20 datasets found
  1. Number of influenza deaths in the United States from 2011-2024

    • statista.com
    Updated Nov 15, 2024
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    Statista (2024). Number of influenza deaths in the United States from 2011-2024 [Dataset]. https://www.statista.com/statistics/1124915/flu-deaths-number-us/
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    Dataset updated
    Nov 15, 2024
    Dataset authored and provided by
    Statistahttp://statista.com/
    Area covered
    United States
    Description

    The burden of influenza in the United States can vary from year to year depending on which viruses are circulating, how many people receive an influenza vaccination, and how effective the vaccination is in that particular year. During the 2023-2024 flu season, around 28,000 people lost their lives to the disease. Although most people recover from influenza without needing medical care, the disease can be deadly among young children, the elderly, and those with weakened immune systems or chronic illnesses. Deaths due to influenza Even though most people recover from influenza without medical care, influenza and pneumonia can be deadly, especially for older people and those with certain preexisting conditions. Influenza is a common cause of pneumonia and although most cases of influenza do not develop into pneumonia, those that do are often more severe and more deadly. Deaths due to influenza are most common among the elderly, with a mortality rate of around 32 per 100,000 population during the 2023-2024 flu season. In comparison, the mortality rate for those aged 50 to 64 years was 9.1 per 100,000 population. Flu vaccinations The most effective way to prevent influenza is to receive an annual influenza vaccination. These vaccines have proven to be safe and are usually cheap and easily accessible. Nevertheless, every year a large share of the population in the United States still fails to get vaccinated against influenza. For example, in the 2022-2023 flu season, only 35 percent of those aged 18 to 49 years received a flu vaccination. Unsurprisingly, children and the elderly are the most likely to get vaccinated. It is estimated that during the 2022-2023 flu season, vaccinations prevented over 929 thousand influenza cases among children aged 6 months to 4 years.

  2. Mortality rate for influenza in the U.S. in 2023-2024, by age group

    • statista.com
    Updated Nov 15, 2024
    + more versions
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    Statista (2024). Mortality rate for influenza in the U.S. in 2023-2024, by age group [Dataset]. https://www.statista.com/statistics/1127799/influenza-us-mortality-rate-by-age-group/
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    Dataset updated
    Nov 15, 2024
    Dataset authored and provided by
    Statistahttp://statista.com/
    Time period covered
    2023 - 2024
    Area covered
    United States
    Description

    The mortality rate from influenza in the United States is by far highest among those aged 65 years and older. During the 2023-2024 flu season, the mortality rate from influenza for this age group was around 32.1 per 100,000 population. The burden of influenza The impact of influenza in the U.S. varies from season to season, but in the 2023-2024 flu season, there were an estimated 40 million cases. These cases resulted in around 470,000 hospitalizations. Although most people recover from influenza without requiring medical treatment, the disease can be deadly for young children, the elderly, and those with weakened immune systems or chronic illnesses. During the 2023-2024 flu season, around 28,000 people in the U.S. lost their lives due to influenza. Impact of vaccinations The most effective way to prevent influenza is to receive an annual vaccination at the beginning of flu season. Flu vaccines are safe and can greatly reduce the burden of the disease. During the 2022-2023 flu season, vaccinations prevented around 2,479 deaths among those aged 65 years and older. Although flu vaccines are usually cheap and easily accessible, every year a large share of the population in the U.S. still does not get vaccinated. For example, during the 2022-2023 flu season, only about 35 percent of those aged 18 to 49 years received a flu vaccination.

  3. Influenza Mortality

    • nationmaster.com
    Updated Jan 5, 2021
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    NationMaster (2021). Influenza Mortality [Dataset]. https://www.nationmaster.com/nmx/ranking/influenza-mortality
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    Dataset updated
    Jan 5, 2021
    Dataset authored and provided by
    NationMaster
    License

    Attribution-NonCommercial 4.0 (CC BY-NC 4.0)https://creativecommons.org/licenses/by-nc/4.0/
    License information was derived automatically

    Time period covered
    1960 - 2019
    Area covered
    Spain, United States, South Africa, Canada, Australia, Chile, Brazil, Iceland, United Kingdom, Netherlands
    Description

    Australia Influenza Mortality jumped by 8% in 2019, from a year earlier.

  4. COVID-19, pneumonia, and influenza deaths reported in the U.S. August 21,...

    • statista.com
    Updated Aug 21, 2023
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    Statista (2023). COVID-19, pneumonia, and influenza deaths reported in the U.S. August 21, 2023 [Dataset]. https://www.statista.com/statistics/1113051/number-reported-deaths-from-covid-pneumonia-and-flu-us/
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    Dataset updated
    Aug 21, 2023
    Dataset authored and provided by
    Statistahttp://statista.com/
    Area covered
    United States
    Description

    Over 12 million people in the United States died from all causes between the beginning of January 2020 and August 21, 2023. Over 1.1 million of those deaths were with confirmed or presumed COVID-19.

    Vaccine rollout in the United States Finding a safe and effective COVID-19 vaccine was an urgent health priority since the very start of the pandemic. In the United States, the first two vaccines were authorized and recommended for use in December 2020. One has been developed by Massachusetts-based biotech company Moderna, and the number of Moderna COVID-19 vaccines administered in the U.S. was over 250 million. Moderna has also said that its vaccine is effective against the coronavirus variants first identified in the UK and South Africa.

  5. Number of influenza cases in the United States from 2011-2024

    • statista.com
    Updated Apr 14, 2025
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    Statista (2025). Number of influenza cases in the United States from 2011-2024 [Dataset]. https://www.statista.com/statistics/861113/estimated-number-of-flu-cases-us/
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    Dataset updated
    Apr 14, 2025
    Dataset authored and provided by
    Statistahttp://statista.com/
    Area covered
    United States
    Description

    Influenza, also called the flu, is one of the most infectious diseases worldwide. Its symptoms range from mild to severe, and include sore throat, cough, runny nose, fever, headache, and muscle pain, but can also cause severe illness and death among high-risk populations such as the elderly and children. During the 2023-2024 flu season, there were 40 million cases of influenza in the United States. Influenza deaths Although influenza does not require medical attention for most people, it can be deadly, and causes thousands of deaths every year. The impact of influenza varies from year to year. The number of influenza deaths during the 2023-2024 flu season was 27,965. The vast majority of deaths attributed to influenza during the 2023-2024 flu season occurred among those aged 65 years and older. Vaccination An annual influenza vaccination remains the most effective way of preventing influenza. During the 2022-2023 flu season, influenza vaccinations prevented an estimated 2,479 deaths among U.S. adults aged 65 years and older. Although, flu vaccinations are accessible and cheap, a large share of the United States population still fails to get vaccinated every year. In 2022-2023, only 35 percent of those aged 18 to 49 years received a flu vaccination, much lower compared to children and the elderly.

  6. Deaths by influenza and pneumonia in the U.S. 1950-2023

    • statista.com
    • abripper.com
    Updated Nov 29, 2025
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    Statista (2025). Deaths by influenza and pneumonia in the U.S. 1950-2023 [Dataset]. https://www.statista.com/statistics/184574/deaths-by-influenza-and-pneumonia-in-the-us-since-1950/
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    Dataset updated
    Nov 29, 2025
    Dataset authored and provided by
    Statistahttp://statista.com/
    Area covered
    United States
    Description

    Influenza and pneumonia caused around 10.9 deaths in the U.S. per 100,000 population in 2023. Influenza, or the flu, is a viral infection that is highly contagious and especially common in the winter season. Influenza is a common cause of pneumonia, although most cases of the flu do not develop into pneumonia. Pneumonia is an infection or inflammation of the lungs and is particularly deadly among young children and the elderly. Influenza cases Influenza is very common in the United States, with an estimated 40 million cases reported in 2023-2024. Common symptoms of the flu include cough, fever, runny or stuffy nose, sore throat and headache. Symptoms can be mild but can also be severe enough to require medical attention. In 2023-2024, there were around 18 million influenza-related medical visits in the United States. Prevention To prevent contracting the flu, people can take everyday precautions such as regularly washing their hands and avoiding those who are sick, but the best way to prevent the flu is by receiving the flu vaccination every year. Receiving a flu vaccination is especially important for young children and the elderly, as they are most susceptible to flu complications and associated death. In 2024, around 70 percent of those aged 65 years and older received a flu vaccine, while only 33 percent of those aged 18 to 49 years had done so.

  7. Leading causes of death, total population, by age group

    • www150.statcan.gc.ca
    • ouvert.canada.ca
    • +1more
    Updated Feb 19, 2025
    + more versions
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    Government of Canada, Statistics Canada (2025). Leading causes of death, total population, by age group [Dataset]. http://doi.org/10.25318/1310039401-eng
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    Dataset updated
    Feb 19, 2025
    Dataset provided by
    Statistics Canadahttps://statcan.gc.ca/en
    Area covered
    Canada
    Description

    Rank, number of deaths, percentage of deaths, and age-specific mortality rates for the leading causes of death, by age group and sex, 2000 to most recent year.

  8. COVID-19 Country Data

    • kaggle.com
    zip
    Updated May 3, 2020
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    Patrick (2020). COVID-19 Country Data [Dataset]. https://www.kaggle.com/datasets/bitsnpieces/covid19-country-data/code
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    zip(190821 bytes)Available download formats
    Dataset updated
    May 3, 2020
    Authors
    Patrick
    License

    http://opendatacommons.org/licenses/dbcl/1.0/http://opendatacommons.org/licenses/dbcl/1.0/

    Description

    Motivation

    Why did I create this dataset? This is my first time creating a notebook in Kaggle and I am interested in learning more about COVID-19 and how different countries are affected by it and why. It might be useful to compare different metrics between different countries. And I also wanted to participate in a challenge, and I've decided to join the COVID-19 datasets challenge. While looking through the projects, I noticed https://www.kaggle.com/koryto/countryinfo and it inspired me to start this project.

    Method

    My approach is to scour the Internet and Kaggle looking for country data that can potentially have an impact on how the COVID-19 pandemic spreads. In the end, I ended up with the following for each country:

    • Monthly temperature and precipitation from Worldbank
    • Latitude and longitude
    • Population, density, gender and age
    • Airport traffic from Worldbank
    • COVID-19 date of first case and number of cases and deaths as of March 26, 2020
    • 2009 H1N1 flu pandemic cases and deaths obtained from Wikipedia
    • Property affordability index and Health care index from Numbeo
    • Number of hospital beds and ICU beds from Wikipedia
    • Flu and pneumonia death rate from Worldlifeexpectancy.com (Age Adjusted Death Rate Estimates: 2017)
    • School closures due to COVID-19
    • Number of COVID-19 tests done
    • Number of COVID-19 genetic strains
    • US Social Distancing Policies from COVID19StatePolicy’s SocialDistancing repository on GitHub
    • DHL Global Connectedness Index 2018 (People Breadth scores)
    • Datasets have been merged by country name whenever possible. I needed to rename some countries by hand, e.g. US to United Sates, etc. but it's possible that I might have missed some. See the output file covid19_merged.csv for the merged result.

    See covid19_data - data_sources.csv for data source details.

    Notebook: https://www.kaggle.com/bitsnpieces/covid19-data

    Caveats

    Since I did not personally collect each datapoint, and because each datasource is different with different objectives, collected at different times, measured in different ways, any inferences from this dataset will need further investigation.

    Other interesting sources of information

    Acknowledgements

    I want to acknowledge the authors of the datasets that made their data publicly available which has made this project possible. Banner image is by Brian.

    I hope that the community finds this dataset useful. Feel free to recommend other datasets that you think will be useful / relevant! Thanks for looking.

  9. COVID-19 deaths worldwide as of May 2, 2023, by country and territory

    • statista.com
    Updated Nov 19, 2025
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    Statista (2025). COVID-19 deaths worldwide as of May 2, 2023, by country and territory [Dataset]. https://www.statista.com/statistics/1093256/novel-coronavirus-2019ncov-deaths-worldwide-by-country/
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    Dataset updated
    Nov 19, 2025
    Dataset authored and provided by
    Statistahttp://statista.com/
    Time period covered
    May 2, 2023
    Area covered
    Worldwide
    Description

    As of May 2, 2023, the outbreak of the coronavirus disease (COVID-19) had spread to almost every country in the world, and more than 6.86 million people had died after contracting the respiratory virus. Over 1.16 million of these deaths occurred in the United States.

    Waves of infections Almost every country and territory worldwide have been affected by the COVID-19 disease. At the end of 2021 the virus was once again circulating at very high rates, even in countries with relatively high vaccination rates such as the United States and Germany. As rates of new infections increased, some countries in Europe, like Germany and Austria, tightened restrictions once again, specifically targeting those who were not yet vaccinated. However, by spring 2022, rates of new infections had decreased in many countries and restrictions were once again lifted.

    What are the symptoms of the virus? It can take up to 14 days for symptoms of the illness to start being noticed. The most commonly reported symptoms are a fever and a dry cough, leading to shortness of breath. The early symptoms are similar to other common viruses such as the common cold and flu. These illnesses spread more during cold months, but there is no conclusive evidence to suggest that temperature impacts the spread of the SARS-CoV-2 virus. Medical advice should be sought if you are experiencing any of these symptoms.

  10. The FluPRINT

    • kaggle.com
    zip
    Updated Mar 1, 2019
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    LogIN (2019). The FluPRINT [Dataset]. https://www.kaggle.com/genular/fluprint
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    zip(121090 bytes)Available download formats
    Dataset updated
    Mar 1, 2019
    Authors
    LogIN
    License

    Attribution 4.0 (CC BY 4.0)https://creativecommons.org/licenses/by/4.0/
    License information was derived automatically

    Description

    https://fluprint.com/about/section_1.png" alt="Influenza vaccination responders">

    The problem

    Influenza virus has a devastating societal impact, causing up to 650,000 deaths every year worldwide. Specifically, vulnerable are children and elderly. It is estimated that 1 in 1000 children and elderly every year are hospitalized due to influenza infection. Vaccination can prevent influenza-like illnesses, and thus lower the risk of the virus outbreak. However, currently available vaccines do not always provide protection, even among otherwise-healthy people, leading to serious pandemics. Development of better vaccines depends on our understanding why current vaccines work in some individuals, while fail in others.

    About dataset

    The FluPRINT is the name of a unified database for a large-scale study exploring novel cellular and molecular underpinnings of successful immunity to influenza vaccines. It contains information on more than 3,000 parameters measured using mass cytometry, flow cytometry, phosphorylation-specific cytometry (phospho-flow), multiplex ELISA, clinical lab tests (hormones and complete blood count), serological profiling with hemagglutination inhibition assay, and virological tests. The dataset represents fully integrated and normalized immunology measurements from 747 individuals from eight clinical studies conducted between 2007 to 2015 at the Human Immune Monitoring Center of Stanford University. The dataset represents a unique source in terms of value and scale, which will broaden our understanding of influenza immunity.

    Additional info: https://zenodo.org/record/3222451#.XOb7MaR7lPY

    Citation

    Tomic A, Tomic I, Dekker CL, Maecker HT and Davis MM. The FluPRINT dataset, a multidimensional analysis of the influenza vaccine imprint on the immune system. Sci Data, doi: 10.1038/s41597-019-0213-4, 2019. 
    
  11. f

    Demographic characteristics of influenza-like illness (ILI) and severe acute...

    • plos.figshare.com
    • datasetcatalog.nlm.nih.gov
    xls
    Updated Jun 21, 2023
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    Ivy Asantewaa Asante; Anne T. Fox; Eric Behene; Yaw Awuku-Larbi; Erasmus Nikoi Kotey; Stephen Nyarko; Richard Asomadu Obeng; Augustina Arjarquah; Gifty Mawuli; Vanessa Magnusen; Naiki Puplampu Attram; Shirley Nimo-Paintsil; Franklin Asiedu-Bekoe; Dennis Odai Laryea; Obed Bangdome Ofori; Edward Owusu Nyarko; Daniel Lartei Mingle; William Asiedu; Andrew Letizia; Terrel Sanders; William Kwabena Ampofo (2023). Demographic characteristics of influenza-like illness (ILI) and severe acute respiratory illness (SARI) cases in Ghana from 2011 to 2019. [Dataset]. http://doi.org/10.1371/journal.pgph.0001104.t001
    Explore at:
    xlsAvailable download formats
    Dataset updated
    Jun 21, 2023
    Dataset provided by
    PLOS Global Public Health
    Authors
    Ivy Asantewaa Asante; Anne T. Fox; Eric Behene; Yaw Awuku-Larbi; Erasmus Nikoi Kotey; Stephen Nyarko; Richard Asomadu Obeng; Augustina Arjarquah; Gifty Mawuli; Vanessa Magnusen; Naiki Puplampu Attram; Shirley Nimo-Paintsil; Franklin Asiedu-Bekoe; Dennis Odai Laryea; Obed Bangdome Ofori; Edward Owusu Nyarko; Daniel Lartei Mingle; William Asiedu; Andrew Letizia; Terrel Sanders; William Kwabena Ampofo
    License

    Attribution 4.0 (CC BY 4.0)https://creativecommons.org/licenses/by/4.0/
    License information was derived automatically

    Area covered
    Ghana
    Description

    Demographic characteristics of influenza-like illness (ILI) and severe acute respiratory illness (SARI) cases in Ghana from 2011 to 2019.

  12. COVID-19 Brazil Full Cases - 17/06/2021

    • kaggle.com
    zip
    Updated Jun 17, 2021
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    Rafael Herrero (2021). COVID-19 Brazil Full Cases - 17/06/2021 [Dataset]. https://www.kaggle.com/rafaelherrero/covid19-brazil-full-cases-17062021
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    zip(58139014 bytes)Available download formats
    Dataset updated
    Jun 17, 2021
    Authors
    Rafael Herrero
    Area covered
    Brazil
    Description

    How did Brazil become a global epicenter of the outbreak? After seeming to ease, is the virus making a comeback?

    A world leader in infections and deaths.

    Latin America became an epicenter of the coronavirus pandemic in May, driven by Brazil’s ballooning caseload. Ten months after its first known case, Brazil has had more than 7.9 million cases and over 200,000 deaths.

    In early June, Brazil began averaging about 1,000 deaths per day from Covid-19, joining the United States — and later India — as the countries with the world’s largest death tolls.

    This dataset contains information about COVID-19 in Brazil extracted on the date 16/06/2021. It is the most updated dataset available about Covid in Brazil

    Features:

    🔍 date: date that the data was collected. format YYYY-MM-DD.
    🔍 state: Abbreviation for States. Example: SP
    🔍 city: Name of the city (if the value is NaN, they are referring to the State, not the city)
    🔍 place_type: Can be City or State
    🔍 order_for_place: Number that identifies the registering order for this location. The line that refers to the first log is going to be shown as 1, and the following information will start the count as an index.
    🔍 is_last: Show if the line was the last update from that place, can be True or False
    🔍 city_ibge_code: IBGE Code from the location
    🔍confirmed: Number of confirmed cases.
    🔍deaths: Number of deaths.
    🔍estimated_population: Estimated population for this city/state in 2020. Data from IBGE
    🔍estimated_population_2019: Estimated population for this city/state in 2019. Data from IBGE.
    🔍confirmed_per_100k_inhabitants: Number of confirmed cases per 100.000 habitants (based on estimated_population).
    🔍death_rate: Death rate (deaths / confirmed cases).
    
    

    Acknowledgements

    This dataset was downloaded from the URL bello. Thanks, Brasil.IO! Their main goal is to make all Brazilian data available to the public DATASET URL: https://brasil.io/dataset/covid19/files/ Cities map file https://geoftp.ibge.gov.br/organizacao_do_territorio/malhas_territoriais/malhas_municipais/municipio_2020/Brasil/BR/

    Similar Datasets

    COVID-19 - https://www.kaggle.com/rafaelherrero/covid19-brazil-full-cases-17062021 COVID-19 - https://www.kaggle.com/imdevskp/corona-virus-report MERS - https://www.kaggle.com/imdevskp/mers-outbreak-dataset-20122019 Ebola Western Africa 2014 Outbreak - https://www.kaggle.com/imdevskp/ebola-outbreak-20142016-complete-dataset H1N1 | Swine Flu 2009 Pandemic Dataset - https://www.kaggle.com/imdevskp/h1n1-swine-flu-2009-pandemic-dataset SARS 2003 Pandemic - https://www.kaggle.com/imdevskp/sars-outbreak-2003-complete-dataset HIV AIDS - https://www.kaggle.com/imdevskp/hiv-aids-dataset

  13. The ILI incidence and mortality information referring to Iranian Influenza...

    • plos.figshare.com
    xls
    Updated Apr 21, 2025
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    Atieh Sedghian; Shahab MohammadEbrahimi; Benn Sartorius; Behzad Kiani (2025). The ILI incidence and mortality information referring to Iranian Influenza Surveillance System (IISS), March 2015-March 2019. [Dataset]. http://doi.org/10.1371/journal.pone.0320990.t001
    Explore at:
    xlsAvailable download formats
    Dataset updated
    Apr 21, 2025
    Dataset provided by
    PLOShttp://plos.org/
    Authors
    Atieh Sedghian; Shahab MohammadEbrahimi; Benn Sartorius; Behzad Kiani
    License

    Attribution 4.0 (CC BY 4.0)https://creativecommons.org/licenses/by/4.0/
    License information was derived automatically

    Area covered
    Iran
    Description

    The ILI incidence and mortality information referring to Iranian Influenza Surveillance System (IISS), March 2015-March 2019.

  14. Data_Sheet_1_Temporal proteomic analyses of human lung cells distinguish...

    • frontiersin.figshare.com
    xlsx
    Updated Jun 1, 2023
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    Mahamud-ur Rashid; Kathleen K. M. Glover; Ying Lao; Victor Spicer; Kevin M. Coombs (2023). Data_Sheet_1_Temporal proteomic analyses of human lung cells distinguish high pathogenicity influenza viruses and coronaviruses from low pathogenicity viruses.xlsx [Dataset]. http://doi.org/10.3389/fmicb.2022.994512.s001
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    xlsxAvailable download formats
    Dataset updated
    Jun 1, 2023
    Dataset provided by
    Frontiers Mediahttp://www.frontiersin.org/
    Authors
    Mahamud-ur Rashid; Kathleen K. M. Glover; Ying Lao; Victor Spicer; Kevin M. Coombs
    License

    Attribution 4.0 (CC BY 4.0)https://creativecommons.org/licenses/by/4.0/
    License information was derived automatically

    Description

    Newly re-emerging viruses are of significant global concern. In late 2019, a new coronavirus, SARS-CoV-2, emerged in China and soon spread worldwide, causing the COVID-19 pandemic, which to date has caused >6 M deaths. There has been a wealth of studies on this new virus since its emergence. The coronaviruses consist of many animal and human pathogens, with some of the human coronavirus, such as strain OC43, normally causing only mild cold-like symptoms. Viruses usurp host cellular processes to successfully replicate. We used tandem mass tag mass spectrometry-based proteomic analyses of human lung MRC-5 cells infected with OC43 for various periods of time to delineate virus-induced host cell alterations. Numerous proteins involved in lipid metabolism, molecular transport, small molecule biochemistry, cell death and survival, humoral immune response, and inflammatory response were dysregulated. Comparison of our findings to previous studies that examined a range of differentially pathogenic influenza A viruses (IAV), and to SARS-CoV-2 data, revealed that proteins involved in the cell cycle, cytokine signaling, DNA replication, and anti-inflammatory responses were generally similarly affected by virtually all tested IAV and CoV. However, proteins involved in necrosis, protein metabolism, ECM regulation, and signal transduction were generally different. In addition, the more pathogenic CoV and IAV activated Rb-dependent repression of E2F-mediated transcription, whereas less pathogenic influenza and coronaviruses either inhibited or had no effect on this pathway.

  15. Deaths by vaccination status, England

    • ons.gov.uk
    • cy.ons.gov.uk
    xlsx
    Updated Aug 25, 2023
    + more versions
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    Office for National Statistics (2023). Deaths by vaccination status, England [Dataset]. https://www.ons.gov.uk/peoplepopulationandcommunity/birthsdeathsandmarriages/deaths/datasets/deathsbyvaccinationstatusengland
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    xlsxAvailable download formats
    Dataset updated
    Aug 25, 2023
    Dataset provided by
    Office for National Statisticshttp://www.ons.gov.uk/
    License

    Open Government Licence 3.0http://www.nationalarchives.gov.uk/doc/open-government-licence/version/3/
    License information was derived automatically

    Description

    Age-standardised mortality rates for deaths involving coronavirus (COVID-19), non-COVID-19 deaths and all deaths by vaccination status, broken down by age group.

  16. f

    Table_1_Impact of patient characteristics on innate immune responses and...

    • figshare.com
    • datasetcatalog.nlm.nih.gov
    pdf
    Updated Oct 13, 2023
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    Chung-Guei Huang; Yi-Cheng Wu; Ming-Ju Hsieh; Ya-Jhu Lin; Tzu-Hsuan Hsieh; Po-Wei Huang; Shu-Li Yang; Kuo-Chien Tsao; Shin-Ru Shih; Li-Ang Lee (2023). Table_1_Impact of patient characteristics on innate immune responses and inflammasome activation in ex vivo human lung tissues infected with influenza A virus.pdf [Dataset]. http://doi.org/10.3389/fcimb.2023.1269329.s001
    Explore at:
    pdfAvailable download formats
    Dataset updated
    Oct 13, 2023
    Dataset provided by
    Frontiers
    Authors
    Chung-Guei Huang; Yi-Cheng Wu; Ming-Ju Hsieh; Ya-Jhu Lin; Tzu-Hsuan Hsieh; Po-Wei Huang; Shu-Li Yang; Kuo-Chien Tsao; Shin-Ru Shih; Li-Ang Lee
    License

    Attribution 4.0 (CC BY 4.0)https://creativecommons.org/licenses/by/4.0/
    License information was derived automatically

    Description

    BackgroundInfluenza A virus (IAV) infection poses a persistent global health challenge, necessitating a nuanced grasp of host immune responses for optimal interventions. While the interplay between aging, immunosenescence, and IAV is recognized as key in severe lower respiratory tract infections, the role of specific patient attributes in shaping innate immune reactions and inflammasome activity during IAV infection remains under-investigated. In this study, we utilized an ex vivo infection model of human lung tissues with H3N2 IAV to discern relationships among patient demographics, IAV nucleoprotein (NP) expression, toll-like receptor (TLR) profiles, PD-1/PD-L1 markers, and cytokine production.MethodsOur cohort consisted of thirty adult patients who underwent video-assisted thoracoscopic surgery during 2018–2019. Post-surgical lung tissues were exposed to H3N2 IAV for ex vivo infections, and the ensuing immune responses were profiled using flow cytometry.ResultsWe observed pronounced IAV activity within lung cells, as indicated by marked NP upregulation in both epithelial cells (P = 0.022) and macrophages (P = 0.003) in the IAV-exposed group relative to controls. Notably, interleukin-2 levels correlated with variations in TLR1 expression on epithelial cells and PD-L1 markers on macrophages. Age emerged as a modulating factor, dampening innate immune reactions, as evidenced by reduced interleukin-2 and interferon-γ concentrations (both adjusted P < 0.05). Intriguingly, a subset of participants with pronounced tumor necrosis factor-alpha post-mock infection (Cluster 1) showed attenuated cytokine responses in contrast to their counterparts in Cluster 2 and Cluster 3 (all adjusted P < 0.05). Individuals in Cluster 2, characterized by a low post-mock infection NP expression in macrophages, exhibited reduced variations in both NP and TLR1–3 expressions on these cells and a decreased variation in interleukin-2 secretion in comparison to their Cluster 3 counterparts, who were identified by their elevated NP macrophage expression (all adjusted P < 0.05).ConclusionOur work elucidates the multifaceted interplay of patient factors, innate immunity, and inflammasome responses in lung tissues subjected to ex vivo H3N2 IAV exposure, reflecting real-world lower respiratory tract infections. While these findings provide a foundation for tailored therapeutic strategies, supplementary studies are requisite for thorough validation and refinement.

  17. Weekly number of excess deaths in England and Wales 2020-2025

    • statista.com
    Updated Sep 11, 2025
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    Statista (2025). Weekly number of excess deaths in England and Wales 2020-2025 [Dataset]. https://www.statista.com/statistics/1131428/excess-deaths-in-england-and-wales/
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    Dataset updated
    Sep 11, 2025
    Dataset authored and provided by
    Statistahttp://statista.com/
    Time period covered
    Jan 2020 - Aug 2025
    Area covered
    Wales, England
    Description

    For the week ending August 29, 2025, weekly deaths in England and Wales were 985 below the number expected, compared with 855 below what was expected in the previous week. In late 2022 and through early 2023, excess deaths were elevated for a number of weeks, with the excess deaths figure for the week ending January 13, 2023, the highest since February 2021. In the middle of April 2020, at the height of the COVID-19 pandemic, there were almost 12,000 excess deaths a week recorded in England and Wales. It was not until two months later, in the week ending June 19, 2020, that the number of deaths began to be lower than the five-year average for the corresponding week. Most deaths since 1918 in 2020 In 2020, there were 689,629 deaths in the United Kingdom, making that year the deadliest since 1918, at the height of the Spanish influenza pandemic. As seen in the excess death figures, April 2020 was by far the worst month in terms of deaths during the pandemic. The weekly number of deaths for weeks 16 and 17 of that year were 22,351, and 21,997 respectively. Although the number of deaths fell to more usual levels for the rest of that year, a winter wave of the disease led to a high number of deaths in January 2021, with 18,676 deaths recorded in the fourth week of that year. For the whole of 2021, there were 667,479 deaths in the UK, 22,150 fewer than in 2020. Life expectancy in the UK goes into reverse In 2022, life expectancy at birth for women in the UK was 82.6 years, while for men it was 78.6 years. This was the lowest life expectancy in the country for ten years, and came after life expectancy improvements stalled throughout the 2010s, and then declined from 2020 onwards. There is also quite a significant regional difference in life expectancy in the UK. In the London borough of Kensington and Chelsea, for example, the life expectancy for men was 81.5 years, and 86.5 years for women. By contrast, in Blackpool, in North West England, male life expectancy was just 73.1 years, while for women, life expectancy was lowest in Glasgow, at 78 years.

  18. Major causes of death in the U.S.: 1900 and 2023

    • statista.com
    Updated Nov 29, 2025
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    Statista (2025). Major causes of death in the U.S.: 1900 and 2023 [Dataset]. https://www.statista.com/statistics/235703/major-causes-of-death-in-the-us/
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    Dataset updated
    Nov 29, 2025
    Dataset authored and provided by
    Statistahttp://statista.com/
    Area covered
    United States
    Description

    The leading causes of death in the United States have changed significantly from the year 1900 to the present. Leading causes of death in 1900, such as tuberculosis, gastrointestinal infections, and diphtheria have seen huge decreases in death rates and are no longer among the leading causes of death in the United States. However, other diseases such as heart disease and cancer have seen increased death rates. Vaccinations One major factor contributing to the decrease in death rates for many diseases since the year 1900 is the introduction of vaccinations. The decrease seen in the rates of death due to pneumonia and influenza is a prime example of this. In 1900, pneumonia and influenza were the leading causes of death, with around *** deaths per 100,000 population. However, in 2023 pneumonia and influenza were not even among the ten leading causes of death. Cancer One disease that has seen a large increase in death rates since 1900 is cancer. Cancer currently accounts for almost ** percent of all deaths in the United States, with death rates among men higher than those for women. The deadliest form of cancer for both men and women is cancer of the lung and bronchus. Some of the most common avoidable risk factors for cancer include smoking, drinking alcohol, sun exposure, and obesity.

  19. Child mortality in the U.S 1800-2020

    • statista.com
    Updated Jul 15, 2022
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    Statista (2022). Child mortality in the U.S 1800-2020 [Dataset]. https://www.statista.com/statistics/1041693/united-states-all-time-child-mortality-rate/
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    Dataset updated
    Jul 15, 2022
    Dataset authored and provided by
    Statistahttp://statista.com/
    Area covered
    United States
    Description

    The child mortality rate in the United States, for children under the age of five, was 462.9 deaths per thousand births in 1800. This means that for every thousand babies born in 1800, over 46 percent did not make it to their fifth birthday. Over the course of the next 220 years, this number has dropped drastically, and the rate has dropped to its lowest point ever in 2020 where it is just seven deaths per thousand births. Although the child mortality rate has decreased greatly over this 220 year period, there were two occasions where it increased; in the 1870s, as a result of the fourth cholera pandemic, smallpox outbreaks, and yellow fever, and in the late 1910s, due to the Spanish Flu pandemic.

  20. Life expectancy in India 1800-2020

    • statista.com
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    Statista, Life expectancy in India 1800-2020 [Dataset]. https://www.statista.com/statistics/1041383/life-expectancy-india-all-time/
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    Dataset authored and provided by
    Statistahttp://statista.com/
    Area covered
    India
    Description

    Life expectancy in India was 25.4 in the year 1800, and over the course of the next 220 years, it has increased to almost 70. Between 1800 and 1920, life expectancy in India remained in the mid to low twenties, with the largest declines coming in the 1870s and 1910s; this was because of the Great Famine of 1876-1878, and the Spanish Flu Pandemic of 1918-1919, both of which were responsible for the deaths of up to six and seventeen million Indians respectively; as well as the presence of other endemic diseases in the region, such as smallpox. From 1920 onwards, India's life expectancy has consistently increased, but it is still below the global average.

  21. Not seeing a result you expected?
    Learn how you can add new datasets to our index.

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Statista (2024). Number of influenza deaths in the United States from 2011-2024 [Dataset]. https://www.statista.com/statistics/1124915/flu-deaths-number-us/
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Number of influenza deaths in the United States from 2011-2024

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Dataset updated
Nov 15, 2024
Dataset authored and provided by
Statistahttp://statista.com/
Area covered
United States
Description

The burden of influenza in the United States can vary from year to year depending on which viruses are circulating, how many people receive an influenza vaccination, and how effective the vaccination is in that particular year. During the 2023-2024 flu season, around 28,000 people lost their lives to the disease. Although most people recover from influenza without needing medical care, the disease can be deadly among young children, the elderly, and those with weakened immune systems or chronic illnesses. Deaths due to influenza Even though most people recover from influenza without medical care, influenza and pneumonia can be deadly, especially for older people and those with certain preexisting conditions. Influenza is a common cause of pneumonia and although most cases of influenza do not develop into pneumonia, those that do are often more severe and more deadly. Deaths due to influenza are most common among the elderly, with a mortality rate of around 32 per 100,000 population during the 2023-2024 flu season. In comparison, the mortality rate for those aged 50 to 64 years was 9.1 per 100,000 population. Flu vaccinations The most effective way to prevent influenza is to receive an annual influenza vaccination. These vaccines have proven to be safe and are usually cheap and easily accessible. Nevertheless, every year a large share of the population in the United States still fails to get vaccinated against influenza. For example, in the 2022-2023 flu season, only 35 percent of those aged 18 to 49 years received a flu vaccination. Unsurprisingly, children and the elderly are the most likely to get vaccinated. It is estimated that during the 2022-2023 flu season, vaccinations prevented over 929 thousand influenza cases among children aged 6 months to 4 years.

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