India reported almost 45 million cases of the coronavirus (COVID-19) as of October 20, 2023, with more than 44 million recoveries and about 532 thousand fatalities. The number of cases in the country had a decreasing trend in the past months.

Burden on the healthcare system

With the world's second largest population in addition to an even worse second wave of the coronavirus pandemic seems to be crushing an already inadequate healthcare system. Despite vast numbers being vaccinated, a new variant seemed to be affecting younger age groups this time around. The lack of ICU beds, black market sales of oxygen cylinders and drugs needed to treat COVID-19, as well as overworked crematoriums resorting to mass burials added to the woes of the country. Foreign aid was promised from various countries including the United States, France, Germany and the United Kingdom. Additionally, funding from the central government was expected to boost vaccine production.

Situation overview
Even though days in April 2021 saw record-breaking numbers compared to any other country worldwide, a nation-wide lockdown has not been implemented. The largest religious gathering - the Kumbh Mela, sacred to the Hindus, along with election rallies in certain states continue to be held. Some states and union territories including Maharashtra, Delhi, and Karnataka had issued curfews and lockdowns to try to curb the spread of infections.

COVID-19: As on Date: Number of Active Cases: Delhi data was reported at 1.000 Case in 24 Mar 2025. This stayed constant from the previous number of 1.000 Case for 17 Mar 2025. COVID-19: As on Date: Number of Active Cases: Delhi data is updated daily, averaging 513.000 Case from Mar 2020 (Median) to 24 Mar 2025, with 1581 observations. The data reached an all-time high of 103,424.000 Case in 29 Apr 2021 and a record low of 0.000 Case in 03 Mar 2025. COVID-19: As on Date: Number of Active Cases: Delhi data remains active status in CEIC and is reported by Ministry of Health and Family Welfare. The data is categorized under High Frequency Database’s Disease Outbreaks – Table IN.HLF006: Disease Outbreaks: Coronavirus 2019: MOHFW.

Executive summary: Studying the spread and epidemiological characteristics of COVID-19 virus specially in household settings are needed to prepare our self-better in preventing and controlling this epidemic. In this study we proposed a conceptual framework of four level of determinates and tried to understand the transmission dynamics of COVID-19 among household contacts along with clinical, epidemiological and virologic characteristics of the infection.

Aims & Objectives:

the proportion of asymptomatic cases and symptomatic cases;

the incubation period of COVID-19 and the duration of infectiousness and of detectable shedding;

the serial interval of COVID-19 infection;

clinical risk factors for COVID-19, and the clinical course and severity of disease;

high-risk population subgroups;

the secondary infection rate and secondary clinical attack rate of COVID-19 infection among household contacts; and

the associations of various factors across four dimensions interaction associated with risk of transmission

Methodology: This was a case-ascertained study where all susceptible contacts of a laboratory confirmed COVID-19 case were studied prospective for four weeks after their enrolment. It was done in New Delhi, during the end of first wave as well as whole second wave from December 2020 to July 2021. The study team collected the key information by questionnaire along with blood and oro-nasal swab during the household visits. Follow-up was done on day 7, 14 and 28 for observing the disease characteristic and symptomatology along with confirmation by serum and oro-nasal swab testing. Daily characteristics of the infection were noted by the participants on symptoms diary.

Results: We enrolled 99 households, each having one laboratory-confirmed COVID-19 index case along with their 318 susceptible contacts. By the end of the follow-up, secondary infection rate was seen at 55.5%, while seroconversion in 46.6%. Hospitalization and case fatality rate was 3.83% and 1.7% respectively. Among epidemiological characteristics we observed serial interval of 8.0 ± 6.7 days, generation time 3.8 ± 6.4, while secondary attack rate was 54.9%. The predictors of secondary infection among individual contact level were being female (OR:2.13, 95% CI:1.27 - 3.57), age of the household contact (1.01;1.00 - 1.03), symptoms at baseline (3.39; 1.61- 7.12) and during follow-up (3.18; 1.64 - 6.19), while only symptoms during follow-up (3.81: 1.43 - 10.14) and being RT-PCR positive (8.32; 3.22 -21.54) was significantly and independently associated with seroconversion among household contacts. Among index case-level age of the primary case (1.03; 1.01 -1.04) and any symptoms during follow-up (6.29; 1.83-21.63) significantly and independently associated with secondary infection while any symptoms during follow-up was associated with seroconversion among household contacts. Among household-level characteristics having more rooms (4.44; 2.16 - 9.13) independently associated with secondary infection, while more rooms (3.98; 1.23 -12.90) along with overcrowding (0.37; 0.16 - 0.82) associated with seroconversion. Among contact pattern only taking care of the index case (2.02;1.21- 3.38) was significantly and independently associated with secondary infection, while none was associated with seroconversion.

Conclusion: A high secondary cases and secondary attack rate was seen in our study. This highlights the need to adopts strict measure and advocate COVID appropriate behaviours in order to break the transmission chain at household level. The targeted approach at household contacts with higher risk would be efficient in limiting the development of infection among susceptible contacts.