It was estimated that as of 2022 around 24.4 million people in the United States had been diagnosed with diabetes. The number of people diagnosed with diabetes in the U.S. has increased in recent years and the disease is now a major health issue. Diabetes is now the eighth leading cause of death in the United States, accounting for three percent of all deaths.

What is prediabetes? A person is considered to have prediabetes if their blood sugar levels are higher than normal but not high enough to be diagnosed with type 2 diabetes. As of 2021, it was estimated that around 53 million men and 44 million women in the United States had prediabetes. However, according to the CDC, around 80 percent of these people do not know they have this condition. Not only does prediabetes increase the risk of developing type 2 diabetes, but also increases the risk of heart disease and stroke. The states with the highest share of adults who had ever been told they have prediabetes are Hawaii, California, and Alaska.

The prevalence of diabetes in the United States As of 2022, around 8.4 percent of adults in the United States had been diagnosed with diabetes, an increase from six percent in the year 2000. Diabetes is much more common among older adults, with almost a quarter of those aged 65 years and older diagnosed with diabetes, compared to just three percent of those aged 18 to 44 years. The states with the highest prevalence of diabetes among adults are Alabama, Mississippi, and West Virginia, while Colorado and Alaska report the lowest rates. In Alabama, around 17 percent of adults have been diagnosed with diabetes.

The number of diabetics worldwide in 2021 was 537 million. That number is expected to grow until at least the year 2045. The projected number of diabetics is expected to reach 783 million by that time. With an increased number of diabetics, the prevalence of diabetes is also projected to increase to around 12 percent by 2045.

Diabetes prevalence globally

Diabetes is a chronic disease that affects the production and use of insulin in the body which affects blood glucose. Diabetes comes in two types, type 1 and type 2, which require different types of medical treatments. Globally, China, followed by India, has the largest number of diabetics as of 2021. Despite having the highest number of diabetics, China is not among the countries with the highest prevalence. French Polynesia, followed by Mauritius, had the highest prevalence of diabetics worldwide as of 2021.

Diabetes pharmaceuticals

Treatment for diabetes includes insulin, a hormone that regulates blood glucose, and pills to help regulate the effectiveness of insulin. Treatment depends on the type of diabete. The top drug for the treatment of diabetes, based on market share in 2017, was NovoRapid by Novo Nordisk. NovoRapid is a rapid-acting insulin marketed for both children and adults.

IntroductionA digital twin is a virtual representation of a patient's disease, facilitating real-time monitoring, analysis, and simulation. This enables the prediction of disease progression, optimization of care delivery, and improvement of outcomes.MethodsHere, we introduce a digital twin framework for type 2 diabetes (T2D) that integrates machine learning with multiomic data, knowledge graphs, and mechanistic models. By analyzing a substantial multiomic and clinical dataset, we constructed predictive machine learning models to forecast disease progression. Furthermore, knowledge graphs were employed to elucidate and contextualize multiomic–disease relationships.Results and discussionOur findings not only reaffirm known targetable disease components but also spotlight novel ones, unveiled through this integrated approach. The versatile components presented in this study can be incorporated into a digital twin system, enhancing our grasp of diseases and propelling the advancement of precision medicine.

Ireland: Diabetes prevalence, percent of population ages 20-79: The latest value from 2021 is 3 percent, a decline from 5.2 percent in 2011. In comparison, the world average is 8.60 percent, based on data from 195 countries. Historically, the average for Ireland from 2011 to 2021 is 4.1 percent. The minimum value, 3 percent, was reached in 2021 while the maximum of 5.2 percent was recorded in 2011.

United States US: Diabetes Prevalence: % of Population Aged 20-79 data was reported at 10.790 % in 2017. United States US: Diabetes Prevalence: % of Population Aged 20-79 data is updated yearly, averaging 10.790 % from Dec 2017 (Median) to 2017, with 1 observations. United States US: Diabetes Prevalence: % of Population Aged 20-79 data remains active status in CEIC and is reported by World Bank. The data is categorized under Global Database’s USA – Table US.World Bank: Health Statistics. Diabetes prevalence refers to the percentage of people ages 20-79 who have type 1 or type 2 diabetes.; ; International Diabetes Federation, Diabetes Atlas.; Weighted average;

In 2021, almost 17 percent of adults between the ages of 20 and 79 had diabetes in Mexico. Other selected countries with a high prevalence of diabetes that year included Turkey, Spain, and the United States. Diabetes is a metabolic disease that causes high blood sugar levels.

Diabetes worldwide

In 2021, an estimated 10.5 percent of the global adult population had diabetes. In concrete numbers, there were about 537 million diabetic adults (20-79 years) worldwide in 2021, and this total is predicted to grow to approximately 783 million by the year 2045.

Spending per patient

The country that spent the most on patients with diabetes in 2021 was the United States. At this time, providing for a diabetic patient here cost an average of almost 12 thousand U.S. dollars. Switzerland stood in second place, spending about 10,500 U.S. dollars per patient. In the same year, the ten countries by lowest average spending per person with diabetes were all African and Asian countries. The Democratic Republic of Congo had the lowest annual diabetes-related health expenditures per person, with about 156 U.S. dollars.

This statistic shows the world regions' age adjusted diabetes prevalence among adults (20-79 years) in 2021 and a 2045 forecast. In 2021, North America and the Caribbean had a 12 percent diabetes prevalence.

Diabetes prevalence (% of population ages 20 to 79) in Hong Kong was reported at 7.8 % in 2021, according to the World Bank collection of development indicators, compiled from officially recognized sources. Hong Kong - Diabetes prevalence (% of population ages 20 to 79) - actual values, historical data, forecasts and projections were sourced from the World Bank on March of 2025.

Diabetes prevalence (% of population ages 20 to 79) in Sri Lanka was reported at 11.3 % in 2021, according to the World Bank collection of development indicators, compiled from officially recognized sources. Sri Lanka - Diabetes prevalence (% of population ages 20 to 79) - actual values, historical data, forecasts and projections were sourced from the World Bank on March of 2025.

Diabetes prevalence (% of population ages 20 to 79) in Spain was reported at 10.3 % in 2021, according to the World Bank collection of development indicators, compiled from officially recognized sources. Spain - Diabetes prevalence (% of population ages 20 to 79) - actual values, historical data, forecasts and projections were sourced from the World Bank on March of 2025.

Diabetes prevalence (% of population ages 20 to 79) in Jamaica was reported at 11.1 % in 2021, according to the World Bank collection of development indicators, compiled from officially recognized sources. Jamaica - Diabetes prevalence (% of population ages 20 to 79) - actual values, historical data, forecasts and projections were sourced from the World Bank on March of 2025.

Diabetes prevalence (% of population ages 20 to 79) in Ireland was reported at 3 % in 2021, according to the World Bank collection of development indicators, compiled from officially recognized sources. Ireland - Diabetes prevalence (% of population ages 20 to 79) - actual values, historical data, forecasts and projections were sourced from the World Bank on March of 2025.

Diabetes prevalence (% of population ages 20 to 79) in Solomon Islands was reported at 19.8 % in 2021, according to the World Bank collection of development indicators, compiled from officially recognized sources. Solomon Islands - Diabetes prevalence (% of population ages 20 to 79) - actual values, historical data, forecasts and projections were sourced from the World Bank on March of 2025.

Dominican Republic: Diabetes prevalence, percent of population ages 20-79: The latest value from 2021 is 10.5 percent, an increase from 8.1 percent in 2011. In comparison, the world average is 8.60 percent, based on data from 195 countries. Historically, the average for Dominican Republic from 2011 to 2021 is 9.3 percent. The minimum value, 8.1 percent, was reached in 2011 while the maximum of 10.5 percent was recorded in 2021.

Guinea-Bissau: Diabetes prevalence, percent of population ages 20-79: The latest value from 2021 is 2.1 percent, a decline from 3 percent in 2011. In comparison, the world average is 8.60 percent, based on data from 195 countries. Historically, the average for Guinea-Bissau from 2011 to 2021 is 2.55 percent. The minimum value, 2.1 percent, was reached in 2021 while the maximum of 3 percent was recorded in 2011.

Diabetes prevalence (% of population ages 20 to 79) in Togo was reported at 2.1 % in 2021, according to the World Bank collection of development indicators, compiled from officially recognized sources. Togo - Diabetes prevalence (% of population ages 20 to 79) - actual values, historical data, forecasts and projections were sourced from the World Bank on March of 2025.

Diabetes prevalence (% of population ages 20 to 79) in Samoa was reported at 9.2 % in 2021, according to the World Bank collection of development indicators, compiled from officially recognized sources. Samoa - Diabetes prevalence (% of population ages 20 to 79) - actual values, historical data, forecasts and projections were sourced from the World Bank on March of 2025.

Monaco: Diabetes prevalence, percent of population ages 20-79: The latest value from 2021 is 6.2 percent, an increase from 5.6 percent in 2011. In comparison, the world average is 8.60 percent, based on data from 195 countries. Historically, the average for Monaco from 2011 to 2021 is 5.9 percent. The minimum value, 5.6 percent, was reached in 2011 while the maximum of 6.2 percent was recorded in 2021.

From 2017 to March 2020, the prevalence of diabetes was highest among those with lower incomes, with around 20 percent of those who earned 130 percent or less of the federal poverty level suffering from diabetes. This statistic shows the prevalence of diabetes in the U.S. from 2017 to March 2020, by family income relative to the federal poverty level (FPL).

Diabetes prevalence (% of population ages 20 to 79) in Sweden was reported at 5 % in 2021, according to the World Bank collection of development indicators, compiled from officially recognized sources. Sweden - Diabetes prevalence (% of population ages 20 to 79) - actual values, historical data, forecasts and projections were sourced from the World Bank on March of 2025.