Clinical information of trials using HAG regimen in this study.

Clinical information of trials using CAG regimen in this study.

Clinical information of trials using intensive chemotherapy in this study.

The Voice Conversion Challenge (VCC) 2016, one of the special sessions at Interspeech 2016, deals with speaker identity conversion, referred as Voice Conversion (VC). The task of the challenge was speaker conversion, i.e., to transform the voice identity of a source speaker into that of a target speaker while preserving the linguistic content. Using a common dataset consisting of 162 utterances for training and 54 utterances for evaluation from each of 5 source and 5 target speakers, 17 groups working in VC around the world developed their own VC systems for every combination of the source and target speakers, i.e., 25 systems in total, and generated voice samples converted by the developed systems. The objective of the VCC was to compare various VC techniques on identical training and evaluation speech data. The samples were evaluated in terms of target speaker similarity and naturalness by 200 listeners in a controlled environment. This section of the VCC repository contains the listening test results for four of the source-target pairs (two intra-gender and two cross-gender) in more detail. Multidimensional scaling was performed to illustrate where each system was perceived to be in an acoustic space compared to the source and target speakers and to each other. See also item 'The Voice Conversion Challenge 2016' (DOI: 10.7488/ds/1430)

Introduction: Sentrin-specific protease 1 (SENP1) is a protein whose main function is deSUMOylation. SENP1 inhibits apoptosis, and increases angiogenesis, estrogen and androgen receptor transcription and c-Jun transcription factor, proliferation, growth, cell migration, and invasion of cancer. The in vivo and in vitro studies also demonstrated which natural compounds, especially phytochemicals, minerals, and vitamins, prevent cancer. More than 3,000 plant species have been reported in modern medicine. Natural compounds have many anti-cancerous andanti-turmeric properties such as antioxidative, antiangiogenic, antiproliferative, and pro-apoptotic properties.Methods: In this study, we investigated the interaction of some natural compounds with SENP1 to inhibit its activity. We also screened the ZINC database including natural compounds. Molecular docking was performed, and toxicity of compounds was determined; then, molecular dynamics simulation (MDS) and essential dynamics (ED) were performed on natural compounds with higher free binding energies and minimal side effects. By searching in a large library, virtual screening of the ZINC database was performed using LibDock and CDOCKER, and the final top 20 compounds were allowed for docking against SENP1. According to the docking study, the top three leading molecules were selected and further analyzed by MDS and ED.Results: The results suggest that resveratrol (from the selected compounds) and ZINC33916875 (from the ZINC database) could be more promising SENP1 inhibitory ligands.Discussion: Because these compounds can inhibit SENP1 activity, then they can be novel candidates for cancer treatment. However, wet laboratory experiments are needed to validate their efficacy as SENP1 inhibitors.