A measure of the number of adults diagnosed with any type of cancer in a year who are still alive five years after diagnosis. Purpose This indicator attempts to capture the success of the NHS in preventing people from dying once they have been diagnosed with any type of cancer. Current version updated: Feb-17 Next version due: Feb-18

A measure of the number of adults diagnosed with any type of cancer in a year who are still alive one year after diagnosis. Purpose This indicator attempts to capture the success of the NHS in preventing people from dying once they have been diagnosed with any type of cancer. Current version updated: Feb-17 Next version due: Feb-18

Age-standardised rate of mortality from oral cancer (ICD-10 codes C00-C14) in persons of all ages and sexes per 100,000 population.RationaleOver the last decade in the UK (between 2003-2005 and 2012-2014), oral cancer mortality rates have increased by 20% for males and 19% for females1Five year survival rates are 56%. Most oral cancers are triggered by tobacco and alcohol, which together account for 75% of cases2. Cigarette smoking is associated with an increased risk of the more common forms of oral cancer. The risk among cigarette smokers is estimated to be 10 times that for non-smokers. More intense use of tobacco increases the risk, while ceasing to smoke for 10 years or more reduces it to almost the same as that of non-smokers3. Oral cancer mortality rates can be used in conjunction with registration data to inform service planning as well as comparing survival rates across areas of England to assess the impact of public health prevention policies such as smoking cessation.References:(1) Cancer Research Campaign. Cancer Statistics: Oral – UK. London: CRC, 2000.(2) Blot WJ, McLaughlin JK, Winn DM et al. Smoking and drinking in relation to oral and pharyngeal cancer. Cancer Res 1988; 48: 3282-7. (3) La Vecchia C, Tavani A, Franceschi S et al. Epidemiology and prevention of oral cancer. Oral Oncology 1997; 33: 302-12.Definition of numeratorAll cancer mortality for lip, oral cavity and pharynx (ICD-10 C00-C14) in the respective calendar years aggregated into quinary age bands (0-4, 5-9,…, 85-89, 90+). This does not include secondary cancers or recurrences. Data are reported according to the calendar year in which the cancer was diagnosed.Counts of deaths for years up to and including 2019 have been adjusted where needed to take account of the MUSE ICD-10 coding change introduced in 2020. Detailed guidance on the MUSE implementation is available at: https://www.ons.gov.uk/peoplepopulationandcommunity/birthsdeathsandmarriages/deaths/articles/causeofdeathcodinginmortalitystatisticssoftwarechanges/january2020Counts of deaths for years up to and including 2013 have been double adjusted by applying comparability ratios from both the IRIS coding change and the MUSE coding change where needed to take account of both the MUSE ICD-10 coding change and the IRIS ICD-10 coding change introduced in 2014. The detailed guidance on the IRIS implementation is available at: https://www.ons.gov.uk/peoplepopulationandcommunity/birthsdeathsandmarriages/deaths/bulletins/impactoftheimplementationofirissoftwareforicd10causeofdeathcodingonmortalitystatisticsenglandandwales/2014-08-08Counts of deaths for years up to and including 2010 have been triple adjusted by applying comparability ratios from the 2011 coding change, the IRIS coding change and the MUSE coding change where needed to take account of the MUSE ICD-10 coding change, the IRIS ICD-10 coding change and the ICD-10 coding change introduced in 2011. The detailed guidance on the 2011 implementation is available at https://webarchive.nationalarchives.gov.uk/ukgwa/20160108084125/http://www.ons.gov.uk/ons/guide-method/classifications/international-standard-classifications/icd-10-for-mortality/comparability-ratios/index.htmlDefinition of denominatorPopulation-years (aggregated populations for the three years) for people of all ages, aggregated into quinary age bands (0-4, 5-9, …, 85-89, 90+)

This dataset presents the mortality rate from cancer among individuals under the age of 75 within the Birmingham and Solihull area. It captures the number of deaths attributed to all cancers (classified under ICD-10 codes C00 to C97) and expresses this as a directly age-standardised rate per 100,000 population. The data is structured in quinary age bands and is available for both single-year and three-year rolling averages, providing a comprehensive view of premature cancer mortality trends in the region.

Rationale Reducing premature mortality from cancer is a key public health priority. This indicator helps track progress in lowering the number of cancer-related deaths among people under 75, supporting efforts to improve early diagnosis, treatment, and prevention strategies.

Numerator The numerator is the number of deaths from all cancers (ICD-10 codes C00 to C97) registered in the respective calendar years, for individuals aged under 75. These figures are aggregated into quinary age bands and sourced from the Death Register.

Denominator The denominator is the population of individuals under 75 years of age, also aggregated into quinary age bands. For single-year rates, the population for that year is used. For three-year rolling averages, the population-years are aggregated across the three years. The source of this data is the 2021 Census.

Caveats Data may not align exactly with published Office for National Statistics (ONS) figures due to differences in postcode lookup versions and the application of comparability ratios in Office for Health Improvement and Disparities (OHID) data. Users should be cautious when comparing this dataset with other national statistics.

External references Further information and related indicators can be found on the OHID Fingertips platform.

Localities ExplainedThis dataset contains data based on either the resident locality or registered locality of the patient, a distinction is made between resident locality and registered locality populations:Resident Locality refers to individuals who live within the defined geographic boundaries of the locality. These boundaries are aligned with official administrative areas such as wards and Lower Layer Super Output Areas (LSOAs).Registered Locality refers to individuals who are registered with GP practices that are assigned to a locality based on the Primary Care Network (PCN) they belong to. These assignments are approximate—PCNs are mapped to a locality based on the location of most of their GP surgeries. As a result, locality-registered patients may live outside the locality, sometimes even in different towns or cities.This distinction is important because some health indicators are only available at GP practice level, without information on where patients actually reside. In such cases, data is attributed to the locality based on GP registration, not residential address.

Click here to explore more from the Birmingham and Solihull Integrated Care Partnerships Outcome Framework.

One-year and five-year net survival for adults (15-99) in England diagnosed with one of 29 common cancers, by age and sex.

A measure of the number of adults diagnosed with breast, lung or colorectal cancer in a year who are still alive five years after diagnosis. ONS still publish survival percentages for individual types of cancers. These can be found at: http://www.ons.gov.uk/ons/rel/cancer-unit/cancer-survival/cancer-survival-in-england--patients-diagnosed-2007-2011-and-followed-up-to-2012/index.html A time series for five-year survival figures for breast, lung and colorectal cancer individually (previous NHS Outcomes Framework indicators 1.4.ii, 1.4.iv and 1.4.vi) is still published and can be found under the link 'Indicator data - previous methodology (.xls)' below. Purpose This indicator attempts to capture the success of the NHS in preventing people from dying once they have been diagnosed with breast, lung or colorectal cancer. Current version updated: May-14 Next version due: To be confirmed

SUMMARYThis analysis, designed and executed by Ribble Rivers Trust, identifies areas across England with the greatest levels of cancer (in persons of all ages). Please read the below information to gain a full understanding of what the data shows and how it should be interpreted.ANALYSIS METHODOLOGYThe analysis was carried out using Quality and Outcomes Framework (QOF) data, derived from NHS Digital, relating to cancer (in persons of all ages).This information was recorded at the GP practice level. However, GP catchment areas are not mutually exclusive: they overlap, with some areas covered by 30+ GP practices. Therefore, to increase the clarity and usability of the data, the GP-level statistics were converted into statistics based on Middle Layer Super Output Area (MSOA) census boundaries.The percentage of each MSOA’s population (all ages) with cancer was estimated. This was achieved by calculating a weighted average based on:The percentage of the MSOA area that was covered by each GP practice’s catchment areaOf the GPs that covered part of that MSOA: the percentage of registered patients that have that illness The estimated percentage of each MSOA’s population with cancer was then combined with Office for National Statistics Mid-Year Population Estimates (2019) data for MSOAs, to estimate the number of people in each MSOA with cancer, within the relevant age range.Each MSOA was assigned a relative score between 1 and 0 (1 = worst, 0 = best) based on:A) the PERCENTAGE of the population within that MSOA who are estimated to have cancerB) the NUMBER of people within that MSOA who are estimated to have cancerAn average of scores A & B was taken, and converted to a relative score between 1 and 0 (1= worst, 0 = best). The closer to 1 the score, the greater both the number and percentage of the population in the MSOA that are estimated to have cancer, compared to other MSOAs. In other words, those are areas where it’s estimated a large number of people suffer from cancer, and where those people make up a large percentage of the population, indicating there is a real issue with cancer within the population and the investment of resources to address that issue could have the greatest benefits.LIMITATIONS1. GP data for the financial year 1st April 2018 – 31st March 2019 was used in preference to data for the financial year 1st April 2019 – 31st March 2020, as the onset of the COVID19 pandemic during the latter year could have affected the reporting of medical statistics by GPs. However, for 53 GPs (out of 7670) that did not submit data in 2018/19, data from 2019/20 was used instead. Note also that some GPs (997 out of 7670) did not submit data in either year. This dataset should be viewed in conjunction with the ‘Health and wellbeing statistics (GP-level, England): Missing data and potential outliers’ dataset, to determine areas where data from 2019/20 was used, where one or more GPs did not submit data in either year, or where there were large discrepancies between the 2018/19 and 2019/20 data (differences in statistics that were > mean +/- 1 St.Dev.), which suggests erroneous data in one of those years (it was not feasible for this study to investigate this further), and thus where data should be interpreted with caution. Note also that there are some rural areas (with little or no population) that do not officially fall into any GP catchment area (although this will not affect the results of this analysis if there are no people living in those areas).2. Although all of the obesity/inactivity-related illnesses listed can be caused or exacerbated by inactivity and obesity, it was not possible to distinguish from the data the cause of the illnesses in patients: obesity and inactivity are highly unlikely to be the cause of all cases of each illness. By combining the data with data relating to levels of obesity and inactivity in adults and children (see the ‘Levels of obesity, inactivity and associated illnesses: Summary (England)’ dataset), we can identify where obesity/inactivity could be a contributing factor, and where interventions to reduce obesity and increase activity could be most beneficial for the health of the local population.3. It was not feasible to incorporate ultra-fine-scale geographic distribution of populations that are registered with each GP practice or who live within each MSOA. Populations might be concentrated in certain areas of a GP practice’s catchment area or MSOA and relatively sparse in other areas. Therefore, the dataset should be used to identify general areas where there are high levels of cancer, rather than interpreting the boundaries between areas as ‘hard’ boundaries that mark definite divisions between areas with differing levels of cancer.TO BE VIEWED IN COMBINATION WITH:This dataset should be viewed alongside the following datasets, which highlight areas of missing data and potential outliers in the data:Health and wellbeing statistics (GP-level, England): Missing data and potential outliersLevels of obesity, inactivity and associated illnesses (England): Missing dataDOWNLOADING THIS DATATo access this data on your desktop GIS, download the ‘Levels of obesity, inactivity and associated illnesses: Summary (England)’ dataset.DATA SOURCESThis dataset was produced using:Quality and Outcomes Framework data: Copyright © 2020, Health and Social Care Information Centre. The Health and Social Care Information Centre is a non-departmental body created by statute, also known as NHS Digital.GP Catchment Outlines. Copyright © 2020, Health and Social Care Information Centre. The Health and Social Care Information Centre is a non-departmental body created by statute, also known as NHS Digital. Data was cleaned by Ribble Rivers Trust before use.MSOA boundaries: © Office for National Statistics licensed under the Open Government Licence v3.0. Contains OS data © Crown copyright and database right 2021.Population data: Mid-2019 (June 30) Population Estimates for Middle Layer Super Output Areas in England and Wales. © Office for National Statistics licensed under the Open Government Licence v3.0. © Crown Copyright 2020.COPYRIGHT NOTICEThe reproduction of this data must be accompanied by the following statement:© Ribble Rivers Trust 2021. Analysis carried out using data that is: Copyright © 2020, Health and Social Care Information Centre. The Health and Social Care Information Centre is a non-departmental body created by statute, also known as NHS Digital; © Office for National Statistics licensed under the Open Government Licence v3.0. Contains OS data © Crown copyright and database right 2021. © Crown Copyright 2020.CaBA HEALTH & WELLBEING EVIDENCE BASEThis dataset forms part of the wider CaBA Health and Wellbeing Evidence Base.

Directly age-standardised registration rate for oral cancer (ICD-10 C00-C14), in persons of all ages, per 100,000 2013 European Standard PopulationRationaleTobacco is a known risk factor for oral cancers (1). In England, 65% of hospital admissions (2014–15) for oral cancer and 64 % of deaths (2014) due to oral cancer were attributed to smoking (2). Oral cancer registration is therefore a direct measure of smoking-related harm. Given the high proportion of these registrations that are due to smoking, a reduction in the prevalence of smoking would reduce the incidence of oral cancer.Towards a Smokefree Generation: A Tobacco Control Plan for England states that tobacco use remains one of our most significant public health challenges and that smoking is the single biggest cause of inequalities in death rates between the richest and poorest in our communities (3).In January 2012 the Public Health Outcomes Framework was published, then updated in 2016. Smoking and smoking related death plays a key role in two of the four domains: Health Improvement and Preventing premature mortality (4).References:(1) GBD 2013 Risk Factors Collaborators. Global, regional and national comparative risk assessment of 79 behavioural, environmental and occupational, and metabolic risks or clusters of risk factors in 188 countries, 1990–2013: a systematic analysis for the Global Burden of Disease Study 2013. The Lancet 2015; 386:10010 2287–2323. (2) Statistics on smoking, England 2016, May 2016; http://content.digital.nhs.uk/catalogue/PUB20781 (3) Towards a Smokefree Generation: A Tobacco Control Plan for England, July 2017 https://www.gov.uk/government/publications/towards-a-smoke-free-generation-tobacco-control-plan-for-england (4) Public Health Outcomes Framework 2016 to 2019, August 2016; https://www.gov.uk/government/publications/public-health-outcomes-framework-2016-to-2019 Definition of numeratorCancer registrations for oral cancer (ICD-10, C00-C14) in the calendar years 2007-09 to 2017-2019. The National Cancer Registration and Analysis Service collects data relating to each new diagnosis of cancer that occurs in England. This does not include secondary cancers. Data are reported according to the calendar year in which the cancer was diagnosed.Definition of denominatorPopulation-years (ONS mid-year population estimates aggregated for the respective years) for people of all ages, aggregated into quinary age bands (0-4, 5-9,…, 85-89, 90+).CaveatsReviews of the quality of UK cancer registry data 1, 2 have concluded that registrations are largely complete, accurate and reliable. The data on cancer registration ‘quality indicators’ (mortality to incidence ratios, zero survival cases and unspecified site) demonstrate that although there is some variability, overall ascertainment and reliability is good. However cancer registrations are continuously being updated, so the number of registrations for each year may not be complete, as there is a small but steady stream of late registrations, some of which only come to light through death certification.1. Huggett C (1995). Review of the Quality and Comparability of Data held by Regional Cancer Registries. Bristol: Bristol Cancer Epidemiology Unit incorporating the South West Cancer Registry. 2. Seddon DJ, Williams EMI (1997). Data quality in population based cancer registration. British Journal of Cancer 76: 667-674.The data presented here replace versions previously published. Population data and the European Standard Population have been revised. ONS have provided an explanation of the change in standard population (available at http://www.ons.gov.uk/ons/guide-method/user-guidance/health-and-life-events/revised-european-standard-population-2013--2013-esp-/index.html )

A measure of the number of adults diagnosed with breast, lung or colorectal cancer in a year who are still alive one year after diagnosis. ONS still publish survival percentages for individual types of cancers. These can be found at: http://www.ons.gov.uk/ons/rel/cancer-unit/cancer-survival/cancer-survival-in-england--patients-diagnosed-2007-2011-and-followed-up-to-2012/index.html A time series for one-year survival figures for breast, lung and colorectal cancer individually (previous NHS Outcomes Framework indicators 1.4.i, 1.4.iii and 1.4.v) is still published and can be found under the link 'Indicator data - previous methodology (.xls)' below. Purpose This indicator attempts to capture the success of the NHS in preventing people from dying once they have been diagnosed with breast, lung or colorectal cancer. Current version updated: Feb-14 Next version due: To be confirmed

Update 2 March 2023: Following the merger of NHS Digital and NHS England on 1st February 2023 we are reviewing the future presentation of the NHS Outcomes Framework indicators. As part of this review, the annual publication which was due to be released in March 2023 has been delayed. Further announcements about this dataset will be made on this page in due course. A measure of the number of adults diagnosed with any type of cancer in a year who are still alive five years after diagnosis. This indicator attempts to capture the success of the NHS in preventing people from dying once they have been diagnosed with any type of cancer. As of May 2020, please refer to the data tables published by Public Health England (PHE). This publication is released on an annual basis. A link to the PHE publications, within which the data is held, is available via the resource link below. On the publication page select the ‘Data Tables index of cancer survival 20xx to 20xx’. The data for this indicator is available by applying suitable filters to the dataset contained within the 'Data_Complete’ tab. Legacy unique identifier: P01735

Rapid Cancer Registration Data (RCRD) provides a quick, indicative source of cancer data. It is provided to support the planning and provision of cancer services. The data is based on a rapid processing of cancer registration data sources, in particular on Cancer Outcomes and Services Dataset (COSD) information. In comparison, National Cancer Registration Data (NCRD) relies on additional data sources, enhanced follow-up with trusts and expert processing by cancer registration officers. The Rapid Cancer Registration Data (RCRD) may be useful for service improvement projects including healthcare planning and prioritisation. However, it is poorly suited for epidemiological research due to limitations in the data quality and completeness.

The Cancer Prevention Studies (CPS) aim to understand why and how certain people develop cancer while others remain cancer-free. In 1982, the CPS-II cohort was established and includes approximately 1.2 million men and women, aged at least 30 years, recruited by American Cancer Society (ACS) volunteers in all 50 states of the United States of America and Puerto Rico. Participants have been followed biannually for mortality. The CPS-II Nutrition Cohort was established as a subgroup of the larger CPS-II cohort, in which approximately 185,000 individuals have been followed biennially for cancer incidence, diet, and other exposures, since 1992. The CPS-II Lifelink Cohort/Biorepository was initiated in 1998, and collected blood samples from 40,000 participants and cheek cell samples from 70,000 participants in the CPS-II Nutrition Survey cohort.

Directly age and sex standardised mortality rate from cancer for people aged under 75 in the respective calendar year per 100,000 registered patients. Current version updated: Sep-16 Next version due: Dec-17

Update 2 March 2023: Following the merger of NHS Digital and NHS England on 1st February 2023 we are reviewing the future presentation of the NHS Outcomes Framework indicators. As part of this review, the annual publication which was due to be released in March 2023 has been delayed. Further announcements about this dataset will be made on this page in due course. A measure of the number of adults diagnosed with any type of cancer in a year who are still alive one year after diagnosis. This indicator attempts to capture the success of the NHS in preventing people from dying once they have been diagnosed with any type of cancer. As of May 2020, please refer to the data tables published by Public Health England (PHE). This publication is released on an annual basis. A link to the PHE publications, within which the data is held, is available via the resource link below. On the publication page select the ‘Data Tables index of cancer survival 20xx to 20xx’. The data for this indicator is available by applying suitable filters to the dataset contained within the 'Data_Complete’ tab. Legacy unique identifier: P01734

The National Cancer Registration and Analysis Service (NCRAS) at Public Health England supplies cancer registration data to NHS Digital. This data is available to be linked to other data held by NHS Digital in order to provide notifications on an individual's cancer status, be available to support research studies and to identify potential research participants for clinical trials.

NCRAS is the population-based cancer registry for England. It collects, quality assures and analyses data on all people living in England who are diagnosed with malignant and pre-malignant neoplasms, with national coverage since 1971.

The Cancer Registration dataset comprises England data to the present day, and Welsh data up to April 2017.

Timescales for dissemination of agreed data can be found under 'Our Service Levels' at the following link: https://digital.nhs.uk/services/data-access-request-service-dars/data-access-request-service-dars-process Standard response

av_patient
Patient information - demographics and death details.

av_tumour
Tumour catalogue and characterisation for all patients with registerable tumour. Table's anon_tumour_id is used to link treatment tables also available in NCRAS. One row per tumour (av* table specific anon_tumour_id), per participant at the point of registration of that cancer/tumour with NCRAS.

av_treatment
Tumour linked catalogue of treatments and sites that provided them for all patients with registerable tumour.

av_imd
The Income Deprivation Domain (IMD table) measures the proportion of the population experiencing deprivation relating to low income. The definition of low income used includes both those people that are out-of-work and those that are in work but who have low earnings.

av_rtd
Routes to Diagnosis: cancer registration data are combined with Administrative Hospital Episode Statistics data, Cancer Waiting Times data and data from the cancer screening programmes. Using these datasets cancers registered in England which were diagnosed in 2006 to 2016 are categorised into one of eight Routes to Diagnosis. The methodology is described in detail in the British Journal of Cancer article 'Routes to Diagnosis for cancer - Determining the patient journey using multiple routine datasets'.

cwt The National Cancer Waiting Times Monitoring Data Set supports the continued management and monitoring of waiting times.

sact
Systemic Anti-Cancer Therapy (chemotherapy detail) data for cancer participants from NHSE covering regimens between 04/2012 and 08/2022. One row per chemotherapy cycle, per tumour (SACT-specific anon_tumour_id), per participant.

rtds
The Radiotherapy Data Set (RTDS) standard (SCCI0111) is an existing standard that has required all NHS Acute Trust providers of radiotherapy services in England to collect and submit standardised data monthly against a nationally defined data set since 2009. The purpose of the standard is to collect consistent and comparable data across all NHS Acute Trust providers of radiotherapy services in England in order to provide intelligence for service planning, commissioning, clinical practice and research and the operational provision of radiotherapy services across England. Data is available from 01/04/2009. The data is linked at a patient level and can be linked to the latest available av_patient table.

ncras_did
The Diagnostic Imaging Dataset (DID) is a central collection of detailed information about diagnostic imaging tests carried out on NHS patients, extracted from local radiology information systems and submitted monthly. The DID captures information about referral source, details of the test (type of test and body site), demographic information such as GP registered practice, patient postcode, ethnicity, gender and date of birth, plus data items about different events (date of imaging request, date of imaging, date of reporting, which allows calculation of time intervals.

lucada_2013 The National Lung Can

This report aims to better understand the joint palliative and end of life care research portfolio of the National Institute for Health and Care Research (NIHR) and Marie Curie. The portfolio analysis brings together data from two UK-based research funders and is intended to inform ongoing strategic efforts to address gaps in the current evidence base. The need for palliative care has been conservatively estimated to be between 69 and 90% of all deaths in high-income countries (Murtagh, 2014; Fantoni et. al., 2023). Yet, palliative and end of life care has been shown to be one of the lowest funded areas of healthcare research in the UK. The UK Clinical Research Collaboration (UKCRC) Health ResearchClassification System (HRCS) 2018 dataset shows that only 0.21% of all non-commercial health-related project and programme research funding is spent on research focusing on palliative and end of life care (UKCRC, 2020).This portfolio analysis draws upon two data sources: a publicly available dataset of health-related research grants or awards active in 2018 (UKCRC, 2020) and created a new dataset (https://nihr.opendatasoft.com/explore/dataset/palliative-and-end-of-life-care/table/) of related research grants and awards from NIHR and Marie Curie (2011 – 2018/19). Analysis found that:In 2018, NIHR was the largest funder of palliative and end of life care research in the UK (46%), followed by Marie Curie as the second-largest funder overall (34%) and the largest charitable funder.The majority of NIHR and Marie Curie awards were projects, with relatively few personal awards.There was variation in investment across the UK, with host organisations located in Northern Ireland and the South West of England receiving least funding, followed by the West and East Midlands.Most awards were associated with ‘generic health relevance’ rather than a particular disease or condition. Where specific conditions were addressed, most awards concentrated on care for people with cancer, followed by neurological (mostly dementia) and respiratory conditions. Only a small number of awards addressed frailty, multimorbidity, Stroke, Oral/Gastrointestinal, Renal, Urogenital and Cardiovascular conditions, or Mental Health.Apart from age, there was very little research addressing relevant palliative and end of life care research questions with respect to protected characteristics.This analysis can be used by funders and researchers to continue to support efforts to fill gaps in the evidence base, and in response both funders have issued further calls for research.

Directly standardised mortality rate from cancer for people aged under 75, per 100,000 population. Purpose To ensure that the NHS is held to account for doing all that it can to prevent deaths from cancer in people under 75. Current version updated: Feb-17 Next version due: Nov-17

BackgroundThyroid and breast cancers are the two most frequent types of endocrine-related tumors among women worldwide, and their incidence is still on the rise. Observational studies have shown a relationship between thyroid and breast cancers. Nevertheless, many confounders predispose the results to interference. Accordingly, we performed a two-sample Mendelian randomization (MR) study to investigate the causal association between thyroid and breast cancers.MethodsWe acquired breast cancer data from the UK Biobank (13,879 breast cancer cases and 198,523 controls) and the Breast Cancer Association Consortium (BCAC; 122,977 breast cancer cases and 105,974 controls), and thyroid cancer data from FinnGen Biobank (989 thyroid cancer and 217,803 controls). Then, the multiplicative random effects inverse variance weighting (IVW), weight median (WM), and MR Egger methods were executed for MR analysis.ResultsOverall, IVW showed a causal effect of breast cancer on thyroid cancer using the BCAC dataset (odds ratio [OR] = 1.17; 95% confidence interval [CI] = 1.036–1.322; P = 0.011), and this relationship was also supported by the UK Biobank dataset (OR = 23.899; 95% CI = 2.331–245.003; P = 0.007), which showed that breast cancer patients were more likely to be diagnosed with thyroid cancer. On the whole, the reverse MR analysis did not show a causal effect of breast cancer on thyroid cancer. However, IVW showed a causal effect of thyroid cancer on estrogen receptor -negative breast cancer using the BCAC dataset (OR = 1.019; 95% CI = 1.001–1.038; P = 0.043), which suggested that people with thyroid cancer were more likely to develop breast cancer.ConclusionsBreast cancer represents a possible risk factor for thyroid cancer and thyroid cancer also represents a possible risk factor for ER-negative breast cancer. Future studies using powerful genetic tools to determine the causal relationship between breast and thyroid cancers are required.