The urban spatial structure in this study refers to the combination of different categories of land use, and the purpose of the study is to reveal the intrinsic correlation characteristics between urban land use structural combination forms and urban functions. Through the integration of land and population maps and other multi-source data, with the help of exploratory spatial data analysis and other models, this research deals with the land use spatial structure characteristics of Changchun city and its coordination relationship with urban functions. Main conclusions of the study are as follows. The overall density of the land use in the central urban area of Changchun shows patterns of the core being higher than the periphery, the large-scale agglomeration being significant and the small-scale relatively scattered, and the pattern of the mixed land use function index has obvious differentiation characteristics. The study shows that, in the context of the spatial pattern, the overall coupling coordination degree of the land use structure index and the urban function index shows a trend of a gradual decrease, from the core to the periphery. In the context of category differences, the coupling coordination of the land use structure with the population distribution and the Baidu thermal distribution is relatively high, and the coupling coordination with various service facilities is relatively low. Finally, in the context of scale differences, all types of coupling coordination degrees have significant sensitivity to the spatial scales. A large scale significantly reflects the overall decrease in the coupling coordination degrees from the core to the periphery, while a small scale shows the polycentric pattern characteristics of the urban spatial structure.