In this dataset, we present data on PFAS measured using nontargeted methods in American Healthy Homes Study (AHHS) II residential tap water. Residential drinking water samples were collected as part of the American Healthy Homes Survey (AHHS) II effort by HUD for surveillance of chemicals of concern. Previous analysis was conducted on the collected media to account for lead, but the stability of PFAS enables follow-up analysis even after lead processing. PFAS were analyzed in ~800 water samples using non-targeted analysis by mass spectrometry. Because the methods are nontargeted and thus performed without prior knowledge of the identity of the PFAS in the sample, values are reported as instrument response integrated areas. This dataset is not publicly accessible because: EPA cannot release personally identifiable information regarding living individuals, according to the Privacy Act and the Freedom of Information Act (FOIA). This dataset contains information about human research subjects. Because there is potential to identify individual participants and disclose personal information, either alone or in combination with other datasets, individual level data are not appropriate to post for public access. Restricted access may be granted to authorized persons by contacting the party listed. It can be accessed through the following means: Data presented in this manuscript is available upon reasonable request by contacting the authors, but locations may be censored to protect confidentiality of study participants. Format: EPA’s Office of Research and Development (ORD) was not directly engaged in the collection of information from human subjects. HUD’s contractor, QuanTech, conducted the field study and collected tap water and house dust samples. QuanTech received IRB Approval CR00077983 for HUD OHHLHC - AHHS II, American Healthy Homes Survey (AHHS) II (Pro00019737). According to the requirements of EPA Order 1000.17 A (Policy and Procedures on Protection of Human Research Subjects) and EPA Regulation 40 CFR 26 (Protection of Human Subjects), it was determined that the EPA investigators were not engaged in human subjects research (HSR-001225). This dataset is associated with the following publication: Boettger, J., N. Deluca, M. Zurek-Ost, K. Miller, C. Fuller, K. Bradham, P. Ashley, W. Friedman, E. Pinzer, D. Cox, G. Dewalt, K. Isaacs, E. Cohen-Hubal, and J. McCord. Emerging Per- and Polyfluoroalkyl Substances in Tap Water from the American Healthy Homes Survey II. ENVIRONMENTAL SCIENCE & TECHNOLOGY. American Chemical Society, Washington, DC, USA, 59(5): 2686–2698, (2025).