It was estimated that as of 2023, around **** million people in the United States had been diagnosed with diabetes. The number of people diagnosed with diabetes in the U.S. has increased in recent years and the disease is now a major health issue. Diabetes is now the seventh leading cause of death in the United States, accounting for ******percent of all deaths. What is prediabetes? A person is considered to have prediabetes if their blood sugar levels are higher than normal but not high enough to be diagnosed with type 2 diabetes. As of 2021, it was estimated that around ** million men and ** million women in the United States had prediabetes. However, according to the CDC, around ** percent of these people do not know they have this condition. Not only does prediabetes increase the risk of developing type 2 diabetes, but also increases the risk of heart disease and stroke. The states with the highest share of adults who had ever been told they have prediabetes are California, Hawaii, and New Mexico. The prevalence of diabetes in the United States As of 2023, around *** percent of adults in the United States had been diagnosed with diabetes, an increase from ****percent in the year 2000. Diabetes is much more common among older adults, with around ** percent of those aged 60 years and older diagnosed with diabetes, compared to just ****percent of those aged 20 to 39 years. The states with the highest prevalence of diabetes among adults are West Virginia, Mississippi, and Louisiana, while Utah and Colorado report the lowest rates. In West Virginia, around ** percent of adults have been diagnosed with diabetes.

IntroductionA digital twin is a virtual representation of a patient's disease, facilitating real-time monitoring, analysis, and simulation. This enables the prediction of disease progression, optimization of care delivery, and improvement of outcomes.MethodsHere, we introduce a digital twin framework for type 2 diabetes (T2D) that integrates machine learning with multiomic data, knowledge graphs, and mechanistic models. By analyzing a substantial multiomic and clinical dataset, we constructed predictive machine learning models to forecast disease progression. Furthermore, knowledge graphs were employed to elucidate and contextualize multiomic–disease relationships.Results and discussionOur findings not only reaffirm known targetable disease components but also spotlight novel ones, unveiled through this integrated approach. The versatile components presented in this study can be incorporated into a digital twin system, enhancing our grasp of diseases and propelling the advancement of precision medicine.

Diabetes prevalence is projected to increase across all world regions by 2050, with the Middle East and North Africa expected to face the highest rates at 21 percent. This alarming trend highlights the growing global health challenge posed by diabetes, which already affects hundreds of millions of people worldwide and strains healthcare systems. Global impact and economic burden The number of diabetics globally is set to rise from nearly 589 million in 2024 to around 853 million by 2050. This surge in cases is accompanied by a significant economic burden, with global expenditures for diabetes treatment expected to grow from about 1.02 trillion U.S. dollars in 2024 to approximately 1.04 trillion U.S. dollars by 2050. The United States alone is projected to spend around 404.5 billion U.S. dollars on diabetes-related healthcare in 2024, underscoring the massive financial implications of this chronic condition. Regional disparities and future outlook While the Middle East and North Africa region is projected to have the highest diabetes prevalence by 2050, other regions will also see substantial increases. Africa is expected to experience a 142 percent rise in diabetic cases from 2024 to 2050, despite having the lowest prevalence among world regions. China is anticipated to remain the country with the highest number of diabetics, reaching approximately 168 million cases by 2050. Notably, Pakistan is forecast to surpass the United States in terms of diabetic population by mid-century, reflecting shifting global health dynamics and the need for targeted interventions in developing nations.

The number of diabetics worldwide in 2024 was almost *** million. That number is expected to grow until at least the year 2050. The projected number of diabetics is expected to reach around *** million by that time. With an increased number of diabetics, the prevalence of diabetes is also projected to increase to around ** percent by 2050. Diabetes prevalence globally Diabetes is a chronic disease that affects the production and use of insulin in the body which affects blood glucose. Diabetes comes in two types, type 1 and type 2, which require different types of medical treatments. Globally, China, followed by India, has the largest number of diabetics as of 2024. Despite having the highest number of diabetics, China is not among the countries with the highest prevalence. Pakistan, followed by the Marshall Islands, had the highest prevalence of diabetics worldwide as of 2024. Diabetes pharmaceuticals Treatment for diabetes includes insulin, a hormone that regulates blood glucose, and pills to help regulate the effectiveness of insulin. Treatment depends on the type of diabetes. Danish drug manufacturer Novo Nordisk is one of the leading diabetes care companies in the world. In 2024, Novo Nordisk generated around *** billion kroner in revenue from its diabetes care segment.

Diabetes prevalence (% of population ages 20 to 79) in Chad was reported at 7.3 % in 2024, according to the World Bank collection of development indicators, compiled from officially recognized sources. Chad - Diabetes prevalence (% of population ages 20 to 79) - actual values, historical data, forecasts and projections were sourced from the World Bank on August of 2025.

Nicaragua: Diabetes prevalence, percent of population ages 20-79: The latest value from 2021 is 9.3 percent, a decline from 11 percent in 2011. In comparison, the world average is 8.60 percent, based on data from 195 countries. Historically, the average for Nicaragua from 2011 to 2021 is 10.15 percent. The minimum value, 9.3 percent, was reached in 2021 while the maximum of 11 percent was recorded in 2011.

2011 to present. BRFSS combined land line and cell phone prevalence data. BRFSS is a continuous, state-based surveillance system that collects information about modifiable risk factors for chronic diseases and other leading causes of death. Data will be updated annually as it becomes available. Detailed information on sampling methodology and quality assurance can be found on the BRFSS website (http://www.cdc.gov/brfss). Methodology: http://www.cdc.gov/brfss/factsheets/pdf/DBS_BRFSS_survey.pdf Glossary: https://chronicdata.cdc.gov/Behavioral-Risk-Factors/Behavioral-Risk-Factor-Surveillance-System-BRFSS-H/iuq5-y9ct

The Philippines: Diabetes prevalence, percent of population ages 20-79: The latest value from 2021 is 7.1 percent, a decline from 9.7 percent in 2011. In comparison, the world average is 8.60 percent, based on data from 195 countries. Historically, the average for the Philippines from 2011 to 2021 is 8.4 percent. The minimum value, 7.1 percent, was reached in 2021 while the maximum of 9.7 percent was recorded in 2011.

Indonesia: Diabetes prevalence, percent of population ages 20-79: The latest value from 2021 is 10.6 percent, an increase from 5.1 percent in 2011. In comparison, the world average is 8.60 percent, based on data from 195 countries. Historically, the average for Indonesia from 2011 to 2021 is 7.85 percent. The minimum value, 5.1 percent, was reached in 2011 while the maximum of 10.6 percent was recorded in 2021.

In 2024, around 16 percent of adults between the ages of 20 and 79 had diabetes in Turkey. Other selected countries with a high prevalence of diabetes that year included Mexico, the United States, and Portugal. Diabetes is a metabolic disease that causes high blood sugar levels. Diabetes worldwide In 2024, an estimated 11 percent of the global adult population had diabetes. In concrete numbers, there were about 589 million diabetic adults (20-79 years) worldwide in 2024, and this total is predicted to grow to approximately 852.5 million by the year 2050. Spending per patient The country that spent the most on patients with diabetes in 2024 was Switzerland. At that time, providing for a diabetic patient in Switzerland cost an average of over 12 thousand U.S. dollars. The United States stood in second place, spending about 10,500 U.S. dollars per patient. In the same year, the ten countries by lowest average spending per person with diabetes were all African and Asian countries. Bangladesh had the lowest annual diabetes-related health expenditures per person, with just 74 U.S. dollars.

Diabetes prevalence (% of population ages 20 to 79) in United States was reported at 13.7 % in 2024, according to the World Bank collection of development indicators, compiled from officially recognized sources. United States - Diabetes prevalence (% of population ages 20 to 79) - actual values, historical data, forecasts and projections were sourced from the World Bank on September of 2025.

United States US: Diabetes Prevalence: % of Population Aged 20-79 data was reported at 10.790 % in 2017. United States US: Diabetes Prevalence: % of Population Aged 20-79 data is updated yearly, averaging 10.790 % from Dec 2017 (Median) to 2017, with 1 observations. United States US: Diabetes Prevalence: % of Population Aged 20-79 data remains active status in CEIC and is reported by World Bank. The data is categorized under Global Database’s USA – Table US.World Bank: Health Statistics. Diabetes prevalence refers to the percentage of people ages 20-79 who have type 1 or type 2 diabetes.; ; International Diabetes Federation, Diabetes Atlas.; Weighted average;

The average for 2021 based on 27 countries was 6.24 percent. The highest value was in Spain: 10.3 percent and the lowest value was in Ireland: 3 percent. The indicator is available from 2000 to 2021. Below is a chart for all countries where data are available.

Number and percentage of persons having been diagnosed with diabetes, by age group and sex.

Mexico: Diabetes prevalence, percent of population ages 20-79: The latest value from 2021 is 16.9 percent, an increase from 15.6 percent in 2011. In comparison, the world average is 8.60 percent, based on data from 195 countries. Historically, the average for Mexico from 2000 to 2021 is 15.57 percent. The minimum value, 14.2 percent, was reached in 2000 while the maximum of 16.9 percent was recorded in 2021.

Tonga: Diabetes prevalence, percent of population ages 20-79: The latest value from 2021 is 15 percent, an increase from 12.7 percent in 2011. In comparison, the world average is 8.60 percent, based on data from 195 countries. Historically, the average for Tonga from 2000 to 2021 is 13.07 percent. The minimum value, 11.5 percent, was reached in 2000 while the maximum of 15 percent was recorded in 2021.

Network of 41 papers and 68 citation links related to "Emerging Targets in Type 2 Diabetes and Diabetic Complications".

Slovakia: Diabetes prevalence, percent of population ages 20-79: The latest value from 2021 is 5.8 percent, an increase from 5.7 percent in 2011. In comparison, the world average is 8.60 percent, based on data from 195 countries. Historically, the average for Slovakia from 2011 to 2021 is 5.75 percent. The minimum value, 5.7 percent, was reached in 2011 while the maximum of 5.8 percent was recorded in 2021.

Hong Kong: Diabetes prevalence, percent of population ages 20-79: The latest value from 2021 is 7.8 percent, an increase from 7.6 percent in 2011. In comparison, the world average is 8.60 percent, based on data from 195 countries. Historically, the average for Hong Kong from 2000 to 2021 is 9.17 percent. The minimum value, 7.6 percent, was reached in 2011 while the maximum of 12.1 percent was recorded in 2000.

Argentina: Diabetes prevalence, percent of population ages 20-79: The latest value from 2021 is 5.4 percent, a decline from 5.5 percent in 2011. In comparison, the world average is 8.60 percent, based on data from 195 countries. Historically, the average for Argentina from 2011 to 2021 is 5.45 percent. The minimum value, 5.4 percent, was reached in 2021 while the maximum of 5.5 percent was recorded in 2011.