Raw data outputs 1-18 Raw data output 1. Differentially expressed genes in AML CSCs compared with GTCs as well as in TCGA AML cancer samples compared with normal ones. This data was generated based on the results of AML microarray and TCGA data analysis. Raw data output 2. Commonly and uniquely differentially expressed genes in AML CSC/GTC microarray and TCGA bulk RNA-seq datasets. This data was generated based on the results of AML microarray and TCGA data analysis. Raw data output 3. Common differentially expressed genes between training and test set samples the microarray dataset. This data was generated based on the results of AML microarray data analysis. Raw data output 4. Detailed information on the samples of the breast cancer microarray dataset (GSE52327) used in this study. Raw data output 5. Differentially expressed genes in breast CSCs compared with GTCs as well as in TCGA BRCA cancer samples compared with normal ones. Raw data output 6. Commonly and uniquely differentially expressed genes in breast cancer CSC/GTC microarray and TCGA BRCA bulk RNA-seq datasets. This data was generated based on the results of breast cancer microarray and TCGA BRCA data analysis. CSC, and GTC are abbreviations of cancer stem cell, and general tumor cell, respectively. Raw data output 7. Differential and common co-expression and protein-protein interaction of genes between CSC and GTC samples. This data was generated based on the results of AML microarray and STRING database-based protein-protein interaction data analysis. CSC, and GTC are abbreviations of cancer stem cell, and general tumor cell, respectively. Raw data output 8. Differentially expressed genes between AML dormant and active CSCs. This data was generated based on the results of AML scRNA-seq data analysis. Raw data output 9. Uniquely expressed genes in dormant or active AML CSCs. This data was generated based on the results of AML scRNA-seq data analysis. Raw data output 10. Intersections between the targeting transcription factors of AML key CSC genes and differentially expressed genes between AML CSCs vs GTCs and between dormant and active AML CSCs or the uniquely expressed genes in either class of CSCs. Raw data output 11. Targeting desirableness score of AML key CSC genes and their targeting transcription factors. These scores were generated based on an in-house scoring function described in the Methods section. Raw data output 12. CSC-specific targeting desirableness score of AML key CSC genes and their targeting transcription factors. These scores were generated based on an in-house scoring function described in the Methods section. Raw data output 13. The protein-protein interactions between AML key CSC genes with themselves and their targeting transcription factors. This data was generated based on the results of AML microarray and STRING database-based protein-protein interaction data analysis. Raw data output 14. The previously confirmed associations of genes having the highest targeting desirableness and CSC-specific targeting desirableness scores with AML or other cancers’ (stem) cells as well as hematopoietic stem cells. These data were generated based on a PubMed database-based literature mining. Raw data output 15. Drug score of available drugs and bioactive small molecules targeting AML key CSC genes and/or their targeting transcription factors. These scores were generated based on an in-house scoring function described in the Methods section. Raw data output 16. CSC-specific drug score of available drugs and bioactive small molecules targeting AML key CSC genes and/or their targeting transcription factors. These scores were generated based on an in-house scoring function described in the Methods section. Raw data output 17. Candidate drugs for experimental validation. These drugs were selected based on their respective (CSC-specific) drug scores. CSC is the abbreviation of cancer stem cell. Raw data output 18. Detailed information on the samples of the AML microarray dataset GSE30375 used in this study.

This is a made-up dataset in the context of a test group vs placebo group study that is used in a report introducing the Kaplan-Meier estimation and the Cox proportional hazards model.

The complete dataset used in the analysis comprises 36 samples, each described by 11 numeric features and 1 target. The attributes considered were caspase 3/7 activity, Mitotracker red CMXRos area and intensity (3 h and 24 h incubations with both compounds), Mitosox oxidation (3 h incubation with the referred compounds) and oxidation rate, DCFDA fluorescence (3 h and 24 h incubations with either compound) and oxidation rate, and DQ BSA hydrolysis. The target of each instance corresponds to one of the 9 possible classes (4 samples per class): Control, 6.25, 12.5, 25 and 50 µM for 6-OHDA and 0.03, 0.06, 0.125 and 0.25 µM for rotenone. The dataset is balanced, it does not contain any missing values and data was standardized across features. The small number of samples prevented a full and strong statistical analysis of the results. Nevertheless, it allowed the identification of relevant hidden patterns and trends.

Exploratory data analysis, information gain, hierarchical clustering, and supervised predictive modeling were performed using Orange Data Mining version 3.25.1 [41]. Hierarchical clustering was performed using the Euclidean distance metric and weighted linkage. Cluster maps were plotted to relate the features with higher mutual information (in rows) with instances (in columns), with the color of each cell representing the normalized level of a particular feature in a specific instance. The information is grouped both in rows and in columns by a two-way hierarchical clustering method using the Euclidean distances and average linkage. Stratified cross-validation was used to train the supervised decision tree. A set of preliminary empirical experiments were performed to choose the best parameters for each algorithm, and we verified that, within moderate variations, there were no significant changes in the outcome. The following settings were adopted for the decision tree algorithm: minimum number of samples in leaves: 2; minimum number of samples required to split an internal node: 5; stop splitting when majority reaches: 95%; criterion: gain ratio. The performance of the supervised model was assessed using accuracy, precision, recall, F-measure and area under the ROC curve (AUC) metrics.

Dataset

This dataset was created by Merve Afranur ARTAR

Contents

Description: This dataset contains detailed information about videos from various YouTube channels that specialize in data science and analytics. It includes metrics such as views, likes, comments, and publication dates. The dataset consists of 22862 rows, providing a robust sample for analyzing trends in content engagement, popularity of topics over time, and comparison of channels' performance.

Column Descriptors:

Channel_Name: The name of the YouTube channel. Title: The title of the video. Published_date: The date when the video was published. Views: The number of views the video has received. Like_count: The number of likes the video has received. Comment_Count: The number of comments on the video.

This dataset contains information from the following YouTube channels:

['sentdex', 'freeCodeCamp.org' ,'CampusX', 'Darshil Parmar',' Keith Galli' ,'Alex The Analyst', 'Socratica' , Krish Naik', 'StatQuest with Josh Starmer', 'Nicholas Renotte', 'Leila Gharani', 'Rob Mulla' ,'Ryan Nolan Data', 'techTFQ', 'Dataquest' ,'WsCube Tech', 'Chandoo', 'Luke Barousse', 'Andrej Karpathy', 'Thu Vu data analytics', 'Guy in a Cube', 'Tableau Tim', 'codebasics', 'DeepLearningAI', 'Rishabh Mishra' 'ExcelIsFun', 'Kevin Stratvert' ' Ken Jee','Kaggle' , 'Tina Huang']

This dataset can be used for various analyses, including but not limited to:

Identifying the most popular videos and channels in the data science field.

Understanding viewer engagement trends over time.

Comparing the performance of different types of content across multiple channels.

Performing a comparison between different channels to find the best-performing ones.

Identifying the best videos to watch for specific topics in data science and analytics.

Conducting a detailed analysis of your favorite YouTube channel to understand its content strategy and performance.

Note: The data is current as of the date of extraction and may not reflect real-time changes on YouTube. For any analyses, ensure to consider the date when the data was last updated to maintain accuracy and relevance.

To create the dataset, the top 10 countries leading in the incidence of COVID-19 in the world were selected as of October 22, 2020 (on the eve of the second full of pandemics), which are presented in the Global 500 ranking for 2020: USA, India, Brazil, Russia, Spain, France and Mexico. For each of these countries, no more than 10 of the largest transnational corporations included in the Global 500 rating for 2020 and 2019 were selected separately. The arithmetic averages were calculated and the change (increase) in indicators such as profitability and profitability of enterprises, their ranking position (competitiveness), asset value and number of employees. The arithmetic mean values of these indicators for all countries of the sample were found, characterizing the situation in international entrepreneurship as a whole in the context of the COVID-19 crisis in 2020 on the eve of the second wave of the pandemic. The data is collected in a general Microsoft Excel table. Dataset is a unique database that combines COVID-19 statistics and entrepreneurship statistics. The dataset is flexible data that can be supplemented with data from other countries and newer statistics on the COVID-19 pandemic. Due to the fact that the data in the dataset are not ready-made numbers, but formulas, when adding and / or changing the values in the original table at the beginning of the dataset, most of the subsequent tables will be automatically recalculated and the graphs will be updated. This allows the dataset to be used not just as an array of data, but as an analytical tool for automating scientific research on the impact of the COVID-19 pandemic and crisis on international entrepreneurship. The dataset includes not only tabular data, but also charts that provide data visualization. The dataset contains not only actual, but also forecast data on morbidity and mortality from COVID-19 for the period of the second wave of the pandemic in 2020. The forecasts are presented in the form of a normal distribution of predicted values and the probability of their occurrence in practice. This allows for a broad scenario analysis of the impact of the COVID-19 pandemic and crisis on international entrepreneurship, substituting various predicted morbidity and mortality rates in risk assessment tables and obtaining automatically calculated consequences (changes) on the characteristics of international entrepreneurship. It is also possible to substitute the actual values identified in the process and following the results of the second wave of the pandemic to check the reliability of pre-made forecasts and conduct a plan-fact analysis. The dataset contains not only the numerical values of the initial and predicted values of the set of studied indicators, but also their qualitative interpretation, reflecting the presence and level of risks of a pandemic and COVID-19 crisis for international entrepreneurship.

This is a dataset downloaded off excelbianalytics.com created off of random VBA logic. I recently performed an extensive exploratory data analysis on it and I included new columns to it, namely: Unit margin, Order year, Order month, Order weekday and Order_Ship_Days which I think can help with analysis on the data. I shared it because I thought it was a great dataset to practice analytical processes on for newbies like myself.

1) Data Introduction • The Sample Sales Data is a retail sales dataset of 2,823 orders and 25 columns that includes a variety of sales-related data, including order numbers, product information, quantity, unit price, sales, order date, order status, customer and delivery information.

2) Data Utilization (1) Sample Sales Data has characteristics that: • This dataset consists of numerical (sales, quantity, unit price, etc.), categorical (product, country, city, customer name, transaction size, etc.), and date (order date) variables, with missing values in some columns (STATE, ADDRESSLINE2, POSTALCODE, etc.). (2) Sample Sales Data can be used to: • Analysis of sales trends and performance by product: Key variables such as order date, product line, and country can be used to visualize and analyze monthly and yearly sales trends, the proportion of sales by product line, and top sales by country and region. • Segmentation and marketing strategies: Segmentation of customer groups based on customer information, transaction size, and regional data, and use them to design targeted marketing and customized promotion strategies.

These data contain the results of GC-MS, LC-MS and immunochemistry analyses of mask sample extracts. The data include tentatively identified compounds through library searches and compound abundance. This dataset is not publicly accessible because: EPA cannot release personally identifiable information regarding living individuals, according to the Privacy Act and the Freedom of Information Act (FOIA). This dataset contains information about human research subjects. Because there is potential to identify individual participants and disclose personal information, either alone or in combination with other datasets, individual level data are not appropriate to post for public access. Restricted access may be granted to authorized persons by contacting the party listed. It can be accessed through the following means: The data can not be accessed. Format: The dataset contains the identification of compounds found in the mask samples as well as the abundance of those compounds for individuals who participated in the trial. This dataset is associated with the following publication: Pleil, J., M. Wallace, J. McCord, M. Madden, J. Sobus, and G. Ferguson. How do cancer-sniffing dogs sort biological samples? Exploring case-control samples with non-targeted LC-Orbitrap, GC-MS, and immunochemistry methods. Journal of Breath Research. Institute of Physics Publishing, Bristol, UK, 14(1): 016006, (2019).

This dataset contains metadata (title, abstract, date of publication, field, etc) for around 1 million academic articles. Each record contains additional information on the country of study and whether the article makes use of data. Machine learning tools were used to classify the country of study and data use.

Our data source of academic articles is the Semantic Scholar Open Research Corpus (S2ORC) (Lo et al. 2020). The corpus contains more than 130 million English language academic papers across multiple disciplines. The papers included in the Semantic Scholar corpus are gathered directly from publishers, from open archives such as arXiv or PubMed, and crawled from the internet.

We placed some restrictions on the articles to make them usable and relevant for our purposes. First, only articles with an abstract and parsed PDF or latex file are included in the analysis. The full text of the abstract is necessary to classify the country of study and whether the article uses data. The parsed PDF and latex file are important for extracting important information like the date of publication and field of study. This restriction eliminated a large number of articles in the original corpus. Around 30 million articles remain after keeping only articles with a parsable (i.e., suitable for digital processing) PDF, and around 26% of those 30 million are eliminated when removing articles without an abstract. Second, only articles from the year 2000 to 2020 were considered. This restriction eliminated an additional 9% of the remaining articles. Finally, articles from the following fields of study were excluded, as we aim to focus on fields that are likely to use data produced by countries’ national statistical system: Biology, Chemistry, Engineering, Physics, Materials Science, Environmental Science, Geology, History, Philosophy, Math, Computer Science, and Art. Fields that are included are: Economics, Political Science, Business, Sociology, Medicine, and Psychology. This third restriction eliminated around 34% of the remaining articles. From an initial corpus of 136 million articles, this resulted in a final corpus of around 10 million articles.

Due to the intensive computer resources required, a set of 1,037,748 articles were randomly selected from the 10 million articles in our restricted corpus as a convenience sample.

The empirical approach employed in this project utilizes text mining with Natural Language Processing (NLP). The goal of NLP is to extract structured information from raw, unstructured text. In this project, NLP is used to extract the country of study and whether the paper makes use of data. We will discuss each of these in turn.

To determine the country or countries of study in each academic article, two approaches are employed based on information found in the title, abstract, or topic fields. The first approach uses regular expression searches based on the presence of ISO3166 country names. A defined set of country names is compiled, and the presence of these names is checked in the relevant fields. This approach is transparent, widely used in social science research, and easily extended to other languages. However, there is a potential for exclusion errors if a country’s name is spelled non-standardly.

The second approach is based on Named Entity Recognition (NER), which uses machine learning to identify objects from text, utilizing the spaCy Python library. The Named Entity Recognition algorithm splits text into named entities, and NER is used in this project to identify countries of study in the academic articles. SpaCy supports multiple languages and has been trained on multiple spellings of countries, overcoming some of the limitations of the regular expression approach. If a country is identified by either the regular expression search or NER, it is linked to the article. Note that one article can be linked to more than one country.

The second task is to classify whether the paper uses data. A supervised machine learning approach is employed, where 3500 publications were first randomly selected and manually labeled by human raters using the Mechanical Turk service (Paszke et al. 2019).[1] To make sure the human raters had a similar and appropriate definition of data in mind, they were given the following instructions before seeing their first paper:

Each of these documents is an academic article. The goal of this study is to measure whether a specific academic article is using data and from which country the data came.

There are two classification tasks in this exercise:

1. identifying whether an academic article is using data from any country

2. Identifying from which country that data came.

For task 1, we are looking specifically at the use of data. Data is any information that has been collected, observed, generated or created to produce research findings. As an example, a study that reports findings or analysis using a survey data, uses data. Some clues to indicate that a study does use data includes whether a survey or census is described, a statistical model estimated, or a table or means or summary statistics is reported.

After an article is classified as using data, please note the type of data used. The options are population or business census, survey data, administrative data, geospatial data, private sector data, and other data. If no data is used, then mark "Not applicable". In cases where multiple data types are used, please click multiple options.[2]

For task 2, we are looking at the country or countries that are studied in the article. In some cases, no country may be applicable. For instance, if the research is theoretical and has no specific country application. In some cases, the research article may involve multiple countries. In these cases, select all countries that are discussed in the paper.

We expect between 10 and 35 percent of all articles to use data.

The median amount of time that a worker spent on an article, measured as the time between when the article was accepted to be classified by the worker and when the classification was submitted was 25.4 minutes. If human raters were exclusively used rather than machine learning tools, then the corpus of 1,037,748 articles examined in this study would take around 50 years of human work time to review at a cost of $3,113,244, which assumes a cost of $3 per article as was paid to MTurk workers.

A model is next trained on the 3,500 labelled articles. We use a distilled version of the BERT (bidirectional Encoder Representations for transformers) model to encode raw text into a numeric format suitable for predictions (Devlin et al. (2018)). BERT is pre-trained on a large corpus comprising the Toronto Book Corpus and Wikipedia. The distilled version (DistilBERT) is a compressed model that is 60% the size of BERT and retains 97% of the language understanding capabilities and is 60% faster (Sanh, Debut, Chaumond, Wolf 2019). We use PyTorch to produce a model to classify articles based on the labeled data. Of the 3,500 articles that were hand coded by the MTurk workers, 900 are fed to the machine learning model. 900 articles were selected because of computational limitations in training the NLP model. A classification of “uses data” was assigned if the model predicted an article used data with at least 90% confidence.

The performance of the models classifying articles to countries and as using data or not can be compared to the classification by the human raters. We consider the human raters as giving us the ground truth. This may underestimate the model performance if the workers at times got the allocation wrong in a way that would not apply to the model. For instance, a human rater could mistake the Republic of Korea for the Democratic People’s Republic of Korea. If both humans and the model perform the same kind of errors, then the performance reported here will be overestimated.

The model was able to predict whether an article made use of data with 87% accuracy evaluated on the set of articles held out of the model training. The correlation between the number of articles written about each country using data estimated under the two approaches is given in the figure below. The number of articles represents an aggregate total of

Each R script replicates all of the example code from one chapter from the book. All required data for each script are also uploaded, as are all data used in the practice problems at the end of each chapter. The data are drawn from a wide array of sources, so please cite the original work if you ever use any of these data sets for research purposes.

The OECD Programme for International Student Assessment (PISA) surveys collected data on students’ performances in reading, mathematics and science, as well as contextual information on students’ background, home characteristics and school factors which could influence performance. This publication includes detailed information on how to analyse the PISA data, enabling researchers to both reproduce the initial results and to undertake further analyses. In addition to the inclusion of the necessary techniques, the manual also includes a detailed account of the PISA 2006 database and worked examples providing full syntax in SPSS.

This dataset gives some data of a hypothetical business that can be used to practice your privacy data transformation and analysis skills.

The dataset contains the following files/tables: 1. customer_orders_for_privacy_exercises.csv contains data of a business about customer orders (columns separated by commas) 2. users_web_browsing_for_privacy_exercises.csv contains data collected by the business website about its users (columns separated by commas) 3. iot_example.csv contains data collected by a smart device on users' bio-metric data (columns separated by commas) 4. members.csv contains data collected by a library on its users (columns separated by commas)

This repository contains the data supporting the manuscript "A Generic Scenario Analysis of End-of-Life Plastic Management: Chemical Additives" (to be) submitted to the Energy and Environmental Science Journal https://pubs.rsc.org/en/journals/journalissues/ee#!recentarticles&adv This repository contains Excel spreadsheets used to calculate material flow throughout the plastics life cycle, with a strong emphasis on chemical additives in the end-of-life stages. Three major scenarios were presented in the manuscript: 1) mechanical recycling (existing recycling infrastructure), 2) implementing chemical recycling to the existing plastics recycling, and 3) extracting chemical additives before the manufacturing stage. Users would primarily modify values on the yellow tab "US 2018 Facts - Sensitivity". Values highlighted in yellow may be changed for sensitivity analysis purposes. Please note that the values shown for MSW generated, recycled, incinerated, landfilled, composted, imported, exported, re-exported, and other categories in this tab were based on 2018 data. Analysis for other years can be made possible with a replicate version of this spreadsheet and the necessary data to replace those of 2018. Most of the tabs, especially those that contain "Stream # - Description", do not require user interaction. They are intermediate calculations that change according to the user inputs. It is available for the user to see so that the calculation/method is transparent. The major results of these individual stream tabs are ultimately compiled into one summary tab. All streams throughout the plastics life cycle, for each respective scenario (1, 2, and 3), are shown in the "US Mat Flow Analysis 2018" tab. For each stream, we accounted the approximate mass of plastics found in MSW, additives that may be present, and non-plastics. Each spreadsheet contains a representative diagram that matches the stream label. This illustration is placed to aid the user with understanding the connection between each stage in the plastics' life cycle. For example, the Scenario 1 spreadsheet uniquely contains Material Flow Analysis Summary, in addition to the LCI. In the "Material Flow Analysis Summary" tab, we represented the input, output, releases, exposures, and greenhouse gas emissions based on the amount of materials inputted into a specific stage in the plastics life cycle. The "Life Cycle Inventory" tab contributes additional calculations to estimate land, air, and water releases. Figures and Data - A gs analysis on eol plastic management This word document contains the raw data used to create all the figures in the main manuscript. The major references used to obtain the data are also included where appropriate.

This dataset compiles the top 2500 datasets from Kaggle, encompassing a diverse range of topics and contributors. It provides insights into dataset creation, usability, popularity, and more, offering valuable information for researchers, analysts, and data enthusiasts.

Research Analysis: Researchers can utilize this dataset to analyze trends in dataset creation, popularity, and usability scores across various categories.

Contributor Insights: Kaggle contributors can explore the dataset to gain insights into factors influencing the success and engagement of their datasets, aiding in optimizing future submissions.

Machine Learning Training: Data scientists and machine learning enthusiasts can use this dataset to train models for predicting dataset popularity or usability based on features such as creator, category, and file types.

Market Analysis: Analysts can leverage the dataset to conduct market analysis, identifying emerging trends and popular topics within the data science community on Kaggle.

Educational Purposes: Educators and students can use this dataset to teach and learn about data analysis, visualization, and interpretation within the context of real-world datasets and community-driven platforms like Kaggle.

Column Definitions:

Dataset Name: Name of the dataset. Created By: Creator(s) of the dataset. Last Updated in number of days: Time elapsed since last update. Usability Score: Score indicating the ease of use. Number of File: Quantity of files included. Type of file: Format of files (e.g., CSV, JSON). Size: Size of the dataset. Total Votes: Number of votes received. Category: Categorization of the dataset's subject matter.

Sample data for exercises in Further Adventures in Data Cleaning.

This data release contains the elemental concentration data for more than 1700 archived stream-sediment samples collected in Alaska. Samples were retrieved from the USGS Mineral Program's sample archive in Denver, CO, and the Alaska Division of Geological and Geophysical Surveys Geologic Materials Center in Anchorage, AK. All samples were analyzed using a multi-element analytical method involving fusion of the sample by sodium peroxide, dissolution of the fusion cake by nitric acid, and elemental analysis by inductively coupled plasma-optical emission spectroscopy (ICP-OES) and inductively coupled plasma-mass spectroscopy (ICP-MS). Additionally, 106 samples from the Nixon Fork area were analyzed by a second multi-element method in which the samples are decomposed by a mixture of hydrochloric, nitric, perchloric, and hydrofluoric acids and the elemental composition is determined by ICP-OES and ICP-MS. New Hg (mercury) concentrations, determined by cold-vapor atomic absorption spectrometry, are reported for 296 samples from southeast Alaska.

This document provides guidance to State agencies on evaluating datasets with PII, PHI, or other forms of private or confidential data. This guidance includes a sample risk benefit analysis form and process to enable agencies to evaluate datasets for publication and help select appropriate privacy protections for open datasets.

These are simulated data without any identifying information or informative birth-level covariates. We also standardize the pollution exposures on each week by subtracting off the median exposure amount on a given week and dividing by the interquartile range (IQR) (as in the actual application to the true NC birth records data). The dataset that we provide includes weekly average pregnancy exposures that have already been standardized in this way while the medians and IQRs are not given. This further protects identifiability of the spatial locations used in the analysis. This dataset is not publicly accessible because: EPA cannot release personally identifiable information regarding living individuals, according to the Privacy Act and the Freedom of Information Act (FOIA). This dataset contains information about human research subjects. Because there is potential to identify individual participants and disclose personal information, either alone or in combination with other datasets, individual level data are not appropriate to post for public access. Restricted access may be granted to authorized persons by contacting the party listed. It can be accessed through the following means: File format: R workspace file; “Simulated_Dataset.RData”. Metadata (including data dictionary) • y: Vector of binary responses (1: adverse outcome, 0: control) • x: Matrix of covariates; one row for each simulated individual • z: Matrix of standardized pollution exposures • n: Number of simulated individuals • m: Number of exposure time periods (e.g., weeks of pregnancy) • p: Number of columns in the covariate design matrix • alpha_true: Vector of “true” critical window locations/magnitudes (i.e., the ground truth that we want to estimate) Code Abstract We provide R statistical software code (“CWVS_LMC.txt”) to fit the linear model of coregionalization (LMC) version of the Critical Window Variable Selection (CWVS) method developed in the manuscript. We also provide R code (“Results_Summary.txt”) to summarize/plot the estimated critical windows and posterior marginal inclusion probabilities. Description “CWVS_LMC.txt”: This code is delivered to the user in the form of a .txt file that contains R statistical software code. Once the “Simulated_Dataset.RData” workspace has been loaded into R, the text in the file can be used to identify/estimate critical windows of susceptibility and posterior marginal inclusion probabilities. “Results_Summary.txt”: This code is also delivered to the user in the form of a .txt file that contains R statistical software code. Once the “CWVS_LMC.txt” code is applied to the simulated dataset and the program has completed, this code can be used to summarize and plot the identified/estimated critical windows and posterior marginal inclusion probabilities (similar to the plots shown in the manuscript). Optional Information (complete as necessary) Required R packages: • For running “CWVS_LMC.txt”: • msm: Sampling from the truncated normal distribution • mnormt: Sampling from the multivariate normal distribution • BayesLogit: Sampling from the Polya-Gamma distribution • For running “Results_Summary.txt”: • plotrix: Plotting the posterior means and credible intervals Instructions for Use Reproducibility (Mandatory) What can be reproduced: The data and code can be used to identify/estimate critical windows from one of the actual simulated datasets generated under setting E4 from the presented simulation study. How to use the information: • Load the “Simulated_Dataset.RData” workspace • Run the code contained in “CWVS_LMC.txt” • Once the “CWVS_LMC.txt” code is complete, run “Results_Summary.txt”. Format: Below is the replication procedure for the attached data set for the portion of the analyses using a simulated data set: Data The data used in the application section of the manuscript consist of geocoded birth records from the North Carolina State Center for Health Statistics, 2005-2008. In the simulation study section of the manuscript, we simulate synthetic data that closely match some of the key features of the birth certificate data while maintaining confidentiality of any actual pregnant women. Availability Due to the highly sensitive and identifying information contained in the birth certificate data (including latitude/longitude and address of residence at delivery), we are unable to make the data from the application section publically available. However, we will make one of the simulated datasets available for any reader interested in applying the method to realistic simulated birth records data. This will also allow the user to become familiar with the required inputs of the model, how the data should be structured, and what type of output is obtained. While we cannot provide the application data here, access to the North Carolina birth records can be requested through the North Carolina State Center for Health Statistics, and requires an appropriate data use agreement. Description Permissions: These are simulated data without any identifying information or informative birth-level covariates. We also standardize the pollution exposures on each week by subtracting off the median exposure amount on a given week and dividing by the interquartile range (IQR) (as in the actual application to the true NC birth records data). The dataset that we provide includes weekly average pregnancy exposures that have already been standardized in this way while the medians and IQRs are not given. This further protects identifiability of the spatial locations used in the analysis. This dataset is associated with the following publication: Warren, J., W. Kong, T. Luben, and H. Chang. Critical Window Variable Selection: Estimating the Impact of Air Pollution on Very Preterm Birth. Biostatistics. Oxford University Press, OXFORD, UK, 1-30, (2019).

As high-throughput methods become more common, training undergraduates to analyze data must include having them generate informative summaries of large datasets. This flexible case study provides an opportunity for undergraduate students to become familiar with the capabilities of R programming in the context of high-throughput evolutionary data collected using macroarrays. The story line introduces a recent graduate hired at a biotech firm and tasked with analysis and visualization of changes in gene expression from 20,000 generations of the Lenski Lab’s Long-Term Evolution Experiment (LTEE). Our main character is not familiar with R and is guided by a coworker to learn about this platform. Initially this involves a step-by-step analysis of the small Iris dataset built into R which includes sepal and petal length of three species of irises. Practice calculating summary statistics and correlations, and making histograms and scatter plots, prepares the protagonist to perform similar analyses with the LTEE dataset. In the LTEE module, students analyze gene expression data from the long-term evolutionary experiments, developing their skills in manipulating and interpreting large scientific datasets through visualizations and statistical analysis. Prerequisite knowledge is basic statistics, the Central Dogma, and basic evolutionary principles. The Iris module provides hands-on experience using R programming to explore and visualize a simple dataset; it can be used independently as an introduction to R for biological data or skipped if students already have some experience with R. Both modules emphasize understanding the utility of R, rather than creation of original code. Pilot testing showed the case study was well-received by students and faculty, who described it as a clear introduction to R and appreciated the value of R for visualizing and analyzing large datasets.