This statistic shows the number of famine deaths per100,000 people worldwide from 1900 to 2010. In the 1920s, about 814 people per 100,000 of the global population died as a result of famine.

Between 2016 and 2022, there were no deaths reported due to lack of food and water in India. However, in 2012, there were 217 deaths due to this reason, making it the highest fatality number since 2010.

According to the Global Hunger Index 2024, which was adopted by the International Food Policy Research Institute, Somalia was the most affected by hunger and malnutrition, with an index of 44.1. Yemen and Chad followed behind. The World Hunger Index combines three indicators: undernourishment, child underweight, and child mortality. Sub-Saharan Africa most affected The index is dominated by countries in Sub-Saharan Africa. In the region, more than one fifth of the population is undernourished . In terms of individuals, however, South Asia has the highest number of undernourished people. Globally, there are 735 million people that are considered undernourished or starving. A lack of food is increasing in over 20 countries worldwide. Undernourishment worldwide The term malnutrition includes both undernutrition and overnutrition. Undernutrition occurs when an individual cannot maintain normal bodily functions such as growth, recovering from disease, and both learning and physical work. Some conditions such as diarrhea, malaria, and HIV/AIDS can all have a negative impact on undernutrition. Rural and agricultural communities can be especially susceptible to hunger during certain seasons. The annual hunger gap occurs when a family’s food supply may run out before the next season’s harvest is available and can result in malnutrition. Nevertheless, the prevalence of people worldwide that are undernourished has decreased over the last decades, from 18.7 percent in 1990-92 to 9.2 percent in 2022, but it has slightly increased since the outbreak of COVID-19. According to the Global Hunger Index, the reduction of global hunger has stagnated over the past decade.

The age-specific mortality rate of nutritional deficiencies at all ages in Canada declined to 0.7 deaths in 2023. Nevertheless, the last two years recorded a significantly higher age-specific mortality rate than the preceding years.

This statistic shows the number of deaths caused by starvation in Latin America in 2015 and 2016, measured in millions. Between the period of consideration, death of starvation increased in the region by more than six percent, from 40 million deaths in 2015 to 42.5 million deaths in 2016.

Recent years have seen an increase in the amount of people suffering from undernourishment around the world. This is a reversal of the trend which had seen declining numbers till 2014. In 2023, almost 734 million people were undernourished around the world. Undernourishment is defined as the status of persons, whose food intake regularly provides less than their minimum energy requirements.

This appendix to the paper "Plague and hunger. Epidemic-induced pressures on household purchasing power in fourteenth-century Flanders" includes information on the construction of bread price series, purchasing power of households and the calculation of caloric deficits.

Code used for the simulations employed in the manuscript "Gradual entry into carbon starvation decreases the death rate of Escherichia coli"

This folder contains the code that simulates the allocation strategy during the shift to starvation, as described in the manuscript. The model is based upon the FCR model, published by Erikson, Schink et al in 2017. In this program you can simulate the dynamics of the shift experiment by fitting the time course of the growth rate with a sigmoid (as in the manuscript) and inserting the values of the parameters of the fit in the program. You can simulate the three different dynamics that we propose: the global regulation one, the targeted towards the survival sector and the targeted towards the harmful. Abstract: Bacterial fitness is determined both by how fast cells grow in nutrient-rich environments and by how well they survive when nutrients are depleted. However, these behaviors are not independent, since the molecular composition of non-growing cells is affected by their prior growth history. For instance, recent work observed that the death rates of Escherichia coli cultures that rapidly entered carbon starvation depend on their prior growth rates, with faster growth leading to exponentially faster death. On the other hand, it is well known that cells adapt their molecular composition as they slow down growth and enter stationary phase, which is generally believed to improve their chance of survival. Hence, the question arises to what extent this adaptation process reduces the subsequent death rate. And how does the duration of the time window during which cells are allowed to adapt determine the reduction in death rate, and thus the fitness benefit of adaptation? Here, we study these quantitative questions by probing the adaptation of E. coli during gradual transitions from exponential growth to carbon starvation. We monitor such transitions in cultures with different initial growth conditions and measure the resulting rates of cell death after the transition. Our experiments demonstrate that cells with the opportunity to adapt their proteome composition before entering a state of starvation exhibit lower death rates compared to those that cannot, across various substrate conditions. The quantitative data is consistent with a theoretical model built on the assumption that before starvation, cells up-regulate a specific sector of the proteome, the effect of which is to decrease the death rate in energy-limiting conditions. This work highlights the influence of the non-genetic memory of a cell, specifically in the form of inherited proteome composition, on bacterial fitness. Our results emphasize that a comprehensive understanding of bacterial fitness requires quantitative characterization of bacterial physiology in all phases of their life cycle, including growth, stationary phase, and death, as well as the transitions between them. Differences with v1: - fixed the values of the parameters gamma_0, tau

The First World War saw the mobilization of more than 65 million soldiers, and the deaths of almost 15 million soldiers and civilians combined. Approximately 8.8 million of these deaths were of military personnel, while six million civilians died as a direct result of the war; mostly through hunger, disease and genocide. The German army suffered the highest number of military losses, totaling at more than two million men. Turkey had the highest civilian death count, largely due to the mass extermination of Armenians, as well as Greeks and Assyrians. Varying estimates suggest that Russia may have suffered the highest number of military and total fatalities in the First World War. However, this is complicated by the subsequent Russian Civil War and Russia's total specific to the First World War remains unclear to this day.

Proportional deaths In 1914, Central and Eastern Europe was largely divided between the empires of Austria-Hungary, Germany and Russia, while the smaller Balkan states had only emerged in prior decades with the decline of the Ottoman Empire. For these reasons, the major powers in the east were able to mobilize millions of men from across their territories, as Britain and France did with their own overseas colonies, and were able to utilize their superior manpower to rotate and replace soldiers, whereas smaller nations did not have this luxury. For example, total military losses for Romania and Serbia are around 12 percent of Germany's total military losses; however, as a share of their total mobilized forces these countries lost roughly 33 percent of their armies, compared to Germany's 15 percent mortality rate. The average mortality rate of all deployed soldiers in the war was around 14 percent.

Unclarity in the totals Despite ending over a century ago, the total number of deaths resulting from the First World War remains unclear. The impact of the Influenza pandemic of 1918, as well as various classifications of when or why fatalities occurred, has resulted in varying totals with differences ranging in the millions. Parallel conflicts, particularly the Russian Civil War, have also made it extremely difficult to define which conflicts the fatalities should be attributed to. Since 2012, the totals given by Hirschfeld et al in Brill's Encyclopedia of the First World War have been viewed by many in the historical community as the most reliable figures on the subject.

Drought-induced tree death has become a serious problem in global forest ecosystems. Two nonexclusive hypotheses, hydraulic failure and carbon starvation, have been proposed to explain tree die-offs. To clarify the mechanisms, we investigated the physiological processes of drought-induced tree death in saplings with contrasting Huber values (sapwood area/total leaf area). First, hydraulic failure and reduced respiration were found in the initial process of tree decline, and in the last stage carbon starvation leaded to tree death. The carbohydrate reserves at the stem bases, low in healthy trees, were accumulated at the beginning of the declining process because of phloem transport failure, and then decreased just before dying. The concentrations of non-structural carbohydrates at the stem bases are a good indicator of tree damage. The physiological processes and carbon sink-source dynamics that occur during lethal drought provide important insight into the adaptive measures underlying forest die-offs under global warming conditions.

According to the Global Hunger Index, India had an index value of **** in 2023. The composition of the index was a combination of different indicators such as undernourishment, child underweight, and child mortality. India's score indicates a serious level of hunger crisis, placing the country at a position of ***** out of 121 countries that year. However, the country had improved the situation from ** index points falling in the category of alarming level in 2000.

Flies are exposed to different host populations, in different habitats, on different days of the hunger cycle, and are able to execute various numbers of steps per cycle.

In the lifecycle of microorganisms, prolonged starvation is prevalent and sustaining life during starvation periods is a vital task. In the literature, it is commonly assumed that survival kinetics of starving microbes follows exponential decay. This assumption, however, has not been rigorously tested. Currently, it is not clear under what circumstances this assumption is true. Also, it is not known when such survival kinetics deviates from exponential decay and if it deviates, what underlying mechanisms for the deviation are. Here, to address these issues, we quantitatively characterized dynamics of survival and death of starving E. coli cells. The results show that the assumption – starving cells die exponentially – is true only at high cell density. At low density, starving cells persevere for extended periods of time, before dying rapidly exponentially. Detailed analyses show intriguing quantitative characteristics of the density-dependent and biphasic survival kinetics, including that the period of the perseverance is inversely proportional to cell density. These characteristics further lead us to identification of key underlying processes relevant for the perseverance of starving cells. Then, using mathematical modeling, we show how these processes contribute to the density-dependent and biphasic survival kinetics observed. Importantly, our model reveals a thrifty strategy employed by bacteria, by which upon sensing impending depletion of a substrate, the limiting substrate is conserved and utilized later during starvation to delay cell death. These findings advance quantitative understanding of survival of microbes in oligotrophic environments and facilitate quantitative analysis and prediction of microbial dynamics in nature. Furthermore, they prompt revision of previous models used to analyze and predict population dynamics of microbes.

The global landscape of mortality has undergone significant changes from 1990 to 2021, but cardiovascular diseases remain the leading cause of death worldwide. In 2021, cardiovascular diseases accounted for 28.6 percent of all deaths, followed by cancers at 14.6 percent. Notably, COVID-19 emerged as the third leading cause of death in 2021, responsible for 11.6 percent of global fatalities. Impact of the COVID-19 pandemic The emergence of COVID-19 as a major cause of death underscores the profound impact of the pandemic on global health. By May 2023, the virus had infected over 687 million people worldwide and claimed nearly 6.87 million lives. The United States, India, and Brazil were among the most severely affected countries. The pandemic's effects extended beyond direct mortality, influencing healthcare systems and potentially exacerbating other health conditions. Shifts in global health priorities While infectious diseases like COVID-19 have gained prominence, long-term health trends reveal significant progress in certain areas. The proportion of neonatal deaths decreased from 6.4 percent in 1990 to 2.7 percent in 2021, reflecting improvements in maternal and child health care. However, challenges persist in addressing malnutrition and hunger, particularly in Sub-Saharan Africa and South Asia. The Global Hunger Index 2024 identified Somalia, Yemen, and Chad as the countries most affected by hunger and malnutrition, highlighting the ongoing need for targeted interventions in these regions.

A moderate heat shock induces Neurospora crassa to synthesize large quantities of heat shock proteins that are protective against higher, otherwise lethal temperatures. However, wild type cells do not survive when carbohydrate deprivation is added to heat shock. In contrast, a mutant strain defective in a stress-activated protein kinase does survive the combined stresses. In order to understand the basis for this difference in survival, we have determined the relative levels of detected proteins in the mutant and wild type strain during dual stress, and we have identified gene transcripts in both strains whose quantities change in response to heat shock or dual stress. These data and supportive experimental evidence point to reasons for survival of the mutant strain. By using alternative respiratory mechanisms, these cells experience less of the oxidative stress that proves damaging to wild type cells. Of central importance, mutant cells recycle limited resources during dual stress by undergoing autophagy, a process that we find utilized by both wild type and mutant cells during heat shock. Evidence points to inappropriate activation of TORC1, the central metabolic regulator, in wild type cells during dual stress, based upon behavior of an additional signaling mutant and inhibitor studies.

Summary of the number of genes congruently (up or down) and uniquely regulated between SFCs and starved AFCs and the GO terms enriched in each category, along with the adjusted p-value. (XLSM)

In 2023, the rate of undernourishment worldwide was 9.1 percent. The region with the largest share of undernourished people was Sub-Saharan Africa, with 23.2 percent. Undernourished people worldwideSouthern Asia and Sub-Saharan Africa have some of the highest numbers of undernourished people in the world, totaling 281 million and 278 million, respectively in 2023. Based on the World Hunger Index 2024, Somalia and Yemen were among the most affected countries by hunger and malnutrition. Worldwide, about 733.4 million people were suffering from malnutrition in 2023. MalnutritionMalnourishment occurs when a person’s diet consists of too little or too much of certain nutrients. Undernutrition occurs when a person does not intake enough calories, protein, or micronutrients. One of the primary causes of malnutrition is due to limited or lack of accessibility to affordable nutritious foods. Malnutrition is considered to contribute to over a third of child deaths globally. In Asia, an estimated 77 million cases of stunting, which is the primary effect of malnutrition, were recorded for children under the age of five in 2022. The FAO reports that food security and nutrition commitments by national governments are essential in eradicating the world hunger problem. Agricultural productivity, accessibility to land, services, and markets, rural development strategies, and social protection are needed to ensure a reduction in malnutrition.

In 2021, Quezon had the highest number of deaths by malnutrition in the Philippines' CALABARZON region, accounting for 229 out of 1,078 total cases in this region. On the other hand, Trece Martires City had only one death in that year.

Following the arrival of Spanish colonizers in 1519, namely Hernando Cortes and his 600 conquistadors, the indigenous population of the Mexican valley saw a dramatic decline. In the first two years of conquest, thousands of indigenous Americans perished while fighting the European invaders, including an estimated 100,000 who died of violence or starvation during Cortes' siege of the Aztec capital city, Tenochtitlan (present-day Mexico City), in 1520. However, the impact of European violence on population decline pales in comparison to the impact of Old World diseases, which saw the indigenous population of the region drop from roughly 22 million to less than two million within eight decades.. Virgin soil pandemics Almost immediately after the Spanish arrival, a wave of smallpox swept across the indigenous populations, with some estimates suggesting that five to eight million natives died in the subsequent pandemic between 1519 and 1520. This outbreak was not an isolated incident, with the entire indigenous population of the Americas dropping by roughly ninety percent in the next two centuries. The Mexican valley specifically, which was the most populous region of the pre-Columbian Americas, suffered greatly due to virgin soil pandemics (where new diseases are introduced to biologically defenseless populations). In the Middle Ages, the majority of Europeans contracted smallpox as children, which generally granted lifelong immunity. In contrast, indigenous Americans had never been exposed to these diseases, and their populations (of all ages) declined rapidly. Cocoliztli Roughly three decades after the smallpox pandemic, another pandemic swept across the valley, to a more devastating effect. This was an outbreak of cocoliztli, which almost wiped out the entire population, and was followed by a second pandemic three decades later. Until recently, historians were still unsure of the exact causes of cocoliztli, with most hypothesizing that it was a rodent-borne disease similar to plague or an extreme form of a haemorrhagic fever. In 2018, however, scientists in Jena, Germany, studied 29 sets of teeth from 16th century skeletons found in the Oaxaca region of Mexico (from a cemetery with known links to the 1545 pandemic); these tests concluded that cocoliztli was most likely an extreme and rare form of the salmonella bacterium, which caused paratyphoid fever. These pandemics coincided with some of the most extreme droughts ever recorded in North America, which exacerbates the spread and symptoms of this disease, and the symptoms described in historical texts give further credence to the claim that cocoliztli was caused by salmonella.

Most estimates place the total number of deaths during the Second World War at around 70-85 million people. Approximately 17 million of these deaths (20-25 percent of the total) were due to crimes against humanity carried out by the Nazi regime in Europe. In comparison to the millions of deaths that took place through conflict, famine, or disease, these 17 million stand out due to the reasoning behind them, along with the systematic nature and scale in which they were carried out. Nazi ideology claimed that the Aryan race (a non-existent ethnic group referring to northern Europeans) was superior to all other ethnicities; this became the justification for German expansion and the extermination of others. During the war, millions of people deemed to be of lesser races were captured and used as slave laborers, with a large share dying of exhaustion, starvation, or individual execution. Murder campaigns were also used for systematic extermination; the most famous of these were the extermination camps, such as at Auschwitz, where roughly 80 percent of the 1.1 million victims were murdered in gas chambers upon arrival at the camp. German death squads in Eastern Europe carried out widespread mass shootings, and up to two million people were killed in this way. In Germany itself, many disabled, homosexual, and "undesirables" were also killed or euthanized as part of a wider eugenics program, which aimed to "purify" German society.

The Holocaust Of all races, the Nazi's viewed Jews as being the most inferior. Conspiracy theories involving Jews go back for centuries in Europe, and they have been repeatedly marginalized throughout history. German fascists used the Jews as scapegoats for the economic struggles during the interwar period. Following Hitler's ascendency to the Chancellorship in 1933, the German authorities began constructing concentration camps for political opponents and so-called undesirables, but the share of Jews being transported to these camps gradually increased in the following years, particularly after Kristallnacht (the Night of Broken Glass) in 1938. In 1939, Germany then invaded Poland, home to Europe's largest Jewish population. German authorities segregated the Jewish population into ghettos, and constructed thousands more concentration and detention camps across Eastern Europe, to which millions of Jews were transported from other territories. By the end of the war, over two thirds of Europe's Jewish population had been killed, and this share is higher still when one excludes the neutral or non-annexed territories.

Lebensraum Another key aspect of Nazi ideology was that of the Lebensraum (living space). Both the populations of the Soviet Union and United States were heavily concentrated in one side of the country, with vast territories extending to the east and west, respectively. Germany was much smaller and more densely populated, therefore Hitler aspired to extend Germany's territory to the east and create new "living space" for Germany's population and industry to grow. While Hitler may have envied the U.S. in this regard, the USSR was seen as undeserving; Slavs were the largest major group in the east and the Nazis viewed them as inferior, which was again used to justify the annexation of their land and subjugation of their people. As the Germans took Slavic lands in Poland, the USSR, and Yugoslavia, ethnic cleansings (often with the help of local conspirators) became commonplace in the annexed territories. It is also believed that the majority of Soviet prisoners of war (PoWs) died through starvation and disease, and they were not given the same treatment as PoWs on the western front. The Soviet Union lost as many as 27 million people during the war, and 10 million of these were due to Nazi genocide. It is estimated that Poland lost up to six million people, and almost all of these were through genocide.