In 2020, there were around four deaths per one million population among female adults in the United States due to malignant mesothelioma. Mesothelioma is a cancer caused by exposure to asbestos. This statistic illustrates the death rate of malignant mesothelioma among female adults in the United States from 1999 to 2020.

Background and aimPatients with interstitial lung diseases, including asbestosis, showed high susceptibility to the SARS-CoV-2 virus and a high risk of severe COVID-19 symptoms. Italy, highly impacted by asbestos-related diseases, in 2020 was among the European countries with the highest number of COVID-19 cases. The mortality related to malignant mesotheliomas and asbestosis in 2020 and its relationship with COVID-19 in Italy are investigated.MethodsAll death certificates involving malignant mesotheliomas or asbestosis in 2010–2020 and those involving COVID-19 in 2020 were retrieved from the National Registry of Causes of Death. Annual mortality rates and rate ratios (RRs) of 2020 and 2010–2014 compared to 2015–2019 were calculated. The association between malignant pleural mesothelioma (MPM) and asbestosis with COVID-19 in deceased adults ≥80 years old was evaluated through a logistic regression analysis (odds ratios: ORs), using MPM and asbestosis deaths COVID-19-free as the reference group. The hospitalization for asbestosis in 2010–2020, based on National Hospital Discharge Database, was analyzed.ResultsIn 2020, 746,343 people died; out of them, 1,348 involved MPM and 286 involved asbestosis. Compared to the period 2015–2019, the mortality involving the two diseases decreased in age groups below 80 years; meanwhile, an increasing trend was observed in subjects aged 80 years and older, with a relative mortality risks of 1.10 for MPM and 1.17 for asbestosis. In subjects aged ≥80 years, deaths with COVID-19 were less likely to have MPM in both genders (men: OR = 0.22; women: OR = 0.44), while no departure was observed for asbestosis. A decrease in hospitalization in 2020 with respect to those in 2010–2019 in all age groups, both considering asbestosis as the primary or secondary diagnosis, was observed.ConclusionsThe increasing mortality involving asbestosis and, even if of slight entity, MPM, observed in people aged over 80 years during the 1st year of the COVID-19 pandemic, aligned in part with the previous temporal trend, could be due to several factors. Although no positive association with COVID-19 mortality was observed, the decrease in hospitalizations for asbestosis among individuals aged over 80 years, coupled with the increase in deaths, highlights the importance of enhancing home-based assistance during the pandemic periods for vulnerable patients with asbestos-related conditions.

From 1999 to 2020, there were around 64 deaths among U.S. female adults working in education services due to malignant mesothelioma. Mesothelioma is a cancer caused by exposure to asbestos. This statistic illustrates the number of malignant mesothelioma deaths among female adults in the United States from 1999 to 2020, by industry.

From 1999 to 2020, around 11,447 white women in the United States died due to malignant mesothelioma, while around 550 deaths due to the disease were reported among Black U.S. women in the same period. Mesothelioma is a cancer caused by exposure to asbestos. This statistic illustrates the number of malignant mesothelioma deaths among female adults in the United States from 1999 to 2020, by race.

Background: Malignant pleural mesothelioma (MPM) is an aggressive cancer associated with asbestos exposure that urgently requires effective therapeutic strategies. Current treatments are unable to increase significantly patient survival, which is often limited to

Financial overview and grant giving statistics of Mesothelioma Research Foundation of America

python notebook of data preparation, analysis, and visualisation of regional mesothelioma mortality time series data

ObjectivesThe study aimed to determine whether the National Cancer Institute's (NCI) recent suggestion of associations between acrylonitrile (AN) exposure and mortality in lung and bladder cancer and pneumonitis is robust to alternative methods of data analysis.Materials and methodsWe used the Richardson method to indirectly adjust risk ratios (RRs) in relation to AN exposure for potential confounding by smoking and asbestos. We repeated key analyses omitting workers from Plant 4 to account for possible local, historical shipyard-related asbestos exposures.ResultsThe adjustment of lung cancer RRs for confounding by both smoking and asbestos and omitting Plant 4 workers yielded mostly decreased RRs and much less evidence of a positive association with cumulative AN exposure.ConclusionOverall, our reanalysis provided little evidence to support NCI's suggestion of associations between AN exposure and mortality in lung and bladder cancer and pneumonitis.

This record contains raw data related to article “Single-Center 20-Year Experience in Surgical Treatment of Malignant Pleural Mesothelioma"

Objectives: We examined a series of malignant pleural mesothelioma (MPM) patients who consecutively underwent surgery in our institution during the last 20 years. Across this period, we changed our surgical approach to MPM, adopting extended pleurectomy and decortication (eP/D) instead of extrapleural pneumonectomy (EPP). In this study, we compare the perioperative outcomes and long-term survival of patients who underwent EPP vs. eP/D.

Methods: A retrospective analysis was carried out of all the MPM patients identified from our departmental database who underwent EPP or P/D from 2000 to 2021. Clavien-Dindo criteria was adopted to score postoperative complications, while Kaplan-Meier methods and a Cox multivariable analysis were used to perform the survival analysis.

Results: Of 163 patients, 78 (48%) underwent EPP and 85 (52%) eP/D. Induction chemotherapy was significantly administrated more often in the eP/D group (88% vs. 51%). Complete trimodality treatment including induction chemotherapy, radical surgery, and adjuvant radiotherapy was administered in 74% of the eP/D group versus 32% of the EPP group (p < 0.001). The postoperative morbidity rate was higher in the eP/D group (54%) compared to the EPP group (36%) (p = 0.02); no statistically significant differences were identified concerning major complications (EPP 43% vs. eP/D 24%, p = 0.08). No statistical differences were identified in 30-day mortality, 90-day mortality, median disease-free, and overall survival statistics between the two groups. The Cox multivariable analysis confirmed no induction chemotherapy (HR, 0.5; p = 0.002), RDW (HR, 1.08; p = 0.02), and the presence of pathological nodal disease (HR, 1.99; p = 0.001) as factors associated with worse survival in the entire series.

Conclusions: Our data support that eP/D is a well-tolerated procedure allowing the implementation of a trimodality strategy (induction chemotherapy, surgery, and radiotherapy) in most MPM patients. When eP/D is offered in this setting, the oncological results are comparable to EPP. To obtain the best oncological results, the goal of surgical resection should be macroscopic complete resection (R0) in carefully selected patients (clinical N0).

The Malignant Mesothelioma market is an evolving sector that focuses on understanding, diagnosing, and treating this aggressive form of cancer primarily linked to asbestos exposure. As a rare yet formidable disease, malignant mesothelioma poses significant challenges to healthcare providers and patients alike. The m

Malignant pleural mesothelioma is an aggressive cancer, heterogeneous in its presentation and behaviour. Despite an increasing knowledge about molecular markers and their diagnostic and prognostic value, they are not used as much as they might be for treatment allocation. It has been recently reported that mesothelioma cells that lack BAP1 (BRCA1 Associated Protein) are sensitive to inhibition of the EZH2 (Enhancer of Zeste Homolog 2) histone methyltransferase. Since we observed strong H3K27me3 (histone H3 lysine 27 trimetylation) immunoreactivity in BAP1 wild-type mesothelioma biopsies, we decided to characterize in vitro the response/resistance of BAP1 wild-type mesothelioma cells to the EZH2 selective inhibitor, EPZ-6438. Here we demonstrate that BAP1 wild-type mesothelioma cells were rendered sensitive to EPZ-6438 upon SIRT1 (Sirtuin 1) silencing/inhibition or when cultured as multicellular spheroids, in which SIRT1 expression was lower compared to cells grown in monolayers. Notably, treatment of spheroids with EPZ-6438 abolished H3K27me3 and induced the expression of CDKN2A (Cyclin-Dependent Kinase Inhibitor 2A), causing cell growth arrest. EPZ-6438 treatment also resulted in a rapid and sustained induction of the genes encoding HIF2α (Hypoxia Inducible Factor 2α), TG2 (Transglutaminase 2) and IL-6 (Interleukin 6). Loss of CDKN2 is a common event in mesothelioma. CDKN2A silencing in combination with EPZ-6438 treatment induced apoptotic death in mesothelioma spheroids. In a CDKN2A wild-type setting apoptosis was induced by combining EPZ-6438 with 1-155, a TG2 selective and irreversible inhibitor. In conclusion, our data suggests that the expression of CDKN2A predicts cell fate in response to EZH2 inhibition and could potentially stratify tumors likely to undergo apoptosis.

Annual data and 5 year summaries of deaths from cancer in Scotland. Data is presented by Cancer Network Region and Health Board; within Scotland and Network levels of reporting, the mortality figures are further broken down by age group and sex. The cancer sites reported on include: bladder, bone and connective tissue, brain and central nervous system, breast colorectal, female genital organs, head and neck, hodgkin lymphoma, kidney, leukaemias, liver, lung and mesothelioma, male genital organs, multiple myeloma, non-hodgkin lymphoma, oesophageal, pancreatic, skin, stomach. Further information on cancer incidence can be found in the annual publication. All publications and supporting material to this topic area can be found on the ISD Scotland Website.

The Malignant Pleural Mesothelioma Treatment market is a critical sector within the healthcare industry, dedicated to addressing one of the most aggressive forms of cancer caused primarily by asbestos exposure. This rare yet deadly condition primarily affects the pleura, the lining of the lungs, and requires prompt,

There are more than 400,000 new cases of kidney cancer each year, and surgery is its most common treatment. Due to the wide variety in kidney and kidney tumor morphology, there is currently great interest in how tumor morphology relates to surgical outcomes, as well as in developing advanced surgical planning techniques. Automatic semantic segmentation is a promising tool for these efforts, but morphological heterogeneity makes it a difficult problem.

The goal of this challenge is to accelerate the development of reliable kidney and kidney tumor semantic segmentation methodologies. We have produced ground truth semantic segmentations for arterial phase abdominal CT scans of 300 unique kidney cancer patients who underwent partial or radical nephrectomy at our institution. 210 of these have been released for model training and validation, and the remaining 90 will be held out for objective model evaluation (see the detailed data description).

https://kits19.grand-challenge.org/

References

1. “Kidney Cancer Statistics.” World Cancer Research Fund, 12 Sept. 2018, www.wcrf.org/dietandcancer/cancer-trends/kidney-cancer-statistics.

2. “Cancer Diagnosis and Treatment Statistics.” Stages | Mesothelioma | Cancer Research UK, 26 Oct. 2017, www.cancerresearchuk.org/health-professional/cancer-statistics/diagnosis-and-treatment.

3. Kutikov, Alexander, and Robert G. Uzzo. "The RENAL nephrometry score: a comprehensive standardized system for quantitating renal tumor size, location and depth." The Journal of urology 182.3 (2009): 844-853.

4. Ficarra, Vincenzo, et al. "Preoperative aspects and dimensions used for an anatomical (PADUA) classification of renal tumours in patients who are candidates for nephron-sparing surgery." European urology 56.5 (2009): 786-793.

5. Taha, Ahmed, et al. "Kid-Net: Convolution Networks for Kidney Vessels Segmentation from CT-Volumes." arXiv preprint arXiv:1806.06769 (2018).

Mesothelioma is a rare cancer with disproportionately higher death rates for shipping and mining populations. These patients have few treatment options, which can be partially attributed to limited chemotherapy responses for tumors. We initially hypothesized that quinacrine could be combined with cisplatin or pemetrexed to synergistically eliminate mesothelioma cells. The combination with cisplatin resulted in synergistic cell death and the combination with pemetrexed was not synergistic, although novel artificially-generated pemetrexed-resistant cells were more sensitive to quinacrine. Unexpectedly, we discovered cells with NF2 mutations were very sensitive to quinacrine. This change of quinacrine sensitivity was confirmed by NF2 ectopic expression and knockdown in NF2 mutant and wildtype cell lines, respectively. There are few common mutations in mesothelioma and inactivating NF2 mutations are present in up to 60% of these tumors. We found quinacrine alters the expression of over 3000 genes in NF2-mutated cells that were significantly different than quinacrine-induced changes in NF2 wildtype cells. Changes to NF2/hippo pathway biomarkers were validated at the mRNA and protein levels. Additionally, quinacrine induces a G1 phase cell cycle arrest in NF2-mutated cells versus the S phase arrest in NF2-wildtype cells. This study suggests quinacrine may have repurposing potential for a large subset of mesothelioma patients.