This statistic presents the distribution of estimated income losses of Liverpool Football Club as a result of the ongoing COVID-19 containment measures. Although these figures are illustrative, not definitive, and an array of other outcomes is possible, these data suggests that Liverpool will experience a total loss of income of over 102 million British pounds, of which 55.2 million British pounds will be lost from Premier League TV revenue.

The great majority of football followers in Great Britain agrees that Liverpool FC with a 25-point lead should be crowned Premier League Champions, regarding the fact that no more fixtures will be held due to the coronavirus outbreak.

BackgroundThe characteristic symptom of coronavirus disease 2019 (COVID-19) is respiratory distress, but neurological symptoms are the most frequent extra-pulmonary symptoms. This study aims to explore the current status and hot topics of neurology-related research on COVID-19 using bibliometric analysis.MethodsPublications regarding neurology and COVID-19 were retrieved from the Web of Science Core Collection (WoSCC) on March 28 2022. The Advanced search was conducted using “TS = (‘COVID 19’ or ‘Novel Coronavirus 2019’ or ‘Coronavirus disease 2019’ or ‘2019-nCOV’ or ‘SARS-CoV-2’ or ‘coronavirus-2’) and TS = (‘neurology’or ‘neurological’ or ‘nervous system’ or ‘neurodegenerative disease’ or ‘brain’ or ‘cerebra’ or ‘nerve’)”. Microsoft Excel 2010 and VOSviewer were used to characterize the largest contributors, including the authors, journals, institutions, and countries. The hot topics and knowledge network were analyzed by CiteSpace and VOSviewer.ResultsA total of 5,329 publications between 2020 and 2022 were retrieved. The United States, Italy, and the United Kingdom were three key contributors to this field. Harvard Medical School, the Tehran University of Medical Sciences, and the UCL Queen Square Institute of Neurology were the major institutions with the largest publications. Josef Finsterer from the University of São Paulo (Austria) was the most prolific author. Tom Solomon from the University of Liverpool (UK) was the most cited author. Neurological Sciences and Frontiers in Neurology were the first two most productive journals, while Journal of Neurology held the first in terms of total citations and citations per publication. Cerebrovascular diseases, neurodegenerative diseases, encephalitis and encephalopathy, neuroimmune complications, neurological presentation in children, long COVID and mental health, and telemedicine were the central topics regarding the neurology-related research on COVID-19.ConclusionNeurology-related research on COVID-19 has attracted considerable attention worldwide. Research topics shifted from “morality, autopsy, and telemedicine” in 2020 to various COVID-19-related neurological symptoms in 2021, such as “stroke,” “Alzheimer's disease,” “Parkinson's disease,” “Guillain–Barre syndrome,” “multiple sclerosis,” “seizures in children,” and “long COVID.” “Applications of telemedicine in neurology during COVID-19 pandemic,” “COVID-19-related neurological complications and mechanism,” and “long COVID” require further study.

Food and drink venues, such as bars and restaurants, were allowed to resume trading in the United Kingdom (UK) in July 2020, following a nationwide lockdown due to the outbreak of coronavirus (COVID-19). As of August, the majority of establishments across Great Britain had resumed trading. In London, 71.2 percent of sites that were open pre-lockdown had re-opened to customers. This lagged behind other major cities, including Liverpool and Manchester.

Background: COVID-19 patients with underlying medical conditions are vulnerable to drug-drug interactions (DDI) due to the use of multiple medications. We conducted a discovery-driven data analysis to identify potential DDIs and associated adverse events (AEs) in COVID-19 patients from the FDA Adverse Event Reporting System (FAERS), a source of post-market drug safety.Materials and Methods: We investigated 18,589 COVID-19 AEs reported in the FAERS database between 2020 and 2021. We applied multivariate logistic regression to account for potential confounding factors, including age, gender, and the number of unique drug exposures. The significance of the DDIs was determined using both additive and multiplicative measures of interaction. We compared our findings with the Liverpool database and conducted a Monte Carlo simulation to validate the identified DDIs.Results: Out of 11,337 COVID-19 drug-Co-medication-AE combinations investigated, our methods identified 424 signals statistically significant, covering 176 drug-drug pairs, composed of 13 COVID-19 drugs and 60 co-medications. Out of the 176 drug-drug pairs, 20 were found to exist in the Liverpool database. The empirical p-value obtained based on 1,000 Monte Carlo simulations was less than 0.001. Remdesivir was discovered to interact with the largest number of concomitant drugs (41). Hydroxychloroquine was detected to be associated with most AEs (39). Furthermore, we identified 323 gender- and 254 age-specific DDI signals.Conclusion: The results, particularly those not found in the Liverpool database, suggest a subsequent need for further pharmacoepidemiology and/or pharmacology studies.

The number of overseas visitors to the institutions that are part of the National Museums Liverpool in England increased significantly in 2022/2023 over the previous fiscal year, following a dramatic decline with the onset of the coronavirus (COVID-19) pandemic. Between April 2022 and March 2023, the museums reported roughly 355 thousand visitors, 45 percent less than the year prior to the pandemic.

Background

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) transmission occurs via airborne droplets and surface contamination. Droplets or other body fluids from infected individuals can contaminate surfaces and viable virus has been detected on such surfaces, including surgical masks, for hours, even days depending on different factors including humidity, temperature and type of surface. Titanium dioxide (TiO₂) coating of surfaces is a promising infection control measure, though to date has not been tested against SARS-CoV-2.

Methods

Virus stability was evaluated on the following surfaces: sterile untreated Sterilin standard Petri dish; TiO₂- and TiO₂–Ag (Ti:Ag atomic ratio 1:0.04)-coated 45 x 45 mm ceramic tiles. After coating the tiles were stored for 2–4 months before use. Surfaces were exposed (610 lx, ambient laboratory light) for 1 h before the start of each experiment to ensure a steady state of radical generation. We tested the stability of both SARS-CoV-2 Spike pseudotyped virions based on a lentiviral system, as well as fully infectious SARS-CoV-2 virus (SARS-CoV-2/human/Liverpool/REMRQ0001/2020). For the former, tile surfaces were inoculated with 10⁵RLU of SARS-CoV-2 spike pseudotyped HIV-1 luciferase virus at time t = 0 and illuminated for up to 6 h. At intervals virus was recovered from surfaces with DMEM complete followed by infection of ACE-2/TMPRSS2-expressing 293T cells. For live virus, after illuminating tiles for 0–300 min virus was recovered from surfaces followed by infection of Vero E6 cells. % of infected cells was determined by flow cytometry detecting SARS-CoV-2 nucleocapsid protein 24 h post-infection.

Results

After 1 h illumination the pseudotyped viral titre was decreased by four orders of magnitude. There was no significant difference between the TiO₂ and TiO₂–Ag coatings. Light alone had no significant effect on viral viability. For live SARS-CoV-2, virus was already significantly inactivated on the TiO₂ surfaces after 20 min illumination. After 5 h no detectable active virus remained. Significantly, SARS-CoV-2 on the untreated surface was still fully infectious at 5 h post-addition of virus. Overall, tiles coated with TiO₂ 120 days previously were able to inactivate SARS-CoV-2 under ambient indoor lighting with 87% reduction in titres at 1h and complete loss by 5h exposure.

Conclusions

In the context of emerging viral variants with increased transmissibility, TiO₂ coatings could be an important tool in containing SARS-CoV-2, particularly in health care facilities where nosocomial infection rates are high.

Monthly visits to the Tate Liverpool in England were higher in the second half of 2021 compared to the first half. The art gallery did not welcome any guests in the first four months of the year due to the coronavirus (COVID-19) pandemic. In the second half of 2021, the establishment reported roughly 186 thousand visitors. Despite the recovery in attendance during this period, the cultural institution was not able to attract as many visitors as it did prior to the global health crisis. For comparison, the gallery reported around 361 thousand guests in the second half of 2019. Due to the restrictions enacted during the pandemic, museums and galleries in the United Kingdom had to stay closed for several months in 2020 and 2021.

The number of visitors to National Museums Liverpool's institutions in England increased significantly in 2022/2023 over the previous fiscal year, following a dramatic decline with the onset of the coronavirus (COVID-19) pandemic. Between April 2022 and March 2023, the institutions reported roughly 2.35 million visitors, 24 percent less than the year before the pandemic. National Museums Liverpool is a group of free museums and galleries operating throughout the city of Liverpool, including organizations such as the Museum of Liverpool, the Walker Art Gallery, and the Merseyside Maritime Museum.

In 2021, the Mexican department store company El Puerto de Liverpool operated 286 stores of the formats Liverpool and Suburbia accross the country. Moreover, the popular retailer also had 28 shopping malls and more than 115 boutiques in Mexico. Due to the COVID-19 pandemic, the revenue generated by Liverpool registered a year-over-year decline in 2020.

The number of visits to the Tate Liverpool gallery in England decreased sharply in 2020/2021 over the previous fiscal year due to the coronavirus (COVID-19) pandemic. The art gallery, part of the Tate group, recorded around 48 thousand visits between March 2020 and April 2021, dropping from roughly 628 thousand in the same period of the previous fiscal year. As a result of the pandemic, museums and galleries in the United Kingdom had to stay closed for several months in 2020 and 2021.