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100+ datasets found
  1. R

    Data from: Asparagine N-linked glycosylation

    • reactome.org
    sbgn, biopax2, pdf +4
  2. e

    N-glycosylation site

    • www.ebi.ac.uk
    Updated Oct 15, 2020
  3. e

    N-glycosylation protein EOS1

    • www.ebi.ac.uk
    Updated Nov 19, 2015
  4. R

    Diseases associated with O-glycosylation of proteins

    • reactome.org
    pdf, sbgn, biopax2 +4
  5. R

    Data from: Diseases of glycosylation

    • reactome.org
    biopax2, sbgn, pdf +4
  6. Data from: Glycosylation of a CNS-specific extracellular matrix...

    • researchdata.edu.au
    Updated Jun 26, 2012
  7. R

    N-linked glycosylation of WNTs

    • reactome.org
    pdf, sbgn, biopax2 +4
  8. e

    CD34 antigen

    • www.ebi.ac.uk
    Updated Apr 9, 2004
  9. R

    Glycosylation of Hh

    • reactome.org
    biopax2, sbgn, pdf +4
  10. o

    Glycosylation analysis of TNF-alpha-induced insulin resistance

    • www.omicsdi.org
    xml
  11. e

    Reversibly glycosylated polypeptide

    • www.ebi.ac.uk
    Updated Nov 14, 2015
  12. s

    O-GLYCBASE

    • scicrunch.org
    Updated Jan 1, 1999
  13. t

    BIOGRID CURATED DATA FOR PUBLICATION: Defects in protein glycosylation cause...

    • thebiogrid.org
    zip
    Updated Jul 1, 2000
  14. o

    Data from: N-glycosylation Profiling of Colorectal Cancer Cell Lines Reveals...

    • www.omicsdi.org
    xml
  15. e

    UDP-GlcNAc-dolichyl-phosphate GlcNAc phosphotransferase

    • www.ebi.ac.uk
    Updated Oct 14, 2016
  16. f

    N-glycosylation sites of Phlebotomus tobbi salivary proteins.

    • plos.figshare.com
    xls
    Updated Dec 2, 2015
  17. e

    Oligosaccharyl transferase, STT3 subunit

    • www.ebi.ac.uk
    Updated Nov 20, 2015
  18. Data from: Separation and characterization of the two Asn-linked...

    • researchdata.edu.au
    Updated Jun 26, 2012
  19. o

    Data from: The metacaspase Mca1p restricts O-glycosylation during...

    • www.omicsdi.org
    • datamed.org
    xml
  20. d

    Mannose glycosylation is an integral step for human NIS localization and...

    • datadryad.org
    zip
    Updated Oct 7, 2019
  21. t

    BIOGRID CURATED DATA FOR PUBLICATION: The role of N-linked glycosylation in...

    • thebiogrid.org
    zip
    Updated May 2, 2003
  22. Data from: Site-specific N-glycosylation of human chorionic...

    • researchdata.edu.au
    Updated Jun 26, 2012
  23. Data from: N-linked glycosylation of native and recombinant cauliflower...

    • researchdata.edu.au
    Updated Jun 26, 2012
  24. Data from: The conformational effects of N-glycosylation on the tailpiece...

    • researchdata.edu.au
    Updated Jun 26, 2012
  25. r

    Data from: N-glycosylation of horseradish peroxidase from cell culture.

    • researchdata.edu.au
    Updated Jun 26, 2012
  26. t

    BIOGRID CURATED DATA FOR PUBLICATION: Roles of N-glycosylation and...

    • thebiogrid.org
    zip
    Updated Jan 22, 2012
  27. Clauder et al. 'IgG Fc N-glycosylation translates MHCII haplotype into...

    • www.narcis.nl
    • search.datacite.org
    Updated Jan 15, 2020
  28. t

    BIOGRID CURATED DATA FOR PUBLICATION: Glycosylation defects activate...

    • thebiogrid.org
    zip
    Updated Apr 17, 2009
  29. o

    Data from: Quantitative proteomics reveals the effect of protein...

    • www.omicsdi.org
    xml
    Updated Jan 9, 2019
  30. f

    Experimental and theoretical occupancy of TfR N-glycosylation sites.

    • plos.figshare.com
    xls
    Updated Dec 2, 2015
  31. Data from: Type II Epithelial-Mesenchymal Transition Upregulates Protein...

    • acs.figshare.com
    xls
    Updated Aug 27, 2019
  32. o

    O-GalNAc–glycosylated nuclear proteins

    • www.omicsdi.org
    xml
  33. o

    Data from: Quantitative Profiling of N-linked Glycosylation Machinery in...

    • www.omicsdi.org
    xml
  34. o

    Irani2015 - Genome-scale metabolic model of P.pastoris N-glycosylation

    • www.omicsdi.org
    xml
  35. Cancer Associated Aberrant Protein O-Glycosylation Can Modify Antigen...

    • plos.figshare.com
    pdf
    Updated Jan 19, 2016
  36. t

    BIOGRID CURATED DATA FOR PUBLICATION: The ALG10 locus of Saccharomyces...

    • thebiogrid.org
    zip
    Updated May 1, 1998
  37. t

    BIOGRID CURATED DATA FOR PUBLICATION: CBP-mediated post-translational...

    • thebiogrid.org
    zip
  38. e

    ATP-binding cassette subfamily A member 12

    • www.ebi.ac.uk
    Updated Nov 18, 2015
  39. t

    BIOGRID CURATED DATA FOR PUBLICATION: Alg14 recruits Alg13 to the...

    • thebiogrid.org
    zip
    Updated Oct 28, 2005
  40. t

    BIOGRID CURATED DATA FOR PUBLICATION: Meigo governs dendrite targeting...

    • thebiogrid.org
    zip
    Updated Jun 1, 2013
  41. a

    congenital disorder of glycosylation

    • www.alliancegenome.org
    Updated May 12, 2018
  42. R

    Diseases associated with N-glycosylation of proteins

    • reactome.org
    pdf, biopax2, sbgn +4
  43. Proteome-Wide Analysis of Single-Nucleotide Variations in the...

    • plos.figshare.com
    xlsx
    Updated Jan 19, 2016
  44. e

    Q06210

    • www.ebi.ac.uk
    Updated Apr 28, 2013
  45. t

    BIOGRID CURATED DATA FOR PUBLICATION: Stress-associated endoplasmic...

    • thebiogrid.org
    zip
    Updated Dec 13, 1999
  46. e

    Gdt1 family

    • www.ebi.ac.uk
    Updated Nov 20, 2015
  47. o

    Deconstruction of protein O-glycosylation

    • www.omicsdi.org
    xml
    Updated May 22, 2020
  48. t

    BIOGRID CURATED DATA FOR PUBLICATION: Glucose-Mediated N-glycosylation of...

    • thebiogrid.org
    zip
  49. N-Glycosylation Is Required for Secretion and Mitosis in C. elegans

    • plos.figshare.com
    tiff
    Updated Jan 18, 2016
  50. e

    Q8NCW6

    • www.ebi.ac.uk
    Updated May 11, 2013
  51. a

    congenital disorder of glycosylation In

    • www.alliancegenome.org
    Updated Sep 4, 2019
  52. Data from: O- and N-glycosylation of the Leishmania mexicana-secreted acid...

    • researchdata.edu.au
    Updated Jun 26, 2012
  53. t

    BIOGRID CURATED DATA FOR PUBLICATION: Disruption of N-linked glycosylation...

    • thebiogrid.org
    zip
    Updated Nov 10, 2009
  54. Data from: Exploring Site-Specific N‑Glycosylation Microheterogeneity of...

    • acs.figshare.com
    xlsx
    Updated Feb 19, 2016
  55. o

    Data from: Site-specific O-Glycosylation Analysis of Human Blood Plasma...

    • www.omicsdi.org
    xml
  56. The significance of glycosylation on the function of the calcium-sensing...

    • researchdata.edu.au
    Updated Sep 20, 2012
  57. Data from: Deciphering Protein O‑Glycosylation: Solid-Phase Chemoenzymatic...

    • figshare.com
    xlsx
    Updated Jun 24, 2018
  58. R

    Glycosylation of Pre-NOTCH by FRINGE

    • reactome.org
    pdf, biopax2, sbgn +4
  59. R

    O-glycosylation of TSR domain-containing proteins

    • www.reactome.org
    biopax2, sbgn, pdf +4
  60. o

    Identification and Quantification of Site-Specific N-Glycosylation in Human...

    • www.omicsdi.org
    xml
  61. Data from: Comprehensive Profiling of N‑Linked Glycosylation Sites in HeLa...

    • acs.figshare.com
    zip
    Updated Feb 20, 2016
  62. R

    N-glycan trimming in the ER and Calnexin/Calreticulin cycle

    • reactome.org
    biopax2, sbgn, pdf +4
  63. Data from: In-Depth N‑Glycosylation Reveals Species-Specific Modifications...

    • acs.figshare.com
    xlsx
    Updated Dec 17, 2015
  64. R

    Glycosylation of Pre-Notch by Fringe

    • reactome.org
    biopax2, sbgn, pdf +4
  65. R

    O-linked glycosylation

    • reactome.org
    pdf, biopax2, sbgn +4
  66. R

    Defective MOGS does not cleave glucose from an N-glycosylated protein

    • reactome.org
    pdf, sbgn, biopax2 +4
  67. R

    Glycosylation of Hh

    • reactome.org
    pdf, biopax2, sbgn +4
  68. R

    Data from: Asparagine N-linked glycosylation

    • reactome.org
    sbgn, pdf, biopax2 +4
    Updated Mar 1, 2010
  69. R

    Data from: O-linked glycosylation of mucins

    • reactome.org
    pdf, sbgn, biopax2 +4
    Updated Dec 16, 2011
  70. Functional Divergence in the Role of N-Linked Glycosylation in Smoothened...

    • plos.figshare.com
    tiff
    Updated Jan 15, 2016
  71. Glycosylation and Folding of HA

    • reactome.org
    pdf, biopax2, sbgn +4
  72. e

    Dol-P-Man:Man(7)GlcNAc(2)-PP-Dol alpha-1,6-mannosyltransferase

    • www.ebi.ac.uk
    Updated Sep 26, 2018
  73. o

    Data from: Site-specific N-glycosylation of HeLa cell glycoproteins

    • www.omicsdi.org
    xml
    Updated Mar 29, 2020
  74. R

    Defective MOGS causes MOGS-CDG (CDG-2b)

    • reactome.org
    pdf, sbgn, biopax2 +4
  75. o

    The role of glycans and glycosylation in cell-type specific effects on viral...

    • omictools.com
    • www.omicsdi.org
    Updated Mar 23, 2012
  76. t

    BIOGRID CURATED DATA FOR PUBLICATION: Pim-1 kinase protects P-glycoprotein...

    • thebiogrid.org
    zip
    Updated May 12, 2010
  77. SIRAH-CoV2 initiative: Glycosylated RBD

    • zenodo.org
    tar
    Updated Jun 22, 2020
  78. General N-and O-Linked Glycosylation of Lipoproteins in Mycoplasmas and Role...

    • plos.figshare.com
    pdf
    Updated Jan 15, 2016
  79. Genetic determinants of genus-level glycan diversity in a bacterial protein...

    • plos.figshare.com
    tiff, pdf
    Updated Jan 14, 2020
  80. SIRAH-CoV2 initiative: RBD triple glycosylated at Asn331, 343, and 481 from...

    • zenodo.org
    tar
    Updated Nov 17, 2020
  81. f

    Effect of Glycosylation on an Immunodominant Region in the V1V2 Variable...

    • plos.figshare.com
    ai
    Updated Oct 12, 2016
  82. o

    Data from: Detecting Proteins Glycosylation by a Homogeneous Reac-tion...

    • www.omicsdi.org
    xml
  83. Rapid chemical de-N-glycosylation and derivatization for liquid...

    • plos.figshare.com
    pdf, ai
    Updated May 4, 2018
  84. Role of N-glycosylation in activation of proMMP-9. A molecular dynamics...

    • plos.figshare.com
    png
    Updated Jan 13, 2018
  85. R

    Defective SLC35C1 causes congenital disorder of glycosylation 2C (CDG2C)

    • reactome.org
    sbgn, biopax2, pdf +4
  86. R

    Advanced glycosylation endproduct receptor signaling

    • reactome.org
    pdf, biopax2, sbgn +4
  87. t

    BIOGRID CURATED DATA FOR PUBLICATION: Over-expression of S. cerevisiae G1...

    • thebiogrid.org
    zip
    Updated Jan 1, 1996
  88. Data from: O-glycosylation of eukaryotic transcription factors: implications...

    • researchdata.edu.au
    Updated Jun 26, 2012
  89. Data from: An Enzymatic Deglycosylation Scheme Enabling Identification of...

    • acs.figshare.com
    xls
    Updated Apr 2, 2020
  90. Data from: Neutralization of pH in the Golgi apparatus causes redistribution...

    • researchdata.edu.au
    Updated Jun 26, 2012
  91. s

    PTMcode

    • scicrunch.org
    Updated Nov 29, 2012
  92. t

    BIOGRID CURATED DATA FOR PUBLICATION: Involvement of aberrant glycosylation...

    • thebiogrid.org
    zip
    Updated Oct 23, 2002
  93. Analysis of site-specific N-glycosylation of recombinant Desmodus rotundus...

    • researchdata.edu.au
    Updated Jun 26, 2012
  94. Data from: Phosphorylation and O-glycosylation sites of bovine chromogranin...

    • researchdata.edu.au
    Updated Jun 26, 2012
  95. o

    Deconstruction of O-glycosylation – Polypeptide GalNAc-T Isoforms Direct...

    • www.omicsdi.org
    • datamed.org
    xml
  96. Data from: Unusual N-glycosylation of a recombinant human erythropoietin...

    • researchdata.edu.au
    Updated Jun 26, 2012
  97. e

    Dehydrodolichyl diphosphate synthase complex subunit Nus1

    • www.ebi.ac.uk
    Updated May 29, 2018
  98. R

    Glycosylation of mouse WNTs

    • reactome.org
    biopax2, pdf, sbgn +4
  99. N-Linked Glycosylation Supports Cross-Talk between Receptor Tyrosine Kinases...

    • plos.figshare.com
    ai
    Updated Jan 18, 2016
  100. E

    Identification of genes involved in congenital disorders of glycosylation...

    • ega-archive.org
    Updated Mar 14, 2018
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D'Eustachio, P., Dall'Olio, G. M., Gagneux, P., & Jassal, B. Asparagine N-linked glycosylation.

Data from: Asparagine N-linked glycosylation

Related Article
sbgn, biopax2, pdf, biopax3, owl, sbml, docxAvailable download formats
Authors
Giovanni Dall'Olio
License

Attribution 4.0 (CC BY 4.0)https://creativecommons.org/licenses/by/4.0/
License information was derived automatically

Description

N-linked glycosylation is the most important form of post-translational modification for proteins synthesized and folded in the Endoplasmic Reticulum (Stanley et al. 2009). An early study in 1999 revealed that about 50% of the proteins in the Swiss-Prot database at the time were N-glycosylated (Apweiler et al. 1999). It is now established that the majority of the proteins in the secretory pathway require glycosylation in order to achieve proper folding.
The addition of an N-glycan to a protein can have several roles (Shental-Bechor & Levy 2009). First, glycans enhance the solubility and stability of the proteins in the ER, the golgi and on the outside of the cell membrane, where the composition of the medium is strongly hydrophilic and where proteins, that are mostly hydrophobic, have difficulty folding properly. Second, N-glycans are used as signal molecules during the folding and transport process of the protein: they have the role of labels to determine when a protein must interact with a chaperon, be transported to the golgi, or targeted for degradation in case of major folding defects. Third, and most importantly, N-glycans on completely folded proteins are involved in a wide range of processes: they help determine the specificity of membrane receptors in innate immunity or in cell-to-cell interactions, they can change the properties of hormones and secreted proteins, or of the proteins in the vesicular system inside the cell.
All N-linked glycans are derived from a common 14-sugar oligosaccharide synthesized in the ER, which is attached co-translationally to a protein while this is being translated inside the reticulum. The process of the synthesis of this glycan, known as Synthesis of the N-glycan precursor or LLO, constitutes one of the most conserved pathways in eukaryotes, and has been also observed in some eubacteria. The attachment usually happens on an asparagine residue within the consensus sequence asparagine-X-threonine by an complex called oligosaccharyl transferase (OST).
After being attached to an unfolded protein, the glycan is used as a label molecule in the folding process (also known as Calnexin/Calreticulin cycle) (Lederkremer 2009). The majority of the glycoproteins in the ER require at least one glycosylated residue in order to achieve proper folding, even if it has been shown that a smaller portion of the proteins in the ER can be folded without this modification.
Once the glycoprotein has achieved proper folding, it is transported via the cis-Golgi through all the Golgi compartments, where the glycan is further modified according to the properties of the glycoprotein. This process involves relatively few enzymes but due to its combinatorial nature, can lead to several millions of different possible modifications. The exact topography of this network of reactions has not been established yet, representing one of the major challenges after the sequencing of the human genome (Hossler et al. 2006).
Since N-glycosylation is involved in an great number of different processes, from cell-cell interaction to folding control, mutations in one of the genes involved in glycan assembly and/or modification can lead to severe development problems (often affecting the central nervous system). All the diseases in genes involved in glycosylation are collectively known as Congenital Disorders of Glycosylation (CDG) (Sparks et al. 2003), and classified as CDG type I for the genes in the LLO synthesis pathway, and CDG type II for the others.

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