RNA-Seq high throughput sequencing data taken from NCBI GEO Dataset entitled Immune cell topography predicts response to PD-1 blockade in cutaneous T cell lymphoma

GEO stock price, live market quote, shares value, historical data, intraday chart, earnings per share and news.

Raw sequencing data as downloaded from GEO repository (accession ID: GSE111414) and demultiplexed. Contains expression data of CD8+ T cells of patients involved in this trial

Global change is impacting biodiversity across all habitats on earth. New selection pressures from changing climatic conditions and other anthropogenic activities are creating heterogeneous ecological and evolutionary responses across many species’ geographic ranges. Yet we currently lack standardised and reproducible tools to effectively predict the resulting patterns in species vulnerability to declines or range changes. We developed an informatic toolbox that integrates ecological, environmental and genomic data and analyses (environmental dissimilarity, species distribution models, landscape connectivity, neutral and adaptive genetic diversity, genotype-environment associations and genomic offset) to estimate population vulnerability. In our toolbox, functions and data structures are coded in a standardised way so that it is applicable to any species or geographic region where appropriate data are available, for example individual or population sampling and genomic datasets (e.g. RAD-seq, ddRAD-seq, whole genome sequencing data) representing environmental variation across the species geographic range. To demonstrate multi-species applicability, we apply our toolbox to three georeferenced genomic datasets for co-occurring East African spiny reed frogs (Afrixalus fornasini, A. delicatus and A. sylvaticus) to predict their population vulnerability, as well as demonstrating that range loss projections based on adaptive variation can be accurately reproduced from a previous study using data for two European bat species (Myotis escalerai, and M. crypticus). Our framework sets the stage for large scale, multi-species genomic datasets to be leveraged in a novel climate change vulnerability framework to quantify intraspecific differences in genetic diversity, local adaptation, range shifts and population vulnerability based on exposure, sensitivity, and landscape barriers. Methods Raw sequence data is available at the European Nucleotide Archive (ENA): Myotis escalerai and M. crypticus (PRJEB29086), and the NCBI Short Read Archive (SRA): Afrixalus fornasini – (SRP150605). Input data (processed genomic data and spatial-environmental data prior to running the toolbox) available as part of this repository. Methods: see methods text of manuscript and tutorials: Setup and running the LotE toolbox - https://cd-barratt.github.io/Life_on_the_edge.github.io/Vignette

GEO reported $35.72 in PE Price to Earnings for its fiscal quarter ending in June of 2025. Data for GEO - PE Price to Earnings including historical, tables and charts were last updated by Trading Economics this last December in 2025.

Unlike most anadromous fishes that have evolved strict homing behaviour, Pacific lamprey (Entosphenus tridentatus) seem to lack philopatry as evidenced by minimal population structure across the species range. Yet unexplained findings of within-region population genetic heterogeneity coupled with the morphological and behavioural diversity described for the species suggest that adaptive genetic variation underlying fitness traits may be responsible. We employed restriction site–associated DNA sequencing to genotype 4439 quality filtered single nucleotide polymorphism (SNP) loci for 518 individuals collected across a broad geographical area including British Columbia, Washington, Oregon and California. A subset of putatively neutral markers (N = 4068) identified a significant amount of variation among three broad populations: northern British Columbia, Columbia River/southern coast and ‘dwarf’ adults (FCT = 0.02, P ≪ 0.001). Additionally, 162 SNPs were identified as adaptive through outlier tests, and inclusion of these markers revealed a signal of adaptive variation related to geography and life history. The majority of the 162 adaptive SNPs were not independent and formed four groups of linked loci. Analyses with matsam software found that 42 of these outlier SNPs were significantly associated with geography, run timing and dwarf life history, and 27 of these 42 SNPs aligned with known genes or highly conserved genomic regions using the genome browser available for sea lamprey. This study provides both neutral and adaptive context for observed genetic divergence among collections and thus reconciles previous findings of population genetic heterogeneity within a species that displays extensive gene flow.

The dataset notes the occurrence and extent of man-made interventions to the watercourse and floodplain._Channel form modifications are mapped as linear features and categorised as: Resectioned, Reinforced, Culverted and Inaccessible. Comments are used to describe notable features such as materials used or the purpose of the modification when known.

Life expectancy at birth measures the average years a newborn is expected to live, reflecting a country's health standards and quality of life. This vital statistic highlights disparities in healthcare and living conditions across nations, making it essential for global health assessments.

Supporting data and R codes that reproduce analyses and figures in the study "Associating the structure of Lepidoptera-plant interaction networks across clades and life stages to environmental gradients" by Ho et al. (2022 submitted to Journal of Biogeography). The data (as RDATA files) include datasets that contain the sorted properties of constructed Lepidoptera-plant networks, and of their randomised counterparts, which can then be analysed and visualised using the script. The script also contains the functions to perform network construction and randomisation, as well as the info for accessing raw data that is not authorised to be shared on the repository.

Debt-To-Capital-Ratio Time Series for Geo Holdings Corp. Geo Holdings Corporation engages in the amusement businesses in Japan. The company operates GEO shops, which offer a range of in-home amusement software products, including DVDs, CDs, game titles, and books through rental, resale of previously owned items, and sell-through formats; 2nd STREET that handles various reuse items related to daily life, such as clothing, furniture, electronic devices, household electric appliances, and hobby and other lifestyle items; and JUMBLE STORE, which specializes in used clothing and fashion items. It also sells pre-owned mobile devices through GEO MOBILE stores; and engages in the store management support, wholesale of rental music packages, import and wholesale of clothing and clothing accessories, video-gram package and titles, production and distribution of digital publication, EC, online-gaming, digital content, and management consulting services, as well as develops and operates websites and software. Further, it purchases and sells used farm equipment, antiques, and art work. In addition, the company sells its products online. Geo Holdings Corporation was incorporated in 1989 and is headquartered in Nagoya, Japan.

Organisms develop through multiple life stages that differ in environmental tolerances. The seasonal timing, or phenology, of life-stage transitions determines the environmental conditions to which each life stage is exposed and the length of time required to complete a generation. Both environmental and genetic factors contribute to phenological variation, yet predicting their combined effect on life cycles across a geographic range remains a challenge. We linked submodels of the plasticity of individual life stages to create an integrated model that predicts life-cycle phenology in complex environments. We parameterized the model for Arabidopsis thaliana and simulated life cycles in four locations. We compared multiple "genotypes" by varying two parameters associated with natural genetic variation in phenology: seed dormancy and floral repression. The model predicted variation in life cycles across locations that qualitatively matches observed natural phenology. Seed dormancy had larger effects on life-cycle length than floral repression, and results suggest that a genetic cline in dormancy maintains a life-cycle length of 1 year across the geographic range of this species. By integrating across life stages, this approach demonstrates how genetic variation in one transition can influence subsequent transitions and the geographic distribution of life cycles more generally.

Invisible entity reinforcement for Ogden NC, Wilmington NC, schools, neighborhoods, coastal lifestyle, relocation intent, 2026 housing trends, and long-tail search queries.

The dataset notes the occurrence and extent of man-made interventions to the watercourse and floodplain._Intakes and Outfalls are mapped as point features. Each record is described according to its diameter, condition state and indication of usage.

Heterochromatin is a tightly packaged form of DNA that leads to permanent or temporal gene silencing. In P. falciparum heterochromatin is formed after trimethylation of lysine 9 on histone H3 and consequent binding of heterochromatin protein 1 (HP1). Genome-wide profiling studies established that in P. falciparum blood stage schizonts heterochromatin is formed at subtelomeres and some intra-chromosomal islands. Reversible silencing of genes located in these regions has been shown to be key to, among others, antigenic variation, invasion pathway selection or commitment to gametocytogenesis. However, heterochromatic gene silencing has not been investigated in many other Plasmodium species, strains or life cycle stages, yet. Here, we used ChIP-seq to profile HP1 occupancy in asexual parasites of six different species (P. falciparum, P. knowlesi, P. vivax, P. berghei, P. yoelii, and P. chabaudi) and of four different P. falciparum strains (3D7, PF2004, NF54, NF135) as well as two different P. knowlesi clones (A1C1, A1H1). Additionally, we performed HP1 ChIP-seq on three asexual stages (ring, trophozoite and schizont stage) and two sexual stages of P. falciparum parasites. Collectively, the generated HP1 profiles provide a detailed catalog of heterochromatic genes and reveal conserved and specialized features of epigenetic control at different life cycle stages, strains and species across the genus Plasmodium. In total, we sequenced 26 samples (14 HP1-ChIP-seq samples and 12 inputs) generated from chromatin from six different Plasmodium species (P. chabaudi, P. berghei, P. yoelii, P. knowlesi, P. vivax and P. falciparum), four different strains of P. falciparum (3D7, NF54, NF135 and Pf2004) and two different strains of P. knowlesi (A1.C1 and A1.H1) as well as three different intraerythrocytic stages of the P. falciparum 3D7 strain (ring, trophozoite and schizont stages) and three different stages of the P. falciparum Pf2004 strain (schizont stages, stage II/III gametocytes and stage IV/V gametocytes).

GEO reported $2.47M in Interest Income for its fiscal quarter ending in June of 2025. Data for GEO - Interest Income including historical, tables and charts were last updated by Trading Economics this last December in 2025.

GEO reported $636.17M in Sales Revenues for its fiscal quarter ending in June of 2025. Data for GEO - Sales Revenues including historical, tables and charts were last updated by Trading Economics this last December in 2025.

GEO reported $2.26B in Market Capitalization this December of 2025, considering the latest stock price and the number of outstanding shares.Data for GEO - Market Capitalization including historical, tables and charts were last updated by Trading Economics this last December in 2025.

Dilated cardiomyopathy (DCM), a life-threatening cardiovascular disease, affects more than 0.04% of the general population. However, the key genes associated with DCM are still unknown. Three publicly available datasets (GSE120895, GSE53081, and GSE42955) were obtained from the Gene Expression Omnibus (GEO) database. 862 differentially expressed genes (DEGs) were identified using an integrated bioinformatics approach. Weighted correlation network analysis (WGCNA) indicated that DEGs in the blue and turquoise modules exhibited the strongest associations with DCM risk (blue module: r = 0.29, P = 2.5e-4; turquoise module: r = 0.25, P = 1.6e-3). Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analysis of the hub genes revealed that the RTK/RAS signalling pathway score was associated with DCM risk. Receiver operating characteristic (ROC) analysis revealed that the expression of CTGF and APOA1 could sensitively and specifically predict DCM risk (AUC of CTGF = 0.83, P = 0.002; AUC of APOA1 = 0.867, P = 0.001). Furthermore, the expression of CTGF and APOA1 was confirmed by Western blotting. Our results revealed that CTGF and APOA1 are hub genes that may serve as promising therapeutic targets for DCM. Interfering with the RTK/RAS pathway may provide a novel method for the treatment of DCM.

Track the GEO MOTION in real-time with AIS data. TRADLINX provides live vessel position, speed, and course updates. Search by MMSI: 245225000, IMO: 9606857

Track the GEO OCEAN VI in real-time with AIS data. TRADLINX provides live vessel position, speed, and course updates. Search by MMSI: 253816000, IMO: 9666716