Chicago residents who are up to date with influenza vaccines by ZIP Code, based on the reported home address and age group of the person vaccinated, as provided by the medical provider in the Illinois Comprehensive Automated Immunization Registry Exchange (I-CARE). “Up to date” refers to individuals aged 6 months and older who have received 1+ doses of influenza vaccine during the current season, defined as the beginning of July (MMWR week 27) through the end of the following June (MMWR week 26). Data Notes: Weekly cumulative totals of people up to date are shown for each combination ZIP Code and age group. Note there are rows where age group is "All ages" so care should be taken when summing rows. Weeks begin on a Sunday and end on a Saturday. Coverage percentages are calculated based on the cumulative number of people in each ZIP Code and age group who are considered up to date as of the week ending date divided by the estimated number of people in that subgroup. Population counts are obtained from the 2020 U.S. Decennial Census. For ZIP Codes mostly outside Chicago, coverage percentages are not calculated because reliable Chicago-only population counts are not available. Actual counts may exceed population estimates and lead to coverage estimates that are greater than 100%, especially in smaller ZIP Codes with smaller populations. Additionally, the medical provider may report a work address or incorrect home address for the person receiving the vaccination, which may lead to over- or underestimation of vaccination coverage by geography. All coverage percentages are capped at 99%. The Chicago Department of Public Health (CDPH) uses the most complete data available to estimate influenza vaccination coverage among Chicagoans, but there are several limitations that impact our estimates. Influenza vaccine administration is not required to be reported in Illinois, except for publicly funded vaccine (e.g., Vaccines for Children, Section 317). Individuals may receive vaccinations that are not recorded in I-CARE, such as those administered in another state, or those administered by a provider that does not submit data to I-CARE, causing underestimation of the number individuals who received an influenza vaccine for the current season. All data are provisional and subject to change. Information is updated as additional details are received and it is, in fact, very common for recent dates to be incomplete and to be updated as time goes on. At any given time, this dataset reflects data currently known to CDPH. Numbers in this dataset may differ from other public sources due to when data are reported and how City of Chicago boundaries are defined. For all datasets related to influenza, see https://data.cityofchicago.org/browse?limitTo=datasets&sortBy=alpha&tags=flu . Data Source: Illinois Comprehensive Automated Immunization Registry Exchange (I-CARE), U.S. Census Bureau 2020 Decennial Census

Chicago residents who are up to date with influenza vaccines by Healthy Chicago Equity Zone (HCEZ), based on the reported address, race-ethnicity, and age group of the person vaccinated, as provided by the medical provider in the Illinois Comprehensive Automated Immunization Registry Exchange (I-CARE). Healthy Chicago Equity Zones is an initiative of the Chicago Department of Public Health to organize and support hyperlocal, community-led efforts that promote health and racial equity. Chicago is divided into six HCEZs. Combinations of Chicago’s 77 community areas make up each HCEZ, based on geography. For more information about HCEZs including which community areas are in each zone see: https://res1datad-o-tcityofchicagod-o-torg.vcapture.xyz/Health-Human-Services/Healthy-Chicago-Equity-Zones/nk2j-663f “Up to date” refers to individuals aged 6 months and older who have received 1+ doses of influenza vaccine during the current season, defined as the beginning of July (MMWR week 27) through the end of the following June (MMWR week 26). Data notes: Weekly cumulative totals of people up to date are shown for each combination of race-ethnicity and age group within an HCEZ. Note that each HCEZ has a row where HCEZ is “Citywide” and each HCEZ has a row where age is "All" and race-ethnicity is “All Race/Ethnicity Groups” so care should be taken when summing rows. Weeks begin on a Sunday and end on a Saturday. Coverage percentages are calculated based on the cumulative number of people in each population subgroup (age group by race-ethnicity within an HCEZ) who are up to date, divided by the estimated number of people in that subgroup. Population counts are from the 2020 U.S. Decennial Census. Actual counts may exceed population estimates and lead to >100% coverage, especially in small race-ethnicity subgroups of each age group within an HCEZ. All coverage percentages are capped at 99%. Summing all race/ethnicity group populations to obtain citywide populations may provide a population count that differs slightly from the citywide population count listed in the dataset. Differences in these estimates are due to how community area populations are calculated. The Chicago Department of Public Health (CDPH) uses the most complete data available to estimate influenza vaccination coverage among Chicagoans, but there are several limitations that impact our estimates. Influenza vaccine administration is not required to be reported in Illinois, except for publicly funded vaccine (e.g., Vaccines for Children, Section 317). Individuals may receive vaccinations that are not recorded in I-CARE, such as those administered in another state, or those administered by a provider that does not submit data to I-CARE, causing underestimation of the number individuals who received an influenza vaccine for the current season. All data are provisional and subject to change. Information is updated as additional details are received and it is, in fact, very common for recent dates to be incomplete and to be updated as time goes on. At any given time, this dataset reflects data currently known to CDPH. Numbers in this dataset may differ from other public sources due to when data are reported and how City of Chicago boundaries are defined. For all datasets related to influenza, see https://res1datad-o-tcityofchicagod-o-torg.vcapture.xyz/browse?limitTo=datasets&sortBy=alpha&tags=flu . Data Source: Illinois Comprehensive Automated Immunization Registry Exchange (I-CARE), U.S. Census Bureau 2020 Decennial Census

NOTE: This dataset pertains only to the 2020-2021 school year and is no longer being updated. For additional data on COVID-19, visit data.ct.gov/coronavirus.

This dataset includes the leading and secondary metrics identified by the Connecticut Department of Health (DPH) and the Department of Education (CSDE) to support local district decision-making on the level of in-person, hybrid (blended), and remote learning model for Pre K-12 education.

Data represent daily averages for two-week periods by date of specimen collection (cases and positivity), date of hospital admission, or date of ED visit. Hospitalization data come from the Connecticut Hospital Association and are based on hospital location, not county of patient residence. COVID-19-like illness includes fever and cough or shortness of breath or difficulty breathing or the presence of coronavirus diagnosis code and excludes patients with influenza-like illness. All data are preliminary.

These data are updated weekly and reflect the previous two full Sunday-Saturday (MMWR) weeks (https://wwwn.cdc.gov/nndss/document/MMWR_week_overview.pdf).

These metrics were adapted from recommendations by the Harvard Global Institute and supplemented by existing DPH measures.

For national data on COVID-19, see COVID View, the national weekly surveillance summary of U.S. COVID-19 activity, at https://www.cdc.gov/coronavirus/2019-ncov/covid-data/covidview/index.html

DPH note about change from 7-day to 14-day metrics: Prior to 10/15/2020, these metrics were calculated using a 7-day average rather than a 14-day average. The 7-day metrics are no longer being updated as of 10/15/2020 but the archived dataset can be accessed here: https://data.ct.gov/Health-and-Human-Services/CT-School-Learning-Model-Indicators-by-County/rpph-4ysy

As you know, we are learning more about COVID-19 all the time, including the best ways to measure COVID-19 activity in our communities. CT DPH has decided to shift to 14-day rates because these are more stable, particularly at the town level, as compared to 7-day rates. In addition, since the school indicators were initially published by DPH last summer, CDC has recommended 14-day rates and other states (e.g., Massachusetts) have started to implement 14-day metrics for monitoring COVID transmission as well.

With respect to geography, we also have learned that many people are looking at the town-level data to inform decision making, despite emphasis on the county-level metrics in the published addenda. This is understandable as there has been variation within counties in COVID-19 activity (for example, rates that are higher in one town than in most other towns in the county).

This is historical data. The update frequency has been set to "Static Data" and is here for historic value. Updated on 8/14/2024

Annual Season Influenza Vaccinations - This indicator shows the percentage of adults who are vaccinated annually against seasonal influenza. For many people, the seasonal flu is a mild illness, but for some it can lead to pneumonia, hospitalization, or death. Vaccination of persons in high-risk populations is especially important to reduce their risk of severe illness or death. Link to Data Details

Influenza viruses pose a serious threat to human health, infecting hundreds of millions of people worldwide each year, resulting in a significant increase in global morbidity and mortality. Influenza activity has declined at the onset of the COVID-19 pandemic, but the genetic diversity of B/Victoria lineage viruses has increased significantly during this period. Therefore, the prevention and treatment of the influenza B Victoria strain virus should continue to attract research attention. In this study, we found that Atractyloside A (AA), one of the effective components in Atractylodes lancea (Thunb.) DC shows potential antiviral properties. This study shows that AA not only possesses anti-influenza B virus infection effects in vivo and in vitro but also can regulate macrophage polarization to the M2 type, which can effectively attenuate the damage caused by influenza B virus infection. Therefore, Atractyloside A may be an effective natural drug against B/Victoria influenza infection.

DPH note about change from 7-day to 14-day metrics: As of 10/15/2020, this dataset is no longer being updated. Starting on 10/15/2020, the school learning model indicator metrics will be calculated using a 14-day average rather than a 7-day average. The new school learning model indicators dataset using 14-day averages can be accessed here: https://data.ct.gov/Health-and-Human-Services/CT-School-Learning-Model-Indicators-by-County-14-d/e4bh-ax24 As you know, we are learning more about COVID-19 all the time, including the best ways to measure COVID-19 activity in our communities. CT DPH has decided to shift to 14-day rates because these are more stable, particularly at the town level, as compared to 7-day rates. In addition, since the school indicators were initially published by DPH last summer, CDC has recommended 14-day rates and other states (e.g., Massachusetts) have started to implement 14-day metrics for monitoring COVID transmission as well. With respect to geography, we also have learned that many people are looking at the town-level data to inform decision making, despite emphasis on the county-level metrics in the published addenda. This is understandable as there has been variation within counties in COVID-19 activity (for example, rates that are higher in one town than in most other towns in the county). This dataset includes the leading and secondary metrics identified by the Connecticut Department of Health (DPH) and the Department of Education (CSDE) to support local district decision-making on the level of in-person, hybrid (blended), and remote learning model for Pre K-12 education. Data represent daily averages for each week by date of specimen collection (cases and positivity), date of hospital admission, or date of ED visit. Hospitalization data come from the Connecticut Hospital Association and are based on hospital _location, not county of patient residence. COVID-19-like illness includes fever and cough or shortness of breath or difficulty breathing or the presence of coronavirus diagnosis code and excludes patients with influenza-like illness. All data are preliminary. These data are updated weekly; the previous week period for each dataset is the previous Sunday-Saturday, known as an MMWR week (https://wwwn.cdc.gov/nndss/document/MMWR_week_overview.pdf). The date listed is the date the dataset was last updated and corresponds to a reporting period of the previous MMWR week. For instance, the data for 8/20/2020 corresponds to a reporting period of 8/9/2020-8/15/2020. These metrics were adapted from recommendations by the Harvard Global Institute and supplemented by existing DPH measures. For national data on COVID-19, see COVID View, the national weekly surveillance summary of U.S. COVID-19 activity, at https://www.cdc.gov/coronavirus/2019-ncov/covid-data/covidview/index.html Notes: 9/25/2020: Data for Mansfield and Middletown for the week of Sept 13-19 were unavailable at the time of reporting due to delays in lab reporting.

Health and Safety Code section 1288.7(a) requires California acute care hospitals to offer influenza vaccine free of charge to all healthcare providers (HCP) or sign a declination form if a HCP chooses not to be vaccinated. Hospitals must report HCP influenza vaccination data to the California Department of Public Health (CDPH), including the percentage of HCP vaccinated. CDPH is required to make this information public on an annual basis [Health and Safety Code section 1288.8 (b)].

California acute care hospitals are required to offer free influenza vaccine to HCP. Hospital HCP must receive an annual vaccine or sign a declination form. Hospitals collect vaccination data for all HCP physically working in the hospital for at least one day during influenza season, regardless of clinical responsibility or patient contact. Hospitals report HCP vaccination rates to the California Department of Public Health (CDPH) and CDPH publishes the hospital results annually. CDPH reports data separately for hospital employees, licensed independent practitioners such as physicians, other contract staff, and trainees and volunteers (Health and Safety Code section 1288.7-1288.8).

Detailed information about the variables included in each dataset are described in the accompanying data dictionaries for the year of interest.

For general information about NHSN, surveillance definitions, and reporting requirements for HCP influenza vaccination, please visit: https://www.cdc.gov/nhsn/hps/vaccination/index.html

To link the CDPH facility IDs with those from other Departments, including OSHPD, please reference the "Licensed Facility Cross-Walk" Open Data table at: https://data.chhs.ca.gov/dataset/licensed-facility-crosswalk.

For information about healthcare personnel influenza vaccinations in California hospitals, please visit: https://www.cdph.ca.gov/Programs/CHCQ/HAI/Pages/HealthcarePersonnelInfluenzaVaccinationReportingInCA_Hospitals.aspx

It is well accepted that influenza A virus predisposes individuals to often more severe superinfections with Streptococcus pneumonia. However, the mechanisms that lead to this synergy are not clearly understood. Recent data suggests that competent Th17 immunity is crucial to clearance and protection from invasive pneumococcal disease of the lung. We demonstrate that early influenza infection significantly reduced levels of pneumococcus driven IL-12p70, IL-23 and IL-27 in human monocytes with significant impairment of IL-17A and IFN-γ in HKSP-treated allogeneic mixed lymphocyte cultures. We also provide evidence to suggest that the hemagglutinin component of the virus is at least partially responsible for this downward pressure on IL-17 responses but surprisingly this suppression occurs despite robust IL-23 levels in hemagglutinin-treated monocyte cultures. This study demonstrates that influenza can directly affect the immunological pathways that promote appropriate responses to Streptococcus pneumonia in human immune cells.ImportanceInfluenza virus is highly contagious and poses substantial public health problems due to its strong association with morbidity and mortality. Approximately 250,000–500,000 deaths are caused by seasonal influenza virus annually, and this figure increases during periods of pandemic infections. Most of these deaths are due to secondary bacterial pneumonia. Influenza-bacterial superinfection can result in hospitalisation and/or death of both patients with pre-existing lung disease or previously healthy individuals. The importance of our research is in determining that influenza and its component haemagglutinin has a direct effect on the classic pneumococcus induced pathways to IL-17A in our human ex vivo model.Our understanding of the mechanism which leaves people exposed to influenza infection during superinfection remain unresolved. This paper demonstrates that early infection of monocytes inhibits an arm of immunity crucial to bacterial clearance. Understanding this mechanism may provide alternative interventions in the case of superinfection with antimicrobial resistant strains of bacteria.

We investigated avian influenza infections in wild birds, poultry, and humans at Eastern Dongting Lake, China. We analyzed 6,621 environmental samples, including fresh fecal and water samples, from wild birds and domestic ducks that were collected from the Eastern Dongting Lake area from November 2011 to April 2012. We also conducted two cross-sectional serological studies in November 2011 and April 2012, with 1,050 serum samples collected from people exposed to wild birds and/or domestic ducks. Environmental samples were tested for the presence of avian influenza virus (AIV) using quantitative PCR assays and virus isolation techniques. Hemagglutination inhibition assays were used to detect antibodies against AIV H5N1, and microneutralization assays were used to confirm these results. Among the environmental samples from wild birds and domestic ducks, AIV prevalence was 5.19 and 5.32%, respectively. We isolated 39 and 5 AIVs from the fecal samples of wild birds and domestic ducks, respectively. Our analysis indicated 12 subtypes of AIV were present, suggesting that wild birds in the Eastern Dongting Lake area carried a diverse array of AIVs with low pathogenicity. We were unable to detect any antibodies against AIV H5N1 in humans, suggesting that human infection with H5N1 was rare in this region.

This dataset contains information from a population-based survey, which investigated human exposure to live poultry, and population psychological response and behavioral changes of the community members during two waves of influenza A(H7N9) epidemics in Southern China in 2013-2014. The dataset including 3 files. * One file named "population_wt.csv" contained population information of the studied sites; * One file named "H7N9 survey China_Que stionarie_eng.doc" was the survey questionaire; * The third file named "dataset_H7N9.csv" contained datasets acquired during the two waves of A(H7N9) epidemics,a data frame with 1657 observations on the following 44 variables. Survey ##a numeric vector: where the subject live## 1= the first wave () 2= the second wave () Place ##a numeric vector: where the subject live## 5=Guangzhou 10=Zijin County, Heyuan City SG3 ##a numeric vector: the gender of the subject## 1=Female 2=Male SG4_b ##a numeric vector: the age group of the subject, unit=years## 1=18-24 2=25-34 3=35-44 4=45-54 5=55-64 6=65+ SG6 ##a numeric vector: the marital status of the subject## 1=Single 2=Married 3=Divorced /separated 4=Widowed 5=Refuse to answer SG8 ##a numeric vector: the educational attainment of the subject## 1=Illiteracy 2=Primary school 3=Middle school 4=High school 5=College and above SG12 ##a numeric vector: the average income of the subject, unit=Chinese Yuan## 1=Less than l,000 2=1,001—2,000 3=2,001—3,000 4=3,001—4,000 5=4,001—6,000 6=6,001—8,000 7=8,001—10,000 8=10,001—2,000 9=15,001—20,000 10=20,001—30,000 11=More than 30,001 12=No income 13=Don’t know 14=Refuse to answer AX1_a ##a numeric vector: the anxiety level of the subject, I feel rested ## 1=Not at all 2=Sometimes 3=Moderately So 4=Very Much So AX1_b ##a numeric vector: the anxiety level of the subject, I feel content ## 1=Not at all 2=Sometimes 3=Moderately So 4=Very Much So AX1_c ##a numeric vector: the anxiety level of the subject, I feel comfortable ## 1=Not at all 2=Sometimes 3=Moderately So 4=Very Much So AX1_d ##a numeric vector: the anxiety level of the subject, I am relaxed ## 1=Not at all 2=Sometimes 3=Moderately So 4=Very Much So AX1_e ##a numeric vector: the anxiety level of the subject, I feel pleasant ## 1=Not at all 2=Sometimes 3=Moderately So 4=Very Much So AX1_f ##a numeric vector: the anxiety level of the subject, I feel anxious ## 1=Not at all 2=Sometimes 3=Moderately So 4=Very Much So AX1_g ##a numeric vector: the anxiety level of the subject, I feel nervous ## 1=Not at all 2=Sometimes 3=Moderately So 4=Very Much So AX1_h ##a numeric vector: the anxiety level of the subject, I am jittery ## 1=Not at all 2=Sometimes 3=Moderately So 4=Very Much So AX1_i ##a numeric vector: the anxiety level of the subject, I feel “high strung” ## 1=Not at all 2=Sometimes 3=Moderately So 4=Very Much So AX1_j ##a numeric vector: the anxiety level of the subject, I feel over-excited and “rattled” ## 1=Not at all 2=Sometimes 3=Moderately So 4=Very Much So BF4b##a numeric vector indicating the subject's rate of worriness towards H7N9 avian flu, 1 being very mild to 10 being very severe## EM1 ##a numeric vector: How often did you go to wet markets in the past year ## 1=1-2/year 2=3-5/year 3=6-11/year 4=1-3/month 5=1-2/week 6=3-5/week 7=Almost every day 8=Almost not EM2 ##a numeric vector: How often did you buy poultry in wet markets in the past year ## 1=1-2/year 2=3-5/year 3=6-11/year 4=1-3/month 5=1-2/week 6=3-5/week 7=Almost every day 8=Almost not EM3 ##a numeric vector: Did you usually pick up the poultry for examination before deciding to buy it ## 1=Yes 2=No 3=Sometime “yes”, sometime “no” EM4 ##a numeric vector: Where was the live poultry slaughtered when you bought it? ## 1=Always in wet market 2=Usually in wet market 3=Usually in my household 4=Always in my household 5=Other places EM5 ##a numeric vector: Have your habit of buying live poultry changed since the first human H7N9 case was released in the past month ## 1=Yes, not buying since then 2=No, still buying and eating live poultry 3=Still buying but less than before EM6 ##a numeric vector: Would you support permanent closure of live poultry markets in order to control avian influenza epidemics ## 1=Strongly agree 2=Agree 3=Not agree 4=Strongly disagree 5=Don’t know EM8 ##a numeric vector: Have your raised live poultry in your backyard in the past year ## 1=Yes 2=No BF1 ##a numeric vector indicating risk perception of the subject: How likely do you think it is that you will contract H7N9 avian flu over the next 1 month ## 1=Never 2=Very unlikely 3=Unlikely 4=Evens 5=Likely 6=Very likely 7=Certain BF2a ##a numeric vector indicating risk perception of the subject: What do you think are your chances of getting H7N9 avian flu over the next 1 month compared to other people outside your family of a similar age ## 1=Not at all 2=Much less 3=Less 4=Evens 5=More 6=Much more 7=Certain BF3_l ##a numeric vector indicating knowledge of the subject: H7N9 avian flu is spread by the body contact with patients ## 1=Yes 2=No 3=Don’t Know BF3_m ##a numeric vector indicating knowledge of the subject: H7N9 avian flu is spread by touching objects that have been contaminated by the virus ## 1=Yes 2=No 3=Don’t Know BF3_n ##a numeric vector indicating knowledge of the subject: H7N9 avian flu is spread by the close contact with chickens in a wet market ## 1=Yes 2=No 3=Don’t Know BF4 ##a numeric vector: If you were to develop flu-like symptoms tomorrow, would you be... ## 1=Not at all worried 2=Much less worried than normal 3=Worried less than normal 4=About same 5=Worried more than normal 6=Worried much more than normal 7=Extremely worried BF4a ##a numeric vector indicating risk perception of the subject: In the past one week, have you ever worried about catching H7N9 avian flu ## 1=No, never think about it 2=Think about it but it doesn’t worry me 3=Worries me a bit 4=Worries me a lot 5=Worry about it all the time BF5a ##a numeric vector indicating risk perception of the subject: How does H7N9 avian flu compare with seasonal flu in terms of seriousness ## 1=Much higher 2=A little higher 3=Same 4=A little lower 5=Much lower 6=Don’t Know BF5b ##a numeric vector indicating risk perception of the subject: How does H7N9 avian flu compare with H5N1 avian flu in terms of seriousness ## 1=Much higher 2=A little higher 3=Same 4=A little lower 5=Much lower 6=Don’t Know BF5c ##a numeric vector indicating risk perception of the subject: How does H7N9 avian flu compare with SARS in terms of seriousness ## 1=Much higher 2=A little higher 3=Same 4=A little lower 5=Much lower 6=Don’t Know BF7 ##a numeric vector evaluating the current performance of the national government in controlling H7N9 avian flu, (0=extremely poor, 5=moderate, 10=excellent) ## BF7a ##a numeric vector evaluating the current performance of the provincial/city government in controlling H7N9 avian flu, (0=extremely poor, 5=moderate, 10=excellent) ## PM2 ##a numeric vector indicating the preventive behavior of the subject, covering the mouth when sneeze or cough ## 1=Always 2=Usually 3=Sometimes 4=Never 5=Don’t know 6=Not applicable (no sneeze or cough) PM3 ##a numeric vector indicating the preventive behavior of the subject, washing hands after sneezing, coughing or touching nose ## 1=Always 2=Usually 3=Sometimes 4=Never 5=Don’t know 6=Not applicable (no sneeze or cough) PM3a ##a numeric vector indicating the preventive behavior of the subject,washing hands after returning home ## 1=Always 2=Usually 3=Sometimes 4=Never 5=Don’t know 6=Not applicable (never go out) PM4 ##a numeric vector indicating the preventive behavior of the subject,using liquid soap when washing hands ## 1=Always 2=Usually 3=Sometimes 4=Never 5=Don’t know PM5 ##a numeric vector indicating the preventive behavior of the subject,wearing face mask ## 1=Always 2=Usually 3=Sometimes 4=Never 5=Don’t know PM7 ##a numeric vector:If free H7N9 flu vaccine is available in the coming month, would you consider receiving it ## 1=Yes 2=No 3=Not sure 4=Don’t know

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A pandemic-capable influenza virus requires a hemagglutinin (HA) surface glycoprotein that is immunologically unseen by most people and is capable of supporting replication and transmission in humans. HA stabilization has been linked to 2009 pH1N1 pandemic potential in humans and H5N1 airborne transmissibility in the ferret model. Swine have served as an intermediate host for zoonotic influenza viruses, yet the evolutionary pressure exerted by this host on HA stability was unknown. For over 70 contemporary swine H1 and H3 isolates, we measured HA activation pH to range from pH 5.1 to 5.9 for H1 viruses and pH 5.3 to 5.8 for H3 viruses. Thus, contemporary swine isolates vary widely in HA stability, having values favored by both avian (pH >5.5) and human and ferret (pH ≤5.5) species. Using an early 2009 pandemic H1N1 (pH1N1) virus backbone, we generated three viruses differing by one HA residue that only altered HA stability: WT (pH 5.5), HA1-Y17H (pH 6.0), and HA2-R106K (pH 5.3). All three replicated in pigs and transmitted from pig-to-pig and pig-to-ferret. WT and R106 viruses maintained HA genotype and phenotype after transmission. Y17H (pH 6.0) acquired HA mutations that stabilized the HA protein to pH 5.8 after transmission to pigs and 5.5 after transmission to ferrets. Overall, we found swine support a broad range of HA activation pH for contact transmission and many recent swine H1N1 and H3N2 isolates have stabilized (human-like) HA proteins. This constitutes a heightened pandemic risk and underscores the importance of ongoing surveillance and control efforts for swine viruses.