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100+ datasets found
  1. R

    Data from: Asparagine N-linked glycosylation

    • reactome.org
  2. R

    O-linked glycosylation of mucins

    • reactome.org
  3. R

    Diseases associated with O-glycosylation of proteins

    • reactome.org
  4. R

    Data from: Diseases of glycosylation

    • reactome.org
  5. f

    Centralized Modularity of N-Linked Glycosylation Pathways in Mammalian Cells...

    • figshare.com
    Updated Jan 18, 2016
  6. f

    Data from: Site-Specific N‑Glycosylation Characterization of Windmill Palm...

    • figshare.com
    Updated May 27, 2016
  7. o

    Glycosylation analysis of TNF-alpha-induced insulin resistance

    • www.omicsdi.org
  8. f

    Data from: Deciphering Protein O‑Glycosylation: Solid-Phase Chemoenzymatic...

    • figshare.com
    Updated Jun 24, 2018
  9. d

    Data from: Mannose glycosylation is an integral step for human NIS...

    • datadryad.org
    • search.datacite.org
    Updated Oct 7, 2019
  10. a

    congenital disorder of glycosylation Im

    • www.alliancegenome.org
    Updated Jan 27, 2020
  11. a

    congenital disorder of glycosylation type I

    • www.alliancegenome.org
    Updated May 12, 2018
  12. w

    Effects of Glycosylation on the Structure and Dynamics of Eel Calcitonin in...

    • www.bmrb.wisc.edu
    • bmrb.cerm.unifi.it
    Updated Dec 3, 1999
  13. t

    BIOGRID CURATED DATA FOR PUBLICATION: The role of N-linked glycosylation in...

    • thebiogrid.org
    Updated May 2, 2003
  14. w

    Effects of Glycosylation on the Structure and Dynamics of Eel Calcitonin

    • www.bmrb.wisc.edu
    • bmrb.cerm.unifi.it
    • +1more
    Updated Jul 13, 2007
  15. t

    BIOGRID CURATED DATA FOR PUBLICATION: Roles of N-glycosylation and...

    • thebiogrid.org
    Updated Jan 22, 2012
  16. o

    The role of glycans and glycosylation in cell-type specific effects on viral...

    • omictools.com
    • www.omicsdi.org
    Updated Mar 23, 2012
  17. o

    To identify glycosylation-specific targets contributing to the interferon...

    • omictools.com
    • www.omicsdi.org
    • +1more
    Updated Apr 20, 2017
  18. a

    congenital disorder of glycosylation type II

    • www.alliancegenome.org
    Updated May 12, 2018
  19. t

    BIOGRID CURATED DATA FOR PUBLICATION: N-linked glycosylation of AtVSR1 is...

    • thebiogrid.org
  20. r

    Data from: Glycosylation of TRPM4 and TRPM5 Channels: Molecular Determinants...

    • www.researchgate.net
    Updated Feb 24, 2014
  21. o

    Data from: The metacaspase Mca1p restricts O-glycosylation during...

    • www.omicsdi.org
    • datamed.org
  22. f

    Proteome-Wide Analysis of Single-Nucleotide Variations in the...

    • figshare.com
    Updated Jan 19, 2016
  23. t

    BIOGRID CURATED DATA FOR PUBLICATION: Glucose-Mediated N-glycosylation of...

    • thebiogrid.org
    Updated Nov 9, 2015
  24. R

    N-linked glycosylation of WNTs

    • reactome.org
  25. d

    In vitro impact of distinct FSH glycosylation variants on FSH...

    • datadryad.org
    • search.datacite.org
    Updated Oct 17, 2019
  26. r

    Acetonitrile in Glycosylation

    • www.researchgate.net
    Updated Jan 1, 2004
  27. o

    Pilot project to determine optimal bioreactor protein glycosylation...

    • omictools.com
    Updated Sep 5, 2014
  28. t

    BIOGRID CURATED DATA FOR PUBLICATION: Glycosylation and stabilization of...

    • thebiogrid.org
    Updated Aug 30, 2016
  29. o

    Data from: Quantitative Profiling of N-linked Glycosylation Machinery in...

    • www.omicsdi.org
  30. f

    Data from: Targeted Mass Spectrometry Approach Enabled Discovery of...

    • figshare.com
    Updated Aug 7, 2017
  31. a

    congenital disorder of glycosylation If

    • www.alliancegenome.org
    Updated Jan 30, 2020
  32. o

    Elucidating mechanisms by which regulated expression of proteoglycans and...

    • omictools.com
    • www.omicsdi.org
    Updated Mar 23, 2012
  33. o

    Deconstruction of protein O-glycosylation

    • www.omicsdi.org
  34. o

    A conserved atypical MFS family member orchestrates a subset of...

    • www.omicsdi.org
  35. t

    BIOGRID CURATED DATA FOR PUBLICATION: Defects in protein glycosylation cause...

    • thebiogrid.org
    Updated Jul 1, 2000
  36. a

    congenital disorder of glycosylation Ii

    • www.alliancegenome.org
    Updated Jan 8, 2020
  37. o

    Data from: Topological N-glycosylation and site-specific N-glycan sulfation...

    • www.omicsdi.org
  38. t

    BIOGRID CURATED DATA FOR PUBLICATION: Structural basis for a human...

    • thebiogrid.org
    Updated Aug 11, 2009
  39. f

    General N-and O-Linked Glycosylation of Lipoproteins in Mycoplasmas and Role...

    • figshare.com
    Updated Jan 15, 2016
  40. r

    S3 Fig

    • www.researchgate.net
    Updated Jun 9, 2016
  41. t

    BIOGRID CURATED DATA FOR PUBLICATION: Pim-1 kinase protects P-glycoprotein...

    • thebiogrid.org
    Updated May 12, 2010
  42. GWAS summary statistics for UPLC IgG N-glycosylation traits

    • search.datacite.org
    Updated Dec 21, 2018
  43. t

    BIOGRID CURATED DATA FOR PUBLICATION: Overelaborated synaptic architecture...

    • thebiogrid.org
    Updated Oct 18, 2014
  44. Data from: Separation and characterization of the two Asn-linked...

    • researchdata.ands.org.au
    Updated Jun 26, 2012
  45. t

    BIOGRID CURATED DATA FOR PUBLICATION: Disruption of N-linked glycosylation...

    • thebiogrid.org
    Updated Nov 10, 2009
  46. R

    O-glycosylation of TSR domain-containing proteins

    • reactome.org
  47. w

    truncated AcrA from Campylobacter jejuni for glycosylation studies

    • www.bmrb.wisc.edu
    • bmrb.cerm.unifi.it
    Updated Jun 2, 2010
  48. t

    BIOGRID CURATED DATA FOR PUBLICATION: Oligosaccharyltransferase subunits...

    • thebiogrid.org
    Updated Dec 1, 2014
  49. R

    O-linked glycosylation

    • reactome.org
  50. s

    O-GLYCBASE

    • scicrunch.org
    Updated Jan 1, 1999
  51. o

    Glycosylation of the HA protein of H5N1 virus increases its virulence in...

    • omictools.com
    • www.omicsdi.org
    Updated May 8, 2019
  52. a

    congenital disorder of glycosylation Ip

    • www.alliancegenome.org
    Updated Jul 27, 2016
  53. E

    Identification of genes involved in congenital disorders of glycosylation...

    • ega-archive.org
    Updated Mar 14, 2018
  54. o

    Data from: RNA-Seq analysis of glycosylation related gene expression in...

    • omictools.com
    • www.omicsdi.org
    • +1more
    Updated Jun 28, 2018
  55. a

    ALG12

    • www.alliancegenome.org
    Updated Oct 19, 2019
  56. a

    ALG10B

    • www.alliancegenome.org
    Updated Oct 19, 2019
  57. r

    Data from: Expression and secretion of a prokaryotic protein streptokinase...

    • www.researchgate.net
    Updated Sep 24, 2004
  58. a

    The significance of glycosylation on the function of the calcium-sensing...

    • researchdata.ands.org.au
    Updated Sep 20, 2012
  59. f

    Prediction of N-linked glycosylation sites using position relative features...

    • figshare.com
    Updated Aug 11, 2017
  60. t

    BIOGRID CURATED DATA FOR PUBLICATION: The ALG10 locus of Saccharomyces...

    • thebiogrid.org
    Updated May 1, 1998
  61. t

    BIOGRID CURATED DATA FOR PUBLICATION: Meigo governs dendrite targeting...

    • thebiogrid.org
    Updated Apr 29, 2013
  62. f

    Data from: Analysis of Congenital Disorder of Glycosylation-Id in a Yeast...

    • figshare.com
    Updated Feb 20, 2016
  63. R

    Diseases associated with N-glycosylation of proteins

    • reactome.org
  64. f

    Data from: Comprehensive Analysis of Protein N‑Glycosylation Sites by...

    • figshare.com
    Updated Feb 18, 2016
  65. t

    BIOGRID CURATED DATA FOR PUBLICATION: The yeast LATS/Ndr kinase Cbk1...

    • thebiogrid.org
    Updated Dec 1, 2008
  66. t

    BIOGRID CURATED DATA FOR PUBLICATION: Alg14 recruits Alg13 to the...

    • thebiogrid.org
    Updated Oct 28, 2005
  67. o

    To understand how glycosylation on human B cells is regulated during...

    • omictools.com
    • datamed.org
    Updated Apr 20, 2017
  68. r

    Figure S2

    • www.researchgate.net
    Updated Jun 10, 2011
  69. o

    Data from: Death receptor O-glycosylation controls tumor-cell sensitivity to...

    • omictools.com
    • www.omicsdi.org
    Updated Oct 29, 2018
  70. R

    O-linked glycosylation

    • reactome.org
    Updated Mar 31, 2019
  71. r

    S3 Fig

    • www.researchgate.net
    Updated Oct 11, 2018
  72. t

    BIOGRID CURATED DATA FOR PUBLICATION: COG7 deficiency in Drosophila...

    • thebiogrid.org
    Updated Nov 1, 2017
  73. Data from: Glycosylation sites and site-specific glycosylation in human...

    • researchdata.ands.org.au
    Updated Jun 26, 2012
  74. r

    Figure S7

    • www.researchgate.net
    Updated Mar 16, 2012
  75. Data from: Protein N-glycosylation is similar in the moss Physcomitrella...

    • researchdata.ands.org.au
    Updated Jun 26, 2012
  76. R

    O-glycosylation of TSR domain-containing proteins

    • www.reactome.org
  77. o

    Irani2015 - Genome-scale metabolic model of P.pastoris N-glycosylation

    • www.omicsdi.org
  78. t

    BIOGRID CURATED DATA FOR PUBLICATION: Over-expression of S. cerevisiae G1...

    • thebiogrid.org
    Updated Jan 1, 1996
  79. r

    File S1

    • www.researchgate.net
    Updated Apr 29, 2013
  80. a

    ALG11

    • www.alliancegenome.org
    Updated Oct 19, 2019
  81. Data from: O- and N-glycosylation of the Leishmania mexicana-secreted acid...

    • researchdata.ands.org.au
    Updated Jun 26, 2012
  82. o

    Data from: N-glycosylation Profiling of Colorectal Cancer Cell Lines Reveals...

    • www.omicsdi.org
    Updated Aug 7, 2018
  83. Table_1_Effects of N-Glycosylation on the Structure, Function, and Stability...

    • figshare.com
    Updated Jun 28, 2019
  84. Data from: Drastic differences in glycosylation of related S-layer...

    • researchdata.ands.org.au
    Updated Jun 26, 2012
  85. o

    N-glycosylation of R-spondin1 at Asn137 negatively regulates its secretion...

    • explore.openaire.eu
    Updated Apr 1, 2016
  86. r

    Figure S1

    • www.researchgate.net
    Updated Jan 3, 2013
  87. o

    Deconstruction of O-glycosylation – Polypeptide GalNAc-T Isoforms Direct...

    • www.omicsdi.org
    • datamed.org
  88. o

    Data from: Detecting Proteins Glycosylation by a Homogeneous Reac-tion...

    • www.omicsdi.org
  89. The glycosylation and structure of human serum IgA1, Fab, and Fc regions and...

    • researchdata.ands.org.au
    Updated Jun 26, 2012
  90. f

    Data from: Identification of Glycopeptides with Multiple Hydroxylysine...

    • figshare.com
    Updated Feb 12, 2016
  91. o

    Proteomics of Campylobacter glycosylation

    • www.omicsdi.org
  92. Dataset pertaining to the publication “Loci Associated with N-Glycosylation...

    • search.datacite.org
    Updated Apr 12, 2016
  93. r

    Data from: Expression and purification of non-N-glycosylated porcine...

    • www.researchgate.net
    Updated Mar 1, 2012
  94. a

    GALNT4

    • www.alliancegenome.org
    Updated Oct 19, 2019
  95. o

    Diagnostic accuracy of urinary prostate protein glycosylation profiling in...

    • explore.openaire.eu
    Updated Oct 15, 2015
  96. r

    Figure S2

    • www.researchgate.net
    Updated Aug 30, 2011
  97. Data from: Glycosylation of eukaryotic peptide chain initiation factor 2...

    • researchdata.ands.org.au
    Updated Jun 26, 2012
  98. Data from: O-linked glycosylation of rat renal gamma-glutamyltranspeptidase...

    • researchdata.ands.org.au
    Updated Jun 26, 2012
  99. s

    GlySeq

    • scicrunch.org
    Updated Jan 1, 2005
  100. r

    Figure S4

    • www.researchgate.net
    Updated Apr 18, 2012
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Data from: Asparagine N-linked glycosylation

Related Article
Authors
Giovanni Dall'Olio
License

Attribution 4.0 (CC BY 4.0)https://creativecommons.org/licenses/by/4.0/
License information was derived automatically

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Description

N-linked glycosylation is the most important form of post-translational modification for proteins synthesized and folded in the Endoplasmic Reticulum (Stanley et al. 2009). An early study in 1999 revealed that about 50% of the proteins in the Swiss-Prot database at the time were N-glycosylated (Apweiler et al. 1999). It is now established that the majority of the proteins in the secretory pathway require glycosylation in order to achieve proper folding.
The addition of an N-glycan to a protein can have several roles (Shental-Bechor & Levy 2009). First, glycans enhance the solubility and stability of the proteins in the ER, the golgi and on the outside of the cell membrane, where the composition of the medium is strongly hydrophilic and where proteins, that are mostly hydrophobic, have difficulty folding properly. Second, N-glycans are used as signal molecules during the folding and transport process of the protein: they have the role of labels to determine when a protein must interact with a chaperon, be transported to the golgi, or targeted for degradation in case of major folding defects. Third, and most importantly, N-glycans on completely folded proteins are involved in a wide range of processes: they help determine the specificity of membrane receptors in innate immunity or in cell-to-cell interactions, they can change the properties of hormones and secreted proteins, or of the proteins in the vesicular system inside the cell.
All N-linked glycans are derived from a common 14-sugar oligosaccharide synthesized in the ER, which is attached co-translationally to a protein while this is being translated inside the reticulum. The process of the synthesis of this glycan, known as Synthesis of the N-glycan precursor or LLO, constitutes one of the most conserved pathways in eukaryotes, and has been also observed in some eubacteria. The attachment usually happens on an asparagine residue within the consensus sequence asparagine-X-threonine by an complex called oligosaccharyl transferase (OST).
After being attached to an unfolded protein, the glycan is used as a label molecule in the folding process (also known as Calnexin/Calreticulin cycle) (Lederkremer 2009). The majority of the glycoproteins in the ER require at least one glycosylated residue in order to achieve proper folding, even if it has been shown that a smaller portion of the proteins in the ER can be folded without this modification.
Once the glycoprotein has achieved proper folding, it is transported via the cis-Golgi through all the Golgi compartments, where the glycan is further modified according to the properties of the glycoprotein. This process involves relatively few enzymes but due to its combinatorial nature, can lead to several millions of different possible modifications. The exact topography of this network of reactions has not been established yet, representing one of the major challenges after the sequencing of the human genome (Hossler et al. 2006).
Since N-glycosylation is involved in an great number of different processes, from cell-cell interaction to folding control, mutations in one of the genes involved in glycan assembly and/or modification can lead to severe development problems (often affecting the central nervous system). All the diseases in genes involved in glycosylation are collectively known as Congenital Disorders of Glycosylation (CDG) (Sparks et al. 2003), and classified as CDG type I for the genes in the LLO synthesis pathway, and CDG type II for the others.

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