A Data. Full data set, organized by transfected plate number. Shown is the average of duplicate wells in each transfection, normalized as F/R/Ba (see S10B File). Samples used in the figures are highlighted in bold, red font. B Example. Illustration of the data processing. Raw firefly counts (F counts) are normalized to the renilla control (R counts) for each well to give “F/R”. The two Ba710 control samples in each plate are averaged to give “Ba”. Each F/R value is then normalized to the Ba value to give “F/R/Ba”. The duplicate F/R/Ba values are averaged to give the activity of each sample for that transfection. This number is used in further analysis as an “n” of 1. (XLSX)

Working Excel spreadsheet compilation of recently published GMarc normalized datasets mapped onto granular segments of canonical Luke and related statistical findings. There are now over 56400 word tokens mapped.

Foraminiferal samples were collected from Chincoteague Bay, Newport Bay, and Tom’s Cove as well as the marshes on the back-barrier side of Assateague Island and the Delmarva (Delaware-Maryland-Virginia) mainland by U.S. Geological Survey (USGS) researchers from the St. Petersburg Coastal and Marine Science Center in March, April (14CTB01), and October (14CTB02) 2014. Samples were also collected by the Woods Hole Coastal and Marine Science Center (WHCMSC) in July 2014 and shipped to the St. Petersburg office for processing. The dataset includes raw foraminiferal and normalized counts for the estuarine grab samples (G), terrestrial surface samples (S), and inner shelf grab samples (G). For further information regarding data collection and sample site coordinates, processing methods, or related datasets, please refer to USGS Data Series 1060 (https://doi.org/10.3133/ds1060), USGS Open-File Report 2015–1219 (https://doi.org/10.3133/ofr20151219), and USGS Open-File Report 2015-1169 (https://doi.org/10.3133/ofr20151169). Downloadable data are available as Excel spreadsheets, comma-separated values text files, and formal Federal Geographic Data Committee metadata.

Background The Infinium EPIC array measures the methylation status of > 850,000 CpG sites. The EPIC BeadChip uses a two-array design: Infinium Type I and Type II probes. These probe types exhibit different technical characteristics which may confound analyses. Numerous normalization and pre-processing methods have been developed to reduce probe type bias as well as other issues such as background and dye bias.
Methods This study evaluates the performance of various normalization methods using 16 replicated samples and three metrics: absolute beta-value difference, overlap of non-replicated CpGs between replicate pairs, and effect on beta-value distributions. Additionally, we carried out Pearson’s correlation and intraclass correlation coefficient (ICC) analyses using both raw and SeSAMe 2 normalized data.Â
Results The method we define as SeSAMe 2, which consists of the application of the regular SeSAMe pipeline with an additional round of QC, pOOBAH masking, was found to be the b...,

Study Participants and SamplesÂ

The whole blood samples were obtained from the Health, Well-being and Aging (Saúde, Ben-estar e Envelhecimento, SABE) study cohort. SABE is a cohort of census-withdrawn elderly from the city of São Paulo, Brazil, followed up every five years since the year 2000, with DNA first collected in 2010. Samples from 24 elderly adults were collected at two time points for a total of 48 samples. The first time point is the 2010 collection wave, performed from 2010 to 2012, and the second time point was set in 2020 in a COVID-19 monitoring project (9±0.71 years apart). The 24 individuals were 67.41±5.52 years of age (mean ± standard deviation) at time point one; and 76.41±6.17 at time point two and comprised 13 men and 11 women.

All individuals enrolled in the SABE cohort provided written consent, and the ethic protocols were approved by local and national institutional review boards COEP/FSP/USP OF.COEP/23/10, CONEP 2044/2014, CEP HIAE 1263-10, University o..., We provide data on an Excel file, with absolute differences in beta values between replicate samples for each probe provided in different tabs for raw data and different normalization methods.

This dataset contains Normalized Difference Vegetation Index (NDVI), Leaf Area Index (LAI) and Phytomass data collected at the Ivotuk field site during the growing season of 1999. The worksheets within this Excel file contain Mean NDVI and LAI data, raw NDVI and LAI data, seasonal mean phytomass, peak phytomass data and raw phytomass data separated by sampling period.

The dataset contains results from Nanostring Digital Spatial Profiling (DSP, trade name is now GeoMx) experiments using colonic punch biopsy FFPE thin sections from IBD and IBS patients. The multiplex probe panel includes barcode-linked antibodies against 26 immune-oncology relevant proteins and 4 reference/normalization proteins.

The IF labeling strategy included Pan-cytokeratin, Tryptase, and DAPI staining for epithelia, mast cells, and sub-mucosal tissues, respectively. 21 FFPE sections were used, representing 19 individuals. 14 pediatric samples included 8 IBD, 5 IBS, and 1 recurring abdominal pain diagnoses. 7 adult samples were studied - 2 normal tissue biopsies from a single healthy control, 3 X-linked Severe Combined Immuno Deficiency (XSCID) samples from 2 individuals, 1 graft-versus-host disease, and 1 eosinophilic gastroenteritis sample. 8 representative ROIs per slide were selected, with a 9th ROI selected representing a lymphoid aggregate where present. Each of the ROIs contained the three masks (PanCK/epithelia, Tryptase/Mast cell, Dapi/submucosa), and therefore generated 24 individual 30-plex protein expression profiles per slide, with a 25th lymphoid ROI per sample (when present).

The data include: 1) Matrix of metadata with sample identifiers and clinical diagnoses (Excel file). 2) A PowerPoint for each sample showing an image of the full slide, images of each selected ROI and QC expression data. 3) An Excel file for each sample containing raw and normalized protein counts. Three normalization methods are reported: a) Normalization by nuclei count, b) Normalization by tissue area, c) Normalization by housekeeping proteins (Histone H3, Ribosomal protein S6).

Analysis derived from these data have been published in two conference proceedings (see references below)

This dataset contains Normalized Difference Vegetation Index (NDVI) images of the 1999 growing season of the Toolik Lake Field station to document differences in on study site in control and treatment plots. For more information, please see the readme file. NOTE: This dataset contains the data in EXCEL format.

A post-processed Excel file (xlsx-files) that contains stride-normalized data. This data includes saggital plane ankle angle, knee angle, hip angle, and non-dimentional ankle power, knee power, and hip power, as well as EMG of the Gastrocnemius (GAS), Rectus femoris (RF), vastus lateralis (VL), biceps femoris (BF), semitendinosis (ST) and erector spinae (ERS). At last, this xlsx file contains ground reaction force in the anterior-posterior (ap), medio-lateral (ml) and vertical (vert) direction. This data is similar to the MAT-files.

Title:

Amazon Financial Dataset: R&D, Marketing, Campaigns, and Profit

Description:

This dataset provides fictional yet insightful financial data of Amazon's business activities across all 50 states of the USA. It is specifically designed to help students, researchers, and practitioners perform various data analysis tasks such as log normalization, Gaussian distribution visualization, and financial performance comparisons.

Each row represents a state and contains the following columns:
- R&D Amount (in $): The investment made in research and development.
- Marketing Amount (in $): The expenditure on marketing activities.
- Campaign Amount (in $): The costs associated with promotional campaigns.
- State: The state in which the data is recorded.
- Profit (in $): The net profit generated from the state.

Additional features include log-normalized and Z-score transformations for advanced analysis.

Use Cases:

This dataset is ideal for practicing:
1. Log Transformation: Normalize skewed data for better modeling and analysis.
2. Statistical Analysis: Explore relationships between financial investments and profit.
3. Visualization: Create compelling graphs such as Gaussian distributions and standard normal distributions.
4. Machine Learning Projects: Build regression models to predict profits based on R&D and marketing spend.

File Information:

• File Format: Excel (.xlsx)
• Number of Records: 50 (one for each state of the USA)
• Columns: 5 primary financial columns and additional preprocessed columns for normalization and Z-scores.

Important Note:

This dataset is synthetically generated and is not based on actual Amazon financial records. It is created solely for educational and practice purposes.

Tags:

• Financial Analysis
• Data Visualization
• Machine Learning
• Statistical Analysis
• Educational Dataset

ERS annually calculates "normalized prices," which smooth out the effects of shortrun seasonal or cyclical variation, for key agricultural inputs and outputs. They are used to evaluate the benefits of projects affecting agriculture.This record was taken from the USDA Enterprise Data Inventory that feeds into the https://data.gov catalog. Data for this record includes the following resources: Web page with links to Excel files For complete information, please visit https://data.gov.

This dataset from the VIRTA Publication Information Service consists of the metadata of 241,575 publications of Finnish universities (publication years 2016–2021) merged from yearly datasets downloaded from https://wiki.eduuni.fi/display/cscvirtajtp/Vuositasoiset+Excel-tiedostot.

The dataset contains following information:

• Organisation: name of the university
• Publication year: the year of publication
• Subfield: one of 66 fields of science based on Statistics Finland field of science classification (in Finnish), see the classification in English: https://www2.stat.fi/en/luokitukset/tieteenala/
• Peer-reviewed: 1=peer-reviewed publications, 0=not peer-reviewed publications
• Science communication: 1=publications aimed at professional and general audiences, 0=peer-reviewed and not peer-reviewed publications aimed at academic audience.
• Bibliodiversity: 1=peer-reviewed book publications (chapters, monographs and edited volumes) and conference articles, 0=peer-reviewed journal articles.
• Multilingualism: share of peer-reviewed publications in languages other than English (Finnish, Swedish and other languages).
• Domestic publishing: 1=peer-reviewed publications in journals and books published in Finland, 0=peer-reviewed publications in journals and books published outside Finland.
• Domestic collaboration: 1=peer-reviewed publications with co-authors from more than one Finnish university, 0=peer-reviewed publications without co-authors from more than one Finnish university.
• International collaboration: 1=share of peer-reviewed publications with co-authors affiliated with foreign institutions, 0=share of peer-reviewed publications without co-authors affiliated with foreign institutions.
• Research performance: 1=peer-reviewed outputs in JUFO levels 2 (“leading”) and 3 (“top”) publication channels, 0=peer-reviewed outputs in JUFO levels 1 (“basic”) and 0 (“other”) publication channels.
• Open access: 1=peer-reviewed open access publications, including gold, hybrid and green OA, 0=peer-reviewed closed publications.

Business licenses issued by the Department of Business Affairs and Consumer Protection in the City of Chicago from 2006 to the present. This dataset contains a large number of records/rows of data and may not be viewed in full in Microsoft Excel. Therefore, when downloading the file, select CSV from the Export menu. Open the file in an ASCII text editor, such as Notepad or Wordpad, to view and search.

Data fields requiring description are detailed below.

APPLICATION TYPE: ‘ISSUE’ is the record associated with the initial license application. ‘RENEW’ is a subsequent renewal record. All renewal records are created with a term start date and term expiration date. ‘C_LOC’ is a change of location record. It means the business moved. ‘C_CAPA’ is a change of capacity record. Only a few license types may file this type of application. ‘C_EXPA’ only applies to businesses that have liquor licenses. It means the business location expanded.

LICENSE STATUS: ‘AAI’ means the license was issued. ‘AAC’ means the license was cancelled during its term. ‘REV’ means the license was revoked. 'REA' means the license revocation has been appealed.

LICENSE STATUS CHANGE DATE: This date corresponds to the date a license was cancelled (AAC), revoked (REV) or appealed (REA).

Business License Owner information may be accessed at: https://data.cityofchicago.org/dataset/Business-Owners/ezma-pppn. To identify the owner of a business, you will need the account number or legal name, which may be obtained from this Business Licenses dataset.

Data Owner: Business Affairs and Consumer Protection. Time Period: January 1, 2006 to present. Frequency: Data is updated daily.

This dataset contains changes in Normalized Difference Vegetation Index (NDVI) data from International Tundra Experiment (ITEX) 1999. This dataset is in Excel Format. For more information, please see the readme file.

Additional table:The compositional variation of the Formula Diet fed to the experimental mice (Table 1), Differentially expressed genes by effect of RS, DJ, and DJ526 (Table 2), The most highly significant up-regulated and down-regulated pathways in the livers of mice on RS, DJ and DJ526 towards those on Ctrl groups (Table 3)Excel file: Globally normalized data (Fold change raw data), Z transformed data (Z-ratio raw data), and GSEA results

A post-processed Excel-file (xlsx-file) that contains stride-normalized data. This data includes saggital plane ankle angle, knee angle, hip angle and pelvis angles, and EMG of the Gastrocnemius (GAS), Rectus femoris (RF), vastus lateralis (VL), biceps femoris (BF), semitendinosis (ST) and erector spinae (ERS). This data is similar to the MAT-files.

The dataset is an excel file that contains meta data, aquatic toxicity data, and summary tables. This dataset is associated with the following publication: Lambert, F., S. Raimondo, and M. Barron. Assessment of a New Approach Method for Grouped Chemical Hazard Estimation: The Toxicity-Normalized Species Sensitivity Distribution (SSDn). ENVIRONMENTAL SCIENCE & TECHNOLOGY. American Chemical Society, Washington, DC, USA, 56(12): 8278-8289, (2022).

Expression (normalized read count) for breast cancer specific 79 fusion-protein and 419 3′-truncated protein transcripts. Expression is the normalized RNA-Seq read counts as estimated using RSEM and followed by upper quartile normalization. File contains expression data for breast cancer specific fusion-protein and 3′-truncated protein transcripts only. The first sheet in the excel file contains the data columns and a key describing the data is on the second excel sheet. (XLSX 33 kb)

This study was performed in accordance with the PHS Policy on Humane Care and Use of Laboratory Animals, federal and state regulations, and was approved by the Institutional Animal Care and Use Committees (IACUC) of Cornell University and the Ethics and Welfare Committee at the Royal Veterinary College.Study design: adult horses were recruited if in good health and following evaluation of the upper airways through endoscopic exam, at rest and during exercise, either overground or on a high-speed treadmill using a wireless videoendoscope. Horses were categorized as “DDSP” affected horses if they presented with exercise-induced intermittent dorsal displacement of the soft palate consistently during multiple (n=3) exercise tests, or “control” horses if they did not experience dorsal displacement of the soft palate during exercise and had no signs compatible with DDSP like palatal instability during exercise, soft palate or sub-epiglottic ulcerations. Horses were instrumented with intramuscular electrodes, in one or both thyro-hyoid muscles for EMG recording, hard wired to a wireless transmitter for remote recording implanted in the cervical area. EMG recordings were then made during an incremental exercise test based on the percentage of maximum heart rate (HRmax). Incremental Exercise Test After surgical instrumentation, each horse performed a 4-step incremental test while recording TH electromyographic activity, heart rate, upper airway videoendoscopy, pharyngeal airway pressures, and gait frequency measurements. Horses were evaluated at exercise intensities corresponding to 50, 80, 90 and 100% of their maximum heart rate with each speed maintained for 1 minute. aryngeal function during the incremental test was recorded using a wireless videoendoscope (Optomed, Les Ulis, France), which was placed into the nasopharynx via the right ventral nasal meatus. Nasopharyngeal pressure was measured using a Teflon catheter (1.3 mm ID, Neoflon) inserted through the left ventral nasal meatus to the level of the left guttural pouch ostium. The catheter was attached to differential pressure transducers (Celesco LCVR, Celesco Transducers Products, Canoga Park, CA, USA) referenced to atmospheric pressure and calibrated from -70 to 70 mmHg. Occurrence of episodes of dorsal displacement of the soft palate was recorded and number of swallows during each exercise trials were counted for each speed interval. EMG recordingEMG data was recorded through a wireless transmitter device implanted subcutaneously. Two different transmitters were used: 1) TR70BB (Telemetry Research Ltd, Auckland, New Zealand) with 12bit A/D conversion resolution, AC coupled amplifier, -3dB point at 1.5Hz, 2KHz sampling frequency (n=5 horses); or 2) ELI (Center for Medical Physics and Biomedical Engineering, Medical University of Vienna, Vienna, Austria) [23], with 12bit A/D conversion resolution, AC coupled amplifier, amplifier gain 1450, 1KHz sampling frequency (n=4 horses). The EMG signal was transmitted through a receiver (TR70BB) or Bluetooth (ELI) to a data acquisition system (PowerLab 16/30 - ML880/P, ADInstruments, Bella Vista, Australia). The EMG signal was amplified with octal bio-amplifier (Octal Bioamp, ML138, ADInstruments, Bella Vista, Australia) with a bandwidth frequency ranging from 20-1000 Hz (input impedance = 200 MV, common mode rejection ratio = 85 dB, gain = 1000), and transmitted to a personal computer. All EMG and pharyngeal pressure signals were collected at 2000 Hz rate with LabChart 6 software (ADInstruments, Bella Vista, Australia) that allows for real-time monitoring and storage for post-processing and analysis.EMG signal processingElectromyographic signals from the TH muscles were processed using two methods; 1) a classical approach to myoelectrical activity and median frequency and 2) wavelet decomposition. For both methods, the beginning and end of recording segments including twenty consecutive breaths, at the end of each speed interval, were marked with comments in the acquisition software (LabChart). The relationship of EMG activity with phase of the respiratory cycle was determined by comparing pharyngeal pressure waveforms with the raw EMG and time-averaged EMG traces.For the classical approach, in a graphical user interface-based software (LabChart), a sixth-order Butterworth filter was applied (common mode rejection ratio, 90 dB; band pass, 20 to 1,000 Hz), the EMG signal was then amplified, full-wave rectified, and smoothed using a triangular Bartlett window (time constant: 150ms). The digitized area under the time-averaged full-wave rectified EMG signal was calculated to define the raw mean electrical activity (MEA) in mV.s. Median Power Frequency (MF) of the EMG power spectrum was calculated after a Fast Fourier Transformation (1024 points, Hann cosine window processing). For the wavelet decomposition, the whole dataset including comments and comment locations was exported as .mat files for processing in MATLAB R2018a with the Signal Processing Toolbox (The MathWorks Inc, Natick, MA, USA). A custom written automated script based on Hodson-Tole & Wakeling [24] was used to first cut the .mat file into the selected 20 breath segments and subsequently process each segment. A bank of 16 wavelets with time and frequency resolution optimized for EMG was used. The center frequencies of the bank ranged from 6.9 Hz to 804.2 Hz [25]. The intensity was summed (mV2) to a total, and the intensity contribution of each wavelet was calculated across all 20 breaths for each horse, with separate results for each trial date and exercise level (80, 90, 100% of HRmax as well as the period preceding episodes of DDSP). To determine the relevant bandwidths for the analysis, a Fast Fourier transform frequency analysis was performed on the horses unaffected by DDSP from 0 to 1000 Hz in increments of 50Hz and the contribution of each interval was calculated in percent of total spectrum as median and interquartile range. According to the Shannon-Nyquist sampling theorem, the relevant signal is below ½ the sample rate and because we had instrumentation sampling either 1000Hz and 2000Hz we choose to perform the frequency analysis up to 1000Hz. The 0-50Hz interval, mostly stride frequency and background noise, was excluded from further analysis. Of the remaining frequency spectrum, we included all intervals from 50-100Hz to 450-500Hz and excluded the remainder because they contributed with less than 5% to the total amplitude.Data analysisAt the end of each exercise speed interval, twenty consecutive breaths were selected and analyzed as described above. To standardize MEA, MF and mV2 within and between horses and trials, and to control for different electrodes size (i.e. different impedance and area of sampling), data were afterward normalized to 80% of HRmax value (HRmax80), referred to as normalized MEA (nMEA), normalized MF (nMF) and normalized mV2 (nmV2). During the initial processing, it became clear that the TH muscle is inconsistently activated at 50% of HRmax and that speed level was therefore excluded from further analysis. The endoscopy video was reviewed and episodes of palatal displacement were marked with comments. For both the classical approach and wavelet analysis, an EMG segment preceding and concurrent to the DDSP episode was analyzed. If multiple episodes were recorded during the same trial, only the period preceding the first palatal displacement was analyzed. In horses that had both TH muscles implanted, the average between the two sides was used for the analysis. Averaged data from multiple trials were considered for each horse. Descriptive data are expressed as means with standard deviation (SD). Normal distribution of data was assessed using the Kolmogorov-Smirnov test and quantile-quantile (Q-Q) plot. To determine the frequency clusters in the EMG signal, a hierarchical agglomerative dendrogram was applied using the packages Matplotlib, pandas, numpy and scipy in python (version 3.6.6) executed through Spyder (version 3.2.2) and Anaconda Navigator. Based on the frequency analysis, wavelets included in the cluster analysis were 92.4 Hz, 128.5 Hz, 170.4 Hz, 218.1 Hz, 271.5 Hz, 330.6 Hz, 395.4 Hz and 465.9 Hz. The number of frequency clusters was set to two based on maximum acceleration in a scree plot and maximum vertical distance in the dendrogram. For continuous outcome measures (number of swallows, MEA, MF, and mV2) a mixed effect model was fitted to the data to determine the relationship between the outcome variable and relevant fixed effects (breed, sex, age, weight, speed, group) using horse as a random effect. Tukey’s post hoc tests and linear contrasts used as appropriate. Statistical analysis was performed using JMP Pro13 (SAS Institute, Cary, NC, USA). Significance set at P < 0.05 throughout.