Due to changes in the collection and availability of data on COVID-19, this dataset is no longer updated. Latest information about COVID-19 is available via the UKHSA data dashboard. The UK government publish daily data, updated weekly, on COVID-19 cases, vaccinations, hospital admissions and deaths. This note provides a summary of the key data for London from this release. Data are published through the UK Coronavirus Dashboard, last updated on 23 March 2023. This update contains: Data on the number of cases identified daily through Pillar 1 and Pillar 2 testing at the national, regional and local authority level Data on the number of people who have been vaccinated against COVID-19 Data on the number of COVID-19 patients in Hospital Data on the number of people who have died within 28 days of a COVID-19 diagnosis Data for London and London boroughs and data disaggregated by age group Data on weekly deaths related to COVID-19, published by the Office for National Statistics and NHS, is also available. Key Points On 23 March 2023 the daily number of people tested positive for COVID-19 in London was reported as 2,775 On 23 March 2023 it was newly reported that 94 people in London died within 28 days of a positive COVID-19 test The total number of COVID-19 cases identified in London to date is 3,146,752 comprising 15.2 percent of the England total of 20,714,868 cases In the most recent week of complete data (12 March 2023 - 18 March 2023) 2,951 new cases were identified in London, a rate of 33 cases per 100,000 population. This compares with 2,883 cases and a rate of 32 for the previous week In England as a whole, 29,426 new cases were identified in the most recent week of data, a rate of 52 cases per 100,000 population. This compares with 26,368 cases and a rate of 47 for the previous week Up to and including 22 March 2023 6,452,895 people in London had received the first dose of a COVID-19 vaccine and 6,068,578 had received two doses Up to and including 22 March 2023 4,435,586 people in London had received either a third vaccine dose or a booster dose On 22 March 2023 there were 1,370 COVID-19 patients in London hospitals. This compares with 1,426 patients on 15 March 2023. On 22 March 2023 there were 70 COVID-19 patients in mechanical ventilation beds in London hospitals. This compares with 72 patients on 15 March 2023. Update: From 1st July updates are weekly From Friday 1 July 2022, this page will be updated weekly rather than daily. This change results from a change to the UK government COVID-19 Dashboard which will move to weekly reporting. Weekly updates will be published every Thursday. Daily data up to the most recent available will continue to be added in each weekly update. Data summary 리소스 CSV phe_vaccines_age_london_boroughs.csv CSV 다운로드 phe_vaccines_age_london_boroughs.csv CSV phe_healthcare_admissions_age.csv CSV 다운로드

Systems biology is an approach to comprehensively study complex interactions within a biological system. Most published systems vaccinology studies have utilized whole blood or peripheral blood mononuclear cells (PBMC) to monitor the immune response after vaccination. Because human blood is comprised of multiple hematopoietic cell types, the potential for masking responses of under-represented cell populations is increased when analyzing whole blood or PBMC. To investigate the contribution of individual cell types to the immune response after vaccination, we established a rapid and efficient method to purify human T and B cells, natural killer (NK) cells, myeloid dendritic cells (mDC), monocytes, and neutrophils from fresh venous blood. Purified cells were fractionated and processed in a single day. RNA-Seq and quantitative shotgun proteomics were performed to determine expression profiles for each cell type prior to and after inactivated seasonal influenza vaccination. Our results show that transcriptomic and proteomic profiles generated from purified immune cells differ significantly from PBMC. Differential expression analysis for each immune cell type also shows unique transcriptomic and proteomic expression profiles as well as changing biological networks at early time points after vaccination. This cell type-specific information provides a more comprehensive approach to monitor vaccine responses. PBMC and six purified cell types from two vaccinated donors were isolated prior to (d0) and at days 1, 3, and 7 post-TIV vaccination for RNA-seq analysis

Summary of stool shedding by participants between Day 0 (including pre-challenge) until completion of challenge, according to vaccine group allocation, challenge outcome and phase of shedding.

Three groups of German Landrace piglets were vaccinated with tetanus toxoid. Transcriptome profiles of PBMC were analysed from blood samples taken 0, 2, 4, 8, 24 and 75 hours after a first vaccination and 0, 2, 4, 8, 24 and 75 hours as well as 14 d after a second vaccination on day 14. pair wise comparison of 0 hours to the respective time points after each vaccination