In 1800, the population of Japan was just over 30 million, a figure which would grow by just two million in the first half of the 19th century. However, with the fall of the Tokugawa shogunate and the restoration of the emperor in the Meiji Restoration of 1868, Japan would begin transforming from an isolated feudal island, to a modernized empire built on Western models. The Meiji period would see a rapid rise in the population of Japan, as industrialization and advancements in healthcare lead to a significant reduction in child mortality rates, while the creation overseas colonies would lead to a strong economic boom. However, this growth would slow beginning in 1937, as Japan entered a prolonged war with the Republic of China, which later grew into a major theater of the Second World War. The war was eventually brought to Japan's home front, with the escalation of Allied air raids on Japanese urban centers from 1944 onwards (Tokyo was the most-bombed city of the Second World War). By the war's end in 1945 and the subsequent occupation of the island by the Allied military, Japan had suffered over two and a half million military fatalities, and over one million civilian deaths.

The population figures of Japan were quick to recover, as the post-war “economic miracle” would see an unprecedented expansion of the Japanese economy, and would lead to the country becoming one of the first fully industrialized nations in East Asia. As living standards rose, the population of Japan would increase from 77 million in 1945, to over 127 million by the end of the century. However, growth would begin to slow in the late 1980s, as birth rates and migration rates fell, and Japan eventually grew to have one of the oldest populations in the world. The population would peak in 2008 at just over 128 million, but has consistently fallen each year since then, as the fertility rate of the country remains below replacement level (despite government initiatives to counter this) and the country's immigrant population remains relatively stable. The population of Japan is expected to continue its decline in the coming years, and in 2020, it is estimated that approximately 126 million people inhabit the island country.

Throughout the Common Era, Japan's population saw relatively steady growth between each century. Failed invasions and distance from Asia's mainland meant that Japan was unaffected by many pandemics, primarily bubonic plague, therefore its development was not drastically impeded in the same way as areas such as China or Europe. Additionally, religious practices meant that hygiene was prioritized much more in Japan than in other regions, and dietary customs saw lower rates of meat consumption and regular boiling of water in meals or tea; both of these factors contributed to lower rates of infection for many parasitic or water-borne diseases. Fewer international conflicts and domestic stability also saw lower mortality in this regard, and Japan was an considered an outlier by Asian standards, as some shifting trends associated with the demographic transition (such as lower child mortality and fertility) began taking place in the 17th century; much earlier time than anywhere else in the world. Yet the most significant changes came in the 20th century, as Japan's advanced healthcare and sanitation systems saw drastic reductions in mortality. Challenges Japan's isolation meant that, when pandemics did arrive, the population had less protection and viruses could have higher mortality rates; smallpox has been cited as the deadliest of these pandemics, although increased international contact in the late 19th century brought new viruses, and population growth slowed. Earlier isolation also meant that crop failure or food shortages could leave large sections of the population vulnerable, and, as mentioned, the Japanese diet contained relatively little meat, therefore there was a higher reliance on crops and vegetables. It is believed that the shortage of arable land and the acidity of the soil due to volcanic activity meant that agriculture was more challenging in Japan than on the Asian mainland. For most of history, paddy fields were the most efficient source of food production in Japan, but the challenging nature of this form of agriculture and changes in employment trends gradually led to an increased reliance in imported crops. Post-Sakoku Japan Distance from the Asian mainland was not the only reason for Japan's isolation; from 1603 to 1853, under the Tokugawa shogunate, international trade was restricted, migration abroad was forbidden, and most foreign interaction was centered around Nagasaki. American neo-imperialism then forced Japan to open trade with the west, and Japan became an imperial power by the early-1900s. Japanese expansion began with a series of military victories against China and Russia at the turn of the century, and the annexation of Taiwan, Korea, and Manchuria by the 1930s, before things escalated further during its invasion of China and the Second World War. Despite its involvement in so many wars, the majority of conflicts involving Japan were overseas, therefore civilian casualties were much lower than those suffered by other Asian countries during this time. After Japan's defeat in 1945, its imperial ambitions were abandoned, it developed strong economic ties with the West, and had the fastest economic growth of any industrial country in the post-WWII period. Today, Japan is one of the most demographically advanced countries in the world, with the highest life expectancy in most years. However, its population has been in a steady decline for over a decade, and low fertility and an over-aged society are considered some of the biggest challenges to Japanese society today.

In 1498, Vasco da Gama became the first known European to sail to India by circumventing Africa, which ushered in a new age of European sea trade with Asia. Initially, Indian rulers were unimpressed and wary of the Portuguese, and Muslim traders in the region were hostile, but the Portuguese were able to assess what could be traded for exotic goods (mostly spices) and lucrative trade routes were established after subsequent journeys. Additionally, the Portuguese quickly learned that they had the technological advantage in conflict, and repelled attacks from their Muslim rivals. Fortified trading posts, known as factories, were then established along the African and Asian coasts to protect these trade routes, and these became the foundation upon which the Portuguese Empire (Europe's longest-lasting) was built.

Colonization and competition In 1494, the Treaty of Tordesillas saw Portugal and Spain draw a line through the Atlantic, with each crown laying claim to all non-Christian lands on their respective side. No other European power acknowledged these claims, but it would take almost a century for the British, Dutch, or French to begin establishing their own maritime empires; this meant that the Portuguese had a near-monopoly on the Indian spice trade for almost 100 years, and this was the century when their trade with Asia was most active. Portuguese traders not only did business with merchants in India, but they also explored further, and established trade routes with present-day China, Indonesia, and Japan, and even facilitated trade between these cultures. In the 1590s, the Dutch then followed the Portuguese model of empire building and quickly emerged as Portugal's biggest rival in Asia. VOC The Dutch and Portuguese were in conflict for over 60 years, across four continents, and the Asian and African conflicts are often referred to as the "Spice War". The Netherlands eventually usurped Portugal as the strongest European trading power in Asia by the mid-1600s. Most of the Dutch trade was done through the Dutch East India Company (VOC), which is often considered the most valuable company to have ever existed. In the 17th century, 56 percent of all ships that travelled from the given countries to Asia were Dutch, and the figure was over 44 percent in the following century. Such companies were not only trading enterprises, but also acted in the military and political interests of their respective crowns. The VOC went into decline in the mid-1700s, as the British Empire gained the upper hand in its rivalry with the Netherlands. The British East India Company then consolidated its power on the Indian subcontinent, and Dutch interests were largely centered in the East Indies (present-day Indonesia), which remained a Dutch colony until the Second World War. For France, its primary colonial power in Asia was in French Indochina, made up of present-day Cambodia, Laos, and Vietnam, although the seven European powers had trade connections all over Asia, and all competed or cooperated with one another at various points in these 300 years.