This statistic shows the number of Golden Retriever dogs registered in the United Kingdom (UK) from 2011 to 2023. During the given time period, the number of registered Golden Retrievers in the UK peaked in 2021, when about **** thousand dogs were registered.

The top dog breed in the UK in 2022, as measured by number of registrations, was the Labrador Retriever breed. Some 44,311 retrievers were newly registered in the UK in 2022. French Bulldogs and Cocker Spaniels rounded out the top three dog breeds in the UK that year.

Surge in UK dog registrations

In 2022, many dog breeds saw a decrease in registrations after large growth in 2021. Over 17 thousand fewer Labrador Retrievers were registered in 2022 than in 2021. Registrations of French Bulldogs and Cocker Spaniels also saw significant decreases in the UK that year.

UK pet food market

Europe and North America produce the most pet food worldwide. In 2022, Europe produced about 11.8 million metric tons of pet food. Though less pet food is produced in North America overall, the United States has the highest pet food revenue worldwide by far. The UK has the second highest revenue, reaching over 6.8 billion U.S. dollars that year.

BackgroundIn canine genetics, the impact of population structure on whole genome association studies is typically addressed by sampling approximately equal numbers of cases and controls from dogs of a single breed, usually from the same country or geographic area. However one way to increase the power of genetic studies is to sample individuals of the same breed but from different geographic areas, with the expectation that independent meiotic events will have shortened the presumed ancestral haplotype around the mutation differently. Little is known, however, about genetic variation among dogs of the same breed collected from different geographic regions.Methodology/Principal FindingsIn this report, we address the magnitude and impact of genetic diversity among common breeds sampled in the U.S. and Europe. The breeds selected, including the Rottweiler, Bernese mountain dog, flat-coated retriever, and golden retriever, share susceptibility to a class of soft tissue cancers typified by malignant histiocytosis in the Bernese mountain dog. We genotyped 722 SNPs at four unlinked loci (between 95 and 271 per locus) on canine chromosome 1 (CFA1). We showed that each population is characterized by distinct genetic diversity that can be correlated with breed history. When the breed studied has a reduced intra-breed diversity, the combination of dogs from international locations does not increase the rate of false positives and potentially increases the power of association studies. However, over-sampling cases from one geographic location is more likely to lead to false positive results in breeds with significant genetic diversity.ConclusionsThese data provide new guidelines for association studies using purebred dogs that take into account population structure.

About this dataset

Do you want to help a dog in need? This dataset contains information on over 3,000 adoptable dogs across the United States. By understanding patterns of dog movement and relocation, we can help these animals find their forever homes.

The data includes information on the origin of each dog, as well as the state they are currently listed for adoption in. This can be used to understand patterns of dog movement across the country, and how different states rely on imported dogs for adoption.

There are several things to keep in mind when using this dataset: - The data represents a single day of data. It is possible that patterns have changed since then. - The data only includes adoptable dogs that were listed on PetFinder.com

How to use the dataset

This dataset of adoptable dogs in the US was collected to better understand how animals are relocated from state to state and imported from outside the US. The data includes information on over 3,000 dogs that were described as having originated in places different from where they were listed for adoption. The findings were published in a visual essay on The Pudding entitled Finding Forever Homes published in October 2019.

This dataset is a snapshot of data collected on a single day and does not include all adoptable dogs in the US. However, it provides valuable insights into the whereabouts of these animals and the journey they take to find their forever homes

So, how should you use it?

This dataset is a great resource for understanding how adoptable dogs are relocated from state to state and imported into the US. The data provides information on the origin of each dog, as well as the state they are currently listed for adoption in. This can be used to understand patterns of dog movement across the country, and how different states rely on imported dogs for adoption.

Research Ideas

• Finding out how many of each type and breed of dog are brought into shelters across the USA in a given year.
• Seeing which states have the most imports of dogs and what breeds/types those are.
• Determining if there are any trends in the types/breeds of dogs being brought into shelters (e.g. more pit bulls than golden retrievers)

Columns

File: dogTravel.csv | Column name | Description | |:------------------|:---------------------------------------------------------------------| | contact_city | The city where the animal is located. (String) | | contact_city | The city where the animal is located. (String) | | contact_state | The state where the animal is located. (String) | | contact_state | The state where the animal is located. (String) | | description | A description of the animal. (String) | | description | A description of the animal. (String) | | found | The date the animal was found. (Date) | | found | The date the animal was found. (Date) | | manual | A manual override for the animal's location. (String) | | manual | A manual override for the animal's location. (String) | | remove | The date the animal was removed from the dataset. (Date) | | remove | The date the animal was removed from the dataset. (Date) | | still_there | Whether or not the animal is still available for adoption. (Boolean) | | still_there | Whether or not the animal is still available for adoption. (Boolean) |

File: allDogDescriptions.csv | Column name | Description | |:--------------------|:-------------------------------------------------------| | contact_city | The city where the animal is located. (String) | | contact_city | The city where the animal is located. (String) | | contact_state | The state where the animal is located. (String) | | contact_state | The state where the animal is located. (String) | | description | A description of the animal. (String) | | description | A description of the animal. (String) | | url | The URL of the animal's profile on PetFinder. (String) | | url | The URL of the animal's profile on PetFinder. (String) | | type.x | The type of animal. (String) | | type.x | The type of animal. (String) | | species | The species of the animal. (S...

Recent evidence demonstrates genomic and morphological continuity in the Arctic ancestral lineage of dogs. Here, we use the Siberian Husky to investigate the genomic legacy of the northeast Eurasian Arctic lineage and model the deep population history using genome-wide SNPs. Utilizing ancient dog calibrated molecular clocks, we found that at least two distinct lineages of Arctic dogs existed in ancient Eurasia at the end of the Pleistocene. This pushes back the origin of sled dogs in the northeast Siberian Arctic with humans likely intentionally selecting dogs to perform different functions and keeping breeding populations that overlap in time and space relatively reproductively isolated. In modern Siberian Huskies, we found significant population structure based on how they are used by humans, recent European breed introgression in about half of the dogs that participate in races, moderate levels of inbreeding, and fewer potentially harmful variants in populations under strong selectio..., , , # Comparative population genomics of Arctic sled dogs reveals a deep and complex history

https://doi.org/10.5061/dryad.8gtht76w4

This dataset contains the SNP genotype data in Plink ped and map format.

Description of the data and file structure

The dataset in these files contains the SNP genotype data for the canids used in this study including Alaskan sled dog (heritage, distance and sprint), Siberian Husky (Pet, Racing, Seppala, Show and Sled-Show), Alaskan Malamute, Chukotka Sled Dog, Greenland sled dog, Golden Retriever, German Shepherd, Saluki, Samoyed, German Shorthaired Pointer, North American Grey Wolf, and three ancient canids (Zhokhov dog, Port au choix pre-contact dog, and Yana wolf).Â

The QC.ped and QC.map files includes the 124905 variant dataset that has been filtered and pruned for to remove variants with missing call rates above 1%, individuals missing more than 33% genotype data, minor allele frequencies below 1%,...

Obesity is a far-reaching, heritable disease, but its genetic basis is incompletely understood. Canine population history facilitates trait mapping. We performed the first successful canine genome-wide association study for body condition score, a measure of obesity, in 241 Labrador retrievers, with a polygenic score replicated in 350 more. Using an innovative cross-species approach, we showed new canine obesity genes are also associated with rare and common forms of obesity in humans. The lead association in dogs was with rs24430444 within the gene DENN domain containing 1B (DENND1B). Each copy of the alternate allele was associated with ~7% greater body fat per allele. We demonstrate a novel role for this gene in regulating signaling and trafficking of melanocortin 4 receptor, a critical controller of energy homeostasis. Thus, canine genetics identified novel obesity genes and mechanisms relevant to both dogs and humans. Methods To summarise, we studied Labrador retriever dogs kept as pets or working assistance dogs. Only adult dogs (age 1-10 years, mean 6 years) were included, free of known or suspected systemic illness and not being treated with medications likely to affect obesity status. Body fat mass was assessed using a well-validated measure of adiposity, Body Condition Score (BCS) which uses a combination of haptic and visual cues to assign dogs to BCS categories 1-9 according to standardized descriptors. DNA was extracted from blood or saliva samples and direct genotyping was performed on the CanineHD Genotyping BeadChip (Illumina) array and data were then imputed to 9.4 million single nucleotide polymorphisms (SNPs). For the GWAS, we retained SNPs called with 70% confidence and which were called in >95% of dogs with an allele frequency > 5% and a Hardy Weinberg equilibrium test p >0.001%. There were 4.5 million SNPs included in the GWAS. We performed a GWAS for BCS in 241 Labrador retriever dogs applying a linear mixed effects model (GCTA MLMA-LOCO). Regression modeling was used to identify factors significantly affecting BCS in the population which were then included as covariates for the GWAS. These included sex, neuter status, and sex: neuter status interaction term. We constructed a PRS comprising 16 SNPs weighted for GWAS effect size on BCS using the ‘clumping and thresholding’ technique and applied the PRS to determine its utility as a predictor of BCS in Labradors and other breeds (FCR, pugs, golden retrievers). This data could not have been collected, nor research conducted without several collaborative efforts and. We are indebted to the owners who volunteered for the study and to the dogs who took part, the Northern England Flatcoated Retriever Association and Kennel Club for helping with recruitment, Guide Dogs UK for sample contributions, Nai-Cheih Liu for gathering phenotypes in pugs. We also used data from the Golden Retriever Lifetime Study in this research, data for which is available via their 'Data Commons' website.

Correlation (r) of the parameters with age and among the parameters in the entire population.

BackgroundCanine hip dysplasia (HD) is a common polygenic trait characterized by hip malformation that results in osteoarthritis (OA). The condition in dogs is very similar to developmental dysplasia of the human hip which also leads to OA.Methodology/Principal FindingsA total of 721 dogs, including both an association and linkage population, were genotyped. The association population included 8 pure breeds (Labrador retriever, Greyhounds, German Shepherd, Newfoundland, Golden retriever, Rottweiler, Border Collie and Bernese Mountain Dog). The linkage population included Labrador retrievers, Greyhounds, and their crosses. Of these, 366 dogs were genotyped at ∼22,000 single nucleotide polymorphism (SNP) loci and a targeted screen across 8 chromosomes with ∼3,300 SNPs was performed on 551 dogs (196 dogs were common to both sets). A mixed linear model approach was used to perform an association study on this combined association and linkage population. The study identified 4 susceptibility SNPs associated with HD and 2 SNPs associated with hip OA.Conclusion/SignificanceThe identified SNPs included those near known genes (PTPRD, PARD3B, and COL15A1) reported to be associated with, or expressed in, OA in humans. This suggested that the canine model could provide a unique opportunity to identify genes underlying natural HD and hip OA, which are common and debilitating conditions in both dogs and humans.

Assistance dogs aid people with various impairments on a daily basis. To become an assistance dog, a strict selection procedure and intensive training period must be successfully completed. Consequently, not every dog acquired for this purpose, becomes an assistance dog. The purpose of this study was to investigate reasons for failure and the financial consequences thereof for assistance dog associations that do not have a dedicated breeding program for their dogs. Data were collected for a total of 537 dogs enlisted between 2001 and 2015 and purchased out of the general dog population by five Belgian assistance dog associations. Only 60 percent of the dogs actually became an assistance dog and the main reasons for failure were related to undesirable behavioural characteristics and orthopaedic disorders. The estimated average financial loss per rejected dog was found to be 10524 euro. A detailed comparison of the two most popular breeds (Golden Retriever and Labrador Retriever) within the guide dogs and mobility assistance dogs revealed no significant difference in probability of successfully completing the training. However, a comparison of orthopaedic screening methods revealed a higher rejection with computed tomography for elbow dysplasia and laxity-based radiographical techniques for hip dysplasia compared to radiography and the standard ventrodorsal hip extend radiograph alone, respectively. Based on these results, we provide several suggestions to increase the probability of success.

BackgroundSeveral adult stem cell populations exhibit myogenic regenerative potential, thus representing attractive candidates for therapeutic approaches of neuromuscular diseases such as Duchenne Muscular Dystrophy (DMD). We have recently shown that systemic delivery of MuStem cells, skeletal muscle-resident stem cells isolated in healthy dog, generates the remodelling of muscle tissue and gives rise to striking clinical benefits in Golden Retriever Muscular Dystrophy (GRMD) dog. This global effect, which is observed in the clinically relevant DMD animal model, leads us to question here the molecular pathways that are impacted by MuStem cell transplantation. To address this issue, we compare the global gene expression profile between healthy, GRMD and MuStem cell treated GRMD dog muscle, four months after allogenic MuStem cell transplantation.ResultsIn the dystrophic context of the GRMD dog, disease-related deregulation is observed in the case of 282 genes related to various processes such as inflammatory response, regeneration, calcium ion binding, extracellular matrix organization, metabolism and apoptosis regulation. Importantly, we reveal the impact of MuStem cell transplantation on several molecular and cellular pathways based on a selection of 31 genes displaying signals specifically modulated by the treatment. Concomitant with a diffuse dystrophin expression, a histological remodelling and a stabilization of GRMD dog clinical status, we show that cell delivery is associated with an up-regulation of genes reflecting a sustained enhancement of muscle regeneration. We also identify a decreased mRNA expression of a set of genes having metabolic functions associated with lipid homeostasis and energy. Interestingly, ubiquitin-mediated protein degradation is highly enhanced in GRMD dog muscle after systemic delivery of MuStem cells.ConclusionsOverall, our results provide the first high-throughput characterization of GRMD dog muscle and throw new light on the complex molecular/cellular effects associated with muscle repair and the clinical efficacy of MuStem cell-based therapy.

Summary of CHDs associations in the included population.

Description of the ten dogs used in the in vivo study.

Sjogren's disease, well-described in people, is rarely identified in veterinary species. In people, Sjogren's disease is one of the most common systemic autoimmune disorders with an incidence of 0.5% in the female population. The hallmark histopathologic finding of primary Sjogren's disease is lymphomononuclear cell infiltrates aggregating as periductal infiltrate in salivary glands. Sjogren's-like disease has been reported in a domestic shorthair cat and golden retriever dog. However, both lacked positive antinuclear antibody (ANA) titers and the dog showed no clinical evidence of dry eye disease. The following case report describes the clinical and immunohistochemical findings suggestive of Sjogren's disease in a 3-year-old spayed female German shepherd cross that was presented for medically refractory absolute dry eye, xerostomia confirmed with oral atropine response tests, and bilateral mandibular salivary gland enlargement. Routine topical lacrostimulants, anti-inflammatories, heterologous serum, ocular lubrication, and oral pilocarpine failed to improve clinical signs or tear production. The ANA titer at 1:160 was interpreted as positive, while the complete blood count and serum biochemistry panels were unremarkable. Head and neck ultrasound revealed bilateral moderately enlarged mandibular salivary glands with a hypoechoic, mottled echotexture consistent with sialoadenitis and regional lymphadenomegaly; thoracic radiography and abdominal ultrasonography were normal. In vivo confocal microscopy and spectral-domain optical coherence tomography of the cornea confirmed lipid keratopathy presumably secondary to corneal desiccation and steroid administration. Salivary gland histopathological and immunohistochemical analyses supported an immune-mediated etiology. Approximately 60% of the salivary section contained inflammatory cells replacing the glandular structures with a focus score of 12. Immunohistochemical markers CD3, CD204, CD79a, and CD20 were evaluated. The inflammatory infiltrate was a mixture of T-cells and macrophages with rare individual immunoreactive B-cells. CD3 and CD4+ T-cells were confirmed using immunohistochemistry and quantitative PCR, respectively. Clinical signs including ocular discharge and mandibular salivary gland enlargement markedly improved following oral immunomodulatory therapy with prednisone (1 mg/kg/d, tapered over 2 months) and long-term leflunomide (2 mg/kg/d). Ocular discomfort improved dramatically decreasing the need for topical lubricants; however, tear production failed to improve likely due to extensive lacrimal gland atrophy. The aim of this report is to increase awareness of Sjogren's disease in dogs and interpret the pathology involved.