EdgeR results from MMGs. Differential expression results calculated by edgeR for MMG counts produced by the stage 2 analysis. Can be downloaded from [43]. (XLSX 428 kb)

Figure S1, Venn diagram showing the number of differentially expressed genes identified by two versions of Cuffdiff2. Figure S2, The effects of biological replicates on the differential expression analysis for Cuffdiff v2.0.2. Figure S3, The detected fold changes of all the differentially expressed genes identified by three tools were compared and shown, including DESeq vs. edgeR (top panel), DESeq vs. Cuffdiff2 (middle panel) and edgeR vs. Cuffdiff2 (bottom panel). File S1, Analysis pipelines, methods and examples of commands for differential expression analysis, subsampling fastq files and generating SAM/BAM files based on simulated count values. File S2, The raw count values for genes with high fold changes were picked up by edgeR but not by DESeq. Genes with high fold changes (the absolute value of log2 fold changes larger than 2) identified as DEGs by edgeR but not by DESeq are listed in the file. The gene ID, the log2 fold changes (logFC) and FDR from DESeq, the logFC and FDR from edgeR, the raw count values for the four replicates of sample K (K1–K4) and sample N (N1–N4) are shown in each of the columns. Table S1, Numbers of reads for the human hbr and uhr samples from the MAQC dataset. Table S2, Numbers of reads for the mouse neurosphere samples for treatment groups of K and N (the K_N dataset). Table S3, The number of reads for each individual sample of the LCL3 dataset. Table S4, The definition for TP, FP, TN, FN, TPR and FPR. Table S5, The false positive rate for Cuffdiff2, DESeq and edgeR based on the LCL1 dataset. (ZIP)

Warden and Wu Preprint: v1

In general, this primarily focuses on the following types of comparisons:

1. Cell line experiments with over-expression or knock-down to define a known causal gene, with processing starting with public reads.
2. Processed TCGA (The Cancer Genome Atlas) data for breast cancer (BRCA) to compare gene expression by immunohistochemistry status (ER/ESR1, PR/PGR, or HER2/ERBB2).

Differential expression methods include the following:

• edgeR (GLM)
• edgeR-robust (GLM)
• edgeR (QL)
• edgeR-robust (QL)
• DESeq1
• DESeq2
• limma-voom
• limma-trend (CPM)
• limma-trend (FPKM/RPKM)
• ANOVA (log2 FRPKM/RPKM)

The most common preprocessing strategies include STAR, TopHat2, and Salmon. However, a limited amount of additional processing with HISAT2, kallisto, Bowtie2 (+eXpress), and Bowtie1 (+RSEM) is also provided.

Most STAR and TopHat2 alignments use htseq-count for quantification, as well as running cuffdiff (for single variable 2-group comparisons). However, a limited amount of additional processing with featureCounts is also provided.

Most STAR and TopHat2 alignments start with the public forward reads, even if paired-end data was available.

A number of factors influence vaccination effectiveness, including age, sex, and comorbidities. A transcriptome analysis was performed via RNA sequencing. The genes with immunological functions are increased in expression in individuals with high pre-existing immunity. Based on the transcriptome analysis, the set of genes can be used to predict a vaccine response.

This data set provides data files and R code to accompany the article Differential methylation analysis of reduced representation bisulfite sequencing experiments using edgeR published by F1000Research. The data consists of Reduced Representation BS-seq methylation profiles of epithelial populations from the mouse mammary gland, with n=2 biological replicates for each of three cell populations. RNA-seq expression profiles of luminal and basal mammary epithelial populations are also provided. The R code undertakes an differential methylation analysis of the BS-seq profiles and demonstrates a strong negative correlation between the differential methylation and differential expression results.

298 Global import shipment records of Lens Edger with prices, volume & current Buyer's suppliers relationships based on actual Global export trade database.

EdgeR results from unique counts. Differential expression results calculated by edgeR for gene counts produced by the stage 1 analysis. Can be downloaded from [43]. (XLSX 2159 kb)

The uploaded files correspond to the following datasets/supporting information: SI 1: Schematic of bioinformatic workflow conducted in this study (PDF). SI 2: Excel file of raw counts of reads mapped to Trinity 'genes' by Kallisto for Pelobates cultripes (spreadsheet 1) and Scaphiopus couchii(spreadsheet 2). The first data column is the Trinity gene identifier for the specie-specific transcriptome, followed by columns of raw counts per sample. The design matrix (spreadsheet 3) indicates which samples belong to which treatment, species and time point. SI 3: Excel file of differential gene expression results as calculated by edgeR's exactTest() function with default settings. Results show pairwise comparisons for each time point (24, 48 or 72 hours; see spreadsheet names) after exposure to reduced water levels to the 24-hour high water control. The data columns refer to: gene_id = Trinity gene identifier, logFC = log fold change, logCPM = log counts per million, FDR = false discovery rate (q value) SI 4: Excel spreadsheet of functional enrichment results from gProfiler. Results show enriched terms for each set of genes (two species and up to three time points, separated into five spreadsheets) identified as differentially expressed by edgeR (SI 2). For descriptions of data columns, see https://biit.cs.ut.ee/gprofiler/gost. The last spreadsheet summarizes overlap of significant enrichment of terms across all five sets. SI 5: Complete lists of ortholgoues detected using the HaMStR pipeline and orhoDB v.9, for Pelobates cultripes (first spreadsheet) and Scaphiopus couchii (second spreadsheet). The data columns refer to: Transcript_ID = Trinity peptide transcript identifiers, OG/OG_name = orthoDB ortholog group identifier/name, DB = orthoDB database, OG_origin = ortholog group origin. SI 6: Thresholding power and dynamic tree cutting for Weighted Gene Correlation Network Analysis (WGCNA). (PDF). SI 7: Excel file of functional enrichment results from gProfiler. Results show enriched terms for each WGCNA module (separated into different spreadsheets). For descriptions of data columns, see https://biit.cs.ut.ee/gprofiler/gost. The last spreadsheet summarizes the significantly enriched terms per module and the response variables that were significantly correlated (p values) with the module eigengene expression (see manuscript text for details). SI 8: Excel file of orthologs that had a significant water effect based on the WGCNA. The data columns refer to: Module = WGCNA module, Ortholog = orthoDB ID (see SI 5), Short Name/ Ortholog description = ortholog name/description, Ensembl = ensembl peptide ID, Gene sig (water) P-Value = gene significance for "water effect" (see manuscript), Edge above 0.025 = boolean if expression correlations > 0.025 (see manuscript), Reactome Pathways = enriched Reactome pathways (for only cyan module). Funding provided by: Ministerio de Economía, Industria y Competitividad, Gobierno de EspañaCrossref Funder Registry ID: http://dx.doi.org/10.13039/501100010198Award Number: CGL2017-83407-P That hardcoded genomes can manifest as plastic phenotypes responding to environmental perturbations is a fascinating feature of living organisms. How such developmental plasticity is regulated at the molecular level is beginning to be uncovered aided by the development of -omic techniques. Here, we compare the transcriptome-wide responses of two species of spadefoot toads with differing capacity for developmental acceleration of their larvae in the face of a shared environmental risk: pond drying. By comparing gene expression profiles over time and performing cross-species network analyses, we identified orthologues and functional gene pathways whose environmental sensitivity in expression have diverged between species. Genes related to lipid, cholesterol and steroid biosynthesis and metabolism make up most of a module of genes environmentally responsive in one species, but canalized in the other. The evolutionary changes in the regulation of the genes identified through these analyses may have been key in the genetic accommodation of developmental plasticity in this system.

Lens Edger Market Outlook

The global lens edger market size was valued at approximately USD 470 million in 2023 and is projected to reach a remarkable USD 690 million by 2032, exhibiting a compound annual growth rate (CAGR) of 4.3% during the forecast period. The market's expansion is primarily driven by the increasing demand for eyewear, propelled by the growing prevalence of vision impairment across the globe, advancements in lens technology, and the rising trend of customized eyewear. These factors continue to stimulate the demand for efficient and accurate lens edging solutions essential for producing high-quality optical lenses.

The lens edger market is witnessing substantial growth due to several prominent factors. A significant driver is the increasing incidence of vision-related issues, such as myopia and presbyopia, driven by lifestyle changes that involve prolonged exposure to digital screens. This growing prevalence necessitates corrective eyewear, thereby fueling the demand for lens edgers in optical shops and eyewear manufacturing facilities. Additionally, advancements in lens materials, such as polycarbonate and high-index plastics, require precise and sophisticated edging technology, further boosting market growth. Furthermore, the shift toward personalized and fashionable eyewear has encouraged optical shops to invest in advanced lens edging equipment to meet diverse consumer preferences.

Technological advancements in lens edging systems have significantly contributed to the growth of the lens edger market. The integration of digital and automated technologies in lens edgers has enhanced precision, efficiency, and productivity, thereby reducing the time required for lens processing. The automation of previously manual tasks has made it easier for optical shops and eyewear manufacturers to produce lenses of varying complexities with consistent quality. This technological evolution is not only attractive to established players but also encourages new entrants to invest in this promising market, thereby expanding the competitive landscape.

Another notable growth factor is the expansion of healthcare infrastructure, particularly in emerging economies. The increasing number of hospitals, clinics, and specialized eye care centers in these regions demands the adoption of advanced lens edging solutions to provide comprehensive eye care services. Furthermore, initiatives by governments and health organizations to address vision impairment issues are promoting the adoption of contemporary optical devices and technologies. With the rise in healthcare spending and the emphasis on improving public health, the lens edger market is poised for significant growth in the upcoming years.

Automatic Eyeglass Edging Machines have become an integral part of modern optical practices, revolutionizing the way lenses are processed and fitted into frames. These machines offer unparalleled precision and efficiency, significantly reducing the time and labor involved in lens edging. By automating complex tasks, they enable optical shops to handle a wide variety of lens materials and prescriptions with ease. The integration of intelligent software in these machines allows for patternless edging, eliminating the need for manual templates and ensuring a perfect fit every time. As the demand for customized eyewear grows, Automatic Eyeglass Edging Machines are increasingly seen as a vital investment for optical retailers looking to enhance their service offerings and maintain a competitive edge in the market.

Regionally, the Asia Pacific holds a substantial share of the lens edger market, driven by the large population base, growing disposable incomes, and increasing awareness about eye health. Countries like China and India are witnessing rapid urbanization and a burgeoning middle class, which contributes to the increasing demand for eyewear products. North America and Europe also exhibit significant market potential due to the high prevalence of vision disorders and the presence of leading optical retailers and manufacturers. The Middle East & Africa and Latin America regions are expected to witness steady growth as awareness about eye care increases and infrastructure improves.

Product Type Analysis

The lens edger market is segmented by product type into manual, automatic, and semi-automatic lens edgers. Manual lens edgers, while traditional, still hold relevance in smaller optical shops and regions where cost constraints are a prima

Explore Market Research Intellect's Glass Edger Market Report, valued at USD 500 million in 2024, with a projected market growth to USD 750 million by 2033, and a CAGR of 5.5% from 2026 to 2033.

Optical Lens Edger Market is Segmented by Type (Manual, Automatic, and More), Application (Eyeglass Lens, Microscope Lens, and More), by End User (Independent Optical Stores, Ophthalmology Hospitals & Clinics, and Others), and Geography. The Market Provides the Value (in USD Million) for the Above-Mentioned Segments.

Optical Lens Edger Market size was valued at USD 518.37 Million in 2024 and is projected to reach USD 837.5 Million by 2032, growing at a CAGR of 6.18% from 2026 to 2032.

Key Market Drivers Increasing Prevalence of Visual Impairments: Visual impairments such as myopia and hyperopia are becoming more common as the world's population ages and screen time grows. This increases the demand for prescription eyewear, which increases the requirement for optical lens edgers to create personalized lenses. Technological Advancements: Innovations in lens edging technology, such as the combination of high-precision cutting and automated systems, improve lens production efficiency and accuracy. These innovations attract investment and adoption by eyewear manufacturers, resulting in market growth. Expansion of Eyewear Fashion Trends: The growing image of eyeglasses as a fashion accessory rather than a vision correction instrument has increased the variety and frequency with which they are purchased. This trend raises demand for a variety of lens designs and finishes, which optical lens edgers generate. Healthcare Expenditure and Accessibility: Rising healthcare spending and improved access to eye care services in emerging economies are making vision correction options more accessible. This expansion contributes to the growth of the optical lens edger market as more consumers seek corrective eyewear options.

Optical Lens Edger Market is segmented By Type (Manual Optical Lens Edger, Automatic Optical Lens Edger, Semi-automatic Optical Lens Edger) andApplication ((Eyeglass Lens, Microscope Lens, Camera Lens, Others (Telescope and Binoculars))

Gardening Electric Edger Market Outlook

The global gardening electric edger market size was valued at approximately USD 1.2 billion in 2023 and is projected to reach around USD 2.5 billion by 2032, growing at a CAGR of 8% during the forecast period. This growth can be attributed to the increasing popularity of home gardening and landscaping activities, as well as advancements in cordless technology that enhance user convenience and product efficiency.

One of the primary growth factors of the gardening electric edger market is the rising trend of home improvement and gardening as a hobby. With an increasing number of people spending more time at home, particularly due to the recent global pandemic, home gardening has seen a significant surge. This has led to a higher demand for garden maintenance tools, including electric edgers, which are pivotal in maintaining neat and well-defined garden edges. Moreover, the inclination towards sustainable and eco-friendly gardening practices has amplified the preference for electric edgers over their gasoline-powered counterparts, which are known for their higher emissions and fuel costs.

The technological advancements in electric gardening tools have also played a crucial role in market growth. Innovations such as improved battery life, lightweight materials, and ergonomic designs have made electric edgers more user-friendly and efficient. Cordless electric edgers, in particular, have seen a surge in demand due to their portability and convenience. These advancements not only enhance user experience but also open up new market opportunities, encouraging more consumers to switch to or upgrade their existing gardening tools.

Additionally, the increasing awareness regarding environmental sustainability is driving the shift from gasoline-powered to electric-powered gardening tools. Governments and environmental organizations worldwide are promoting the use of electric tools to reduce carbon footprints. This trend is significantly influencing consumer preferences, thereby bolstering the demand for electric edgers. Furthermore, the reduction in noise pollution compared to gas-powered models is another factor contributing to their growing popularity, especially in residential areas where noise regulations are stringent.

From a regional perspective, North America currently holds the largest share of the gardening electric edger market, driven by the high disposable income and the widespread culture of home gardening. However, the Asia Pacific region is expected to witness the fastest growth during the forecast period. This rapid growth is fueled by increasing urbanization, rising disposable incomes, and a growing interest in home gardening in countries like China and India. Europe also presents significant growth opportunities, supported by the environmental regulations promoting the use of electric-powered gardening tools.

Product Type Analysis

The gardening electric edger market is segmented into corded electric edgers and cordless electric edgers. Corded electric edgers have traditionally been popular due to their consistent power supply and generally lower cost compared to their cordless counterparts. They are particularly suitable for small to medium-sized gardens where access to power outlets is convenient. However, the limitation of being tethered to a power source can be a significant drawback for larger yards or gardens with complex layouts.

On the other hand, cordless electric edgers are witnessing a surge in popularity due to their portability and the convenience they offer. Powered by rechargeable batteries, these edgers allow users to move freely without being limited by a power cord. Advances in battery technology, such as lithium-ion batteries, have improved the run-time and efficiency of these devices, making them a viable option for both residential and commercial applications. Despite being generally more expensive than corded models, the enhanced flexibility and ease of use make them an attractive choice for consumers.

The shift towards cordless electric edgers is further supported by innovations aimed at improving battery life and reducing charging times. Manufacturers are focusing on integrating fast-charging technologies and producing lightweight, durable batteries to enhance user experience. This segment is expected to see significant growth, especially among consumers looking for hassle-free, high-performance gardening tools.

While corded electric edgers will continue to hold a steady market share, particularly among budget-cons

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Eyeglasses Lens Edger Market Outlook

The global eyeglasses lens edger market size is projected to grow significantly from USD 912 million in 2023 to USD 1,472 million by 2032, registering a compound annual growth rate (CAGR) of 5.5% during the forecast period. The growth of the market is driven by the increasing demand for precision in eyeglass manufacturing and the rising prevalence of vision disorders globally.

One of the primary growth factors for the eyeglasses lens edger market is the heightened demand for personalized eyewear. As consumers increasingly seek customized solutions to fit their specific vision needs and aesthetic preferences, the need for precise lens edging technology grows. Advances in digital measurement technologies have enabled manufacturers to produce lenses with higher accuracy, contributing to market expansion. Additionally, the growing awareness of eye health and the importance of regular eye check-ups have driven consumers towards better-quality eyewear, further bolstering market growth.

Technological advancements in lens edging machines also play a critical role in driving market growth. Innovations such as automated edgers, which offer higher precision and reduced manual labor, are gaining traction. These advanced machines can handle complex and varied lens shapes, catering to the modern demand for diverse frame designs. Furthermore, the integration of digital interfaces and software in lens edgers allows for more efficient operations, real-time adjustments, and better inventory management, making them indispensable for optical businesses.

The increasing prevalence of vision issues, particularly among the aging population, is another significant factor contributing to the market's growth. As the global population ages, conditions such as presbyopia and cataracts become more common, necessitating corrective eyewear. This demographic trend necessitates more advanced and efficient lens edgers to meet the rising demand for eyeglasses. Moreover, the growing screen time among younger populations has led to an increase in vision problems, thereby expanding the customer base for eyeglasses and, consequently, lens edgers.

Regionally, the eyeglasses lens edger market is witnessing substantial growth in Asia Pacific due to its large population base and increasing disposable incomes. Countries like China and India, where the demand for eyewear is rapidly increasing, are significant contributors to this growth. North America and Europe also exhibit strong market dynamics, driven by technological advancements and higher awareness of eye care. These regions are expected to maintain steady growth rates owing to their established healthcare infrastructure and high adoption rates of advanced technologies.

The Eyeglass Lens Grinding Machine is an essential component in the production of high-quality lenses, providing the precision and accuracy needed to meet the demands of modern eyewear. These machines are designed to grind and polish lenses to exact specifications, ensuring that each lens fits perfectly within its frame and provides optimal vision correction. As the demand for customized and complex lens designs increases, the role of grinding machines becomes even more critical. They enable manufacturers to produce lenses that cater to specific vision needs and aesthetic preferences, thereby enhancing the overall quality and functionality of eyewear. The integration of advanced technologies in these machines, such as automated controls and digital interfaces, further improves their efficiency and precision, making them indispensable in the competitive eyewear industry.

Product Type Analysis

The eyeglasses lens edger market is segmented by product type into manual lens edgers, automatic lens edgers, and semi-automatic lens edgers. Manual lens edgers, although traditional, still hold a significant portion of the market due to their affordability and ease of use. These machines are particularly prevalent in smaller optical shops and regions with limited access to advanced technology. However, their market share is gradually declining as automation becomes more widespread and accessible.

Automatic lens edgers are experiencing robust growth owing to their precision, efficiency, and ability to handle a variety of lens shapes and materials. These machines significantly reduce the margin for error and minimize the need for skilled labor, making them a preferred choice for larg

Explore Market Research Intellect's Automatic Lens Edger Machine Market Report, valued at USD 620 million in 2024, with a projected market growth to USD 950 million by 2033, and a CAGR of 5.5% from 2026 to 2033.

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Explore the growth potential of Market Research Intellect's Optical Lens Edger Market Report, valued at USD 450 million in 2024, with a forecasted market size of USD 650 million by 2033, growing at a CAGR of 5.2% from 2026 to 2033.

According to Cognitive Market Research, the global Automatic Lens Edger Machine market size will be USD XX million in 2024. It will expand at a compound annual growth rate (CAGR) of 7.20% from 2024 to 2031.

North America held the major market share for more than 40% of the global revenue with a market size of USD XX million in 2024 and will grow at a compound annual growth rate (CAGR) of 5.4% from 2024 to 2031.
Europe accounted for a market share of over 30% of the global revenue with a market size of USD XX million.
Asia Pacific held a market share of around 23% of the global revenue with a market size of USD XX million in 2024 and will grow at a compound annual growth rate (CAGR) of 9.2% from 2024 to 2031.
Latin America had a market share of more than 5% of the global revenue with a market size of USD XX million in 2024 and will grow at a compound annual growth rate (CAGR) of 6.6% from 2024 to 2031.
Middle East and Africa had a market share of around 2% of the global revenue and was estimated at a market size of USD XX million in 2024 and will grow at a compound annual growth rate (CAGR) of 6.9% from 2024 to 2031.
The Fully Automatic Type category is the fastest growing segment of the Automatic Lens Edger Machine industry

Market Dynamics of Automatic Lens Edger Machine Market

Key Drivers for Automatic Lens Edger Machine Market

Rising Demand For Precision In Eyeglass Manufacturing To Boost Market Growth

The growing need for precision in eyeglass manufacturing is a key factor driving the Automatic Lens Edger Machine Market. As consumers demand high-quality eyewear tailored to their vision requirements, optical labs and manufacturers invest in advanced machinery to ensure accuracy and consistency. Automatic lens edger machines provide precise lens cutting, edging, and shaping, reducing errors and improving efficiency. These machines enable manufacturers to meet the increasing demand for customized eyewear, enhancing both productivity and customer satisfaction. With technological advancements, these machines now offer better control and seamless operations, making them essential tools in modern optical workshops. This focus on precision aligns with the evolving expectations of the eyewear industry, fueling market growth. For instance, in November 2021, Crystalvue launched the Automatic Lens Edger & Tracer (CV-700), an advanced automated workstation designed for lens processing. This innovative device integrates multiple functions including tracing, edging, beveling, grooving, and blocking, all within a single machine.

Increasing Adoption Of Automation In Optical Labs To Drive Market Growth

The growing use of automation in optical labs is a major factor driving the Automatic Lens Edger Machine Market. Optical labs are adopting advanced automated systems to enhance efficiency, reduce manual errors, and speed up production processes. Automatic lens edger machines streamline operations by cutting and shaping lenses with high precision, eliminating the need for manual intervention. This shift towards automation helps labs meet the rising demand for accurate and customized eyewear, while also saving time and labor costs. As technology evolves, these machines are becoming more sophisticated, offering enhanced features for seamless integration into lab workflows. The increasing reliance on automation reflects the industry’s commitment to improving quality and productivity, driving further market growth.

Restraint Factor for the Automatic Lens Edger Machine Market

Limited Adoption In Small-Scale Optical Labs, Will Limit Market Growth

The Automatic Lens Edger Machine Market faces limitations due to side effects associated with prolonged use. While the Automatic Lens Edger Machine is effective in providing quick relief for respiratory conditions, extended or excessive usage can lead to adverse effects such as increased heart rate, tremors, headaches, and muscle cramps. In some cases, patients may develop tolerance, requiring higher doses for the same effect, which further raises the risk of side effects. These concerns make healthcare providers cautious about long-term prescriptions, impacting the market’s growth. Additionally, patients may seek alternative therapies with fewer side effects, reducing dependence on Automatic Lens Edger Machine. As awareness of these risks increases, it emphasizes the need for better management strategies, which could influence t...