: By 2030, ensure universal access to sexual and reproductive health-care services, including for family planning, information and education, and the integration of reproductive health into national strategies and programmesIndicator 3.7.1: Proportion of women of reproductive age (aged 15–49 years) who have their need for family planning satisfied with modern methodsSH_FPL_MTMM: Proportion of women of reproductive age (aged 15-49 years) who have their need for family planning satisfied with modern methods (% of women aged 15-49 years)Indicator 3.7.2: Adolescent birth rate (aged 10–14 years; aged 15–19 years) per 1,000 women in that age groupSP_DYN_ADKL: Adolescent birth rate (per 1,000 women aged 15-19 years)Target 3.8: Achieve universal health coverage, including financial risk protection, access to quality essential health-care services and access to safe, effective, quality and affordable essential medicines and vaccines for allIndicator 3.8.1: Coverage of essential health servicesSH_ACS_UNHC: Universal health coverage (UHC) service coverage indexIndicator 3.8.2: Proportion of population with large household expenditures on health as a share of total household expenditure or incomeSH_XPD_EARN25: Proportion of population with large household expenditures on health (greater than 25%) as a share of total household expenditure or income (%)SH_XPD_EARN10: Proportion of population with large household expenditures on health (greater than 10%) as a share of total household expenditure or income (%)Target 3.9: By 2030, substantially reduce the number of deaths and illnesses from hazardous chemicals and air, water and soil pollution and contaminationIndicator 3.9.1: Mortality rate attributed to household and ambient air pollutionSH_HAP_ASMORT: Age-standardized mortality rate attributed to household air pollution (deaths per 100,000 population)SH_STA_AIRP: Crude death rate attributed to household and ambient air pollution (deaths per 100,000 population)SH_STA_ASAIRP: Age-standardized mortality rate attributed to household and ambient air pollution (deaths per 100,000 population)SH_AAP_MORT: Crude death rate attributed to ambient air pollution (deaths per 100,000 population)SH_AAP_ASMORT: Age-standardized mortality rate attributed to ambient air pollution (deaths per 100,000 population)SH_HAP_MORT: Crude death rate attributed to household air pollution (deaths per 100,000 population)Indicator 3.9.2: Mortality rate attributed to unsafe water, unsafe sanitation and lack of hygiene (exposure to unsafe Water, Sanitation and Hygiene for All (WASH) services)SH_STA_WASH: Mortality rate attributed to unsafe water, unsafe sanitation and lack of hygiene (deaths per 100,000 population)Indicator 3.9.3: Mortality rate attributed to unintentional poisoningSH_STA_POISN: Mortality rate attributed to unintentional poisonings, by sex (deaths per 100,000 population)Target 3.a: Strengthen the implementation of the World Health Organization Framework Convention on Tobacco Control in all countries, as appropriateIndicator 3.a.1: Age-standardized prevalence of current tobacco use among persons aged 15 years and olderSH_PRV_SMOK: Age-standardized prevalence of current tobacco use among persons aged 15 years and older, by sex (%)Target 3.b: Support the research and development of vaccines and medicines for the communicable and non-communicable diseases that primarily affect developing countries, provide access to affordable essential medicines and vaccines, in accordance with the Doha Declaration on the TRIPS Agreement and Public Health, which affirms the right of developing countries to use to the full the provisions in the Agreement on Trade-Related Aspects of Intellectual Property Rights regarding flexibilities to protect public health, and, in particular, provide access to medicines for allIndicator 3.b.1: Proportion of the target population covered by all vaccines included in their national programmeSH_ACS_DTP3: Proportion of the target population with access to 3 doses of diphtheria-tetanus-pertussis (DTP3) (%)SH_ACS_MCV2: Proportion of the target population with access to measles-containing-vaccine second-dose (MCV2) (%)SH_ACS_PCV3: Proportion of the target population with access to pneumococcal conjugate 3rd dose (PCV3) (%)SH_ACS_HPV: Proportion of the target population with access to affordable medicines and vaccines on a sustainable basis, human papillomavirus (HPV) (%)Indicator 3.b.2: Total net official development assistance to medical research and basic health sectorsDC_TOF_HLTHNT: Total official development assistance to medical research and basic heath sectors, net disbursement, by recipient countries (millions of constant 2018 United States dollars)DC_TOF_HLTHL: Total official development assistance to medical research and basic heath sectors, gross disbursement, by recipient countries (millions of constant 2018 United States dollars)Indicator 3.b.3: Proportion of health facilities that have a core set of relevant essential medicines available and affordable on a sustainable basisSH_HLF_EMED: Proportion of health facilities that have a core set of relevant essential medicines available and affordable on a sustainable basis (%)Target 3.c: Substantially increase health financing and the recruitment, development, training and retention of the health workforce in developing countries, especially in least developed countries and small island developing StatesIndicator 3.c.1: Health worker density and distributionSH_MED_DEN: Health worker density, by type of occupation (per 10,000 population)SH_MED_HWRKDIS: Health worker distribution, by sex and type of occupation (%)Target 3.d: Strengthen the capacity of all countries, in particular developing countries, for early warning, risk reduction and management of national and global health risksIndicator 3.d.1: International Health Regulations (IHR) capacity and health emergency preparednessSH_IHR_CAPS: International Health Regulations (IHR) capacity, by type of IHR capacity (%)Indicator 3.d.2: Percentage of bloodstream infections due to selected antimicrobial-resistant organismsiSH_BLD_MRSA: Percentage of bloodstream infection due to methicillin-resistant Staphylococcus aureus (MRSA) among patients seeking care and whose

Relative one-year cancer survival rates in the Baltic states are lower than the European mean; in the Nordic countries they are higher than the mean. This study investigated the likelihood of General Practitioners (GPs) investigating or referring patients with a low but significant risk of cancer in these two regions, and how this was affected by GP demographics. A survey of GPs using clinical vignettes. General Practice in Denmark, Estonia, Finland, Latvia, Lithuania, Norway, and Sweden. General Practitioners. A regional comparison of GPs’ stated immediate diagnostic actions (whether or not they would perform a key diagnostic test and/or refer to a specialist) for patients with a low but significant risk of cancer (between 1.2 and 3.6%). Of the 427 GPs that completed the questionnaire, those in the Baltic states, and GPs that were more experienced, were more likely to arrange a key diagnostic test and/or refer their patient to a specialist than those in Nordic Countries or who were less experienced (p < 0.001 for both measures). Neither GP sex nor practice location within a country showed a significant association with these measures. While relative one-year cancer survival rates are lower in the Baltic states than in four Nordic countries, we found no evidence that this is due to their GPs’ reluctance to take immediate diagnostic action, as GPs in the Baltic states were more likely to investigate and/or refer at the first consultation. Research on patient and secondary care factors is needed to explain the survival differences.

BackgroundPancreatic cancer is the fourth leading cause of cancer death in Western countries, with the lowest 1-year survival rate among commonly diagnosed cancers. Reliable biomarkers for pancreatic cancer diagnosis are lacking and are urgently needed to allow for curative surgery. As microRNA (miRNA) recently emerged as candidate biomarkers for this disease, we explored in the present pilot study the differences in salivary microRNA profiles between patients with pancreatic tumors that are not eligible for surgery, precancerous lesions, inflammatory disease or cancer-free patients as a potential early diagnostic tool.MethodsWhole saliva samples from patients with pancreatic cancer (n = 7), pancreatitis (n = 4), IPMN (n = 2), or healthy controls (n = 4) were obtained during endoscopic examination. After total RNA isolation, expression of 94 candidate miRNAs was screened by q(RT)PCR using Biomark Fluidgm. Human-derived pancreatic cancer cells were xenografted in athymic mice as an experimental model of pancreatic cancer.ResultsWe identified hsa-miR-21, hsa-miR-23a, hsa-miR-23b and miR-29c as being significantly upregulated in saliva of pancreatic cancer patients compared to control, showing sensitivities of 71.4%, 85.7%, 85,7% and 57%, respectively and excellent specificity (100%). Interestingly, hsa-miR-23a and hsa-miR23b are overexpressed in the saliva of patients with pancreatic cancer precursor lesions. We found that hsa-miR-210 and let-7c are overexpressed in the saliva of patients with pancreatitis as compared to the control group, with sensitivity of 100% and 75%, and specificity of 100% and 80%, respectively. Last hsa-miR-216 was upregulated in cancer patients as compared to patients diagnosed with pancreatitis, with sensitivity of 50% and specificity of 100%. In experimental models of PDAC, salivary microRNA detection precedes systemic detection of cancer cells markers.ConclusionsOur novel findings indicate that salivary miRNA are discriminatory in pancreatic cancer patients that are not eligible for surgery. In addition, we demonstrate in experimental models that salivary miRNA detection precedes systemic detection of cancer cells markers. This study stems for the use of salivary miRNA as biomarker for the early diagnosis of patients with unresectable pancreatic cancer.

BackgroundNumerous studies have demonstrated that individuals with low calcium intake are at increased risk of developing colorectal cancer (CRC), and calcium intake exhibits significant global variation. However, a comprehensive analysis of the diet low in calcium-attributable colorectal cancer (DLCACRC) disease burden remains lacking.ObjectiveThis study aimed to investigate the global distribution and temporal trends of DLCACRC from 1990 to 2021, providing evidence to support the development of evidence-based nutrition policies. Methods: Data on deaths, disability-adjusted life years (DALYs), mortality rates, and DALYs of DLCACRC between 1990 and 2021 were extracted from the GBD database. Age-standardized data were utilized to facilitate comparisons across regions and countries. Joinpoint regression analysis was conducted to assess temporal patterns in disease burden. Estimated annual percentage changes (EAPCs) were calculated to quantify the rate of change in relevant indicators. Pearson correlation analysis was performed to determine the relationship between the disease burden and the Social Development Index (SDI).ResultIn 2021, the global age-standardized mortality rate (ASMR) of DLCACRC reached 1.06 (95% CI: 0.77–1.33), while the age-standardized disability-adjusted life year rate (ASDR) was 24.7 (95% CI: 18.17–31.02). These metrics demonstrated a downward trend, showing 31.3 and 33.3% reductions, respectively, compared to 1990. The most rapid reductions in ASMR and ASDR were occurred during 2004 and 2007, with annual percentage change (APC) of −2.12 (95% CI: −2.80–1.43) and −2.29 (95% CI: −2.92–1.65), respectively. Significant differences in disease burden were observed across countries and regions, with Southeast Asia reporting the highest ASMR and ASDR of DLCACRC. At the national level, Zambia recorded the highest ASMR and ASDR. Women experienced a higher disease burden than men, and the disease burden was positively correlated with age.ConclusionFrom 1990 to 2021, the global disease burden of DLCACRC declined, although substantial regional disparities persist. Governments in these regions should adopt targeted strategies to enhance calcium intake among residents, thereby alleviating the disease burden. Particular attention should be given to women and older adults.

BackgroundGlobally, the incidence and mortality due to esophageal cancer are increasing, particularly in low- and middle-income countries. Cancer of the esophagus is the eighth in incidence and seventh in cancer mortality in Ethiopia. A few studies have shown an increasing burden, however, little is known about the survival pattern and its determinants among esophageal cancer patients in Ethiopia. Therefore, we assessed the survival pattern and its determinants among esophageal cancer patients.MethodsWe conducted a retrospective cohort study among 349 esophageal cancer patients who were diagnosed at or referred to Tikur Anbessa Specialized Hospital, Ethiopia from January 2010 to May 2017. Using an abstraction form, nurses who were working at the oncology department extracted the data from patient charts. To estimate and compare the probability of survival among covariate categories, we performed a Kaplan–Meier survival analysis with the log-rank test. To identify the prognostic determinants of survival, we performed a multivariable Cox proportional regression analysis.ResultsThe median follow-up time was 32 months with interquartile range of 15 to 42. Overall, the median survival time after diagnosis with esophageal cancer was 4 months with one-, two- and three-year survival of 14.4, 6.3, and 2.4% respectively. In the multivariable Cox proportional hazards model, receiving chemotherapy [Adjusted Hazard Ratio (AHR)=0.36, 95%CI: 0.27–0.49], radiotherapy [AHR=0.38, 95%CI: 0.23–0.63] and surgery [AHR=0.70, 95%CI: 0.54–0.89] were statistically significant.ConclusionsIn Ethiopia, esophageal cancer patients have a very low one-, two- and three-year survival. Despite a very low overall survival, patients who received either chemotherapy, radiotherapy or surgery showed a better survival compared with those who did not receive any treatment. Hence, it is essential to improve the survival of patients with esophageal cancer through early detection and timely initiation of the available treatment options.

BackgroundDespite rising incidence and mortality rates in Africa, cancer has been given low priority in the research field and in healthcare services. Indeed, 57% of all new cancer cases around the world occur in low income countries exacerbated by lack of awareness, lack of preventive strategies, and increased life expectancies. Despite recent efforts devoted to cancer epidemiology, statistics on cancer rates in Africa are often dispersed across different registries. In this study our goal included identifying the most promising prevention and treatment approaches available in Africa. To do this, we collated and analyzed the incidence and fatality rates for the 10 most common and fatal cancers in 56 African countries grouped into 5 different regions (North, West, East, Central and South) over 16-years (2002–2018). We examined temporal and regional trends by investigating the most important risk factors associated to each cancer type. Data were analyzed by cancer type, African region, gender, measures of socioeconomic status and the availability of medical devices.ResultsWe observed that Northern and Southern Africa were most similar in their cancer incidences and fatality rates compared to other African regions. The most prevalent cancers are breast, bladder and liver cancers in Northern Africa; prostate, lung and colorectal cancers in Southern Africa; and esophageal and cervical cancer in East Africa. In Southern Africa, fatality rates from prostate cancer and cervical cancer have increased. In addition, these three cancers are less fatal in Northern and Southern Africa compared to other regions, which correlates with the Human Development Index and the availability of medical devices. With the exception of thyroid cancer, all other cancers have higher incidences in males than females.ConclusionOur results show that the African continent suffers from a shortage of medical equipment, research resources and epidemiological expertise. While recognizing that risk factors are interconnected, we focused on risk factors more or less specific to each cancer type. This helps identify specific preventive and therapeutic options in Africa. We see a need for implementing more accurate preventive strategies to tackle this disease as many cases are likely preventable. Opportunities exist for vaccination programs for cervical and liver cancer, genetic testing and use of new targeted therapies for breast and prostate cancer, and positive changes in lifestyle for lung, colorectal and bladder cancers. Such recommendations should be tailored for the different African regions depending on their disease profiles and specific needs.