In 2023, around 72,776 people in the United States died from a drug overdose that involved fentanyl. This was the second-highest number of fentanyl overdose deaths ever recorded in the United States, and a significant increase from the number of deaths reported in 2019. Fentanyl overdoses are now the driving force behind the opioid epidemic, accounting for the majority of overdose deaths in the United States. What is fentanyl? Fentanyl is an extremely potent synthetic opioid similar to morphine, but more powerful. It is a prescription drug but is also manufactured illegally and is sometimes mixed with other illicit drugs such as heroin and cocaine, often without the user’s knowledge. The potency of fentanyl makes it very addictive and puts users at a high risk for overdose. Illegally manufactured fentanyl has become more prevalent in the United States in recent years, leading to a huge increase in drug overdose deaths. In 2022, the rate of drug overdose death involving fentanyl was 22.7 per 100,000 population, compared to a rate of just one per 100,000 population in the year 2013. Fentanyl overdoses by gender and race/ethnicity As of 2022, the rate of drug overdose deaths involving fentanyl in the United States is over two times higher among men than women. Rates of overdose death involving fentanyl were low for both men and women until around the year 2014 when they began to quickly increase, especially for men. In 2022, there were around 19,880 drug overdose deaths among women that involved fentanyl compared to 53,958 such deaths among men. At that time, the rate of fentanyl overdose deaths was highest among non-Hispanic American Indian or Alaska Natives and lowest among non-Hispanic Asians. However, from the years 2014 to 2018, non-Hispanic whites had the highest fentanyl overdose death rates.

The graph illustrates the number of deaths from fentanyl in the United States from 1999 to 2022. The x-axis represents the years, spanning from '99 to '22, while the y-axis displays the annual number of fentanyl-related fatalities. Over this 24-year period, deaths rise dramatically from 730 in 1999 to a peak of 73,838 in 2022. Notable milestones include an increase to 1,742 deaths in 2005, a significant jump to 9,580 in 2015, and a sharp escalation to 70,601 deaths by 2021. The data reveals a consistent and severe upward trend in fentanyl-related deaths, particularly accelerating in the mid-2010s. This information is presented in a line graph format, effectively highlighting the dramatic increase in fatalities due to fentanyl across the United States over the specified years.

In 2023, there were around ** overdose deaths involving fentanyl among non-Hispanic American Indian and Alaska natives in the United States per 100,000 population, making it the most affected ethnicity among every other in the analyzed period.

The graph displays the number of drug overdose deaths in the U.S. from 2003 to 2023, with the x-axis representing the years and the y-axis showing the total overdose deaths each year. The data reveals a steady increase in deaths from 25,785 in 2003 to over 107,000 in 2022, highlighting the growing severity of the overdose crisis. The highest number of deaths occurred in 2022 (107,941), while 2023 saw a slight decrease to 105,007 deaths. A sharp rise is observed between 2015 and 2021, coinciding with the opioid epidemic and increased fentanyl-related overdoses. The data underscores the urgent need for stronger prevention and intervention efforts.

This data presents provisional counts for drug overdose deaths based on a current flow of mortality data in the National Vital Statistics System. Counts for the most recent final annual data are provided for comparison. National provisional counts include deaths occurring within the 50 states and the District of Columbia as of the date specified and may not include all deaths that occurred during a given time period. Provisional counts are often incomplete and causes of death may be pending investigation resulting in an underestimate relative to final counts. To address this, methods were developed to adjust provisional counts for reporting delays by generating a set of predicted provisional counts. Several data quality metrics, including the percent completeness in overall death reporting, percentage of deaths with cause of death pending further investigation, and the percentage of drug overdose deaths with specific drugs or drug classes reported are included to aid in interpretation of provisional data as these measures are related to the accuracy of provisional counts. Reporting of the specific drugs and drug classes involved in drug overdose deaths varies by jurisdiction, and comparisons of death rates involving specific drugs across selected jurisdictions should not be made. Provisional data presented will be updated on a monthly basis as additional records are received. For more information please visit: https://www.cdc.gov/nchs/nvss/vsrr/drug-overdose-data.htm

In 2024, there were a total of 7,146 deaths in Canada due to opioid overdose, with around 74 percent of these deaths involving fentanyl. This statistic shows the share of deaths from opioid overdose in Canada from 2016 to 2024 that involved select drugs.

Network of 46 papers and 57 citation links related to "Co-occurring Illicit Fentanyl Use and Psychiatric Disorders in Emergency Department Patients".

Network of 27 papers and 32 citation links related to "Multifactorial analysis of the effect of fentanyl on nociceptive hemodynamic responses".

In 2024, there were a total of 7,146 deaths in Canada due to opioid overdose, with around 28 percent of deaths occurring among those aged 30 to 39 years. This statistic shows the distribution of deaths from opioid overdose in Canada from 2016 to 2024, by age.

Network of 34 papers and 51 citation links related to "Analgesic effects of combined regular acetaminophen drip infusion and constant fentanyl infusion after thoracotomy".

Rank, number of deaths, percentage of deaths, and age-specific mortality rates for the leading causes of death, by age group and sex, 2000 to most recent year.

BackgroundPost-induction hypotension (PIH) is a common complication associated with anesthesia, particularly in high-risk groups, such as elderly, malnourished patients with multiple comorbidities undergoing thoracoscopic esophagectomy. The selection of induction agents plays a significant role in influencing hemodynamic stability. However, there is a lack of comprehensive comparative data regarding the impact of different opioid agents on PIH.MethodsThis retrospective cohort study included 289 patients undergoing thoracoscopic esophagectomy, who received etomidate combined with either fentanyl (Fentanyl group) or remifentanil (Remifentanil group) for anesthesia induction. A logistic regression model was used to examine the association between the induction regimen and PIH. Confounding factors were adjusted using a directed acyclic graph, and least absolute shrinkage and selection operator (LASSO) regression was employed to select covariates, ensuring robustness of the primary outcome analysis. Hemodynamic changes in systolic blood pressure, mean arterial pressure, and heart rate during the first 15 min post-induction were analyzed using generalized estimating equations to account for correlated observations. Subgroup analyses were performed for key clinical subgroups.ResultsAmong 289 patients analyzed, the incidence of PIH was significantly lower in the Remifentanil group compared to the Fentanyl group (23.7% vs. 42.3%, P = 0.001; adjusted odds ratio (OR) = 0.42, 95% confidence interval (CI): 0.25–0.73). Sensitivity analysis using LASSO-selected covariates yielded consistent results (adjusted OR = 0.41, 95% CI: 0.22–0.69, P = 0.001). Bradycardia occurred more frequently with remifentanil (11.9% vs. 4.5%, P = 0.03), whereas post-intubation hypertension and phenylephrine use were higher in the fentanyl group. No significant differences were observed in cardiovascular complications or postoperative hospital stay. Subgroup analyses revealed no significant effect modification across age, hemoglobin, or albumin levels. Remifentanil was also associated with more stable hemodynamics, including attenuated systolic blood pressure decline and lower variability during the first 15 min post-induction.ConclusionRemifentanil-based general anesthesia induction reduces the risk of PIH and enhances hemodynamic stability in patients undergoing thoracoscopic esophagectomy.

Introduction

Opioid Statistics: Opioids are a class of drugs that bind to opioid receptors in the brain and nervous system to relieve pain. But they also pose significant risks, including addiction and overdose.

They are categorized into natural opioids (like morphine), semi-synthetic opioids (such as oxycodone), and synthetic opioids (including fentanyl).

While they are effective for managing severe pain and are used in anesthesia. Their misuse has led to a major public health crisis characterized by high addiction rates and overdose deaths.

Efforts to address this crisis involve stricter prescription guidelines, enhanced addiction treatment, and public health initiatives aimed at reducing misuse and improving safety.

During 2024, there were a total of 7,146 deaths from opioid overdose in Canada, 2,231 of which occurred in the province of Ontario. This statistic shows the number of deaths from opioid overdose in Canada in 2024, by province. Opioid Use and Misuse Opioids are commonly prescribed as both short-term and long-term pain management strategies. Unfortunately, opioids are sometimes used problematically, including taking increased amounts, tampering with the route of administration, or using with the goal to improve mood, all of which can lead to addiction, overdose, and even death. In 2023, there were around 6,462 hospitalizations in Canada due to opioid poisoning. Opioid Crisis in Canada Among Canadian adults, the majority view the opioid issues of the country as a serious problem or a crisis. Moreover, many opioid deaths also involve the use of a stimulant, which adds to the polysubstance nature of the opioid crisis. Efforts against the opioid crisis in Canada are multi-faceted. One way is focused on reducing possible harm from using illicit opioid sources such as heroin or other street opioids through the use of opioid agonist treatment methods including methadone and naloxone.

Network of 24 papers and 34 citation links related to "Placental transfer of temazepam and fentanyl in early human pregnancy".

Network of 45 papers and 71 citation links related to "Motor blocks and operative deliveries with ropivacaine and fentanyl for labor epidural analgesia: A meta‐analysis".

BackgroundIn neonates, uncontrolled pain and opioid exposure are both correlated with short- and long-term adverse events. Therefore, managing pain using opioid-sparing approaches is critical in neonatal populations. Multimodal pain control offers the opportunity to manage pain while reducing short- and long-term opioid-related adverse events. Intravenous (IV) acetaminophen may represent an appropriate adjunct to opioid-based postoperative pain control regimes. However, no trials assess this drug in patients less than 36 weeks post-conceptual age or weighing less than 1500 g.ObjectiveThe proposed study aims to determine the feasibility of conducting a randomized control trial to compare IV acetaminophen and fentanyl to a saline placebo and fentanyl for patients admitted to the neonatal intensive care unit (NICU) undergoing major abdominal or thoracic surgery.Methods and designThis protocol is for a single-centre, external pilot randomized controlled trial (RCT). Infants in the NICU who have undergone major thoracic or abdominal surgery will be enrolled. Sixty participants will undergo 1:1 randomization to receive intravenous acetaminophen and fentanyl or saline placebo and fentanyl. After surgery, IV acetaminophen or placebo will be given routinely for eight days (192 hours). Appropriate dosing will be determined based on the participant’s gestational age. Patients will be followed for eight days after surgery and will undergo a chart review at 90 days. Primarily feasibility outcomes include recruitment rate, follow-up rate, compliance, and blinding index. Secondary clinical outcomes will be collected as well.ConclusionThis external pilot RCT will assess the feasibility of performing a multicenter RCT comparing IV acetaminophen and fentanyl to a saline placebo and fentanyl in NICU patients following major abdominal and thoracic surgery. The results will inform the design of a multicenter RCT, which will have the appropriate power to determine the efficacy of this treatment.Trial registrationClinicalTrials.gov NCT05678244, Registered December 6, 2022.

During 2023, the Italian police reported *** deaths from drug misuse across the country. This statistic breaks down this figure by region where these deaths occurred. According to the data, Veneto, Emilia-Romagna, and Tuscany, were the regions where the most drug-related deaths were recorded. Drug deaths by age, gender, and type of drug To heroin were attributed most of drug-related deaths in Italy, with ** deaths out of 227 reported in 2023. The second most common drug that implicated deaths in Italy was cocaine, with ** cases, while ** drug misuse deaths were attributed to unknown substances in the same year. The majority of those who died because of drug misuse in this year in Italy were adults aged 40 years or older, with *** and ** deaths recorded among men and women in this age category, respectively. Since 2011, the number of deaths due to drug use have been significantly higher among men compared to women, although this figure has significantly decreased for men over time. Treatment for drug addiction in Italy As of 2022, there were over six hundred outpatient facilities in Italy that offered services for the treatment, prevention, and rehabilitation of people with drug addiction. These facilities served over *** thousand people struggling with drug addiction, the majority of whom used opioids as their primary substance of abuse at ** percent. The highest number of patients were aged between 45 and 49 years old, numbering ****** patients in total. This was closely followed by the age group from 50 to 54 years old, with ****** patients.