NOTE: This dataset has been retired and marked as historical-only.

Only Chicago residents are included based on the home ZIP Code as provided by the medical provider. If a ZIP was missing or was not valid, it is displayed as "Unknown".

Cases with a positive molecular (PCR) or antigen test are included in this dataset. Cases are counted based on the week the test specimen was collected. For privacy reasons, until a ZIP Code reaches five cumulative cases, both the weekly and cumulative case counts will be blank. Therefore, summing the “Cases - Weekly” column is not a reliable way to determine case totals. Deaths are those that have occurred among cases based on the week of death.

For tests, each test is counted once, based on the week the test specimen was collected. Tests performed prior to 3/1/2020 are not included. Test counts include multiple tests for the same person (a change made on 10/29/2020). PCR and antigen tests reported to Chicago Department of Public Health (CDPH) through electronic lab reporting are included. Electronic lab reporting has taken time to onboard and testing availability has shifted over time, so these counts are likely an underestimate of community infection.

The “Percent Tested Positive” columns are calculated by dividing the number of positive tests by the number of total tests . Because of the data limitations for the Tests columns, such as persons being tested multiple times as a requirement for employment, these percentages may vary in either direction from the actual disease prevalence in the ZIP Code.

All data are provisional and subject to change. Information is updated as additional details are received.

To compare ZIP Codes to Chicago Community Areas, please see http://data.cmap.illinois.gov/opendata/uploads/CKAN/NONCENSUS/ADMINISTRATIVE_POLITICAL_BOUNDARIES/CCAzip.pdf. Both ZIP Codes and Community Areas are also geographic datasets on this data portal.

Data Source: Illinois National Electronic Disease Surveillance System, Cook County Medical Examiner’s Office, Illinois Vital Records, American Community Survey (2018)

View daily updates and historical trends for Illinois Coronavirus Cases Currently Hospitalized. Source: US Department of Health & Human Services. Track ec…

NOTE: This dataset has been retired and marked as historical-only. This dataset is a companion to the COVID-19 Daily Cases and Deaths dataset (https://data.cityofchicago.org/d/naz8-j4nc). The major difference in this dataset is that the case, death, and hospitalization corresponding rates per 100,000 population are not those for the single date indicated. They are rolling averages for the seven-day period ending on that date. This rolling average is used to account for fluctuations that may occur in the data, such as fewer cases being reported on weekends, and small numbers. The intent is to give a more representative view of the ongoing COVID-19 experience, less affected by what is essentially noise in the data. All rates are per 100,000 population in the indicated group, or Chicago, as a whole, for “Total” columns. Only Chicago residents are included based on the home address as provided by the medical provider. Cases with a positive molecular (PCR) or antigen test are included in this dataset. Cases are counted based on the date the test specimen was collected. Deaths among cases are aggregated by day of death. Hospitalizations are reported by date of first hospital admission. Demographic data are based on what is reported by medical providers or collected by CDPH during follow-up investigation. Denominators are from the U.S. Census Bureau American Community Survey 1-year estimate for 2018 and can be seen in the Citywide, 2018 row of the Chicago Population Counts dataset (https://data.cityofchicago.org/d/85cm-7uqa). All data are provisional and subject to change. Information is updated as additional details are received and it is, in fact, very common for recent dates to be incomplete and to be updated as time goes on. At any given time, this dataset reflects cases and deaths currently known to CDPH. Numbers in this dataset may differ from other public sources due to definitions of COVID-19-related cases and deaths, sources used, how cases and deaths are associated to a specific date, and similar factors. Data Source: Illinois National Electronic Disease Surveillance System, Cook County Medical Examiner’s Office, U.S. Census Bureau American Community Survey

View daily updates and historical trends for Illinois Coronavirus Cases (DISCONTINUED). Source: Center for Disease Control and Prevention. Track economic …

This is the place to look for important information about how to use this dataset, so please expand this box and read on!

This is the source data for some of the metrics available at https://www.chicago.gov/city/en/sites/covid-19/home/latest-data.html.

For all datasets related to COVID-19, see https://data.cityofchicago.org/browse?limitTo=datasets&sortBy=alpha&tags=covid-19.

Only Chicago residents are included based on the home ZIP Code as provided by the medical provider. If a ZIP was missing or was not valid, it is displayed as "Unknown".

Confirmed cases are counted based on the week the test specimen was collected. For privacy reasons, until a ZIP Code reaches five cumulative cases, both the weekly and cumulative case counts will be blank. Therefore, summing the “Cases - Weekly” column is not a reliable way to determine case totals. Deaths are those that have occurred among confirmed cases based on the week of death.

For tests, each individual is counted once, based on the week the test specimen was collected. Tests performed prior to 3/1/2020 are not included. Test counts do not include multiple tests for the same person or some negative tests not reported to CDPH.

The “Percent Tested Positive” columns are calculated by dividing the corresponding Cases and Tests columns. Because of the data limitations for the Tests columns, as well as strict criteria for performing COVID-19 tests, these percentages may vary in either direction from the actual disease prevalence in the ZIP Code. Of particular note, these rates do not represent population-level disease surveillance.

Population counts are from the 2010 Decennial Census.

All data are provisional and subject to change. Information is updated as additional details are received.

To compare ZIP Codes to Chicago Community Areas, please see http://data.cmap.illinois.gov/opendata/uploads/CKAN/NONCENSUS/ADMINISTRATIVE_POLITICAL_BOUNDARIES/CCAzip.pdf. Both ZIP Codes and Community Areas are also geographic datasets on this data portal.

Data Source: Illinois National Electronic Disease Surveillance System, Cook County Medical Examiner’s Office, Illinois Vital Records

United States SB: Illinois (IL): COVID-19 Impact: Large Negative Effect data was reported at 25.000 % in 11 Apr 2022. This records a decrease from the previous number of 25.500 % for 04 Apr 2022. United States SB: Illinois (IL): COVID-19 Impact: Large Negative Effect data is updated weekly, averaging 24.900 % from Nov 2021 (Median) to 11 Apr 2022, with 18 observations. The data reached an all-time high of 27.400 % in 21 Feb 2022 and a record low of 21.200 % in 27 Dec 2021. United States SB: Illinois (IL): COVID-19 Impact: Large Negative Effect data remains active status in CEIC and is reported by U.S. Census Bureau. The data is categorized under Global Database’s United States – Table US.S047: Small Business Pulse Survey: by State: Midwest Region: Weekly, Beg Monday (Discontinued).

Effective April 1, 2022, the Cook County Medical Examiner’s Office no longer takes jurisdiction over hospital, nursing home or hospice COVID-19 deaths unless there is another factor that falls within the Office’s jurisdiction. Data continues to be collected for COVID-19 deaths in Cook County on the Illinois Dept. of Public Health COVID-19 dashboard (https://dph.illinois.gov/covid19/data.html).

This contains information about deaths that occurred in Cook County that were under the Medical Examiner’s jurisdiction. Not all deaths that occur in Cook County are reported to the Medical Examiner or fall under the jurisdiction of the Medical Examiner. The Medical Examiner’s Office determines cause and manner of death for those cases that fall under its jurisdiction. Cause of death describes the reason the person died. This dataset includes information from deaths starting in August 2014 to the present, with information updated daily.

Changes: December 16, 2022: The Cook County Commissioner District field now reflects the boundaries that went into effect December 5, 2022.

September 8, 2023: The Primary Cause field is now a combination of the Primary Cause Line A, Line B, and Line C fields.

SB: IL: COVID Test/Vaccine: Proof of COVID Vaccination: Yes data was reported at 10.500 % in 11 Apr 2022. This records an increase from the previous number of 9.100 % for 04 Apr 2022. SB: IL: COVID Test/Vaccine: Proof of COVID Vaccination: Yes data is updated weekly, averaging 14.050 % from Nov 2021 (Median) to 11 Apr 2022, with 18 observations. The data reached an all-time high of 16.600 % in 10 Jan 2022 and a record low of 8.500 % in 21 Mar 2022. SB: IL: COVID Test/Vaccine: Proof of COVID Vaccination: Yes data remains active status in CEIC and is reported by U.S. Census Bureau. The data is categorized under Global Database’s United States – Table US.S047: Small Business Pulse Survey: by State: Midwest Region: Weekly, Beg Monday (Discontinued).

To gather news articles from the web that discuss the Cochrane Review, we used Altmetric Explorer from Altmetric.com and retrieved articles on August 1, 2023. We selected all articles that were written in English, published in the United States, and had a publication date prior to March 10, 2023 (according to the “Mention Date” on Altmetric.com). This date is significant as it is when Cochrane issued a statement about the "misleading interpretation" of the Cochrane Review. The collection of news articles is presented in the Altmetric_data.csv file. The dataset contains the following data that we exported from Altmetric Explorer: - Publication date of the news article - Title of the news article - Source/publication venue of the news article - URL - Country We manually checked and added the following information: - Whether the article still exists - Whether the article is accessible - Whether the article is from the original source We assigned MAXQDA IDs to the news articles. News articles were assigned the same ID when they were (a) identical or (b) in the case of Article 207, closely paraphrased, paragraph by paragraph. Inaccessible items were assigned a MAXQDA ID based on their "Mention Title". For each article from Altmetric.com, we first tried to use the Web Collector for MAXQDA to download the article from the website and imported it into MAXQDA (version 22.7.0). If an article could not be retrieved using the Web Collector, we either downloaded the .html file or in the case of Article 128, retrieved it from the NewsBank database through the University of Illinois Library. We then manually extracted direct quotations from the articles using MAXQDA. We included surrounding words and sentences, and in one case, a news agency’s commentary, around direct quotations for context where needed. The quotations (with context) are the positions in our analysis. We also identified who was quoted. We excluded quotations when we could not identify who or what was being quoted. We annotated quotations with codes representing groups (government agencies, other organizations, and research publications) and individuals (authors of the Cochrane Review, government agency representatives, journalists, and other experts such as epidemiologists). The MAXQDA_data.csv file contains excerpts from the news articles that contain the direct quotations we identified. For each excerpt, we included the following information: - MAXQDA ID of the document from which the excerpt originates; - The collection date and source of the document; - The code with which the excerpt is annotated; - The code category; - The excerpt itself.

NOTE: This dataset has been retired and marked as historical-only.

Weekly rates of COVID-19 cases, hospitalizations, and deaths among people living in Chicago by vaccination status and age.

Rates for fully vaccinated and unvaccinated begin the week ending April 3, 2021 when COVID-19 vaccines became widely available in Chicago. Rates for boosted begin the week ending October 23, 2021 after booster shots were recommended by the Centers for Disease Control and Prevention (CDC) for adults 65+ years old and adults in certain populations and high risk occupational and institutional settings who received Pfizer or Moderna for their primary series or anyone who received the Johnson & Johnson vaccine.

Chicago residency is based on home address, as reported in the Illinois Comprehensive Automated Immunization Registry Exchange (I-CARE) and Illinois National Electronic Disease Surveillance System (I-NEDSS).

Outcomes: • Cases: People with a positive molecular (PCR) or antigen COVID-19 test result from an FDA-authorized COVID-19 test that was reported into I-NEDSS. A person can become re-infected with SARS-CoV-2 over time and so may be counted more than once in this dataset. Cases are counted by week the test specimen was collected. • Hospitalizations: COVID-19 cases who are hospitalized due to a documented COVID-19 related illness or who are admitted for any reason within 14 days of a positive SARS-CoV-2 test. Hospitalizations are counted by week of hospital admission. • Deaths: COVID-19 cases who died from COVID-19-related health complications as determined by vital records or a public health investigation. Deaths are counted by week of death.

Vaccination status: • Fully vaccinated: Completion of primary series of a U.S. Food and Drug Administration (FDA)-authorized or approved COVID-19 vaccine at least 14 days prior to a positive test (with no other positive tests in the previous 45 days). • Boosted: Fully vaccinated with an additional or booster dose of any FDA-authorized or approved COVID-19 vaccine received at least 14 days prior to a positive test (with no other positive tests in the previous 45 days). • Unvaccinated: No evidence of having received a dose of an FDA-authorized or approved vaccine prior to a positive test.

CLARIFYING NOTE: Those who started but did not complete all recommended doses of an FDA-authorized or approved vaccine prior to a positive test (i.e., partially vaccinated) are excluded from this dataset.

Incidence rates for fully vaccinated but not boosted people (Vaccinated columns) are calculated as total fully vaccinated but not boosted with outcome divided by cumulative fully vaccinated but not boosted at the end of each week. Incidence rates for boosted (Boosted columns) are calculated as total boosted with outcome divided by cumulative boosted at the end of each week. Incidence rates for unvaccinated (Unvaccinated columns) are calculated as total unvaccinated with outcome divided by total population minus cumulative boosted, fully, and partially vaccinated at the end of each week. All rates are multiplied by 100,000.

Incidence rate ratios (IRRs) are calculated by dividing the weekly incidence rates among unvaccinated people by those among fully vaccinated but not boosted and boosted people.

Overall age-adjusted incidence rates and IRRs are standardized using the 2000 U.S. Census standard population.

Population totals are from U.S. Census Bureau American Community Survey 1-year estimates for 2019.

All data are provisional and subject to change. Information is updated as additional details are received and it is, in fact, very common for recent dates to be incomplete and to be updated as time goes on. This dataset reflects data known to CDPH at the time when the dataset is updated each week.

Numbers in this dataset may differ from other public sources due to when data are reported and how City of Chicago boundaries are defined.

For all datasets related to COVID-19, see https://data.cityofchic

NOTE: This dataset is historical-only as of 5/10/2023. All data currently in the dataset will remain, but new data will not be added. The recommended alternative dataset for similar data beyond that date is  https://healthdata.gov/Hospital/COVID-19-Reported-Patient-Impact-and-Hospital-Capa/anag-cw7u. (This is not a City of Chicago site. Please direct any questions or comments through the contact information on the site.)

During the COVID-19 pandemic, the Chicago Department of Public Health (CDPH) required EMS Region XI (Chicago area) hospitals to report hospital capacity and patient impact metrics related to COVID-19 to CDPH through the statewide EMResource system. This requirement has been lifted as of May 9, 2023, in alignment with the expiration of the national and statewide COVID-19 public health emergency declarations on May 11, 2023. However, all hospitals will still be required by the U.S. Department of Health and Human Services (HHS) to report COVID-19 hospital capacity and utilization metrics into the HHS Protect system through the CDC’s National Healthcare Safety Network until April 30, 2024. Facility-level data from the HHS Protect system can be found at healthdata.gov.

Until May 9, 2023, all Chicago (EMS Region XI) hospitals (n=28) were required to report bed and ventilator capacity, availability, and occupancy to the Chicago Department of Public Health (CDPH) daily. A list of reporting hospitals is included below. All data represent hospital status as of 11:59 pm for that calendar day. Counts include Chicago residents and non-residents.

ICU bed counts include both adult and pediatric ICU beds. Neonatal ICU beds are not included. Capacity refers to all staffed adult and pediatric ICU beds. Availability refers to all available/vacant adult and pediatric ICU beds. Hospitals began reporting COVID-19 confirmed and suspected (PUI) cases in ICU on 03/19/2020. Hospitals began reporting ICU surge capacity as part of total capacity on 5/18/2020.

Acute non-ICU bed counts include burn unit, emergency department, medical/surgery (ward), other, pediatrics (pediatric ward) and psychiatry beds. Burn beds include those approved by the American Burn Association or self-designated. Capacity refers to all staffed acute non-ICU beds. An additional 500 acute/non-ICU beds were added at the McCormick Place Treatment Facility on 4/15/2020. These beds are not included in the total capacity count. The McCormick Place Treatment Facility closed on 05/08/2020. Availability refers to all available/vacant acute non-ICU beds. Hospitals began reporting COVID-19 confirmed and suspected (PUI) cases in acute non-ICU beds on 04/03/2020.

Ventilator counts prior to 04/24/2020 include all full-functioning mechanical ventilators, with ventilators with bilevel positive airway pressure (BiPAP), anesthesia machines, and portable/transport ventilators counted as surge. Beginning 04/24/2020, ventilator counts include all full-functioning mechanical ventilators, BiPAP, anesthesia machines and portable/transport ventilators. Ventilators are counted regardless of ability to staff. Hospitals began reporting COVID-19 confirmed and suspected (PUI) cases on ventilators on 03/19/2020. CDPH has access to additional ventilators from the EAMC (Emergency Asset Management Center) cache. These ventilators are included in the total capacity count.

Chicago (EMS Region 11) hospitals: Advocate Illinois Masonic Medical Center, Advocate Trinity Hospital, AMITA Resurrection Medical Center Chicago, AMITA Saint Joseph Hospital Chicago, AMITA Saints Mary & Elizabeth Medical Center, Ann & Robert H Lurie Children's Hospital, Comer Children's Hospital, Community First Medical Center, Holy Cross Hospital, Jackson Park Hospital & Medical Center, John H. Stroger Jr. Hospital of Cook County, Loretto Hospital, Mercy Hospital and Medical Center, , Mount Sinai Hospital, Northwestern Memorial Hospital, Norwegian American Hospital, Roseland Community Hospital, Rush University Medical Center, Saint Anthony Hospital, Saint Bernard Hospital, South Shore Hospital, Swedish Hospital, Thorek Memorial Hospital, Thorek Hospital Andersonville. University of Chicago Medical Center, University of Illinois Hospital & Health Sciences System, Weiss Memorial Hospital.

Chicago (EMS Region 11) specialty hospitals: Provident Hospital/Cook County, RML Specialty Hospital, Chicago, Montrose Behavioral Health (previously Lakeshore Hospital.) Shirley Ryan AbilityLab (previously RIC), Jesse Brown VA Medical Center, Kindred Chicago – North, Hartgrove Hospital, Kindred Chicago – Lakeshore, Kindred Chicago – Central, Shriners Hospital for Children – Chicago, LaRabida Hospital.

Data Source: Hospitals reporting to CDPH via EMResource (Juvare)

United States SB: IL: COVID-19 Impact: Moderate Positive Effect data was reported at 9.100 % in 11 Apr 2022. This records an increase from the previous number of 6.500 % for 04 Apr 2022. United States SB: IL: COVID-19 Impact: Moderate Positive Effect data is updated weekly, averaging 6.950 % from Nov 2021 (Median) to 11 Apr 2022, with 18 observations. The data reached an all-time high of 9.100 % in 11 Apr 2022 and a record low of 5.200 % in 03 Jan 2022. United States SB: IL: COVID-19 Impact: Moderate Positive Effect data remains active status in CEIC and is reported by U.S. Census Bureau. The data is categorized under Global Database’s United States – Table US.S037: Small Business Pulse Survey: by State: Midwest Region: Weekly, Beg Monday (Discontinued).

Clinical data from 102 Japanese patients with COVID-19.

United States SB: IL: COVID-19 Impact: Moderate Negative Effect data was reported at 41.900 % in 11 Apr 2022. This records a decrease from the previous number of 43.300 % for 04 Apr 2022. United States SB: IL: COVID-19 Impact: Moderate Negative Effect data is updated weekly, averaging 43.400 % from Nov 2021 (Median) to 11 Apr 2022, with 18 observations. The data reached an all-time high of 50.400 % in 28 Feb 2022 and a record low of 39.200 % in 22 Nov 2021. United States SB: IL: COVID-19 Impact: Moderate Negative Effect data remains active status in CEIC and is reported by U.S. Census Bureau. The data is categorized under Global Database’s United States – Table US.S047: Small Business Pulse Survey: by State: Midwest Region: Weekly, Beg Monday (Discontinued).

NOTE: This dataset has been retired and marked as historical-only. The recommended dataset to use in its place is https://data.cityofchicago.org/Health-Human-Services/COVID-19-Vaccination-Coverage-Citywide/6859-spec.

COVID-19 vaccinations administered to Chicago residents based on the reported race-ethnicity and age group of the person vaccinated, as provided by the medical provider in the Illinois Comprehensive Automated Immunization Registry Exchange (I-CARE).

Vaccination Status Definitions:

·People with at least one vaccine dose: Number of people who have received at least one dose of any COVID-19 vaccine, including the single-dose Johnson & Johnson COVID-19 vaccine.

·People with a completed vaccine series: Number of people who have completed a primary COVID-19 vaccine series. Requirements vary depending on age and type of primary vaccine series received.

··People with an original booster dose: Number of people who have a completed vaccine series and have received at least one additional monovalent dose. This includes people who received a monovalent booster dose and immunocompromised people who received an additional primary dose of COVID-19 vaccine. Monovalent doses were created from the original strain of the virus that causes COVID-19.

• People with a bivalent dose: Number of people who received a bivalent (updated) dose of vaccine. Updated, bivalent doses became available in Fall 2022 and were created with the original strain of COVID-19 and newer Omicron variant strains.

Weekly cumulative totals by vaccination status are shown for each combination of race-ethnicity and age group. Note that each age group has a row where race-ethnicity is "All" so care should be taken when summing rows.

Vaccinations are counted based on the date on which they were administered. Weekly cumulative totals are reported from the week ending Saturday, December 19, 2020 onward (after December 15, when vaccines were first administered in Chicago) through the Saturday prior to the dataset being updated.

Population counts are from the U.S. Census Bureau American Community Survey (ACS) 2019 1-year estimates. For some of the age groups by which COVID-19 vaccine has been authorized in the United States, race-ethnicity distributions were specifically reported in the ACS estimates. For others, race-ethnicity distributions were estimated by the Chicago Department of Public Health (CDPH) by weighting the available race-ethnicity distributions, using proportions of constituent age groups.

Coverage percentages are calculated based on the cumulative number of people in each population subgroup (age group by race-ethnicity) who have each vaccination status as of the date, divided by the estimated number of Chicago residents in each subgroup.

Actual counts may exceed population estimates and lead to >100% coverage, especially in small race-ethnicity subgroups of each age group. All coverage percentages are capped at 99%.

All data are provisional and subject to change. Information is updated as additional details are received and it is, in fact, very common for recent dates to be incomplete and to be updated as time goes on. At any given time, this dataset reflects data currently known to CDPH.

Numbers in this dataset may differ from other public sources due to when data are reported and how City of Chicago boundaries are defined.

CDPH uses the most complete data available to estimate COVID-19 vaccination coverage among Chicagoans, but there are several limitations that impact our estimates. Data reported in I-CARE only include doses administered in Illinois and some doses administered outside of Illinois reported historically by Illinois providers. Doses administered by the federal Bureau of Prisons and Department of Defense are also not currently reported in I-CARE. The Veterans Health Administration began reporting doses in I-CARE beginning September 2022. Due to people receiving vaccinations that are not recorded in I-CARE that can be linked to their record, such as someone receiving a vaccine dose in another state, the number of people with a completed series or a booster dose is underestimated. Inconsistencies in records of separate doses administered to the same person, such as slight variations in dates of birth, can result in duplicate first dose records for a person and overestimate of the number of people with at least one dose and underestimate the number of people with a completed series or booster dose

For all datasets related to COVID-19, see https://data.cityofchicago.org/browse?limitTo=datasets&sortBy=alpha&tags=covid-19.

Data Source: Illinois Comprehensive Automated Immunization Registry Exchange (I-CARE), U.S. Census Bureau American Community Survey

As of March 10, 2023, the death rate from COVID-19 in the state of New York was 397 per 100,000 people. New York is one of the states with the highest number of COVID-19 cases.

Data supporting the manuscript title: IL-6 and cfDNA monitoring throughout COVID-19 hospitalization are accurate markers of its outcomes

The information presented here is compiled from the Cook County Medical Examiner’s Office.The data sets include information from deaths starting in August 2014 to the present, with information updated daily.It contains information about deaths that occurred in Cook County that were under the Medical Examiner’s jurisdiction. Not all deaths that occur in Cook County are reported to the Medical Examiner or fall under the jurisdiction of the Medical Examiner.Effective April 1, 2022, the Cook County Medical Examiner’s Office no longer takes jurisdiction over hospital, nursing home or hospice COVID-19 deaths unless there is another factor that falls within the Office’s jurisdiction. Data continues to be collected for COVID-19 deaths in Cook County on the Illinois Dept. of Public Health COVID-19 dashboard (https://dph.illinois.gov/covid19/data.html).The Medical Examiner’s Office determines cause and manner of death for those cases that fall under its jurisdiction.Cause of death describes the reason the person died.Manner of death falls under one of five categories:· Homicide· Suicide· Natural· Accident· UndeterminedThe information posted here may be graphic in nature and may not be appropriate for all users.Published 11/21/17 and updated daily.

IntroductionDespite of massive endeavors to characterize inflammation in COVID-19 patients, the core network of inflammatory mediators responsible for severe pneumonia stillremain remains elusive. MethodsHere, we performed quantitative and kinetic analysis of 191 inflammatory factors in 955 plasma samples from 80 normal controls (sample n = 80) and 347 confirmed COVID-19 pneumonia patients (sample n = 875), including 8 deceased patients. ResultsDifferential expression analysis showed that 76% of plasmaproteins (145 factors) were upregulated in severe COVID-19 patients comparedwith moderate patients, confirming overt inflammatory responses in severe COVID-19 pneumonia patients. Global correlation analysis of the plasma factorsrevealed two core inflammatory modules, core I and II, comprising mainly myeloid cell and lymphoid cell compartments, respectively, with enhanced impact in a severity-dependent manner. We observed elevated IFNA1 and suppressed IL12p40, presenting a robust inverse correlation in severe patients, which was strongly associated with persistent hyperinflammation in 8.3% of moderate pneumonia patients and 59.4% of severe patients. DiscussionAberrant persistence of pulmonary and systemic inflammation might be associated with long COVID-19 sequelae. Our comprehensive analysis of inflammatory mediators in plasmarevealed the complexity of pneumonic inflammation in COVID-19 patients anddefined critical modules responsible for severe pneumonic progression.

Multisystem inflammatory syndrome in children (MIS-C) is an imperative pediatric inflammatory condition closely linked to COVID-19, which garners substantial attention since the onset of the pandemic. Like Kawasaki illness, this condition is characterized by an overactive immune response, leading to symptoms including pyrexia, cardiac and renal complications. To elucidate the pathogenesis of MIS-C and identify potential biomarkers, we conducted an extensive examination of specific cytokines (IL-6, IL-1β, IL-6R, IL-10, and TNF-α) and microRNA (miRNA) expression profiles at various intervals (ranging from 3 to 20 days) in the peripheral blood sample of a severely affected MIS-C patient. Our investigation revealed a gradual decline in circulating levels of IL-6, IL-1β, IL-10, and TNF-α following intravenous immune globulin (IVIG) therapy. Notably, IL-6 exhibited a significant reduction from 74.30 to 1.49 pg./mL, while IL-6R levels remained consistently stable throughout the disease course. Furthermore, we observed an inverse correlation between the expression of hsa-miR-596 and hsa-miR-224-5p and the aforementioned cytokines. Our findings underscore a robust association between blood cytokine and miRNA concentrations and the severity of MIS-C. These insights enhance our understanding of the genetic regulatory mechanisms implicated in MIS-C pathogenesis, offering potential avenues for early biomarker detection and therapy monitoring through miRNA analysis.