In 2023, **** percent of Americans were unaffiliated with any religion. A further **** percent of Americans were White evangelical Protestants, and an additional **** percent were White mainline Protestants. Religious trends in the United States Although the United States is still home to the largest number of Christians worldwide, the nation has started to reflect a more diverse religious landscape in recent years. Americans now report a wide range of religious beliefs and backgrounds, in addition to an increasing number of people who are choosing to identify with no religion at all. Studies suggest that many Americans have left their previous religion to instead identify as atheist, agnostic, or nothing in particular, with many reasoning that they stopped believing in the religion's teachings, that they didn't approve of negative teachings or treatment of LGBTQ+ people, or that their family was never that religious growing up. Christian controversies Over the last few years, controversies linked to Christian denominations have plagued the nation, including reports of child sexual abuse by the Catholic Church, the Church of Jesus Christ of Latter-day Saints, and the Southern Baptist Convention. Christian churches have also been accused of supporting discriminatory actions against LGBTQ+ people and people belonging to other religious groups. In addition, there have been increasing concerns about Christian nationalism, the political ideology that asserts that America was founded to be a Christian nation. Although the majority of Americans still think that declaring the United States a Christian nation would go against the U.S. Constitution, studies found that most Republicans would be in favor of this change.

This graph shows the largest Christian denominations in the United States in 2010, by number of adherents. In 2010, the Lattar-day Saints were among the largest Christian groups with about 6.3 million adherents in the United States.

This dataset is the centerpiece of Pew Research Center's 2014 Religious Landscape Study, a nationally representative telephone survey conducted June 4-Sept. 30, 2014, among a sample of 35,071 U.S. adults. Approximately 60 percent of the interviews were conducted with respondents reached on cellphones (n=21,160) and 40 percent were completed on landlines (n=13,911). A minimum of 300 interviews were conducted in every state and the District of Columbia. Interviewing was conducted in English and Spanish. The survey is estimated to cover 97 percent of the non-institutionalized U.S. adult population; 3 percent of U.S. adults are not reachable by telephone or do not speak English or Spanish well enough to participate in the survey. No adjustments have been made to the data to attempt to account for the small amount of non-coverage.

The size of the national sample is unusually large for a religion survey. There are two main reasons for this. First, the large sample size makes it possible to estimate the religious composition of the U.S. with a high degree of precision. After taking into account the survey's design effect (based on the sample design and survey weights), the margin of error for the results based on the full sample is +/- 0.6 percentage points.

Second, the large sample size makes it possible to describe the characteristics of a wide variety of religious groups, including relatively small groups that cannot be analyzed using data from smaller surveys. With more than 35,000 respondents in total, the Religious Landscape Study includes interviews with roughly 350 in religious groups that account for just 1 percent of the U.S. population, and with 100 or more people in religious groups that are as small as three-tenths of 1 percent of the overall population. For instance, the study includes interviews with 245 Jehovah's Witnesses, a group that accounts for less than 1 percent of the U.S. population and is typically represented by only a few dozen respondents in smaller surveys.

This statistic shows the share of adults in the United States affiliated to a religious denomination in January 2017, by race/ethnicity. As of January 2017, 15 percent of Asian or Pacific Islanders in the United States identified themselves as Hindu.

The 2008 Conversion Recontact Survey, conducted by the Pew Research Center's Forum on Religion & Public Life, is a follow-up to the 2007 "U.S. Religious Landscape Survey." One of the most striking findings from the Landscape Survey was the large number of people who have left their childhood faith. The Landscape Survey found that more than one in four American adults (28%) have changed their religious affiliation from that in which they were raised. This number includes people who have changed from one major religious tradition to another, for instance, from Protestantism to Catholicism or from Judaism to no religion. If change within religious traditions is included (e.g., from one Protestant denominational family to another), the survey found that roughly 44% of Americans now profess a religious affiliation different from that in which they were raised.

The Conversion Recontact Survey is designed to offer a fuller picture of this churn within American religion, with a special focus on the reasons that people change religious affiliation. The Conversion Recontact Survey is based on follow-up interviews with Landscape Survey respondents, including those from the largest segments of the population that have changed religious affiliation as well as those who still belong to the religious faith in which they were raised. Interviews were conducted by telephone with a nationally representative sample of 2,867 adults living in continental United States telephone households. The survey was conducted by Princeton Survey Research Associates International (PSRAI). Interviews were conducted on landline telephones in English and Spanish by Princeton Data Source (PDS), LLC from Oct. 3 to Nov. 7, 2008. Statistical results are weighted to correct known demographic discrepancies. A full report on the survey's findings, "Faith in Flux: Changes in Religious Affiliation in the U.S.," is available on the Pew Forum's "http://www.pewforum.org/2009/04/27/faith-in-flux/" Target="_blank">website.

The World Religion Project (WRP) aims to provide detailed information about religious adherence worldwide since 1945. It contains data about the number of adherents by religion in each of the states in the international system. These numbers are given for every half-decade period (1945, 1950, etc., through 2010). Percentages of the states' populations that practice a given religion are also provided. (Note: These percentages are expressed as decimals, ranging from 0 to 1, where 0 indicates that 0 percent of the population practices a given religion and 1 indicates that 100 percent of the population practices that religion.) Some of the religions are divided into religious families. To the extent data are available, the breakdown of adherents within a given religion into religious families is also provided.

The project was developed in three stages. The first stage consisted of the formation of a religion tree. A religion tree is a systematic classification of major religions and of religious families within those major religions. To develop the religion tree we prepared a comprehensive literature review, the aim of which was (i) to define a religion, (ii) to find tangible indicators of a given religion of religious families within a major religion, and (iii) to identify existing efforts at classifying world religions. (Please see the original survey instrument to view the structure of the religion tree.) The second stage consisted of the identification of major data sources of religious adherence and the collection of data from these sources according to the religion tree classification. This created a dataset that included multiple records for some states for a given point in time. It also contained multiple missing data for specific states, specific time periods and specific religions. The third stage consisted of cleaning the data, reconciling discrepancies of information from different sources and imputing data for the missing cases.

The National Religion Dataset: The observation in this dataset is a state-five-year unit. This dataset provides information regarding the number of adherents by religions, as well as the percentage of the state's population practicing a given religion.

The landscape of religious organizations has evolved, reflecting broader societal shifts and economic variables. These institutions have adapted to challenges by embracing digital platforms and enhancing community engagement, leveraging technological innovations to maintain spiritual connections. Economic fluctuations have also impacted how people donate, yet organizations have successfully navigated these changes by offering online donation options and fostering community bonds. Diversification in revenue streams and focusing on inclusivity have allowed many groups to maintain positive revenue growth. Cultural dynamics emphasizing equality have prompted many to adopt practices that resonate with contemporary values, further supporting their mission and outreach. Industry-wide revenue is expected to rise at a CAGR of 0.5% over the past five years, including an estimated 2.5% expansion in 2025 and a total of $159.8 billion. Religious entities have demonstrated resilience, with profitability supported by strategic financial management. Wages constitute a substantial part of budgets, particularly for larger organizations, but careful planning ensures funds are allocated efficiently. Religious entities have managed to end fiscal years with budget surpluses, attributed to diligent cost control and donor support. Digital engagement has become a cornerstone for sustaining financial contributions, allowing steady income and reduced dependency on in-person donations. Though shifting economic conditions posed revenue fluctuations, strategic planning and community-centric approaches have driven ongoing resilience and sustainability. The anticipated trajectory for these organizations suggests a continued embrace of innovative outreach and technology to bolster engagement. Organizations will likely enhance efforts to connect with younger demographics, shaping experiences that align with evolving cultural preferences. The expected rise in donations, influenced by demographic changes and economic stability, presents opportunities for expanded programs and community outreach. By staying attuned to societal shifts and integrating technology, religious groups aim to maintain their relevance and engage broader audiences. The future promises growth through diversified funding, engagement strategies targeting younger members and leveraging technological advancements to strengthen spiritual and communal ties. Industry revenue is expected to boost at a CAGR of 1.4% over the next five years, reaching $171.6 billion in 2030.

This graph shows the number of ordained clergy serving religious parishes in the United States in 2009, by church. In 2009, about 105 thousand clergy members were serving the Southern Baptist Convention.

Islam is the major religion in many African countries, especially in the north of the continent. In Comoros, Libya, Western Sahara, at least 99 percent of the population was Muslim as of 202. These were the highest percentages on the continent. However, also in many other African nations, the majority of the population was Muslim. In Egypt, for instance, Islam was the religion of 79 percent of the people. Islam and other religions in Africa Africa accounts for an important share of the world’s Muslim population. As of 2019, 16 percent of the Muslims worldwide lived in Sub-Saharan Africa, while 20 percent of them lived in the Middle East and North Africa (MENA) region. Together with Christianity, Islam is the most common religious affiliation in Africa, followed by several traditional African religions. Although to a smaller extent, numerous other religions are practiced on the continent: these include Judaism, the Baha’i Faith, Hinduism, and Buddhism. Number of Muslims worldwide Islam is one of the most widespread religions in the world. There are approximately 1.9 billion Muslims globally, with the largest Muslim communities living in the Asia-Pacific region. Specifically, Indonesia hosts the highest number of Muslims worldwide, amounting to over 200 million, followed by India, Pakistan, and Bangladesh. Islam is also present in Europe and America. The largest Islamic communities in Europe are in France (5.72 million), Germany (4.95 million), and the United Kingdom (4.13 million). In the United States, there is an estimated number of around 3.45 million Muslims.

This graph shows the largest Christian denominations in the United States in 2010, by number of congregations. In 2010, the Latter-day Saints were among the largest Christian denominations with around14,393 congregations in the United States.

The New Immigrant Survey (NIS) was a nationally representative, longitudinal study of new legal immigrants to the United States and their children. The sampling frame was based on the electronic administrative records compiled for new legal permanent residents (LPRs) by the U.S. government (via, formerly, the U.S. Immigration and Naturalization Service (INS) and now its successor agencies, the U.S. Citizenship and Immigration Services (USCIS) and the Office of Immigration Statistics (OIS)). The sample was drawn from new legal immigrants during May through November of 2003. The geographic sampling design took advantage of the natural clustering of immigrants. It included all top 85 Metropolitan Statistical Areas (MSAs) and all top 38 counties, plus a random sample of MSAs and counties. The baseline survey (ICPSR 38031) was conducted from June 2003 to June 2004 and yielded data on: 8,573 Adult Sample respondents, 810 sponsor-parents of the Sampled Child, 4,915 spouses, and 1,072 children aged 8-12. This study contains the follow-up interview, conducted from June 2007 to October 2009, and yielded data on: 3,902 Adult Sample respondents, 351 sponsor-parents of the Sampled Child, 1,771 spouses, and 41 now-adult main children. Interviews were conducted in the respondents' language of choice. Round 2 instruments were designed to track changes from the baseline and also included new questions. As with the Round 1 questionnaire, questions that were used in social-demographic-migration surveys around the world as well as the major U.S. longitudinal surveys were reviewed in order to achieve comparability. The NIS content includes the following information: demographics, health and insurance, migration history, living conditions, transfers, employment history, income, assets, social networks, religion, housing environment, and child assessment tests.

Islam and Christianity form the two dominant religions in Nigeria. The basis of traditional religions was systematically exterminated in the religio-cultural life of the Nigerian people after their contact with colonialism. Approximately 90 percent of the Nigerian people have since preferred to be identified with either Islam or Christianity.Nigeria’s contact with Islam predated that of Christianity and European colonialism; its spread was facilitated into Sub-Saharan Africa through trade and commerce. The northern part of Nigeria is symbolic to the history of Islam, as it penetrated the area through the Kanem-Borno Empire in the 11th century before spreading to the other predominately Hausa states. Islam was then introduced into the traditional societies of the Yoruba-speaking people of south-west Nigeria through their established commercial relationship with people of the North, particularly the Nupe and Fulani.Christianity reached Nigeria in the 15th century with the visitation of the Roman and Catholic missionaries to the coastal areas of the Niger-Delta region, although there were few recorded converts and churches built during this period. Christianity soon recorded a boost in the southern region given its opposition to the slave trade and its promotion of Western education. In contrast to the smooth process Christian evangelization underwent in the South, its process in the North was difficult because Islam had already become well-established.Given the philosophy of Islam as a complete way of life for a Muslim, Islam has always been closely attached to politics in Nigeria. The emergence of particular Islamic groups was significantly influenced by international events, particularly the 1979 Iranian revolution and the corresponding disenchantment from the West. These developments shaped Nigerian national politics of the period as Muslims radically redefined their political interests in line with religion and began to clamor for the incorporation of the Sharia legal system into the country’s judicial system. Nigeria then tried to harness opportunities accruable from other Muslim countries by becoming a registered member with the Organization of Islamic Conference (OIC) in 1985. This inflamed Christians and nurtured the fear of domination by their Muslim counterparts and the possibility of a gradual extinction of their religio-political strength in the national political structure. The distinct religious separation has also instigated violence in present-day Nigeria, including the Sharia riot in Kaduna in 2000, ongoing ethno-religious violence in Jos since 2001, and the 2011 post-election violence that erupted in some northern states. Nigerians’ continued loyalty to religion compared to that of the country continues to sustain major political debate, conflict, and violent outbreaks between populations of the two faiths.

ISO3 - International Organization for Standardization 3-digit country code

AREA_AFF - Geographic area affected by disease

DT_START - Date health event started

DT_END - Date health event ended

TYPE - Type of disease group

DISEASE - Name of disease

NUM_DTH - Number of people reported dead from disease

NUM_AFF - Number of people affected from disease

SOURCE_DT - Source creation date

SOURCE - Primary source

Collection

This HGIS was created using information collected from several websites. EM-DAT, the World Health Organization, and news reports provided information about the outbreaks.

The data included herein have not been derived from a registered survey and should be considered approximate unless otherwise defined. While rigorous steps have been taken to ensure the quality of each dataset, DigitalGlobe Analytics is not responsible for the accuracy and completeness of data compiled from outside sources.

Sources (HGIS)

Egunganga, Vincent, Ami Sadiq, and Hir Joseph. All AfricaHIR JOSEPH, "Nigeria: Lassa Fever Returns Vicio." Last modified March 09, 2013. Accessed April 16, 2013. http://allafrica.com/.

EM DAT, "Country Database; Nigeria." Last modified March 2013. Accessed April 16, 2013. http://www.emdat.be/.

World Health Organization, "Global Health Observatory; Nigeria." Last modified 2012. Accessed April 16, 2013. http://www.who.int/en/.

Sources (Metadata)

Encyclopedia of the Nations, "Nigeria Country Specific Information." Last modified 2013. Accessed March 28, 2013. http://www.nationsencyclopedia.com.

Kates, Jennifer, and Alyssa Wilson Leggoe. The Henry J. Kaiser Family Foundation, "HIV/AIDS; The HIV/AIDS Epidemic in Nigeria." Last modified October 2005. Accessed April 16, 2013. http://www.kff.org/.

United States Embassy in Nigeria, "Nigeria Malaria Fact Sheet." Last modified December 2011. Accessed April 16, 2013. http://nigeria.usembassy.gov.

World Health Organization, "Global Task Force on Cholera Control." Last modified January 18, 2012. Accessed April 16, 2013. http://www.who.int/.

World Health Organization, "Meningococcal disease: situation in the African Meningitis Belt." Last modified 2012. Accessed March 14, 2013. http://www.who.int/csr/don/2012_05_24/en/index.html.

Anti-Jewish attacks were the most common form of anti-religious group hate crimes in the United States in 2023, with ***** cases. Anti-Islamic hate crimes were the second most common anti-religious hate crimes in that year, with *** incidents.

This poll, conducted January 26-29, 1995, is part of a series of monthly surveys that solicit public opinion on the presidency and on a range of other political and social issues. Respondents were asked to give their opinions of President Bill Clinton and his handling of the presidency and the economy. A series of questions addressed whether President Clinton and the Republicans in Congress were trying to work with or against each other and whether this was a good or bad thing, whether Clinton or the Republicans would do a better job dealing with the country's problems, whether the changes they were seeking were right or wrong for the country, and which cared more about serving lower income, middle income, and upper income people. Questions were posed regarding how well the United States Congress was doing its job, whether Congress was able to deal with the main issues facing the country, and whether the federal government should be allowed to impose regulations on state and local governments without providing the necessary funding. Respondents were polled on whether they supported or opposed issues such as banning assault weapons, raising the minimum wage, imposing term limits for United States Representatives, and giving loan guarantees to Mexico. Those surveyed were asked whether balancing the federal budget would make the country's problems better or worse, whether it could be done without cutting useful government programs, which programs should be cut, the percentage of federal tax dollars that they felt were wasted, and whether they supported or opposed a constitutional amendment requiring a balanced federal budget. Questions regarding the professional major league baseball strike polled respondents on whether they sided with the players or the owners, whether there should be a limit on players' earnings, whether they believed the owners' claims that some teams could be forced to move if players' salaries were not limited, and whether replacement players should be used. Several questions asked whether respondents considered themselves baseball fans, how closely they would follow the season if replacement players were used, whether the league playoffs and World Series should be cancelled if the strike was not settled by the end of the season, whether the strike would hurt baseball's popularity, and whether or not President Clinton and Congress should force a settlement of the strike. A series of questions addressed how often respondents flew on commercial airlines, what factors were important in choosing an airline, and the overall safety of commercial air travel. Opinions were solicited on Newt Gingrich's handling of his job as Speaker of the House of Representatives, whether respondents had heard or read anything about his book publishing contract, and if he did anything illegal or wrong in the book deal. Respondents were also polled on whether their family's financial situation was better, worse, or about the same compared to two years ago and the degree to which President Clinton was responsible, whether they considered themselves religious or spiritual, and how often they prayed or attended religious services. Additional questions asked respondents how closely they followed the O.J. Simpson case, whether he was guilty or not guilty, and whether the news coverage of the trial was good or bad. Background variables include sex, age, ethnicity, household income, marital status, employment status, religion, education, subjective size of community, political orientation, political party, labor union membership, social class, whether the respondent was registered to vote, whether they voted in the 1992 presidential election, and if so, for whom (Democrat Bill Clinton, Republican George H.W. Bush, or Independent candidate Ross Perot).

The Faith Communities Today (FACT) surveys comprise a series of national surveys of U.S. congregations conducted by the Cooperative Congregational Studies Partnership. The inaugural FACT survey, launched in 2000, represents the largest national survey of congregations ever undertaken in the United States. Coordinated by the Hartford Institute for Religion Research at Hartford Seminary, these surveys aim to compare and contrast congregational life across religious traditions and offer insights into the evolving nature of congregational life in the U.S.

The 2020 Faith Communities Today national data set is the result of a collaborative venture of 21 denominations and religious groups in this cooperative partnership. These partners developed a common core questionnaire of 180 questions consisting of items from the previous surveys plus original (first-time) items. This dataset contains information from the Evangelical Lutheran Church in America (ELCA).

Voices from the Pagan Census provides unprecedented insight into the expanding but largely unstudied religious movement of Neo-Paganism in the United States. Helen A. Berger, Evan A. Leach, and Leigh S. Shaffer present the findings of "The Pagan Census," which was created and distributed by Berger and Andras Corban Arthen of the Earthspirit Community. Analyzing the most comprehensive and largest-scale survey of Neo-Pagans to date, the authors offer a portrait of this emerging religious community, including an examination of Neo-Pagan political activism, educational achievements, family life, worship methods, experiences with the paranormal, and beliefs about such issues as life after death. A collection of religious groups whose practices evolved from Great Britain's Wicca movement of the 1940s, Neo-Paganism spread to the United States in the 1960s. While the number of people who identify themselves with the religion has continued to rise, quantitative study of Neo-Paganism has been difficult given the movement's lack of centralized leadership and doctrine and its development as scattered, independent groups and individuals. Endorsed by all major Neo-Pagan leaders, "The Pagan Census" generated a demographically diverse response. In contrast to most previous surveys, which were limited to Neo-Pagan festivals, this survey incorporates input from the large population of practitioners who do not participate in such events. Keenly anticipated by the academic and Neo-Pagan communities, the results of the census provide the most in-depth information about the group yet assembled. Comparing Neo-Pagans with American society at large, Berger, Leach, and Shaffer show that although the two groups share certain statistical characteristics, there are differences as well. The scholars also identify variations within the Neo-Pagan population, including those related to geography and to the movement's multiple spiritual paths.

According to a 2022 survey, 31 percent of Americans never attend church or synagogue, compared to 20 percent of Americans who attend every week.

Religiosity in the United States

Despite only about a fifth of Americans attending church or synagogue on a weekly basis, almost 40 percent consider themselves to be very religious. Additionally, states in the Deep South such as Mississippi, Alabama, and Louisiana had the most residents identifying as very religious. In contrast, New England states like Vermont, Maine, and New Hampshire had the most people identifying as nonreligious.

A Christian nation?

Despite the official separation of church and state embedded in the Constitution, many would still consider the United States to be a Christian nation. Catholicism has the largest number of adherents in the United States, due to there being many different Protestant denominations. The Southern Baptist Convention had the largest number of Evangelical adherents, while the United Methodist Church was the largest Mainline Protestant denomination.

The USA faith-based tourism market size is estimated to be valued at US$ 1,001 Million in 2022 and exhibit growth at a CAGR of 9.2% from 2022 to 2032.

Scope of the Report

The overall aim was to conduct a wide-ranging survey of Catholic adults living in Britain, which asked about many aspects of their lives, including their socio-demographic circumstances, the nature and extent of their religious engagement (belonging, behaviour and beliefs), their views of the Catholic Church’s leadership, institutions and teachings, and their social and political attitudes. The survey was conducted online by Savanta ComRes, in October-November 2019. This is a cross-sectional dataset, based on interviews with 1,823 self-identifying Catholics adults in Britain (aged 18 and over).

In recent decades, the religious profile of British society has changed significantly, with a marked increase in 'religious nones', declining proportions identifying as Anglican or with a particular Non-Conformist tradition, an increase in non-denominational Christians, and the spread of non-Christian faiths. Within this wider context, Roman Catholics have remained broadly stable as a proportion of the adult population and represent the second largest Christian denomination in Britain, after Anglicans. However, there have been significant internal and external developments which have affected the institutional church and wider Roman Catholic community in Britain, and which could have shaped how Catholics' think about and engage with their faith and how it impacts their daily lives. Recent years have seen demographic change through significant inflows of Catholic migrants coming from Eastern Europe, the papal visit of Pope Benedict XVI to Britain in autumn 2010 (the first since 1982), Pope Francis's pontificate from 2013 onwards, Catholic leaders' political interventions against 'aggressive secularism' and in other policy debates, and internal crises and debates impacting on the perceived authority of the Catholic Church. The last major academic investigation of the Catholic community (and only in England and Wales) was undertaken in the late 1970s (Hornsby-Smith and Lee 1979; Hornsby-Smith 1987, 1991). It found that the 'distinctive subculture' of the Catholic community in the post-war period was evolving and dissolving in complex ways due to processes of social change and developments within the wider faith, such as the Second Vatican Council (Hornsby-Smith 1987, 1991). It also demonstrated growing internal heterogeneity in Catholics' religious beliefs, practices and social attitudes (Hornsby-Smith 1987, 1991). However, while there has been some recent scholarship on particular topics relating to Catholics and Catholicism in Britain, using both general social surveys and limited one-off denomination-specific opinion polls (Clements 2014a, 2014b; 2016; Bullivant 2016a, 2016b), there has been no systematic academic inquiry into the Roman Catholic population in Britain. In comparison, an academic-led survey series has profiled the Catholic population in the United States on five occasions between 1987 and 2011, with other large-scale surveys carried out in recent years by organisations such as the Pew Research Center. Most existing research into the waning of religious belief, practice, and affiliation in Britain has focused either on the very large, macro level or on the very small, micro level. While both are important and necessary, largely missing has been sustained sociological attention on how secularising trends have affected - and are being mediated within - individual religious communities. This project would undertake such a task for Roman Catholics in Britain, by conducting a large-scale, thematically wide-ranging and nationally representative survey. It would provide a detailed study of personal faith, social attitudes and political engagement within a significant religious minority with distinctive historical roots and in which 'tribal' feelings of belonging have been strong. The core topics would consist of personal faith, religiosity and associational involvement in parish life; attitudes towards leadership and governance within the institutional church; attitudes on social and moral issues; and political attitudes and engagement. It would be thematically wide-ranging and analytically rich, providing a detailed portrait of contemporary social, religious and attitudinal heterogeneity amongst Catholics. By undertaking this large-scale and wide-ranging survey, an important and distinctive contribution would be made to the sociology of religion in Britain in general and to the study of its Catholic population in particular.

Investigate associations between religion and spirituality (R&S) and DNA methylation of four HPA-axis genes (i.e. 14 CpG sites) among 992 adults from the Hispanic Community Health Study/Study of Latinos cohorts. We assessed 1) the association between R&S measures and mean percent methylation overall and stratified by nativity status (US-born or immigrant) and 2) if interactions between R&S and methylation differed by nativity status. Among individuals with the FKBP5 CC genotype, increased spirituality scores were associated with significantly lower methylation levels among immigrants, compared to US-born participants. Organizational religiosity (e.g. service attendance) was associated with increased FKBP5 (CC genotype) methylation among immigrants. R&S may influence HPA-axis functioning differently based on nativity status; a finding that could offer insight into mechanisms leading to health disparities. Hispanics/Latinos, the largest racial/ethnic minority group in the United States, face significant stressors and health challenges. Religion and spirituality are key sources of resilience, particularly for immigrants. However, the ways in which religion and spirituality influence genes related to health outcomes are not yet fully understood. In this study, we found that religion and spirituality impact a key gene in the body’s stress response system differently between immigrants and US-born individuals. We suggest that future research should explore how varying stressors and resilience factors affect these two groups, with the goal of improving health outcomes for all Hispanics/Latinos.