As of 2023, the third leading cause of death among teenagers aged 15 to 19 years in the United States was intentional self-harm or suicide, contributing to around 17 percent of deaths among this age group. The leading cause of death at that time was unintentional injuries, contributing to around 38.6 percent of deaths, while 20.7 percent of all deaths in this age group were due to assault or homicide. Cancer and heart disease, the overall leading causes of death in the United States, are also among the leading causes of death among U.S. teenagers. Adolescent suicide in the United States In 2021, around 22 percent of students in grades 9 to 12 reported that they had seriously considered attempting suicide in the past year. Female students were around twice as likely to report seriously considering suicide compared to male students. In 2023, New Mexico had the highest rate of suicides among U.S. teenagers, with around 28 deaths per 100,000 teenagers, followed by Idaho with a rate of 22.5 per 100,000. The states with the lowest death rates among adolescents are New Jersey and New York. Mental health treatment Suicidal thoughts are a clear symptom of mental health issues. Mental health issues are not rare among children and adolescents, and treatment for such issues has become increasingly accepted and accessible. In 2021, around 15 percent of boys and girls aged 5 to 17 years had received some form of mental health treatment in the past year. At that time, around 35 percent of youths aged 12 to 17 years in the United States who were receiving specialty mental health services were doing so because they had thought about killing themselves or had already tried to kill themselves.

Over the last few years, gun violence in the United States has become an increasingly deadly public health crisis. In 2021, firearms were the leading cause of death for children and adolescents aged one to 19 years old for a second year in a row in the United States, with ***** deaths from firearms, which accounted for more deaths than car crashes and other diseases in that year. This is an increase from the previous year, when there were ***** deaths from firearms. Gun violence in the U.S. Along with a rise in gun-related deaths, the United States has been experiencing an overall increase in gun violence, including mass shootings, school shootings, and gun homicides. Not surprisingly, the United States has also reported in increase in gun sales, with the unit sales for firearms reaching a new high in recent years. A uniquely American problem Despite the rise of gun violence and gun-related deaths, guns remain easily accessible in the United States and gun control has become a divisive issue throughout the nation. However, gun control proponents often call attention to the uniquely American phenomenon of school shootings. Since 2018, the annual number of incidents involving firearms at K-12 schools in the U.S. reached over *** in each year, while similar incidents in other countries with strict gun laws are exceptionally rare.

Rank, number of deaths, percentage of deaths, and age-specific mortality rates for the leading causes of death, by age group and sex, 2000 to most recent year.

In 2023, the leading cause of death among teenagers in the United States aged 15 to 19 was accidents or unintentional injuries. At that time, there were 4,937 deaths among teens aged 15 to 19 years due to accidents. Homicide was the second leading cause of death among teens in this age group, with 2,648 deaths.

This statistic presents the global death rates for the leading causes of death among adolescents aged 10 to 19 years in 2015, per 100,000 population. At this time, road injuries were the leading cause of global deaths among adolescents aged 10 to 19 years with a death rate of *** per 100,000 population.

Number of deaths and age-specific mortality rates for selected grouped causes, by age group and sex, 2000 to most recent year.

Abstract Mortality indicators for Brazilians aged between 10 and 24 years old were analyzed. Data were obtained from the Global Burden of Disease (GBD) 2019 Study, and absolute numbers, proportion of deaths and specific mortality rates from 1990 to 2019 were analyzed, according to age group (10 to 14, 15 to 19 and 20 to 24 years), sex and causes of death for Brazil, regions and Brazilian states. There was a reduction of 11.8% in the mortality rates of individuals aged between 10 and 24 years in the investigated period. In 2019, there were 13,459 deaths among women, corresponding to a reduction of 30.8% in the period. Among men there were 39,362 deaths, a reduction of only 6.2%. There was an increase in mortality rates in the North and Northeast and a reduction in the Southeast and South states. In 2019, the leading cause of death among women was traffic injuries, followed by interpersonal violence, maternal deaths and suicide. For men, interpersonal violence was the leading cause of death, especially in the Northeast, followed by traffic injuries, suicide and drowning. Police executions moved from 77th to 6th place. This study revealed inequalities in the mortality of adolescents and young adults according to sex, causes of death, regions and Brazilian states.

ObjectivePromoting adolescent health is essential to achieving the goals of the Healthy China 2030 (HC 2030) initiative. As socioeconomic conditions improve and medical practices and disease patterns evolve, adolescent mortality rates and causes of death vary considerably. This study provides up-to-date data on adolescent mortality and causes of death in China, highlighting key areas of focus for investment in adolescent health.MethodsData regarding mortality and causes of death in Chinese adolescents aged 10–19 years were extracted from the Global Burden of Disease study from 1990 to 2019. The data variables were examined according to year, sex, and age. The autoregressive integrated moving average model was used to predict non-communicable disease (NCD) mortality rates and rank changes in the leading causes of death until 2030.ResultsThe all-cause mortality rate (per 100,000 population) of Chinese adolescents aged 10–19 years steadily declined from 1990 (72.6/100,000) to 2019 (28.8). Male adolescents had a higher mortality (37.5/100,000 vs. 18.6 in 2019) and a slower decline rate (percent: −58.7 vs. −65.0) than female adolescents. Regarding age, compared with those aged 10–14 years, the mortality rate of adolescents aged 15–19 years had a higher mortality (35.9/100,000 vs. 21.2 in 2019) and a slower decrease rate (percent: −57.6 vs. −63.2). From 1990 to 2019, the rates of communicable, maternal, and nutritional diseases declined the most (percent: −80.0), while injury and NCDs mortality rates were relatively slow (percent: −50.0 and −60.0). In 2019, the five leading causes of death were road injuries (6.1/100,000), drowning (4.5), self-harm (1.9), leukemia (1.9), and congenital birth defects (1.3). Furthermore, NCDs' mortality rate decreased by −46.6% and −45.4% between 2015–2030 and 2016–2030, respectively.ConclusionA notable decline was observed in all-cause mortality rates among Chinese adolescents aged 10–19 years. In addition, the mortality rates of NCDs are projected to meet the target from the Global Strategy for Women's, Children's, and Adolescents' Health (2016–2030) and HC2030 reduction indicators by 2030. However, it should be noted that injury is the leading cause of death, with sexual and age disparities remaining consistent.

Introductionour objective was to analyze the trends in the leading causes of death among the pediatric population aged 1–19 years in Mexico and the United States (US) from 2000 to 2022. Methods. Data for Mexico were sourced from the National Institute of Statistics and Geography (INEGI), while the US data were extracted from the Centers for Disease Control and Prevention’s Wide-ranging Online Data for Epidemiologic Research (CDC-WONDER) databases.ResultsHomicide has been the leading cause of death since 2017 in Mexico and since 2019 in US youths aged 1–19. In Mexico, it reached 6.5 deaths per 100,000 people in 2022. Despite the overall pediatric mortality decline from 2000 to 2022 in both countries, the pediatric homicide rate has increased by 93.3 and 35.8% In Mexico and the US, respectively, and suicide by 86.6 and 36.9%. In both countries, death by firearm-related injuries had risen in a parallel sense. In the US, deaths by drug overdose and poisoning have increased by 314.8%.ConclusionDespite advancements in infant healthcare over the past two decades in Mexico, there remains a significant gap in the provision of healthcare services to the adolescent population. Addressing issues related to violence, mental health, and substance abuse through targeted public policies is imperative for both Mexico and the US, especially given their shared border region.

Number of deaths and mortality rates, by age group, sex, and place of residence, 1991 to most recent year.

To: State, territorial, tribal, and local policymakers and administrators of agencies and programs focused on child, youth, and family health and well-being Dear Colleagues, Thank you for your work to support children, youth, and families. Populations served by Administration for Children and Families (ACF)-funded programs — including victims of trafficking or violence, those who are unhoused, and young people and families involved in the child welfare system — are often at particularly high risk for substance use and overdose. A variety of efforts are underway at the federal, state, and local levels to reduce overdose deaths. These efforts focus on stopping drugs from entering communities, providing life-saving resources, and preventing drug use before it starts. Initiatives across the country are already saving lives: the overdose death rate has declined over the past year but remains too high at 32.6 per 100,000 individuals. Fentanyl, a powerful synthetic opioid, raises the risk of overdose deaths because even a tiny amount can be deadly. Young people are particularly at risk for fentanyl exposure, driven in part by widespread availability of counterfeit pills containing fentanyl that are marketed to youth through social media. While overdose deaths among teens have recently begun to decline, there were 6,696 deaths among adolescents and young adults in 2022 (the latest year with data available)[1], making unintentional drug overdose the second leading cause of death for youth ages 15—19 and the first leading cause of death among young adults ages 20-24.[2] Often these deaths happen with others nearby and can be prevented when opioid overdose reversal medications, like naloxone, are administered in time. CDC’s State Unintentional Drug Overdose Reporting System dashboard shows that in all 30 jurisdictions with available data, 64.7% of drug overdose deaths had at least one potential opportunity for intervention.[3] Naloxone rapidly reverses an overdose and should be given to any person who shows signs of an opioid overdose or when an overdose is suspected. It can be given as a nasal spray. Studies show that naloxone administration reduces death rates and does not cause harm if used on a person who is not overdosing on opioids. States have different policies and regulations regarding naloxone distribution and administration. Forty-nine states and the District of Columbia have Good Samaritan laws protecting bystanders who aid at the scene of an overdose.[4] ACF grant recipients and partners can play a critical role in reducing overdose deaths by taking the following actions: Stop Overdose Now (U.S. Centers for Disease Control and Prevention) Integrating Harm Reduction Strategies into Services and Supports for Young Adults Experiencing Homelessness (PDF) (ACF) Thank you for your dedication and partnership. If you have any questions, please contact your local public health department or state behavioral health agency. Together, we can meaningfully reduce overdose deaths in every community. /s/ Meg Sullivan Principal Deputy Assistant Secretary [1] Products - Data Briefs - Number 491 - March 2024 [2] WISQARS Leading Causes of Death Visualization Tool [3] SUDORS Dashboard: Fatal Drug Overdose Data | Overdose Prevention | CDC [4] Based on 2024 report from the Legislative Analysis and Public Policy Association (PDF). Note that the state of Kansas adopted protections as well following the publication of this report. Metadata-only record linking to the original dataset. Open original dataset below.

The leading causes of death among children aged 5 to 9 years in the United States in 2023 were unintentional injuries, cancer, and congenital malformations, deformations, and chromosomal abnormalities. At that time, unintentional injuries accounted for around 27 percent of all deaths among this age group. Child abuse in the U.S. Sadly, assault or homicide was the fourth leading cause of death among those aged 5 to 9 years in the United States in 2023, accounting for around 8.4 percent of all deaths. That year, there were around 112,808 cases of child abuse in the U.S. among children aged 6 to 9 years and 128,004 cases among children aged 2 to 5 years. In 2023, there were around 5.39 child deaths per day in the United States due to abuse and neglect. Suicide among children Assault or homicide was also among the top five leading causes of death among children aged 10 to 14 years, but perhaps even more troubling is that suicide is the second leading cause of death among this age group. As with younger children, unintentional injuries are the leading cause of death among those aged 10 to 14 years; however, suicide accounts for around 14 percent of all deaths among this age group. Comparatively, suicide is not among the ten leading causes of death among children from the ages of 1 to 9 years.

EMSIndicators:The number of individual patients administered naloxone by EMSThe number of naloxone administrations by EMSThe rate of EMS calls involving naloxone administrations per 10,000 residentsData Source:The Vermont Statewide Incident Reporting Network (SIREN) is a comprehensive electronic prehospital patient care data collection, analysis, and reporting system. EMS reporting serves several important functions, including legal documentation, quality improvement initiatives, billing, and evaluation of individual and agency performance measures.Law Enforcement Indicators:The Number of law enforcement responses to accidental opioid-related non-fatal overdosesData Source:The Drug Monitoring Initiative (DMI) was established by the Vermont Intelligence Center (VIC) in an effort to combat the opioid epidemic in Vermont. It serves as a repository of drug data for Vermont and manages overdose and seizure databases. Notes:Overdose data provided in this dashboard are derived from multiple sources and should be considered preliminary and therefore subject to change. Overdoses included are those that Vermont law enforcement responded to. Law enforcement personnel do not respond to every overdose, and therefore, the numbers in this report are not representative of all overdoses in the state. The overdoses included are limited to those that are suspected to have been caused, at least in part, by opioids. Inclusion is based on law enforcement's perception and representation in Records Management Systems (RMS). All Vermont law enforcement agencies are represented, with the exception of Norwich Police Department, Hartford Police Department, and Windsor Police Department, due to RMS access. Questions regarding this dataset can be directed to the Vermont Intelligence Center at dps.vicdrugs@vermont.gov.Overdoses Indicators:The number of accidental and undetermined opioid-related deathsThe number of accidental and undetermined opioid-related deaths with cocaine involvementThe percent of accidental and undetermined opioid-related deaths with cocaine involvementThe rate of accidental and undetermined opioid-related deathsThe rate of heroin nonfatal overdose per 10,000 ED visitsThe rate of opioid nonfatal overdose per 10,000 ED visitsThe rate of stimulant nonfatal overdose per 10,000 ED visitsData Source:Vermont requires towns to report all births, marriages, and deaths. These records, particularly birth and death records are used to study and monitor the health of a population. Deaths are reported via the Electronic Death Registration System. Vermont publishes annual Vital Statistics reports.The Electronic Surveillance System for the Early Notification of Community-based Epidemics (ESSENCE) captures and analyzes recent Emergency Department visit data for trends and signals of abnormal activity that may indicate the occurrence of significant public health events.Population Health Indicators:The percent of adolescents in grades 6-8 who used marijuana in the past 30 daysThe percent of adolescents in grades 9-12 who used marijuana in the past 30 daysThe percent of adolescents in grades 9-12 who drank any alcohol in the past 30 daysThe percent of adolescents in grades 9-12 who binge drank in the past 30 daysThe percent of adolescents in grades 9-12 who misused any prescription medications in the past 30 daysThe percent of adults who consumed alcohol in the past 30 daysThe percent of adults who binge drank in the past 30 daysThe percent of adults who used marijuana in the past 30 daysData Sources:The Vermont Youth Risk Behavior Survey (YRBS) is part of a national school-based surveillance system conducted by the Centers for Disease Control and Prevention (CDC). The YRBS monitors health risk behaviors that contribute to the leading causes of death and disability among youth and young adults.The Behavioral Risk Factor Surveillance System (BRFSS) is a telephone survey conducted annually among adults 18 and older. The Vermont BRFSS is completed by the Vermont Department of Health in collaboration with the Centers for Disease Control and Prevention (CDC).Notes:Prevalence estimates and trends for the 2021 Vermont YRBS were likely impacted by significant factors unique to 2021, including the COVID-19 pandemic and the delay of the survey administration period resulting in a younger population completing the survey. Students who participated in the 2021 YRBS may have had a different educational and social experience compared to previous participants. Disruptions, including remote learning, lack of social interactions, and extracurricular activities, are likely reflected in the survey results. As a result, no trend data is included in the 2021 report and caution should be used when interpreting and comparing the 2021 results to other years.The Vermont Department of Health (VDH) seeks to promote destigmatizing and equitable language. While the VDH uses the term "cannabis" to reflect updated terminology, the data sources referenced in this data brief use the term "marijuana" to refer to cannabis. Prescription Drugs Indicators:The average daily MMEThe average day's supplyThe average day's supply for opioid analgesic prescriptionsThe number of prescriptionsThe percent of the population receiving at least one prescriptionThe percent of prescriptionsThe proportion of opioid analgesic prescriptionsThe rate of prescriptions per 100 residentsData Source:The Vermont Prescription Monitoring System (VPMS) is an electronic data system that collects information on Schedule II-IV controlled substance prescriptions dispensed by pharmacies. VPMS proactively safeguards public health and safety while supporting the appropriate use of controlled substances. The program helps healthcare providers improve patient care. VPMS data is also a health statistics tool that is used to monitor statewide trends in the dispensing of prescriptions.Treatment Indicators:The number of times a new substance use disorder is diagnosed (Medicaid recipients index events)The number of times substance use disorder treatment is started within 14 days of diagnosis (Medicaid recipients initiation events)The number of times two or more treatment services are provided within 34 days of starting treatment (Medicaid recipients engagement events)The percent of times substance use disorder treatment is started within 14 days of diagnosis (Medicaid recipients initiation rate)The percent of times two or more treatment services are provided within 34 days of starting treatment (Medicaid recipients engagement rate)The MOUD treatment rate per 10,000 peopleThe number of people who received MOUD treatmentData Source:Vermont Medicaid ClaimsThe Vermont Prescription Monitoring System (VPMS)Substance Abuse Treatment Information System (SATIS)

NOTE. RRfem, Relative risk for females compared with males; CI, confidence interval; χ2, chi-squared.aStatistics presented exclude deaths with undetermined cause (n = 174); of 238 NCD deaths, 13 ‘other’ NCDs are excluded from main cause of death analysis.bCD, communicable diseases (HIV, TB, malaria, other common infections).cHIV/TB is the combination of all deaths diagnosed with either TB or HIV as the cause of death.dSignificantly higher proportion of deaths in males, inverse RRmales presented [in brackets].

IntroductionSuicide is the leading cause of death among Korean adolescents. Suicide has been found to be associated with body mass index (BMI), height, and subjective body image among adults, but investigations of these associations among adolescents are limited. Thus, we aimed to examine to what extent suicide ideation is associated with height, BMI, and subjective body image among Korean adolescents.MethodsThis study examined the data of 6,261 adolescents, selected from a nationally representative survey. The participants were divided into subgroups by sex, suicide ideation, and subjective body image. Logistic regression analyses were performed to examine the association of suicide ideation with height, BMI, and subjective body image.ResultsThe proportion of perceived obesity was high in the total sample; the height Z-score was lower for the group with suicide ideation than the group without suicide ideation; the height Z-scores were also lower for female participants with suicide ideation than those female participants without suicide ideation. The proportions of depressed mood, suicide ideation, and suicide attempts were higher among the total sample and female participants with perceived obesity than among those with a normal body image. On logistic regression, perceived obesity was positively associated with suicide ideation even after adjusting for age, height Z-score, weight Z-score, and depressed mood, whereas height Z-score was negatively associated with suicide ideation. These relationships were more prominent among female participants than among male participants.ConclusionLow height and perceived obesity, not real obesity, are associated with suicide ideation among Korean adolescents. These findings indicate that the need for an integrated approach to growth, body image, and suicide in adolescents is warranted.

This statistic presents the global death rates for the leading causes of deaths among females aged 15 to 19 years in 2015, per 100,000 population. Maternal conditions emerged as the leading cause of global deaths among adolescent females aged 15 to 19 years with a death rate of **** per 100,000 population, followed by self-harm and road injury.

Suicide among children and young people (CYP) is a leading cause of death. In the UK children identified as suicidal are referred to Child and Adolescent Mental Health Services (CAMHS) for assessment and treatment. However, the number of children referred for suicidality, and their care journey is unknown. This retrospective cohort study conducted in two distinct CAMHS teams, in Scotland, UK, aimed to quantify the numbers of children referred for suicidality, describing this population and the outcomes of these referrals. All CAMHS referrals (n = 1159) over a 6-month period (Jan-June 2019) were screened to identify those referred primarily for suicidality. Data extracted included: age, gender, source of referral, reason for referral including underlying issues, whether offered an assessment, and referral outcome. Area based deprivation scores were attached to each referral. Associations between the referred CYP's characteristics (including source of referral and underlying issues) and referral outcomes were explored using Chi Square, Fishers Exact test, and one-way ANOVA. Referrals for 284 children were identified as being for suicidality across the two sites (Site A n = 104; Site B n = 180). These represented 25% of all referrals to these CAMHS over a six-month period. One third of these concerned children under 12. The underlying issues, referrals sources, and demographic indicators were similar in both sites. In site A 31% were offered an assessment, whilst in Site B which had a dedicated team for suicidal CYP, 82% were offered an assessment. Similarly, more children in Site B were offered treatment (47.8%), than Site A (7.7%). Referrals from A&E were prioritized in both areas, and those who had attempted suicide offered an assessment more often. Older children were more likely to be offered treatment, although they were more likely to present with a history of self-harming behavior and/or previous suicide attempt. There are high numbers of children being referred to CAMHS for suicidality, and many are young children (

Curfew-Based Driver Alerts for Teens Market Outlook

According to our latest research, the Curfew-Based Driver Alerts for Teens market size reached USD 1.34 billion globally in 2024, with a robust CAGR of 13.2% projected through the forecast period. By 2033, the market is expected to attain USD 4.13 billion, driven by increasing parental concerns about teen driver safety and the rapid adoption of connected vehicle technologies. As per our most recent analysis, the market’s growth is propelled by technological advancements, legislative support for teen safety, and a rising awareness of the importance of monitoring young drivers.

One of the primary growth factors for the Curfew-Based Driver Alerts for Teens market is the escalating concern among parents and guardians regarding the safety of teenage drivers. With road accidents ranking as a leading cause of death among adolescents, there is a growing demand for proactive solutions that minimize risky driving behaviors. Curfew-based alerts, which notify stakeholders when a teen operates a vehicle outside designated safe hours, have become crucial tools in this context. The combination of real-time monitoring and automated alerts empowers parents and guardians to intervene promptly, reducing the likelihood of accidents and unauthorized vehicle use. This heightened awareness, coupled with a societal shift towards prioritizing youth safety, is significantly bolstering market growth.

Another significant driver is the integration of advanced telematics and IoT-based technologies into both new and existing vehicles. The proliferation of GPS, cellular, and Bluetooth connectivity has enabled the seamless implementation of curfew-based alert systems, making them more accessible and reliable. Automotive manufacturers and aftermarket solution providers are increasingly embedding these technologies as standard or optional features, thus expanding their reach. Moreover, the software and hardware ecosystem supporting these alerts is evolving rapidly, with enhanced user interfaces, robust data analytics, and improved alert accuracy. This technological evolution not only enhances the effectiveness of curfew-based driver alerts but also contributes to their widespread adoption across different vehicle types and use cases.

Legislative initiatives and insurance incentives are also playing a pivotal role in driving market expansion. Governments in several regions are enacting stricter regulations aimed at improving teen driver safety, such as graduated driver licensing (GDL) programs and mandatory parental supervision. Insurance companies, in turn, are offering premium discounts and tailored policies for families that adopt curfew-based monitoring solutions. These regulatory and financial incentives are encouraging more parents, schools, and fleet operators to invest in such systems, thereby accelerating market penetration. Furthermore, public awareness campaigns and partnerships between technology providers and educational institutions are fostering a culture of responsible driving among teens, further supporting market growth.

From a regional perspective, North America currently dominates the Curfew-Based Driver Alerts for Teens market, accounting for the largest share in 2024, followed closely by Europe and Asia Pacific. The United States, in particular, has witnessed widespread adoption due to high vehicle ownership rates, supportive insurance frameworks, and proactive legislation. Meanwhile, rapid urbanization and increasing disposable incomes in Asia Pacific are expected to drive substantial growth in the coming years, with the region forecasted to achieve the highest CAGR during the forecast period. Europe’s focus on road safety and stringent regulatory standards also contribute to its significant market presence. Latin America and the Middle East & Africa, while still emerging, are showing promising growth potential as awareness and infrastructure improve.

Component Analysis

The Curfew-Based Driver Ale

ABSTRACT This article analyzes maternal deaths of adolescents in Piauí and describes the stories of those who died due to induced abortion between 2008 and 2013. The study was conducted in two stages. The first, quantitative, obtained demographic data and basic causes of deaths from the Mortality Information System. In the second, qualitative, the mothers of the adolescents were interviewed. Adolescents’ deaths accounted for 17.2% (50 cases) of total maternal deaths. The majority of the adolescents lived in inner cities (78%) and was black (70%). The causes of death were hypertensive disorders (28%), puerperal infection (16%), hemorrhage (12%), thromboembolism (12%) and abortion (10%). The use of medication occurred in all cases of abortion, with abundant bleeding and pelvic pain being the main reasons for seeking hospital care. There was delay in the diagnosis and appropriate treatment of abortion complications, which may have contributed to the death of the adolescents. Maternal deaths among adolescents were mostly caused by conditions considered preventable. The stories of young women who died of abortion complications have highlighted the need for better-qualified health care, as well as laws and public policies that protect women who decide to terminate their pregnancies.

A quarter of the global human population is estimated to be latently infected by Mycobacterium tuberculosis (Mtb), the causative agent of tuberculosis (TB). TB remains the global leading cause of death by a single pathogen and ranks among the top-10 causes of overall global mortality. Current immunodiagnostic tests cannot discriminate between latent, active and past TB, nor predict progression of latent infection to active disease. The only registered TB vaccine, Bacillus Calmette-Guérin (BCG), does not adequately prevent pulmonary TB in adolescents and adults, thus permitting continued TB-transmission. Several Mtb proteins, mostly discovered through IFN-γ centered approaches, have been proposed as targets for new TB-diagnostic tests or -vaccines. Recently, however, we identified novel Mtb antigens capable of eliciting multiple cytokines, including antigens that did not induce IFN-γ but several other cytokines. These antigens had been selected based on high Mtb gene-expression in the lung in vivo, and have been termed in vivo expressed (IVE-TB) antigens. Here, we extend and validate our previous findings in an independent Southern European cohort, consisting of adults and adolescents with either LTBI or TB. Our results confirm that responses to IVE-TB antigens, and also DosR-regulon and Rpf stage-specific Mtb antigens are marked by multiple cytokines, including strong responses, such as for TNF-α, in the absence of detectable IFN-γ production. Except for TNF-α, the magnitude of those responses were significantly higher in LTBI subjects. Additional unbiased analyses of high dimensional flow-cytometry data revealed that TNF-α+ cells responding to Mtb antigens comprised 17 highly heterogeneous cell types. Among these 17 TNF-α+ cells clusters identified, those with CD8+TEMRA or CD8+CD4+ phenotypes, defined by the expression of multiple intracellular markers, were the most prominent in adult LTBI, while CD14+ TNF-α+ myeloid-like clusters were mostly abundant in adolescent LTBI. Our findings, although limited to a small cohort, stress the importance of assessing broader immune responses than IFN-γ alone in Mtb antigen discovery as well as the importance of screening individuals of different age groups. In addition, our results provide proof of concept showing how unbiased multidimensional multiparametric cell subset analysis can identify unanticipated blood cell subsets that could play a role in the immune response against Mtb.