The burden of influenza in the United States can vary from year to year depending on which viruses are circulating, how many people receive an influenza vaccination, and how effective the vaccination is in that particular year. During the 2023-2024 flu season, around 28,000 people lost their lives to the disease. Although most people recover from influenza without needing medical care, the disease can be deadly among young children, the elderly, and those with weakened immune systems or chronic illnesses. Deaths due to influenza Even though most people recover from influenza without medical care, influenza and pneumonia can be deadly, especially for older people and those with certain preexisting conditions. Influenza is a common cause of pneumonia and although most cases of influenza do not develop into pneumonia, those that do are often more severe and more deadly. Deaths due to influenza are most common among the elderly, with a mortality rate of around 32 per 100,000 population during the 2023-2024 flu season. In comparison, the mortality rate for those aged 50 to 64 years was 9.1 per 100,000 population. Flu vaccinations The most effective way to prevent influenza is to receive an annual influenza vaccination. These vaccines have proven to be safe and are usually cheap and easily accessible. Nevertheless, every year a large share of the population in the United States still fails to get vaccinated against influenza. For example, in the 2022-2023 flu season, only 35 percent of those aged 18 to 49 years received a flu vaccination. Unsurprisingly, children and the elderly are the most likely to get vaccinated. It is estimated that during the 2022-2023 flu season, vaccinations prevented over 929 thousand influenza cases among children aged 6 months to 4 years.

The graph illustrates the number of flu-related deaths in the United States for each flu season from 2010-2011 to 2023-2024*. The x-axis represents the flu seasons, labeled from '10-11 to '23*-24*, while the y-axis shows the annual number of flu deaths. Throughout this period, flu deaths vary significantly, ranging from a low of 4,900 in the 2021-2022* season to a high of 51,000 in both the 2014-2015 and 2017-2018 seasons. Other notable figures include 36,000 deaths in 2010-2011, 42,000 in 2012-2013, and a recent increase to 28,000 in the 2023*-2024* season. The data exhibits considerable fluctuations with no consistent upward or downward trend, highlighting the variability in flu mortality rates over the years. This information is presented in a line graph format, effectively showcasing the yearly changes and peaks in flu-related deaths across the United States.

*Data for the 2021-2022 and 2022-2023 seasons are estimated.

During the 2023-2024 flu season in the United States, an estimated 27,965 people died from influenza. The vast majority of deaths due to influenza occur among the elderly, with those aged 65 years and older accounting for 19,038 deaths during the 2023-2024 flu season. During this time, the mortality rate from influenza among those aged 65 years and older was around 32 per 100,000 population, compared to a mortality rate of two per 100,000 population among those aged 18 to 49 years. Influenza deaths Although most people recover from influenza without the need of medical care, influenza and pneumonia are still major causes of death in the United States. Influenza is a common cause of pneumonia and cases in which influenza develops into pneumonia tend to be more severe and more deadly. However, the impact of influenza varies from year to year depending on which viruses are circulating. For example, during the 2017-2018 flu season around 52,000 people died due to influenza, whereas in 2023-2024 total deaths amounted to 28,000. Preventing death The most effective way to prevent influenza is to receive an annual influenza vaccination. These vaccines have proven to be safe and are usually cheap and easily accessible. Each year, flu vaccinations prevent thousands of influenza cases, hospitalizations and deaths. It was estimated that during the 2022-2023 flu season, vaccinations prevented the deaths of around 2,479 people aged 65 years and older.

Australia Influenza Mortality jumped by 8% in 2019, from a year earlier.

Over 12 million people in the United States died from all causes between the beginning of January 2020 and August 21, 2023. Over 1.1 million of those deaths were with confirmed or presumed COVID-19.

Vaccine rollout in the United States Finding a safe and effective COVID-19 vaccine was an urgent health priority since the very start of the pandemic. In the United States, the first two vaccines were authorized and recommended for use in December 2020. One has been developed by Massachusetts-based biotech company Moderna, and the number of Moderna COVID-19 vaccines administered in the U.S. was over 250 million. Moderna has also said that its vaccine is effective against the coronavirus variants first identified in the UK and South Africa.

Influenza and pneumonia caused around 12.3 deaths in the U.S. per 100,000 population in 2019. Influenza and pneumonia are among the leading causes of death in the United States, accounting for around 1.6 percent of all deaths in 2020. Influenza, or the flu, is a viral infection that is highly contagious and especially common in the winter season. Influenza is a common cause of pneumonia, although most cases of the flu do not develop into pneumonia. Pneumonia is an infection or inflammation of the lungs and is particularly deadly among young children and the elderly.

Influenza cases

Influenza is very common in the United States, with an estimated 35 million cases reported in 2019-2020. Common symptoms of the flu include cough, fever, runny or stuffy nose, sore throat and headache. Symptoms can be mild but can also be severe enough to require medical attention. In 2019-2020, there were around 16 million influenza-related medical visits in the United States.

Prevention

To prevent contracting the flu people can take everyday precautions such as regularly washing their hands and avoiding those who are sick, but the best way to prevent the flu is by receiving the flu vaccination every year. Receiving a flu vaccination is especially important for young children and the elderly as they are most susceptible to flu complications and associated death. In 2021, around 75 percent of those aged 65 years and older received a flu vaccine, while only 38 percent of those aged 18 to 49 years had done so.

Influenza, also called the flu, is one of the most infectious diseases worldwide. Its symptoms range from mild to severe, and include sore throat, cough, runny nose, fever, headache, and muscle pain, but can also cause severe illness and death among high-risk populations such as the elderly and children. During the 2023-2024 flu season, there were 40 million cases of influenza in the United States. Influenza deaths Although influenza does not require medical attention for most people, it can be deadly, and causes thousands of deaths every year. The impact of influenza varies from year to year. The number of influenza deaths during the 2023-2024 flu season was 27,965. The vast majority of deaths attributed to influenza during the 2023-2024 flu season occurred among those aged 65 years and older. Vaccination An annual influenza vaccination remains the most effective way of preventing influenza. During the 2022-2023 flu season, influenza vaccinations prevented an estimated 2,479 deaths among U.S. adults aged 65 years and older. Although, flu vaccinations are accessible and cheap, a large share of the United States population still fails to get vaccinated every year. In 2022-2023, only 35 percent of those aged 18 to 49 years received a flu vaccination, much lower compared to children and the elderly.

WHO: Influenza A (H1N1): Number of Deaths: Japan data was reported at 0.000 Person in 06 Jul 2009. This stayed constant from the previous number of 0.000 Person for 05 Jul 2009. WHO: Influenza A (H1N1): Number of Deaths: Japan data is updated daily, averaging 0.000 Person from Apr 2009 (Median) to 06 Jul 2009, with 74 observations. The data reached an all-time high of 0.000 Person in 06 Jul 2009 and a record low of 0.000 Person in 06 Jul 2009. WHO: Influenza A (H1N1): Number of Deaths: Japan data remains active status in CEIC and is reported by World Health Organization. The data is categorized under High Frequency Database’s Disease Outbreaks – Table WHO.D002: World Heath Organization: Influenza A (H1N1): By Countries.

WHO: Influenza A (H1N1): Number of Deaths: New Zealand data was reported at 3.000 Person in 06 Jul 2009. This records an increase from the previous number of 0.000 Person for 05 Jul 2009. WHO: Influenza A (H1N1): Number of Deaths: New Zealand data is updated daily, averaging 0.000 Person from Apr 2009 (Median) to 06 Jul 2009, with 74 observations. The data reached an all-time high of 3.000 Person in 06 Jul 2009 and a record low of 0.000 Person in 05 Jul 2009. WHO: Influenza A (H1N1): Number of Deaths: New Zealand data remains active status in CEIC and is reported by World Health Organization. The data is categorized under High Frequency Database’s Disease Outbreaks – Table WHO.D002: World Heath Organization: Influenza A (H1N1): By Countries.

Project Tycho datasets contain case counts for reported disease conditions for countries around the world. The Project Tycho data curation team extracts these case counts from various reputable sources, typically from national or international health authorities, such as the US Centers for Disease Control or the World Health Organization. These original data sources include both open- and restricted-access sources. For restricted-access sources, the Project Tycho team has obtained permission for redistribution from data contributors. All datasets contain case count data that are identical to counts published in the original source and no counts have been modified in any way by the Project Tycho team. The Project Tycho team has pre-processed datasets by adding new variables, such as standard disease and location identifiers, that improve data interpretabilty. We also formatted the data into a standard data format.

Each Project Tycho dataset contains case counts for a specific condition (e.g. measles) and for a specific country (e.g. The United States). Case counts are reported per time interval. In addition to case counts, datsets include information about these counts (attributes), such as the location, age group, subpopulation, diagnostic certainty, place of aquisition, and the source from which we extracted case counts. One dataset can include many series of case count time intervals, such as "US measles cases as reported by CDC", or "US measles cases reported by WHO", or "US measles cases that originated abroad", etc.

Depending on the intended use of a dataset, we recommend a few data processing steps before analysis:

• Analyze missing data: Project Tycho datasets do not inlcude time intervals for which no case count was reported (for many datasets, time series of case counts are incomplete, due to incompleteness of source documents) and users will need to add time intervals for which no count value is available. Project Tycho datasets do include time intervals for which a case count value of zero was reported.
• Separate cumulative from non-cumulative time interval series. Case count time series in Project Tycho datasets can be "cumulative" or "fixed-intervals". Cumulative case count time series consist of overlapping case count intervals starting on the same date, but ending on different dates. For example, each interval in a cumulative count time series can start on January 1st, but end on January 7th, 14th, 21st, etc. It is common practice among public health agencies to report cases for cumulative time intervals. Case count series with fixed time intervals consist of mutually exxclusive time intervals that all start and end on different dates and all have identical length (day, week, month, year). Given the different nature of these two types of case count data, we indicated this with an attribute for each count value, named "PartOfCumulativeCountSeries".

WHO: Influenza A (H1N1): Number of Deaths: India data was reported at 0.000 Person in 06 Jul 2009. This stayed constant from the previous number of 0.000 Person for 05 Jul 2009. WHO: Influenza A (H1N1): Number of Deaths: India data is updated daily, averaging 0.000 Person from Apr 2009 (Median) to 06 Jul 2009, with 74 observations. The data reached an all-time high of 0.000 Person in 06 Jul 2009 and a record low of 0.000 Person in 06 Jul 2009. WHO: Influenza A (H1N1): Number of Deaths: India data remains active status in CEIC and is reported by World Health Organization. The data is categorized under High Frequency Database’s Disease Outbreaks – Table WHO.D002: World Heath Organization: Influenza A (H1N1): By Countries.

WHO: Influenza A (H1N1): Number of Deaths: Mauritius data was reported at 0.000 Person in 06 Jul 2009. This stayed constant from the previous number of 0.000 Person for 05 Jul 2009. WHO: Influenza A (H1N1): Number of Deaths: Mauritius data is updated daily, averaging 0.000 Person from Apr 2009 (Median) to 06 Jul 2009, with 74 observations. The data reached an all-time high of 0.000 Person in 06 Jul 2009 and a record low of 0.000 Person in 06 Jul 2009. WHO: Influenza A (H1N1): Number of Deaths: Mauritius data remains active status in CEIC and is reported by World Health Organization. The data is categorized under High Frequency Database’s Disease Outbreaks – Table WHO.D002: World Heath Organization: Influenza A (H1N1): By Countries.

Effective September 27, 2023, this dataset will no longer be updated. Similar data are accessible from wonder.cdc.gov.

Deaths involving COVID-19, pneumonia, and influenza reported to NCHS by sex, age group, and jurisdiction of occurrence.

WHO: Influenza A (H1N1): Number of Deaths: China data was reported at 0.000 Person in 06 Jul 2009. This stayed constant from the previous number of 0.000 Person for 05 Jul 2009. WHO: Influenza A (H1N1): Number of Deaths: China data is updated daily, averaging 0.000 Person from Apr 2009 (Median) to 06 Jul 2009, with 74 observations. The data reached an all-time high of 0.000 Person in 06 Jul 2009 and a record low of 0.000 Person in 06 Jul 2009. WHO: Influenza A (H1N1): Number of Deaths: China data remains active status in CEIC and is reported by World Health Organization. The data is categorized under High Frequency Database’s Disease Outbreaks – Table WHO.D002: World Heath Organization: Influenza A (H1N1): By Countries.

Global Influenza Mortality Share by Country (Units (Male Deaths)), 2023 Discover more data with ReportLinker!

In 2023, the number of deaths from influenza in Japan decreased to 1383 cases, which marked an increase compared to just 24 cases in the previous year. The death rate from influenza amounted to 1.1 death cases per 100,000 inhabitants in 2023.

Global Influenza Mortality by Country, 2023 Discover more data with ReportLinker!

Market Overview:

The global seasonal Influenza Vaccine market is expected to grow from USD 7.5 billion in 2017 to USD 11.8 billion by 2030, at a CAGR of 5.1% from 2022 to 2030. The growth in the market can be attributed to the increasing incidence of seasonal influenza, raising awareness about the benefits of vaccination, and technological advancements in vaccine production. Based on type, the global seasonal influenza vaccine sales market is segmented into trivalent influenza vaccine and quadrivalent influenza vaccine.

Product Definition:

A vaccine is a biological preparation that improves immunity to a particular disease. Seasonal Influenza Vaccine Sales usually refers to the sale of vaccines used to prevent seasonal influenza, also known as the flu. The importance of seasonal influenza vaccine sales is that they help protect people from getting sick during the flu season.

Trivalent Influenza Vaccine:

The trivalent influenza vaccine is a type of vaccine that provides protection against three strains of the flu; there are two types of vaccines available on the market, one trivalent and the other quadrivalent. Trivalent Influenza Vaccines have been available for many years whereas quadrivalent ones are relatively new. The difference between them is only in the number of viruses included in their composition, both provide a similar level of protection against the seasonal flu virus.

Quadrivalent Influenza Vaccine:

The quadrivalent influenza vaccine is a type of influenza vaccine that protects against four different strains of the flu. It is approved for use in people over 65 years of age and individuals with chronic conditions, such as cardiovascular disease, diabetes mellitus, renal disease, or immunosuppression. The seasonal flu vaccination has been recommended by the CDC since 2010 to reduce hospitalizations by 30% and deaths by 50%.

Application Insights:

Based on application, the global seasonal influenza vaccine market is segmented into children, adults, and the elderly. The adult segment held around 60% of the overall revenue share in 2015. This can be attributed to growing awareness about health hazards associated with circulating viruses and increasing healthcare spending in developed countries like the U.S., Germany, etc. The growing geriatric population across the globe is expected to boost demand for vaccines in upcoming years which would drive growth further during the forecast period. The elderly segment held another 40% of the overall revenue share in 2015 due to the growing incidence of diseases related to old age such as Alzheimer's disease, Parkinson disease, etc., especially in high-income countries like Japan and Italy respectively owing to which these two segments are expected generate significant demand for seasonal influenza vaccine over next eight years (through 2030).

Regional Analysis:

North America dominated the global market in terms of revenue share in 2020 with a value of USD X billion and is expected to grow at a lucrative rate over the forecast period. The presence of high-income countries such as the U.S., favorable government initiatives, and increasing awareness about seasonal vaccines are some factors attributing to its largest market share throughout the forecast period. Asia Pacific is anticipated to be one of the fastest growing regional markets from 2022 to 2030 owing to the rising demand for Flu Vaccine across this region due to the increasing number of susceptible people along with rapid economic development in emerging economies including China and India which are among top 10 countries where most people get infected each year (as per WHO). These two countries alone account for more than 50% population who get infected every year thus creating huge potential for seasonal influenza vaccine sales within the Asia Pacific region over the next eight years (as per GSK).

Growth Factors:

• Increasing awareness about the benefits of the seasonal influenza vaccine among people.
• Government initiatives and campaigns to promote vaccination against seasonal influenza.
• Growing demand for preventive healthcare services.
• Rising incidence of seasonal influenza outbreaks.
• Technological advancements in the manufacturing of seasonal influenza vaccines.

Report Scope

Background # Seasonal influenza virus is a common cause of acute lower respiratory infection (ALRI) in young children. In 2008, we estimated that 20 million influenza-virus-associated ALRI and 1 million influenza-virus-associated severe ALRI occurred in children under 5 years globally. Despite this substantial burden, only a few low-income and middle-income countries have adopted routine influenza vaccination policies for children and, where present, these have achieved only low or unknown levels of vaccine uptake. Moreover, the influenza burden might have changed due to the emergence and circulation of influenza A/H1N1pdm09. We aimed to incorporate new data to update estimates of the global number of cases, hospital admissions, and mortality from influenza-virus-associated respiratory infections in children under 5 years in 2018. # Methods # We estimated the regional and global burden of influenza-associated respiratory infections in children under 5 years from a systematic review of 100 studies published between Jan 1, 1995, and Dec 31, 2018, and a further 57 high-quality unpublished studies. We adapted the Newcastle-Ottawa Scale to assess the risk of bias. We estimated incidence and hospitalisation rates of influenza-virus-associated respiratory infections by severity, case ascertainment, region, and age. We estimated in-hospital deaths from influenza virus ALRI by combining hospital admissions and in-hospital case-fatality ratios of influenza virus ALRI. We estimated the upper bound of influenza virus-associated ALRI deaths based on the number of in-hospital deaths, US paediatric influenza-associated death data, and population-based childhood all-cause pneumonia mortality data in six sites in low-income and lower-middle-income countries. # Findings # In 2018, among children under 5 years globally, there were an estimated 109*5 million influenza virus episodes (uncertainty range [UR] 63*1-190*6), 10*1 million influenza-virus-associated ALRI cases (6*8-15*1); 870 000 influenza-virus-associated ALRI hospital admissions (543 000-1 415 000), 15 300 in-hospital deaths (5800-43 800), and up to 34 800 (13 200-97 200) overall influenza-virus-associated ALRI deaths. Influenza virus accounted for 7% of ALRI cases, 5% of ALRI hospital admissions, and 4% of ALRI deaths in children under 5 years. About 23% of the hospital admissions and 36% of the in-hospital deaths were in infants under 6 months. About 82% of the in-hospital deaths occurred in low-income and lower-middle-income countries. # Interpretation # A large proportion of the influenza-associated burden occurs among young infants and in low-income and lower middle-income countries. Our findings provide new and important evidence for maternal and paediatric influenza immunisation, and should inform future immunisation policy particularly in low-income and middle-income countries.

WHO: Influenza A (H1N1): Number of Deaths: Cyprus data was reported at 0.000 Person in 06 Jul 2009. This stayed constant from the previous number of 0.000 Person for 05 Jul 2009. WHO: Influenza A (H1N1): Number of Deaths: Cyprus data is updated daily, averaging 0.000 Person from Apr 2009 (Median) to 06 Jul 2009, with 74 observations. The data reached an all-time high of 0.000 Person in 06 Jul 2009 and a record low of 0.000 Person in 06 Jul 2009. WHO: Influenza A (H1N1): Number of Deaths: Cyprus data remains active status in CEIC and is reported by World Health Organization. The data is categorized under High Frequency Database’s Disease Outbreaks – Table WHO.D002: World Heath Organization: Influenza A (H1N1): By Countries.