The mortality rate from influenza in the United States is by far highest among those aged 65 years and older. During the 2023-2024 flu season, the mortality rate from influenza for this age group was around 32.1 per 100,000 population. The burden of influenza The impact of influenza in the U.S. varies from season to season, but in the 2023-2024 flu season, there were an estimated 40 million cases. These cases resulted in around 470,000 hospitalizations. Although most people recover from influenza without requiring medical treatment, the disease can be deadly for young children, the elderly, and those with weakened immune systems or chronic illnesses. During the 2023-2024 flu season, around 28,000 people in the U.S. lost their lives due to influenza. Impact of vaccinations The most effective way to prevent influenza is to receive an annual vaccination at the beginning of flu season. Flu vaccines are safe and can greatly reduce the burden of the disease. During the 2022-2023 flu season, vaccinations prevented around 2,479 deaths among those aged 65 years and older. Although flu vaccines are usually cheap and easily accessible, every year a large share of the population in the U.S. still does not get vaccinated. For example, during the 2022-2023 flu season, only about 35 percent of those aged 18 to 49 years received a flu vaccination.

This statistic shows the deaths with influenza as an underlying cause in England and Wales in 2023, by age and gender. In this year, influenza was the underlying cause of *** deaths for women aged 90 years and over. Respiratory disease burden in the UK As of 2023, tuberculosis cases had also been on the rise, with ***** new cases and relapses reported in 2023. The ***** age group was most affected by this respiratory disease, accounting for approximately ***** cases. Pneumonia, another serious respiratory condition, caused over ***** deaths among women aged 90 and older in the same year, with a further ***** men in the same age group having pneumonia as their underlying cause of death. Vaccination prevalence and accessibility In the years 2014-2015, **** percent of individuals aged 65 and over in the North West of England were immunized against influenza. This was the region with the highest share of elderly vaccinated against influenza, while this figure was the lowest in London, around **** percent. Community pharmacies have played a crucial role in providing seasonal influenza vaccination services – as of 2023/24, ** percent of community pharmacies in the South of England offered influenza vaccination advanced service, while in London, the figure reached ** percent.

Deaths counts for influenza, pneumonia, and COVID-19 reported to NCHS by week ending date, by state and HHS region, and age group.

In 2022, a total of 5,985 people died from influenza and pneumonia in Canada. With 2,068 deaths reported during that year, individuals aged 90 years and older were the most affected age group by these diseases. This statistic shows the number of deaths from influenza and pneumonia in Canada in 2022, by age.

The graph illustrates the number of flu-related deaths in the United States for each flu season from 2010-2011 to 2023-2024*. The x-axis represents the flu seasons, labeled from '10-11 to '23*-24*, while the y-axis shows the annual number of flu deaths. Throughout this period, flu deaths vary significantly, ranging from a low of 4,900 in the 2021-2022* season to a high of 51,000 in both the 2014-2015 and 2017-2018 seasons. Other notable figures include 36,000 deaths in 2010-2011, 42,000 in 2012-2013, and a recent increase to 28,000 in the 2023*-2024* season. The data exhibits considerable fluctuations with no consistent upward or downward trend, highlighting the variability in flu mortality rates over the years. This information is presented in a line graph format, effectively showcasing the yearly changes and peaks in flu-related deaths across the United States.

*Data for the 2021-2022 and 2022-2023 seasons are estimated.

Rank, number of deaths, percentage of deaths, and age-specific mortality rates for the leading causes of death, by age group and sex, 2000 to most recent year.

This file contains the complete set of data reported to 122 Cities Mortality Reposting System. The system was retired as of 10/6/2016. While the system was running each week, the vital statistics offices of 122 cities across the United States reported the total number of death certificates processed and the number of those for which pneumonia or influenza was listed as the underlying or contributing cause of death by age group (Under 28 days, 28 days - 1 year, 1-14 years, 15-24 years, 25-44 years, 45-64 years, 65-74 years, 75-84 years, and - 85 years). U:Unavailable. - : No reported cases.* Mortality data in this table were voluntarily reported from 122 cities in the United States, most of which have populations of >100,000. A death is reported by the place of its occurrence and by the week that the death certificate was filed. Fetal deaths are not included. Total includes unknown ages. More information on Flu Activity & Surveillance is available at http://www.cdc.gov/flu/weekly/fluactivitysurv.htm.

this graph was created in OurDataWorld, R , Loocker and Tableau

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Introduction: Seasonal influenza, often perceived as a common illness, carries a significant global burden, claiming hundreds of thousands of lives annually. Despite advancements in healthcare and vaccination efforts, the flu remains a formidable threat, particularly affecting vulnerable populations such as infants and the elderly. This article delves into the intricacies of influenza-related mortality, examining regional disparities, contributing factors, and the implications for public health.

The Global Landscape of Influenza Mortality: Data from the Global Pandemic Mortality Project II sheds light on the magnitude of influenza-related deaths, drawing from surveillance metrics spanning from 2002 to 2011. These estimates, while informative, underscore the challenge of accurately gauging mortality rates, especially in low-income countries where testing and mortality records may be lacking.

Respiratory Symptoms and Beyond: The conventional understanding of influenza-related fatalities primarily revolves around respiratory complications. Pneumonia and other respiratory ailments serve as prominent causes of death, contributing to the staggering toll of 400,000 lives claimed annually. However, it is imperative to acknowledge that the impact of influenza extends beyond respiratory symptoms. Complications such as strokes and heart attacks, though not explicitly captured in mortality estimates, further amplify the disease's lethality, warranting comprehensive preventive measures.

Vulnerability Across Age Groups: Influenza's lethality is not uniform across age demographics. Infants and the elderly emerge as the most susceptible cohorts, bearing the brunt of severe complications and mortality. Among individuals aged over 65, the mortality rate stands at approximately 31 per 100,000 in Europe alone, reflecting the disproportionate impact on older populations. The interplay of age-related factors, including weakened immune responses and underlying health conditions, exacerbates the severity of influenza outcomes among these groups.

Regional Disparities and Determinants: A notable aspect of influenza mortality lies in its disparate distribution across regions. While Europe and North America exhibit relatively lower death rates, countries in South America, Africa, and South Asia grapple with higher mortality burdens. This regional divide underscores the complex interplay of socio-economic factors, healthcare accessibility, and vaccination coverage. Poverty, inadequate healthcare infrastructure, and suboptimal vaccination rates converge to heighten vulnerability to influenza-related complications, amplifying mortality rates in resource-constrained settings.

Implications for Public Health: The revelation of significant regional differentials in influenza mortality necessitates a tailored approach to public health interventions. Strengthening healthcare systems, particularly in low-income regions, is paramount to bolstering surveillance, enhancing diagnostic capabilities, and facilitating timely interventions. Furthermore, targeted vaccination campaigns, coupled with education initiatives, hold promise in mitigating influenza's toll, especially among vulnerable populations. Addressing socio-economic disparities and bolstering healthcare resilience emerge as pivotal strategies in fortifying global defenses against seasonal influenza.

Conclusion: Seasonal influenza, often underestimated in its impact, exacts a substantial toll on global health each year. The multifaceted nature of influenza-related mortality underscores the need for a nuanced understanding and comprehensive mitigation strategies. By addressing regional disparities, prioritizing vulnerable populations, and fortifying healthcare systems, the global community can strive towards mitigating the burden of seasonal influenza, safeguarding lives, and fostering resilient health systems for generations to come.

TABLE III. Deaths in 122 U.S. cities - 2014.
122 Cities Mortality Reporting System — Each week, the vital statistics offices of 122 cities across the United States report the total number of death certificates processed and the number of those for which pneumonia or influenza was listed as the underlying or contributing cause of death by age group (Under 28 days, 28 days –1 year, 1-14 years, 15-24 years, 25-44 years, 45-64 years, 65-74 years, 75-84 years, and ≥ 85 years).

FOOTNOTE:
U: Unavailable. —: No reported cases.

• Mortality data in this table are voluntarily reported from 122 cities in the United States, most of which have populations of >100,000. A death is reported by the place of its occurrence and by the week that the death certificate was filed. Fetal deaths are not included.

† Pneumonia and influenza.

§ Because of changes in reporting methods in this Pennsylvania city, these numbers are partial counts for the current week. Complete counts will be available in 4 to 6 weeks.

¶ Total includes unknown ages.

More information on Flu Activity & Surveillance is available at http://www.cdc.gov/flu/weekly/fluactivitysurv.htm.

Effective September 27, 2023, this dataset will no longer be updated. Similar data are accessible from wonder.cdc.gov. Deaths involving COVID-19, pneumonia, and influenza reported to NCHS by sex, age group, and jurisdiction of occurrence.

Project Tycho datasets contain case counts for reported disease conditions for countries around the world. The Project Tycho data curation team extracts these case counts from various reputable sources, typically from national or international health authorities, such as the US Centers for Disease Control or the World Health Organization. These original data sources include both open- and restricted-access sources. For restricted-access sources, the Project Tycho team has obtained permission for redistribution from data contributors. All datasets contain case count data that are identical to counts published in the original source and no counts have been modified in any way by the Project Tycho team. The Project Tycho team has pre-processed datasets by adding new variables, such as standard disease and location identifiers, that improve data interpretabilty. We also formatted the data into a standard data format.

Each Project Tycho dataset contains case counts for a specific condition (e.g. measles) and for a specific country (e.g. The United States). Case counts are reported per time interval. In addition to case counts, datsets include information about these counts (attributes), such as the location, age group, subpopulation, diagnostic certainty, place of aquisition, and the source from which we extracted case counts. One dataset can include many series of case count time intervals, such as "US measles cases as reported by CDC", or "US measles cases reported by WHO", or "US measles cases that originated abroad", etc.

Depending on the intended use of a dataset, we recommend a few data processing steps before analysis:

• Analyze missing data: Project Tycho datasets do not inlcude time intervals for which no case count was reported (for many datasets, time series of case counts are incomplete, due to incompleteness of source documents) and users will need to add time intervals for which no count value is available. Project Tycho datasets do include time intervals for which a case count value of zero was reported.
• Separate cumulative from non-cumulative time interval series. Case count time series in Project Tycho datasets can be "cumulative" or "fixed-intervals". Cumulative case count time series consist of overlapping case count intervals starting on the same date, but ending on different dates. For example, each interval in a cumulative count time series can start on January 1st, but end on January 7th, 14th, 21st, etc. It is common practice among public health agencies to report cases for cumulative time intervals. Case count series with fixed time intervals consist of mutually exxclusive time intervals that all start and end on different dates and all have identical length (day, week, month, year). Given the different nature of these two types of case count data, we indicated this with an attribute for each count value, named "PartOfCumulativeCountSeries".

In the United States, the highest rate of hospitalizations due to influenza are among those aged 65 years and older. During the 2023-2024 flu season, the rate of hospitalizations due to influenza among this age group was about 401 per 100,000 population, compared to a rate of around 47 per 100,000 for those aged 5 to 17 years. Influenza is a common viral infection that usually does not require medical treatment. However, for the very young, the old, and those with certain pre-existing conditions, influenza can be serious and even deadly. The burden of influenza in the United States The impact of influenza in the United States varies from year to year depending on the strain that is most prevalent during that season and the immunity in the population. Preliminary estimates show that around 28,000 people died from influenza during the 2023-2024 flu season. However, during the 2017-2018 flu season, an estimated 52,000 people lost their lives to influenza. The importance of flu vaccines The best way to avoid catching the flu and to reduce the virus’s overall burden on society is by receiving an annual flu vaccination. The CDC currently recommends that everyone over 6 months of age should get a flu vaccination every year, preferably by the end of October. The flu vaccine is safe, efficient, and reduces the number of illnesses, hospitalizations, and deaths caused by the virus. For example, during the 2022-2023 flu season, it was estimated that vaccinations averted almost 65 thousand influenza-related hospitalizations. However, despite the proven benefits and wide availability of flu vaccinations, a large percentage of people in the United States fail to receive a vaccination every year. During the 2022-2023 flu season, only about 35 percent of those aged 18 to 49 years were vaccinated against influenza, compared to 70 percent of those aged 65 years and older.

This file contains the provisional percent of total deaths by week for COVID-19, Influenza, and Respiratory Syncytial Virus for deaths occurring among residents in the United States, by sex, age group, and race and Hispanic origin. Provisional data are based on non-final counts of deaths based on the flow of mortality data in National Vital Statistics System.

Estimated average annual influenza excess mortality per age group and annual excess mortality rate per 100,000 individuals, 2006−2015.

In 2022, the highest death rate from influenza and pneumonia in Canada per 100,000 population was reported among those aged 90 years and older, with around *** deaths. Individuals between 85 and 89 years followed, with a mortality rate from influenza and pneumonia of almost *** deaths per 100,000 people. This statistic displays the death rate from influenza and pneumonia per 100,000 population in Canada during 2022, by age.

Estimated excess influenza-associated deaths versus nationally registered influenza deaths per age group.

BackgroundWe assessed the severity of the 2009 influenza pandemic by comparing pandemic mortality to seasonal influenza mortality. However, reported pandemic deaths were laboratory-confirmed – and thus an underestimation – whereas seasonal influenza mortality is often more inclusively estimated. For a valid comparison, our study used the same statistical methodology and data types to estimate pandemic and seasonal influenza mortality. Methods and FindingsWe used data on all-cause mortality (1999–2010, 100% coverage, 16.5 million Dutch population) and influenza-like-illness (ILI) incidence (0.8% coverage). Data was aggregated by week and age category. Using generalized estimating equation regression models, we attributed mortality to influenza by associating mortality with ILI-incidence, while adjusting for annual shifts in association. We also adjusted for respiratory syncytial virus, hot/cold weather, other seasonal factors and autocorrelation. For the 2009 pandemic season, we estimated 612 (range 266–958) influenza-attributed deaths; for seasonal influenza 1,956 (range 0–3,990). 15,845 years-of-life-lost were estimated for the pandemic; for an average seasonal epidemic 17,908. For 0–4 yrs of age the number of influenza-attributed deaths during the pandemic were higher than in any seasonal epidemic; 77 deaths (range 61–93) compared to 16 deaths (range 0–45). The ≥75 yrs of age showed a far below average number of deaths. Using pneumonia/influenza and respiratory/cardiovascular instead of all-cause deaths consistently resulted in relatively low total pandemic mortality, combined with high impact in the youngest age category. ConclusionThe pandemic had an overall moderate impact on mortality compared to 10 preceding seasonal epidemics, with higher mortality in young children and low mortality in the elderly. This resulted in a total number of pandemic deaths far below the average for seasonal influenza, and a total number of years-of-life-lost somewhat below average. Comparing pandemic and seasonal influenza mortality as in our study will help assessing the worldwide impact of the 2009 pandemic.

Analysis of ‘Deaths in 122 U.S. cities - 1962-2016. 122 Cities Mortality Reporting System’ provided by Analyst-2 (analyst-2.ai), based on source dataset retrieved from https://catalog.data.gov/dataset/259d9312-191c-4914-8c84-865676d22824 on 12 February 2022.

--- Dataset description provided by original source is as follows ---

This file contains the complete set of data reported to 122 Cities Mortality Reposting System. The system was retired as of 10/6/2016. While the system was running each week, the vital statistics offices of 122 cities across the United States reported the total number of death certificates processed and the number of those for which pneumonia or influenza was listed as the underlying or contributing cause of death by age group (Under 28 days, 28 days - 1 year, 1-14 years, 15-24 years, 25-44 years, 45-64 years, 65-74 years, 75-84 years, and - 85 years). U:Unavailable. - : No reported cases.* Mortality data in this table were voluntarily reported from 122 cities in the United States, most of which have populations of >100,000. A death is reported by the place of its occurrence and by the week that the death certificate was filed. Fetal deaths are not included. Total includes unknown ages. More information on Flu Activity & Surveillance is available at http://www.cdc.gov/flu/weekly/fluactivitysurv.htm.

--- Original source retains full ownership of the source dataset ---

The burden of influenza in the United States can vary from year to year depending on which viruses are circulating, how many people receive an influenza vaccination, and how effective the vaccination is in that particular year. During the 2023-2024 flu season, around 28,000 people lost their lives to the disease. Although most people recover from influenza without needing medical care, the disease can be deadly among young children, the elderly, and those with weakened immune systems or chronic illnesses. Deaths due to influenza Even though most people recover from influenza without medical care, influenza and pneumonia can be deadly, especially for older people and those with certain preexisting conditions. Influenza is a common cause of pneumonia and although most cases of influenza do not develop into pneumonia, those that do are often more severe and more deadly. Deaths due to influenza are most common among the elderly, with a mortality rate of around 32 per 100,000 population during the 2023-2024 flu season. In comparison, the mortality rate for those aged 50 to 64 years was 9.1 per 100,000 population. Flu vaccinations The most effective way to prevent influenza is to receive an annual influenza vaccination. These vaccines have proven to be safe and are usually cheap and easily accessible. Nevertheless, every year a large share of the population in the United States still fails to get vaccinated against influenza. For example, in the 2022-2023 flu season, only 35 percent of those aged 18 to 49 years received a flu vaccination. Unsurprisingly, children and the elderly are the most likely to get vaccinated. It is estimated that during the 2022-2023 flu season, vaccinations prevented over 929 thousand influenza cases among children aged 6 months to 4 years.