Comprehensive demographic dataset for Saint-Andre-Du-Lac-Saint-Jean, QC, CA including population statistics, household income, housing units, education levels, employment data, and transportation with year-over-year changes.

This table contains 27840 series, with data for years 2005 - 2005 (not all combinations necessarily have data for all years), and is no longer being released. This table contains data described by the following dimensions (Not all combinations are available): Geography (29 items: Quebec; Région du Bas-Saint-Laurent, Quebec; Région du Saguenay - Lac-Saint-Jean, Quebec; Région de la Capitale Nationale, Quebec; ...); Age group (10 items: Total, 15 to 74 years; 15 to 19 years; 20 to 34 years; 20 to 24 years; ...); Sex (3 items: Both sexes; Males; Females); Decision latitude at work (4 items: Total population for the variable decision latitude at work; High decision latitude at work; Low or medium decision latitude at work; Decision latitude at work, not stated); Characteristics (8 items: Number of persons; Low 95% confidence interval, number of persons; High 95% confidence interval, number of persons; Coefficient of variation for number of persons; ...).

This table contains 27840 series, with data for years 2005 - 2005 (not all combinations necessarily have data for all years), and is no longer being released. This table contains data described by the following dimensions (Not all combinations are available): Geography (29 items: Quebec; Région du Bas-Saint-Laurent, Quebec; Région du Saguenay - Lac-Saint-Jean, Quebec; Région de la Capitale Nationale, Quebec; ...); Age group (10 items: Total, 15 to 74 years; 15 to 19 years; 20 to 34 years; 20 to 24 years; ...); Sex (3 items: Both sexes; Males; Females); Decision latitude at work (4 items: Total population for the variable decision latitude at work; High decision latitude at work; Low or medium decision latitude at work; Decision latitude at work, not stated); Characteristics (8 items: Number of persons; Low 95% confidence interval, number of persons; High 95% confidence interval, number of persons; Coefficient of variation for number of persons; ...).

Ce tableau contient 27840 séries, avec des données pour les années 2005 - 2005 (il n'y a pas nécessairement de données pour toutes les années pour l'ensemble des combinaisons), et sa mise à jour n'a plus lieu. Ce tableau contient des données telles que décrites par les dimensions suivantes (Les combinaisons ne sont pas toutes disponibles) : Géographie (29 éléments : Québec; Région du Bas-Saint-Laurent, Québec; Région du Saguenay - Lac-Saint-Jean, Québec; Région de la Capitale Nationale, Québec; ...) ; Groupe d'âge (10 éléments : Total, 15 à 74 ans; 15 à 19 ans; 20 à 34 ans; 20 à 24 ans; ...) ; Sexe (3 éléments : Les deux sexes; Hommes; Femmes) ; Latitude de décision au travail (4 éléments : Population totale pour la variable latitude de décision au travail; Latitude élevée de décision au travail; Latitude faible ou moyenne de décision au travail; Latitude de décision au travail, non déclarée) ; Caractéristiques (8 éléments : Nombre de personnes; Limite inférieure de l'intervalle de confiance de 95 %, nombre de personnes; Limite supérieure de l'intervalle de confiance de 95 %, nombre de personnes; Coefficient de variation pour le nombre de personnes; ...).

BackgroundVitamin D-dependant rickets type 1A (VDDR1A) is a rare autosomal recessive disorder caused by pathogenic variants in the CYP27B1 gene. This gene is essential for vitamin D activation. Although VDDR1A is a rare condition worldwide, its prevalence is high in the Saguenay-Lac-Saint-Jean (SLSJ) region due to a founder effect. Daily intake of calcitriol before the onset of clinical manifestations can prevent them in affected children.MethodsA genetic screening test was developed and validated for the CYP27B1 gene c.262del pathogenic variant. Newborn screening was implemented in the SLSJ region for this variant, and the feasibility and acceptability were assessed. Sixteen medical records of children affected with VDDR1A were reviewed to document the consequences of the disease at diagnosis.ResultsA total of 2000 newborns were tested for VDDR1A. Most families (96.5%) accepted the genetic test. We found a carrier rate of 1/29 for the c.262delG variant in our cohort, which is suggestive of a founder effect. We identified one child affected with VDDR1A and treatment was initiated before the onset of clinical manifestations. On average, children with VDDR1A were diagnosed at 13.8 ± 5 months of age, they had a significant failure to thrive at diagnosis, among other harmful health consequences.ConclusionOur study showed that in our population, the newborn genetic screening program is safe and feasible, it has high acceptability, and it is efficient to identify affected children. VDDR1A health consequences can be prevented by early initiation of treatment. Therefore, screening programs should be available for populations where it is deemed as beneficial from a public health perspective.