It is estimated that the largest cities in Western Europe in 1330 were Paris and Granada. At this time, Paris was the seat of power in northern France, while Granada had become the largest multicultural city in southern Spain, controlled by the Muslim, Nasrid Kingdom during Spain's Reconquista period. The next three largest cities were Venice, Genoa and Milan, all in northern Italy, renowned as important trading cities during the middle ages. In October 1347, the first wave of the Black Death had arrived in Sicily and then began spreading throughout Europe, decimating the population.

Throughout the Common Era, Western Europe's population development fluctuated greatly. The population was very similar at the beginning and end of the first millennium, at around 25 million people. The largest decline in this period occurred in the sixth century, due to the Plague of Justinian, which the source claims to have killed around one third of the continent's population (although recent studies dispute this). Similarly, the population fell by almost 17 million throughout the 14th century, due to the Black Death.

Improvements in agriculture and infrastructure then saw population growth increase once more from the 15th century onwards, before the onset of the demographic transition saw a population boom throughout the 19th and 20th centuries.

The earliest point where scientists can make reasonable estimates for the population of global regions is around 10,000 years before the Common Era (or 12,000 years ago). Estimates suggest that Asia has consistently been the most populated continent, and the least populated continent has generally been Oceania (although it was more heavily populated than areas such as North America in very early years). Population growth was very slow, but an increase can be observed between most of the given time periods. There were, however, dips in population due to pandemics, the most notable of these being the impact of plague in Eurasia in the 14th century, and the impact of European contact with the indigenous populations of the Americas after 1492, where it took almost four centuries for the population of Latin America to return to its pre-1500 level. The world's population first reached one billion people in 1803, which also coincided with a spike in population growth, due to the onset of the demographic transition. This wave of growth first spread across the most industrially developed countries in the 19th century, and the correlation between demographic development and industrial or economic maturity continued until today, with Africa being the final major region to begin its transition in the late-1900s.

It is estimated that, between the 14th and 19th centuries, fewer than 10 percent of Europe's population lived in urban areas with a population of more than 10,000 people, and fewer than 13 percent lived in urban areas with more than 5,000 people. The two given sources use different methodologies* for their estimates, which gives varying but comparable estimates for urbanization rates across Europe. Perhaps surprisingly, Bairoch estimates that the urbanization rate increased during the 14th century, a period where Europe's population fell by 25-33 percent due to the Black Death. From the 19th century onwards, urbanization in Europe rose significantly due to the rise of industrialization and increased agricultural efficiency.

The Italian city of Venice was one of the largest cities in medieval and Renaissance era Europe. It was the center of the Republic of Venice, a maritime empire in the Mediterranean, and had one of Europe's largest ports for exotic goods (particularly from Asia), or luxury goods such as glassware. Impact of plague While its population was relatively small by modern standards, it is believed that Venice was among the five most populous cities in Western Europe in the given years between 1050 and 1650. The city's population did fluctuate over time due to devastating pandemics, and it is believed that Venice was one of the main points of entry for the Black Death in Europe. Venice was one of the hardest-hit cities during the Black Death; estimates fluctuate greatly across sources, but it is believed that the city lost around 40 percent of its population during the initial outbreak in the 1340s. Decline Furthermore, Venice lost roughly a third of its population during further plague pandemics (both introduced via war) in the 1570s and 1630s. Because of this, the population was kept fairly consistent across the given years between 1600 and 1800. The 18th century also saw the decline of the Venetian Empire, as other states gained power and influence in the Mediterranean. Venice also lost its importance as the entry point of exotic goods into Europe, as other European powers had already established their own maritime empires and trade routes across the globe. Eventually, the crumbling Venetian Empire fell to Napoleon in 1796, and its overseas territories were gradually taken by or split among various other powers. While the empire fell, the city itself continued to be a center for art and culture in Europe, and it has maintained this status until today. In 2021, Venice had a population of more than 250,000 people.

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In 1500, the largest city was Paris, with an estimated 225 thousand inhabitants, almost double the population of the second-largest city, Naples. As in 1330, Venice and Milan remain the third and fourth largest cities in Western Europe, however Genoa's population almost halved from 1330 until 1500, as it was struck heavily by the bubonic plague in the mid-1300s. In lists prior to this, the largest cities were generally in Spain and Italy, however, as time progressed, the largest populations could be found more often in Italy and France. The year 1500 is around the beginning of what we now consider modern history, a time that saw the birth of many European empires and inter-continental globalization.

The world's Jewish population has had a complex and tumultuous history over the past millennia, regularly dealing with persecution, pogroms, and even genocide. The legacy of expulsion and persecution of Jews, including bans on land ownership, meant that Jewish communities disproportionately lived in urban areas, working as artisans or traders, and often lived in their own settlements separate to the rest of the urban population. This separation contributed to the impression that events such as pandemics, famines, or economic shocks did not affect Jews as much as other populations, and such factors came to form the basis of the mistrust and stereotypes of wealth (characterized as greed) that have made up anti-Semitic rhetoric for centuries. Development since the Middle Ages The concentration of Jewish populations across the world has shifted across different centuries. In the Middle Ages, the largest Jewish populations were found in Palestine and the wider Levant region, with other sizeable populations in present-day France, Italy, and Spain. Later, however, the Jewish disapora became increasingly concentrated in Eastern Europe after waves of pogroms in the west saw Jewish communities move eastward. Poland in particular was often considered a refuge for Jews from the late-Middle Ages until the 18th century, when it was then partitioned between Austria, Prussia, and Russia, and persecution increased. Push factors such as major pogroms in the Russian Empire in the 19th century and growing oppression in the west during the interwar period then saw many Jews migrate to the United States in search of opportunity.

It is only in the past two centuries where demographics and the development of human populations has emerged as a subject in its own right, as industrialization and improvements in medicine gave way to exponential growth of the world's population. There are very few known demographic studies conducted before the 1800s, which means that modern scholars have had to use a variety of documents from centuries gone by, along with archeological and anthropological studies, to try and gain a better understanding of the world's demographic development. Genealogical records One such method is the study of genealogical records from the past; luckily, there are many genealogies relating to European families that date back as far as medieval times. Unfortunately, however, all of these studies relate to families in the upper and elite classes; this is not entirely representative of the overall population as these families had a much higher standard of living and were less susceptible to famine or malnutrition than the average person (although elites were more likely to die during times of war). Nonetheless, there is much to be learned from this data. Impact of the Black Death In the centuries between 1200 and 1745, English male aristocrats who made it to their 21st birthday were generally expected to live to an age between 62 and 72 years old. The only century where life expectancy among this group was much lower was in the 1300s, where the Black Death caused life expectancy among adult English noblemen to drop to just 45 years. Experts assume that the pre-plague population of England was somewhere between four and seven million people in the thirteenth century, and just two million in the fourteenth century, meaning that Britain lost at least half of its population due to the plague. Although the plague only peaked in England for approximately eighteen months, between 1348 and 1350, it devastated the entire population, and further outbreaks in the following decades caused life expectancy in the decade to drop further. The bubonic plague did return to England sporadically until the mid-seventeenth century, although life expectancy among English male aristocrats rose again in the centuries following the worst outbreak, and even peaked at more than 71 years in the first half of the sixteenth century.