As of July 2023, China's .cn was the most popular country code top-level domain (ccTLD) worldwide with approximately 32.41 million registrations. Tokelau's .tk was ranked second with 27.54 million registered domains. During the measured period there were approximately 300 million domains registered to country TLDs.

STAT proteins (Signal Transducers and Activators of Transcription) are a family of transcription factors that are specifically activated to regulate gene transcription when cells encounter cytokines and growth factors. STATs share 6 structurally and functionally conserved domains including: an N-terminal domain (ND) that strengthens interactions between STAT dimers on adjacent DNA-binding sites; a coiled-coil STAT domain (CCD) that is implicated in protein-protein interactions; a DNA-binding domain (DBD) with an immunoglobulin-like fold similar to p53 tumour suppressor protein; an EF-hand-like linker domain connecting the DNA-binding and SH2 domains; an SH2 domain that acts as a phosphorylation-dependent switch to control receptor recognition and DNA-binding; and a C-terminal transactivation domain. This entry represents the coiled-coil domain (CCD)

National Domain Name (DN) Registration Quantity Statistics Table

The number of .tw domain registrations in Taiwan has dropped below ***********. As of December 2021, a total of ******* .tw domain names were registered in Taiwan, a significant decrease from around *********** registrations by the end of 2018.

The STAT protein (Signal Transducers and Activators of Transcription) family contains transcription factors that are specifically activated to regulate gene transcription when cells encounter cytokines and growth factors, hence they act as signal transducers in the cytoplasm and transcription activators in the nucleus . Binding of these factors to cell-surface receptors leads to receptor autophosphorylation at a tyrosine, the phosphotyrosine being recognised by the STAT SH2 domain, which mediates the recruitment of STAT proteins from the cytosol and their association with the activated receptor. The STAT proteins are then activated by phosphorylation via members of the JAK family of protein kinases, causing them to dimerise and translocated to the nucleus, where they bind to specific promoter sequences in target genes. In mammals, STATs comprise a family of seven structurally and functionally related proteins: Stat1, Stat2, Stat3, Stat4, Stat5a and Stat5b, Stat6. STAT proteins play a critical role in regulating innate and acquired host immune responses. Dysregulation of at least two STAT signalling cascades (i.e. Stat3 and Stat5) is associated with cellular transformation.Signalling through the JAK/STAT pathway is initiated when a cytokine binds to its corresponding receptor. This leads to conformational changes in the cytoplasmic portion of the receptor, initiating activation of receptor associated members of the JAK family of kinases. The JAKs, in turn, mediate phosphorylation at the specific receptor tyrosine residues, which then serve as docking sites for STATs and other signalling molecules. Once recruited to the receptor, STATs also become phosphorylated by JAKs, on a single tyrosine residue. Activated STATs dissociate from the receptor, dimerise, translocate to the nucleus and bind to members of the GAS (gamma activated site) family of enhancers.The seven STAT proteins identified in mammals range in size from 750 and 850 amino acids. The chromosomal distribution of these STATs, as well as the identification of STATs in more primitive eukaryotes, suggest that this family arose from a single primordial gene. STATs share 6 structurally and functionally conserved domains including: an N-terminal domain (ND) that strengthens interactions between STAT dimers on adjacent DNA-binding sites; a coiled-coil STAT domain (CCD) that is implicated in protein-protein interactions; a DNA-binding domain (DBD) with an immunoglobulin-like fold similar to p53 tumour suppressor protein; an EF-hand-like linker domain connecting the DNA-binding and SH2 domains; an SH2 domain ([interpro:IPR000980]) that acts as a phosphorylation-dependent switch to control receptor recognition and DNA-binding; and a C-terminal transactivation domain . The crystal structure of the N terminus of Stat4 reveals a dimer. The interface of this dimer is formed by a ring-shaped element consisting of five short helices. Several studies suggest that this N-terminal dimerisation promotes cooperativity of binding to tandem GAS elements and with the transcriptional coactivator CBP/p300.

The expiring and deleted domains statistics cover both generic top-level domains (gTLDs) and country-code top-level domains (ccTLDs). This dataset helps you stay up to date and make data-driven decisions in the domain industry based on daily updates.

As of August 2024, the most popular new generic top-level domain (gTLD) was .xyz with approximately 4.16 million domains, accounting for16.71 percent of gTLDs. The second-most popular gTLD was .online with 3.63 million registrations. Domains that do not have a country or geographic designation are often referred to by the term generic TLDs.

The main entity of this document is a entry with accession number G3DSA:1.20.58.240

Cleaned Newly Registered Domain names Count offers an up-to-date overview of newly registered domains, including both generic top-level domains (gTLDs) and country-code top-level domains (ccTLDs). Stay up-to-dated and make data-driven decisions in the domain industry with our regularly updated dataset.

In 2024, the World Intellectual Property Organization (WIPO) received 1929 cybersquatting cases. The total number of domain names was over 4,000 domain names. The number of cases filed to the World Intellectual Property Organization had increased, especially since 2012, when there were around, 2900 such disputes.

This domain is found in Dd-STATa, a STAT protein (signal transducer and activator of transcription A) which transcriptionally regulates cellular differentiation in Dictyostelium discoideum. The EF-hand domains are predicted to contain several basic residues that lie close to the DNA backbone .

Gross domestic product, output and jobs for sport and culture, product perspective, quarterly.

The statistic shows the trend in the global number of internet hosts in the domain name system from 1993 to 2019. In January 2019, approximately 1.01 billion internet hosts were available on the DNS.

The main entity of this document is a entry with accession number G3DSA:2.60.40.630

Explore the historical Whois records related to stat-ease.com (Domain). Get insights into ownership history and changes over time.

Explore the historical Whois records related to stat-us.com (Domain). Get insights into ownership history and changes over time.

A domain monitor is a tool that tracks domain names for changes in status, availability, and WHOIS information. It can alert users to domain expiration dates, enabling timely renewals. For example, if a monitored domain becomes available for registration, the monitor can notify the user to secure it. These tools are valuable for domain investors, businesses, and individuals managing multiple domains, ensuring they stay informed and can act promptly on domain-related matters.

Explore the historical Whois records related to stats.do (Domain). Get insights into ownership history and changes over time.

Thailand Number of .th Domain data was reported at 70,211.000 Unit in Nov 2018. This records an increase from the previous number of 69,947.000 Unit for Oct 2018. Thailand Number of .th Domain data is updated monthly, averaging 27,893.500 Unit from Jun 1997 (Median) to Nov 2018, with 258 observations. The data reached an all-time high of 70,211.000 Unit in Nov 2018 and a record low of 558.000 Unit in Aug 1997. Thailand Number of .th Domain data remains active status in CEIC and is reported by ALL.IN.TH. The data is categorized under Global Database’s Thailand – Table TH.TB002: Internet Statistics: Thailand Network Information Center .

Explore the historical Whois records related to stats-watch.com (Domain). Get insights into ownership history and changes over time.